Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-beta 1.

PubWeight™: 1.34‹?› | Rank: Top 10%

🔗 View Article (PMC 3992381)

Published in J Immunol on October 01, 2008

Authors

Lucy Woodman1, Salman Siddiqui, Glenn Cruse, Amanda Sutcliffe, Ruth Saunders, Davinder Kaur, Peter Bradding, Christopher Brightling

Author Affiliations

1: Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, United Kingdom.

Articles citing this

Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol (2009) 3.13

IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways. Am J Respir Crit Care Med (2010) 2.36

Point: alterations in airway smooth muscle phenotype do/do not cause airway hyperresponsiveness in asthma. J Appl Physiol (1985) (2012) 2.31

Mast cell-airway smooth muscle crosstalk: the role of thymic stromal lymphopoietin. Chest (2012) 1.50

Tissue remodeling in eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol (2012) 1.20

Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma. J Immunol (2011) 1.11

The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin. J Biol Chem (2009) 1.06

Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma. Am J Respir Crit Care Med (2011) 1.05

The pivotal role of airway smooth muscle in asthma pathophysiology. J Allergy (Cairo) (2011) 0.98

Airway smooth muscle in asthma: just a target for bronchodilation? Clin Chest Med (2012) 0.96

Differentiation of adult stem cells into smooth muscle for vascular tissue engineering. J Surg Res (2009) 0.96

Mast cells are an essential component of human radiation proctitis and contribute to experimental colorectal damage in mice. Am J Pathol (2011) 0.94

Targeting the airway smooth muscle for asthma treatment. Transl Res (2009) 0.94

Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M. J Immunol (2015) 0.92

The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis. PLoS One (2013) 0.92

The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling. Front Immunol (2012) 0.90

Targeting mast cells tryptase in tumor microenvironment: a potential antiangiogenetic strategy. Biomed Res Int (2014) 0.89

CADM1 is a key receptor mediating human mast cell adhesion to human lung fibroblasts and airway smooth muscle cells. PLoS One (2013) 0.88

Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model. Am J Respir Cell Mol Biol (2012) 0.88

Airway smooth muscle proliferation and survival is not modulated by mast cells. Clin Exp Allergy (2009) 0.87

IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk. Allergy (2015) 0.87

Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations. J Allergy Clin Immunol (2009) 0.87

Anti-inflammatory dimethylfumarate: a potential new therapy for asthma? Mediators Inflamm (2013) 0.86

Cytokine and anti-cytokine therapy in asthma: ready for the clinic? Clin Exp Immunol (2009) 0.85

Mast cells in allergic asthma and beyond. Yonsei Med J (2010) 0.85

Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation. PLoS One (2012) 0.85

Airway smooth muscle hypercontractility in asthma. J Allergy (Cairo) (2013) 0.83

CCL2 release by airway smooth muscle is increased in asthma and promotes fibrocyte migration. Allergy (2014) 0.83

Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway. J Immunol (2013) 0.82

Airway smooth muscle chemokine receptor expression and function in asthma. Clin Exp Allergy (2009) 0.80

Do mast cells link obesity and asthma? Allergy (2012) 0.80

Cross-talk between human mast cells and bronchial epithelial cells in plasminogen activator inhibitor-1 production via transforming growth factor-β1. Am J Respir Cell Mol Biol (2015) 0.79

Mast cells in airway diseases and interstitial lung disease. Eur J Pharmacol (2015) 0.79

CADM1 controls actin cytoskeleton assembly and regulates extracellular matrix adhesion in human mast cells. PLoS One (2014) 0.79

Bidirectional Counterregulation of Human Lung Mast Cell and Airway Smooth Muscle β2 Adrenoceptors. J Immunol (2015) 0.76

Lipoxin A4 Attenuates Constitutive and TGF-β1-Dependent Profibrotic Activity in Human Lung Myofibroblasts. J Immunol (2015) 0.75

HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4. J Allergy Clin Immunol (2017) 0.75

Articles cited by this

Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med (2002) 6.52

British Thoracic Society guidelines on diagnostic flexible bronchoscopy. Thorax (2001) 3.95

Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med (1999) 3.84

Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med (2004) 2.81

The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects. Am J Respir Crit Care Med (1997) 2.28

The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med (2005) 1.95

TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol (2002) 1.92

Impaired vascular contractility and blood pressure homeostasis in the smooth muscle alpha-actin null mouse. FASEB J (2000) 1.91

Immunohistochemistry on resin sections: a comparison of resin embedding techniques for small mucosal biopsies. Biotech Histochem (1993) 1.79

Comparison of airway immunopathology of eosinophilic bronchitis and asthma. Thorax (2003) 1.75

Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response. Am J Respir Crit Care Med (1997) 1.71

Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 1.68

Regulation of smooth muscle actin expression and contraction in adult human mesenchymal stem cells. Exp Cell Res (2002) 1.63

Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J (2002) 1.45

Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis. FASEB J (2003) 1.44

Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma. Clin Exp Allergy (2003) 1.37

Multiple roles of alpha-smooth muscle actin in mechanotransduction. Exp Cell Res (2005) 1.33

The differentiation and function of myofibroblasts is regulated by mast cell mediators. J Invest Dermatol (2001) 1.33

The contractile apparatus and mechanical properties of airway smooth muscle. Eur Respir J (2000) 1.33

Eosinophils in asthma and other allergic diseases. Br Med Bull (2000) 1.32

p38 inhibitors prevent TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts. Invest Ophthalmol Vis Sci (2006) 1.28

Cultured lung fibroblasts from ovalbumin-challenged "asthmatic" mice differ functionally from normal. Am J Respir Cell Mol Biol (2007) 1.22

Transforming growth factor-beta induces airway smooth muscle hypertrophy. Am J Respir Cell Mol Biol (2005) 1.20

Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. J Immunol (1995) 1.17

Inflammatory cell microlocalisation and airway dysfunction: cause and effect? Eur Respir J (2007) 1.11

Epidemiology of asthma: the year in review. Curr Opin Pulm Med (2000) 1.08

Immunological and clinical changes in allergic asthmatics following treatment with omalizumab. Int Arch Allergy Immunol (2003) 1.06

Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma. J Allergy Clin Immunol (2001) 1.05

Pathology of mild, severe, and fatal asthma. Am J Respir Crit Care Med (1996) 1.01

Mast cell tryptase potentiates histamine-induced contraction in human sensitized bronchus. Eur Respir J (1997) 0.98

Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone. J Med Chem (2003) 0.96

Decreased expression of smooth muscle alpha-actin results in decreased contractile function of the mouse bladder. J Urol (2004) 0.92

Modulation of enzymatic activity of human mast cell tryptase and chymase by protease inhibitors. Acta Pharmacol Sin (2003) 0.89

Lactoferrin, a potent tryptase inhibitor, abolishes late-phase airway responses in allergic sheep. Am J Respir Crit Care Med (1997) 0.89

Airway remodeling: a comparison between fatal and nonfatal asthma. J Asthma (2004) 0.87

The mast cell as a source of cytokines in asthma. Ann N Y Acad Sci (1996) 0.83

Voltage-dependent and calcium-activated ion channels in the human mast cell line HMC-1. J Leukoc Biol (2001) 0.83

Inhibitors of mast cell tryptase beta as therapeutics for the treatment of asthma and inflammatory disorders. Pulm Pharmacol Ther (2004) 0.82

Number of pericryptal fibroblasts correlates with density of distinct mast cell phenotypes in the crypt lamina propria of human duodenum: implications for the homeostasis of villous architecture. Anat Rec A Discov Mol Cell Evol Biol (2006) 0.81

Articles by these authors

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet (2002) 8.57

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J (2013) 8.39

Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med (2009) 8.36

Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med (2002) 6.52

Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma. Am J Respir Crit Care Med (2013) 4.95

Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med (2006) 4.83

Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax (2007) 2.37

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol (2012) 2.24

Self-efficacy partially mediates the effect of a school-based physical-activity intervention among adolescent girls. Prev Med (2004) 2.23

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma. Eur Respir J (2012) 2.11

Vibratory Urticaria Associated with a Missense Variant in ADGRE2. N Engl J Med (2016) 2.09

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med (2012) 2.08

Induced sputum inflammatory mediator concentrations in chronic cough. Am J Respir Crit Care Med (2003) 1.98

The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med (2005) 1.95

Increased sputum and bronchial biopsy IL-13 expression in severe asthma. J Allergy Clin Immunol (2008) 1.92

TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol (2002) 1.92

IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma. Am J Respir Crit Care Med (2010) 1.91

Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol (2005) 1.87

Enjoyment mediates effects of a school-based physical-activity intervention. Med Sci Sports Exerc (2005) 1.77

Airway hyperresponsiveness is dissociated from airway wall structural remodeling. J Allergy Clin Immunol (2008) 1.76

Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. Chest (2010) 1.73

Acylhydrazide Schiff bases: DPPH radical and superoxide anion scavengers. Med Chem (2012) 1.55

Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma. Am J Respir Crit Care Med (2006) 1.53

Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis. J Allergy Clin Immunol (2004) 1.52

Validation of a photoacoustic gas analyser for the measurement of functional residual capacity using multiple-breath inert gas washout. Respiration (2014) 1.44

C3a, mast cells, and asthma. FASEB J (2005) 1.42

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma. J Allergy Clin Immunol (2011) 1.38

Differences in physical activity between black and white girls living in rural and urban areas. J Sch Health (2002) 1.37

The faith, activity, and nutrition (FAN) program: design of a participatory research intervention to increase physical activity and improve dietary habits in African American churches. Contemp Clin Trials (2010) 1.37

Correlates of physical activity among U.S. young adults, 18 to 30 years of age, from NHANES III. Ann Behav Med (2003) 1.35

Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses. FASEB J (2006) 1.30

Relationships between stigma, social support, and depression in HIV-infected African American women living in the rural Southeastern United States. J Assoc Nurses AIDS Care (2009) 1.30

Functional transient receptor potential melastatin 7 channels are critical for human mast cell survival. J Immunol (2007) 1.30

Translating policies into practice: a framework to prevent childhood obesity in afterschool programs. Health Promot Pract (2012) 1.28

Clinical, radiologic, and induced sputum features of chronic obstructive pulmonary disease in nonsmokers: a descriptive study. Am J Respir Crit Care Med (2002) 1.27

The Faith, Activity, and Nutrition program: a randomized controlled trial in African-American churches. Am J Prev Med (2013) 1.26

Using the RE-AIM framework to evaluate a physical activity intervention in churches. Prev Chronic Dis (2007) 1.25

Implementation of a faith-based physical activity intervention: insights from church health directors. J Community Health (2008) 1.24

Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol (2008) 1.23

KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation. Am J Respir Cell Mol Biol (2007) 1.20

Physical self-concept and self-esteem mediate cross-sectional relations of physical activity and sport participation with depression symptoms among adolescent girls. Health Psychol (2006) 1.20

Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. J Allergy Clin Immunol (2013) 1.19

Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes. Thorax (2010) 1.19

Validity of social-cognitive measures for physical activity in middle-school girls. J Pediatr Psychol (2009) 1.17

Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis. J Allergy Clin Immunol (2007) 1.17

Psychosocial correlates of physical activity in white and African-American girls. J Adolesc Health (2002) 1.16

An overview of "The Active by Choice Today" (ACT) trial for increasing physical activity. Contemp Clin Trials (2007) 1.16

Structured physical activity and psychosocial correlates in middle-school girls. Prev Med (2007) 1.15

The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells. J Allergy Clin Immunol (2004) 1.15

Results of the "Active by Choice Today" (ACT) randomized trial for increasing physical activity in low-income and minority adolescents. Health Psychol (2011) 1.15

Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: implications for tissue mast cell migration. J Leukoc Biol (2005) 1.14

The reclassification of asthma based on subphenotypes. Curr Opin Allergy Clin Immunol (2007) 1.14

Evaluation of internal medicine residents as exercise role models and associations with self-reported counseling behavior, confidence, and perceived success. Teach Learn Med (2006) 1.10

Bronchoalveolar lavage invariant natural killer T cells are not increased in asthma. J Allergy Clin Immunol (2007) 1.08

Activation of human mast cells through the platelet-activating factor receptor. J Allergy Clin Immunol (2010) 1.08

Determinants of physical activity in middle school children. Am J Health Behav (2002) 1.06

Factors that influence exercise among adults with arthritis in three activity levels. Prev Chronic Dis (2006) 1.05

Inhibition of human mast cell proliferation and survival by tamoxifen in association with ion channel modulation. J Allergy Clin Immunol (2003) 1.05

Long-term effects of a physical activity intervention in high school girls. Am J Prev Med (2007) 1.05

Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma. Am J Respir Crit Care Med (2011) 1.05

8 Steps to Fitness: a faith-based, behavior change physical activity intervention for African Americans. J Phys Act Health (2009) 1.05

Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor. Eur J Immunol (2007) 1.04

TNF-alpha in asthma. Curr Opin Pharmacol (2007) 1.04

The relationship between clinical outcomes and medication adherence in difficult-to-control asthma. Thorax (2012) 1.04

Physical activities and sedentary pursuits in African American and Caucasian girls. Res Q Exerc Sport (2004) 1.04

Self-regulation and physical activity: the relationship in older adults. Am J Health Behav (2007) 1.03

Putting lung function and physiology into perspective: cystic fibrosis in adults. Respirology (2014) 1.02

The tissue microlocalisation and cellular expression of CD163, VEGF, HLA-DR, iNOS, and MRP 8/14 is correlated to clinical outcome in NSCLC. PLoS One (2011) 1.01

Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J Immunol (2006) 1.00

Beta2-adrenoceptor regulation of the K+ channel iKCa1 in human mast cells. FASEB J (2005) 0.99

Measuring physical activity self-regulation strategies in older adults. J Phys Act Health (2009) 0.98

Airway wall expression of OX40/OX40L and interleukin-4 in asthma. Chest (2010) 0.96

Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin. J Immunol (2010) 0.96

CRACM/Orai ion channel expression and function in human lung mast cells. J Allergy Clin Immunol (2012) 0.96

Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13. Respir Res (2010) 0.95

Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma. Thorax (2011) 0.95

Functional KCa3.1 K+ channels are required for human fibrocyte migration. J Allergy Clin Immunol (2011) 0.95