Published in J Neurosci on January 26, 2005
Variation in dopamine genes influences responsivity of the human reward system. Proc Natl Acad Sci U S A (2008) 2.13
Gene-gene interaction associated with neural reward sensitivity. Proc Natl Acad Sci U S A (2007) 2.02
Genetic approaches to addiction: genes and alcohol. Addiction (2008) 1.70
The neurobiology of psychopathic traits in youths. Nat Rev Neurosci (2013) 1.67
Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. Schizophr Bull (2008) 1.59
Imaging phenotypes of major depressive disorder: genetic correlates. Neuroscience (2009) 1.49
Genes, cognition and brain through a COMT lens. Neuroscience (2009) 1.43
Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk. Am J Psychiatry (2008) 1.33
Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia. Hum Genet (2006) 1.29
Urbanicity, social adversity and psychosis. World Psychiatry (2013) 1.29
Intermediate phenotypes in psychiatric disorders. Curr Opin Genet Dev (2011) 1.27
The genetic basis of addictive disorders. Psychiatr Clin North Am (2012) 1.20
Genetic variation in 5HTTLPR is associated with emotional resilience. Am J Med Genet B Neuropsychiatr Genet (2009) 1.19
Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans. J Neurosci (2009) 1.18
Variations in catechol-O-methyltransferase gene interact with parenting to influence attention in early development. Neuroscience (2009) 1.16
COMT val158met genotype affects recruitment of neural mechanisms supporting fluid intelligence. Cereb Cortex (2008) 1.16
COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition. Biol Psychiatry (2012) 1.16
Complex patterns of genomic admixture within southern Africa. PLoS Genet (2013) 1.12
Dissociable patterns of abnormal frontal cortical activation during anticipation of an uncertain reward or loss in bipolar versus major depression. Bipolar Disord (2013) 1.11
Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans. J Neurosci (2009) 1.11
Dopamine modulation of hippocampal-prefrontal cortical interaction drives memory-guided behavior. Cereb Cortex (2007) 1.11
Impact of interacting functional variants in COMT on regional gray matter volume in human brain. Neuroimage (2008) 1.10
A neurogenetic approach to impulsivity. J Pers (2008) 1.10
Do low levels of stress reactivity signal poor states of health? Biol Psychol (2010) 1.08
Imaging genetics of mood disorders. Neuroimage (2010) 1.06
The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults. Neuroimage (2009) 1.05
Influence of SLC6A3 and COMT variation on neural activation during response inhibition. Biol Psychol (2009) 1.04
The effects of the COMT Val108/158Met polymorphism on BOLD activation during working memory, planning, and response inhibition: a role for the posterior cingulate cortex? Neuropsychopharmacology (2010) 1.04
COMT Val158Met and cognition: main effects and interaction with educational attainment. Genes Brain Behav (2008) 0.98
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Frequency shifts in the anterior default mode network and the salience network in chronic pain disorder. BMC Psychiatry (2013) 0.97
Genetic influences on the dynamics of pain and affect in fibromyalgia. Health Psychol (2010) 0.97
A consideration of select pre-trauma factors as key vulnerabilities in PTSD. Clin Psychol Rev (2012) 0.96
COMT but not serotonin-related genes modulates the influence of childhood abuse on anger traits. Genes Brain Behav (2009) 0.94
Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder. J Psychiatry Neurosci (2009) 0.94
COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge. PLoS One (2013) 0.93
Genetic associations with performance on a behavioral measure of distress intolerance. J Psychiatr Res (2011) 0.93
DRD2 polymorphisms modulate reward and emotion processing, dopamine neurotransmission and openness to experience. Cortex (2012) 0.92
How might stress contribute to increased risk for schizophrenia in children with chromosome 22q11.2 deletion syndrome? J Neurodev Disord (2010) 0.91
Does erotic stimulus presentation design affect brain activation patterns? Event-related vs. blocked fMRI designs. Behav Brain Funct (2008) 0.90
Association between COMT, PTSD, and increased smoking following hurricane exposure in an epidemiologic sample. Psychiatry (2009) 0.88
Catechol-O-methyltransferase modulation of cortisol secretion in psychiatrically at-risk and healthy adolescents. Psychiatr Genet (2010) 0.88
COMT val158met polymorphism and neural pain processing. PLoS One (2012) 0.88
Catechol O-methyltransferase (COMT) VAL158MET functional polymorphism, dental mercury exposure, and self-reported symptoms and mood. J Toxicol Environ Health A (2009) 0.87
Additive gene-environment effects on hippocampal structure in healthy humans. J Neurosci (2014) 0.86
Imaging oxytocin × dopamine interactions: an epistasis effect of CD38 and COMT gene variants influences the impact of oxytocin on amygdala activation to social stimuli. Front Neurosci (2013) 0.86
Review. Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders. Philos Trans R Soc Lond B Biol Sci (2008) 0.86
Gene expression in the anterior cingulate cortex and amygdala of adolescent marmoset monkeys following parental separations in infancy. Int J Neuropsychopharmacol (2008) 0.86
COMT Val158Met genotype as a risk factor for problem behaviors in youth. J Am Acad Child Adolesc Psychiatry (2010) 0.86
The serotonin transporter gene polymorphism and the effect of baseline on amygdala response to emotional faces. Neuropsychologia (2010) 0.86
The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-cardio-facial syndrome (22q11.2 deletion syndrome): An fMRI study. Neuroimage (2010) 0.85
Stressful life events, perceived stress, and 12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms. Stress (2012) 0.85
Emotional symptoms in children: The effect of maternal depression, life events, and COMT genotype. Am J Med Genet B Neuropsychiatr Genet (2009) 0.85
The amygdala: inside and out. F1000 Biol Rep (2011) 0.85
Interaction of chronic stress with serotonin transporter and catechol-O-methyltransferase polymorphisms in predicting youth depression. Depress Anxiety (2010) 0.84
The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation. Mol Pain (2010) 0.83
Distinct effects of repeated restraint stress on basolateral amygdala neuronal membrane properties in resilient adolescent and adult rats. Neuropsychopharmacology (2014) 0.83
Variation in genes involved in dopamine clearance influence the startle response in older adults. J Neural Transm (Vienna) (2011) 0.83
Ratio of dopamine synthesis capacity to D2 receptor availability in ventral striatum correlates with central processing of affective stimuli. Eur J Nucl Med Mol Imaging (2008) 0.82
Generation and characterization of humanized mice carrying COMT158 Met/Val alleles. Neuropsychopharmacology (2014) 0.81
Interaction of catechol O-methyltransferase and serotonin transporter genes modulates effective connectivity in a facial emotion-processing circuitry. Transl Psychiatry (2012) 0.81
Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a meta-analysis. Psychiatr Genet (2014) 0.81
Investigating the molecular basis of major depressive disorder etiology: a functional convergent genetic approach. Ann N Y Acad Sci (2008) 0.80
COMT Val158Met polymorphism and socioeconomic status interact to predict attention deficit/hyperactivity problems in children aged 10-14. Eur Child Adolesc Psychiatry (2009) 0.80
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Differential regulation of catechol-O-methyltransferase expression in a mouse model of aggression. Brain Struct Funct (2011) 0.80
The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation. Dev Sci (2012) 0.80
Catechol-o-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow in medication-free patients with schizophrenia. Biol Psychiatry (2009) 0.80
Affect-modulated startle: interactive influence of catechol-O-methyltransferase Val158Met genotype and childhood trauma. PLoS One (2012) 0.79
Influence of COMT val158met genotype on the depressed brain during emotional processing and working memory. PLoS One (2013) 0.79
Effectiveness, relapse prevention and mechanisms of change of cognitive therapy vs. interpersonal therapy for depression: Study protocol for a randomised controlled trial. Trials (2011) 0.79
Older age may offset genetic influence on affect: The COMT polymorphism and affective well-being across the life span. Psychol Aging (2016) 0.78
Effects of AKAP5 Pro100Leu genotype on working memory for emotional stimuli. PLoS One (2013) 0.78
Catechol-O-methyltransferase Val158Met polymorphism modulates gray matter volume and functional connectivity of the default mode network. PLoS One (2013) 0.78
Genetic influences on the neural and physiological bases of acute threat: A research domain criteria (RDoC) perspective. Am J Med Genet B Neuropsychiatr Genet (2015) 0.78
Common polymorphisms in dopamine-related genes combine to produce a 'schizophrenia-like' prefrontal hypoactivity. Transl Psychiatry (2014) 0.78
Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study. Biol Mood Anxiety Disord (2013) 0.78
Dopaminergic modulation of memory and affective processing in Parkinson depression. Psychiatry Res (2013) 0.78
The influence of COMT Val¹⁵⁸Met genotype on the character dimension cooperativeness in healthy females. Brain Behav (2014) 0.78
Mechanisms of the placebo effect in pain and psychiatric disorders. Pharmacogenomics J (2016) 0.78
Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity. Int J Neuropsychopharmacol (2014) 0.77
Children at risk for depression: memory biases, self-schemas, and genotypic variation. J Affect Disord (2014) 0.77
COMT Val(158)Met genotypes differentially influence subgenual cingulate functional connectivity in healthy females. Front Hum Neurosci (2014) 0.77
Multilevel impact of the dopamine system on the emotion-potentiated startle reflex. Psychopharmacology (Berl) (2014) 0.77
Catechol-O-methyltransferase val158met genotype determines effect of reboxetine on emotional memory in healthy male volunteers. J Psychiatry Neurosci (2014) 0.76
Catechol-O-methyltransferase inhibition alters pain and anxiety-related volitional behaviors through activation of β-adrenergic receptors in the rat. Neuroscience (2015) 0.76
Childhood Trauma and COMT Genotype Interact to Increase Hippocampal Activation in Resilient Individuals. Front Psychiatry (2016) 0.76
COMT genotype and resting brain perfusion in children. Neuroimage (2009) 0.76
The enzymatic activities of brain catechol-O-methyltransferase (COMT) and methionine sulphoxide reductase are correlated in a COMT Val/Met allele-dependent fashion. Neuropathol Appl Neurobiol (2015) 0.75
The role of the COMT val158met polymorphism in mediating aversive learning in visual cortex. Neuroimage (2015) 0.75
Dopaminergic Modulation of Medial Prefrontal Cortex Deactivation in Parkinson Depression. Parkinsons Dis (2015) 0.75
The mediating effect of prefrontal asymmetry on the relationship between the COMT Val(158)Met SNP and trait consummatory positive affect. Cogn Emot (2014) 0.75
Prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study. PLoS One (2014) 0.75
Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making. Soc Cogn Affect Neurosci (2017) 0.75
Further evidence of the limited role of candidate genes in relation to infant-mother attachment outcomes. Attach Hum Dev (2016) 0.75
Drugs as instruments: a new framework for non-addictive psychoactive drug use. Behav Brain Sci (2011) 14.12
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell (2003) 12.50
Serotonin transporter genetic variation and the response of the human amygdala. Science (2002) 9.31
Topiramate for treating alcohol dependence: a randomized controlled trial. JAMA (2007) 6.81
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet (2006) 6.27
Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet (2004) 5.87
Odor cues during slow-wave sleep prompt declarative memory consolidation. Science (2007) 5.51
A genome-wide association study of alcohol dependence. Proc Natl Acad Sci U S A (2010) 4.94
An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry (2008) 4.91
COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science (2003) 4.72
An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res (2005) 3.94
Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study. Arch Gen Psychiatry (2010) 3.88
Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet (2012) 3.73
Temporal and spatial dynamics of brain structure changes during extensive learning. J Neurosci (2006) 3.65
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nat Med (2004) 3.63
Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci (2004) 3.56
Dysfunction of ventral striatal reward prediction in schizophrenia. Neuroimage (2005) 3.48
Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry (2006) 3.44
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med (2006) 3.38
Dissociable systems for gain- and loss-related value predictions and errors of prediction in the human brain. J Neurosci (2006) 3.30
Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals. Neuroimage (2007) 3.25
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Biol Psychiatry (2007) 3.13
Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol Alcohol (2008) 3.13
Genome-wide association study of alcohol dependence. Arch Gen Psychiatry (2009) 3.08
Disconnection of speech-relevant brain areas in persistent developmental stuttering. Lancet (2002) 3.03
The career expectations of medical students: findings of a nationwide survey in Germany. Dtsch Arztebl Int (2012) 2.97
Different assessment tools for intensive care unit delirium: which score to use? Crit Care Med (2010) 2.91
Pathological gambling is linked to reduced activation of the mesolimbic reward system. Nat Neurosci (2005) 2.90
Episodic future thinking reduces reward delay discounting through an enhancement of prefrontal-mediotemporal interactions. Neuron (2010) 2.85
Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving. Am J Psychiatry (2004) 2.84
Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry (2003) 2.82
Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain (2006) 2.75
Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics. Neuroimage (2007) 2.73
Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet (2004) 2.71
Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics. Psychopharmacology (Berl) (2004) 2.69
Broca's area and the language instinct. Nat Neurosci (2003) 2.69
Labile or stable: opposing consequences for memory when reactivated during waking and sleep. Nat Neurosci (2011) 2.66
Genetic variation in human NPY expression affects stress response and emotion. Nature (2008) 2.65
Placebo analgesia: psychological and neurobiological mechanisms. Pain (2013) 2.65
Training-induced brain structure changes in the elderly. J Neurosci (2008) 2.65
A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet (2002) 2.60
Deficient fear conditioning in psychopathy: a functional magnetic resonance imaging study. Arch Gen Psychiatry (2005) 2.58
Changes in gray matter induced by learning--revisited. PLoS One (2008) 2.56
Activation of the opioidergic descending pain control system underlies placebo analgesia. Neuron (2009) 2.55
A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry (2002) 2.51
Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biol Psychiatry (2004) 2.49
Take home maintenance medication in opiate dependence. Dtsch Arztebl Int (2013) 2.46
Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain (2010) 2.41
Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry (2006) 2.31
The neural mechanisms of inter-temporal decision-making: understanding variability. Trends Cogn Sci (2011) 2.27
Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholics. Biol Psychiatry (2009) 2.24
Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics. Psychopharmacology (Berl) (2006) 2.23
A bibliometric analysis of European versus USA research in the field of addiction. Research on alcohol, narcotics, prescription drug abuse, tobacco and steroids 2001-2011. Eur Addict Res (2013) 2.22
The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med (2009) 2.20
Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain (2004) 2.17
Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J Neurosci (2005) 2.15
Escitalopram for the prevention of peginterferon-α2a-associated depression in hepatitis C virus-infected patients without previous psychiatric disease: a randomized trial. Ann Intern Med (2012) 2.14
Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans. Proc Natl Acad Sci U S A (2010) 2.13
Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch Gen Psychiatry (2004) 2.12
Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry (2006) 2.09
Mirrored, imagined and executed movements differentially activate sensorimotor cortex in amputees with and without phantom limb pain. Pain (2010) 2.05
The unpleasantness of perceived dyspnea is processed in the anterior insula and amygdala. Am J Respir Crit Care Med (2008) 2.05
Viewing videotape of themselves while experiencing delirium tremens could reduce the relapse rate in alcohol-dependent patients. Addiction (2007) 2.05
Test-retest reliability of resting-state connectivity network characteristics using fMRI and graph theoretical measures. Neuroimage (2011) 2.03
Gene-gene interaction associated with neural reward sensitivity. Proc Natl Acad Sci U S A (2007) 2.02
A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature (2010) 2.00
Using ancestry-informative markers to define populations and detect population stratification. J Psychopharmacol (2006) 1.98
Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. Arch Gen Psychiatry (2004) 1.98
Adolescent impulsivity phenotypes characterized by distinct brain networks. Nat Neurosci (2012) 1.98
Long-term alteration of pain sensitivity in school-aged children with early pain experiences. Pain (2006) 1.96
Cerebral processing of pain in school-aged children with neonatal nociceptive input: an exploratory fMRI study. Pain (2010) 1.93
Overlapping and distinct neural systems code for subjective value during intertemporal and risky decision making. J Neurosci (2009) 1.92
Oxytocin and reduction of social threat hypersensitivity in women with borderline personality disorder. Am J Psychiatry (2013) 1.91
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav (2014) 1.90