Functional KCa3.1 K+ channels are required for human fibrocyte migration.

The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis. PLoS One (2013) 0.92

Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model. Am J Respir Cell Mol Biol (2012) 0.88

Circulating fibrocytes prepare the lung for cancer metastasis by recruiting Ly-6C+ monocytes via CCL2. J Immunol (2013) 0.87

Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent. Respir Res (2014) 0.86

K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma. PLoS One (2013) 0.84

Functional KCa3.1 channels regulate steroid insensitivity in bronchial smooth muscle cells. J Immunol (2013) 0.82

Complementary roles of KCa3.1 channels and β1-integrin during alveolar epithelial repair. Respir Res (2015) 0.81

Hydrogen Sulfide: A Therapeutic Candidate for Fibrotic Disease? Oxid Med Cell Longev (2015) 0.79

The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling. Mol Biol Cell (2015) 0.78

The calcium-activated potassium channel KCa3.1 is an important modulator of hepatic injury. Sci Rep (2016) 0.77

X-ray irradiation activates K+ channels via H2O2 signaling. Sci Rep (2015) 0.77

Orai/CRACM1 and KCa3.1 ion channels interact in the human lung mast cell plasma membrane. Cell Commun Signal (2015) 0.76

KCa3.1 K+ Channel Expression and Function in Human Bronchial Epithelial Cells. PLoS One (2015) 0.76

Exon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy. Proc Natl Acad Sci U S A (2016) 0.75

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet (2002) 8.57

Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest (2004) 7.91

Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol (2001) 7.40

Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med (1994) 7.19

Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest (2004) 5.97

Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol (2003) 4.69

Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A (2000) 4.01

The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab Invest (2007) 3.15

K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci (2004) 3.12

Impaired endothelium-derived hyperpolarizing factor-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+ channel. Circ Res (2006) 2.67

Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease. Biochem Biophys Res Commun (2006) 2.52

Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis. Am J Respir Cell Mol Biol (2003) 2.51

Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis. Int J Biochem Cell Biol (2008) 2.42

The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med (2005) 1.95

The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest (2008) 1.82

Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. J Biol Chem (2004) 1.81

TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain. J Biol Chem (2006) 1.75

Increased circulating fibrocytes in asthma with chronic airflow obstruction. Am J Respir Crit Care Med (2008) 1.65

Chemokine receptor antagonists: overcoming developmental hurdles. Nat Rev Drug Discov (2008) 1.64

Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia. Blood (2008) 1.61

Functional KCa3.1 K+ channels are required for human lung mast cell migration. Thorax (2006) 1.39

ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood (2002) 1.37

Upregulation of intermediate-conductance Ca2+-activated K+ channel (IKCa1) mediates phenotypic modulation of coronary smooth muscle. Am J Physiol Heart Circ Physiol (2006) 1.35

Fibrocyte localization to the airway smooth muscle is a feature of asthma. J Allergy Clin Immunol (2008) 1.35

Small and intermediate conductance Ca(2+)-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum. Naunyn Schmiedebergs Arch Pharmacol (2004) 1.32

Functional transient receptor potential melastatin 7 channels are critical for human mast cell survival. J Immunol (2007) 1.30

Tissue fibrocytes in patients with mild asthma: a possible link to thickness of reticular basement membrane? Respir Res (2006) 1.25

Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol (2008) 1.23

KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation. Am J Respir Cell Mol Biol (2007) 1.20

Functional importance of Ca2+-activated K+ channels for lysophosphatidic acid-induced microglial migration. Eur J Neurosci (2004) 1.16

The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells. J Allergy Clin Immunol (2004) 1.15

Activation of the human intermediate-conductance Ca(2+)-activated K(+) channel by 1-ethyl-2-benzimidazolinone is strongly Ca(2+)-dependent. Biochim Biophys Acta (1999) 1.14

Resting and activation-dependent ion channels in human mast cells. J Immunol (2001) 1.10

The K+ channels K(Ca)3.1 and K(v)1.3 as novel targets for asthma therapy. Br J Pharmacol (2009) 1.08

Inhibition of human mast cell proliferation and survival by tamoxifen in association with ion channel modulation. J Allergy Clin Immunol (2003) 1.05

Disruption of the Gardos channel (KCa3.1) in mice causes subtle erythrocyte macrocytosis and progressive splenomegaly. Pflugers Arch (2008) 1.04

K(+) channel-dependent migration of fibroblasts and human melanoma cells. Cell Physiol Biochem (1999) 1.00

Polarized ion transport during migration of transformed Madin-Darby canine kidney cells. Pflugers Arch (1995) 0.99

Beta2-adrenoceptor regulation of the K+ channel iKCa1 in human mast cells. FASEB J (2005) 0.99

CCL11 and GM-CSF differentially use the Rho GTPase pathway to regulate motility of human eosinophils in a three-dimensional microenvironment. J Immunol (2008) 0.92

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet (2002) 8.57

Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med (2009) 8.36

Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med (2002) 6.52

Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma. Am J Respir Crit Care Med (2013) 4.95

Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med (2006) 4.83

Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol (2010) 3.12

The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. Am J Respir Crit Care Med (2007) 2.44

Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax (2007) 2.37

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol (2012) 2.24

Self-efficacy partially mediates the effect of a school-based physical-activity intervention among adolescent girls. Prev Med (2004) 2.23

Induced sputum inflammatory mediator concentrations in chronic cough. Am J Respir Crit Care Med (2003) 1.98

The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med (2005) 1.95

Increased sputum and bronchial biopsy IL-13 expression in severe asthma. J Allergy Clin Immunol (2008) 1.92

TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol (2002) 1.92

IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma. Am J Respir Crit Care Med (2010) 1.91

Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol (2005) 1.87

The influence of age on induced sputum differential cell counts in normal subjects. Chest (2004) 1.82

Enjoyment mediates effects of a school-based physical-activity intervention. Med Sci Sports Exerc (2005) 1.77

Airway hyperresponsiveness is dissociated from airway wall structural remodeling. J Allergy Clin Immunol (2008) 1.76

Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma. Am J Respir Crit Care Med (2006) 1.53

Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis. J Allergy Clin Immunol (2004) 1.52

Dedicated Severe Asthma Services Improve Health-care Use and Quality of Life. Chest (2015) 1.50

C3a, mast cells, and asthma. FASEB J (2005) 1.42

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma. J Allergy Clin Immunol (2011) 1.38

The faith, activity, and nutrition (FAN) program: design of a participatory research intervention to increase physical activity and improve dietary habits in African American churches. Contemp Clin Trials (2010) 1.37

Differences in physical activity between black and white girls living in rural and urban areas. J Sch Health (2002) 1.37

Correlates of physical activity among U.S. young adults, 18 to 30 years of age, from NHANES III. Ann Behav Med (2003) 1.35

Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-beta 1. J Immunol (2008) 1.34

Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses. FASEB J (2006) 1.30

Relationships between stigma, social support, and depression in HIV-infected African American women living in the rural Southeastern United States. J Assoc Nurses AIDS Care (2009) 1.30

Functional transient receptor potential melastatin 7 channels are critical for human mast cell survival. J Immunol (2007) 1.30

Translating policies into practice: a framework to prevent childhood obesity in afterschool programs. Health Promot Pract (2012) 1.28

Clinical, radiologic, and induced sputum features of chronic obstructive pulmonary disease in nonsmokers: a descriptive study. Am J Respir Crit Care Med (2002) 1.27

The Faith, Activity, and Nutrition program: a randomized controlled trial in African-American churches. Am J Prev Med (2013) 1.26

Using the RE-AIM framework to evaluate a physical activity intervention in churches. Prev Chronic Dis (2007) 1.25

Implementation of a faith-based physical activity intervention: insights from church health directors. J Community Health (2008) 1.24

Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol (2008) 1.23

KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation. Am J Respir Cell Mol Biol (2007) 1.20

Physical self-concept and self-esteem mediate cross-sectional relations of physical activity and sport participation with depression symptoms among adolescent girls. Health Psychol (2006) 1.20

Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes. Thorax (2010) 1.19

Validity of social-cognitive measures for physical activity in middle-school girls. J Pediatr Psychol (2009) 1.17

Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis. J Allergy Clin Immunol (2007) 1.17

Psychosocial correlates of physical activity in white and African-American girls. J Adolesc Health (2002) 1.16

An overview of "The Active by Choice Today" (ACT) trial for increasing physical activity. Contemp Clin Trials (2007) 1.16

Structured physical activity and psychosocial correlates in middle-school girls. Prev Med (2007) 1.15

Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry. Thorax (2010) 1.15

The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells. J Allergy Clin Immunol (2004) 1.15

Results of the "Active by Choice Today" (ACT) randomized trial for increasing physical activity in low-income and minority adolescents. Health Psychol (2011) 1.15

Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: implications for tissue mast cell migration. J Leukoc Biol (2005) 1.14

The reclassification of asthma based on subphenotypes. Curr Opin Allergy Clin Immunol (2007) 1.14

Evaluation of internal medicine residents as exercise role models and associations with self-reported counseling behavior, confidence, and perceived success. Teach Learn Med (2006) 1.10

Activation of human mast cells through the platelet-activating factor receptor. J Allergy Clin Immunol (2010) 1.08

Determinants of physical activity in middle school children. Am J Health Behav (2002) 1.06

Factors that influence exercise among adults with arthritis in three activity levels. Prev Chronic Dis (2006) 1.05

Long-term effects of a physical activity intervention in high school girls. Am J Prev Med (2007) 1.05

Inhibition of human mast cell proliferation and survival by tamoxifen in association with ion channel modulation. J Allergy Clin Immunol (2003) 1.05

Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma. Am J Respir Crit Care Med (2011) 1.05

8 Steps to Fitness: a faith-based, behavior change physical activity intervention for African Americans. J Phys Act Health (2009) 1.05

Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor. Eur J Immunol (2007) 1.04

The relationship between clinical outcomes and medication adherence in difficult-to-control asthma. Thorax (2012) 1.04

Physical activities and sedentary pursuits in African American and Caucasian girls. Res Q Exerc Sport (2004) 1.04

Self-regulation and physical activity: the relationship in older adults. Am J Health Behav (2007) 1.03

The tissue microlocalisation and cellular expression of CD163, VEGF, HLA-DR, iNOS, and MRP 8/14 is correlated to clinical outcome in NSCLC. PLoS One (2011) 1.01

Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J Immunol (2006) 1.00

Beta2-adrenoceptor regulation of the K+ channel iKCa1 in human mast cells. FASEB J (2005) 0.99

Measuring physical activity self-regulation strategies in older adults. J Phys Act Health (2009) 0.98

Airway wall expression of OX40/OX40L and interleukin-4 in asthma. Chest (2010) 0.96

Chromosome 17q21 SNP and severe asthma. J Hum Genet (2010) 0.96

Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin. J Immunol (2010) 0.96

CRACM/Orai ion channel expression and function in human lung mast cells. J Allergy Clin Immunol (2012) 0.96

Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma. Thorax (2011) 0.95

Chemokine receptor expression in tumour islets and stroma in non-small cell lung cancer. BMC Cancer (2010) 0.95

Key factors for providing appropriate medical care in secondary school athletics: athletic training services and budget. J Athl Train (2010) 0.94

Origins of increased airway smooth muscle mass in asthma. BMC Med (2013) 0.94

IgE alone promotes human lung mast cell survival through the autocrine production of IL-6. BMC Immunol (2008) 0.94

Correlates of self-regulation for physical activity among older adults. Am J Health Behav (2006) 0.94

CCL11 and GM-CSF differentially use the Rho GTPase pathway to regulate motility of human eosinophils in a three-dimensional microenvironment. J Immunol (2008) 0.92

HIV-disclosure, social support, and depression among HIV-infected African American women living in the rural southeastern United States. AIDS Educ Prev (2011) 0.91

A novel FcεRIβ-chain truncation regulates human mast cell proliferation and survival. FASEB J (2010) 0.89

A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells. Immunity (2013) 0.89

A physician fitness program: enhancing the physician as an "exercise" role model for patients. Teach Learn Med (2005) 0.89

Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration. Eur J Immunol (2008) 0.89

Factors associated with exercise participation in adults with arthritis. J Aging Phys Act (2008) 0.89

CADM1 is a key receptor mediating human mast cell adhesion to human lung fibroblasts and airway smooth muscle cells. PLoS One (2013) 0.88

Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model. Am J Respir Cell Mol Biol (2012) 0.88

Inflammatory and satellite cells in the quadriceps of patients with COPD and response to resistance training. Chest (2012) 0.88