PubRank

Martin Blackledge

Author PubWeight™ 107.43‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structural characterization of flexible proteins using small-angle X-ray scattering. J Am Chem Soc 2007 6.53
2 Identification of slow correlated motions in proteins using residual dipolar and hydrogen-bond scalar couplings. Proc Natl Acad Sci U S A 2005 2.35
3 A structural model for unfolded proteins from residual dipolar couplings and small-angle x-ray scattering. Proc Natl Acad Sci U S A 2005 2.28
4 Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A 2008 2.14
5 Exploring multiple timescale motions in protein GB3 using accelerated molecular dynamics and NMR spectroscopy. J Am Chem Soc 2007 2.04
6 Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings. J Am Chem Soc 2005 1.75
7 Toward a unified representation of protein structural dynamics in solution. J Am Chem Soc 2009 1.55
8 Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation. J Am Chem Soc 2007 1.49
9 A thermodynamic switch modulates abscisic acid receptor sensitivity. EMBO J 2011 1.44
10 NMR characterization of long-range order in intrinsically disordered proteins. J Am Chem Soc 2010 1.43
11 Protein conformational flexibility from structure-free analysis of NMR dipolar couplings: quantitative and absolute determination of backbone motion in ubiquitin. Angew Chem Int Ed Engl 2009 1.38
12 Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings. Structure 2009 1.33
13 Intrinsic disorder in measles virus nucleocapsids. Proc Natl Acad Sci U S A 2011 1.27
14 Quantitative description of backbone conformational sampling of unfolded proteins at amino acid resolution from NMR residual dipolar couplings. J Am Chem Soc 2009 1.24
15 Flexible-meccano: a tool for the generation of explicit ensemble descriptions of intrinsically disordered proteins and their associated experimental observables. Bioinformatics 2012 1.22
16 Describing intrinsically disordered proteins at atomic resolution by NMR. Curr Opin Struct Biol 2013 1.22
17 Simultaneous determination of protein backbone structure and dynamics from residual dipolar couplings. J Am Chem Soc 2006 1.22
18 Domain conformation of tau protein studied by solution small-angle X-ray scattering. Biochemistry 2008 1.20
19 Structure of the vesicular stomatitis virus N⁰-P complex. PLoS Pathog 2011 1.20
20 Mapping the potential energy landscape of intrinsically disordered proteins at amino acid resolution. J Am Chem Soc 2012 1.19
21 Enhanced conformational space sampling improves the prediction of chemical shifts in proteins. J Am Chem Soc 2010 1.18
22 Structural characterization of alpha-synuclein in an aggregation prone state. Protein Sci 2009 1.18
23 Structural biology: Proteins in dynamic equilibrium. Nature 2010 1.16
24 Defining conformational ensembles of intrinsically disordered and partially folded proteins directly from chemical shifts. J Am Chem Soc 2010 1.15
25 Quantitative conformational analysis of partially folded proteins from residual dipolar couplings: application to the molecular recognition element of Sendai virus nucleoprotein. J Am Chem Soc 2008 1.15
26 Anisotropic small amplitude Peptide plane dynamics in proteins from residual dipolar couplings. J Am Chem Soc 2004 1.14
27 pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins. Nucleic Acids Res 2013 1.13
28 Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules. Biochemistry 2009 1.12
29 Solution structure of the C-terminal X domain of the measles virus phosphoprotein and interaction with the intrinsically disordered C-terminal domain of the nucleoprotein. J Mol Recognit 2010 1.10
30 Solution structure of the C-terminal nucleoprotein-RNA binding domain of the vesicular stomatitis virus phosphoprotein. J Mol Biol 2008 1.10
31 Site-specific measurement of slow motions in proteins. J Am Chem Soc 2011 1.10
32 Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy. Chem Rev 2014 1.08
33 Conformational distributions of unfolded polypeptides from novel NMR techniques. J Chem Phys 2008 1.06
34 Structure and dynamics of the nucleocapsid-binding domain of the Sendai virus phosphoprotein in solution. Virology 2004 1.06
35 Intrinsically disordered proteins: from sequence and conformational properties toward drug discovery. Chembiochem 2012 1.03
36 Testing the validity of ensemble descriptions of intrinsically disordered proteins. Proc Natl Acad Sci U S A 2014 1.02
37 Side-chain chi(1) conformations in urea-denatured ubiquitin and protein G from (3)J coupling constants and residual dipolar couplings. J Am Chem Soc 2010 1.02
38 Simultaneous definition of high resolution protein structure and backbone conformational dynamics using NMR residual dipolar couplings. Chemphyschem 2007 1.02
39 ProtSA: a web application for calculating sequence specific protein solvent accessibilities in the unfolded ensemble. BMC Bioinformatics 2009 1.01
40 Sequence-specific solvent accessibilities of protein residues in unfolded protein ensembles. Biophys J 2006 1.00
41 Solution structure and dynamics of Crh, the Bacillus subtilis catabolite repression HPr. J Mol Biol 2002 0.99
42 Structural dynamics of protein backbone phi angles: extended molecular dynamics simulations versus experimental (3) J scalar couplings. J Biomol NMR 2009 0.98
43 Anisotropic collective motion contributes to nuclear spin relaxation in crystalline proteins. J Am Chem Soc 2010 0.98
44 Towards a robust description of intrinsic protein disorder using nuclear magnetic resonance spectroscopy. Mol Biosyst 2011 0.98
45 Visualizing the molecular recognition trajectory of an intrinsically disordered protein using multinuclear relaxation dispersion NMR. J Am Chem Soc 2015 0.97
46 Direct observation of dipolar couplings and hydrogen bonds across a beta-hairpin in 8 M urea. J Am Chem Soc 2007 0.96
47 Nuclear magnetic resonance provides a quantitative description of protein conformational flexibility on physiologically important time scales. Biochemistry 2011 0.96
48 Site-specific backbone dynamics from a crystalline protein by solid-state NMR spectroscopy. J Am Chem Soc 2004 0.95
49 Amino acid bulkiness defines the local conformations and dynamics of natively unfolded alpha-synuclein and tau. J Am Chem Soc 2007 0.94
50 Relaxation-based structure refinement and backbone molecular dynamics of the dynein motor domain-associated light chain. Biochemistry 2003 0.94
51 Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau. J Am Chem Soc 2011 0.94
52 Quantitative analysis of backbone dynamics in a crystalline protein from nitrogen-15 spin-lattice relaxation. J Am Chem Soc 2005 0.93
53 Local dynamic amplitudes on the protein backbone from dipolar couplings: toward the elucidation of slower motions in biomolecules. J Am Chem Soc 2004 0.93
54 The N(0)-binding region of the vesicular stomatitis virus phosphoprotein is globally disordered but contains transient α-helices. Protein Sci 2011 0.93
55 Observation of heteronuclear overhauser effects confirms the 15N-1H dipolar relaxation mechanism in a crystalline protein. J Am Chem Soc 2006 0.93
56 Conformational propensities of intrinsically disordered proteins from NMR chemical shifts. Chemphyschem 2013 0.92
57 Transient electrostatic interactions dominate the conformational equilibrium sampled by multidomain splicing factor U2AF65: a combined NMR and SAXS study. J Am Chem Soc 2014 0.92
58 Structure of the tetramerization domain of measles virus phosphoprotein. J Virol 2013 0.92
59 Accurate characterization of weak macromolecular interactions by titration of NMR residual dipolar couplings: application to the CD2AP SH3-C:ubiquitin complex. Nucleic Acids Res 2009 0.92
60 Measurement of site-specific 13C spin-lattice relaxation in a crystalline protein. J Am Chem Soc 2010 0.91
61 Mapping the population of protein conformational energy sub-states from NMR dipolar couplings. Angew Chem Int Ed Engl 2013 0.89
62 A self-consistent description of the conformational behavior of chemically denatured proteins from NMR and small angle scattering. Biophys J 2009 0.89
63 Mapping the conformational landscape of urea-denatured ubiquitin using residual dipolar couplings. J Am Chem Soc 2007 0.87
64 Pilotin-secretin recognition in the type II secretion system of Klebsiella oxytoca. Mol Microbiol 2011 0.87
65 Sequence-specific mapping of the interaction between urea and unfolded ubiquitin from ensemble analysis of NMR and small angle scattering data. J Am Chem Soc 2012 0.87
66 Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2. Biochemistry 2013 0.87
67 16-fold degeneracy of peptide plane orientations from residual dipolar couplings: analytical treatment and implications for protein structure determination. J Am Chem Soc 2008 0.86
68 Intrinsic dynamics of the partly unstructured PX domain from the Sendai virus RNA polymerase cofactor P. Biophys J 2007 0.85
69 Multi-timescale conformational dynamics of the SH3 domain of CD2-associated protein using NMR spectroscopy and accelerated molecular dynamics. Angew Chem Int Ed Engl 2012 0.84
70 Solution structure, dynamics and thermodynamics of the three SH3 domains of CD2AP. J Biomol NMR 2011 0.84
71 Structure, dynamics, and kinetics of weak protein-protein complexes from NMR spin relaxation measurements of titrated solutions. Angew Chem Int Ed Engl 2011 0.84
72 Solution structure of the sulfite reductase flavodoxin-like domain from Escherichia coli. Biochemistry 2005 0.84
73 Protein backbone dynamics from N-HN dipolar couplings in partially aligned systems: a comparison of motional models in the presence of structural noise. J Magn Reson 2005 0.83
74 Atomic resolution description of the interaction between the nucleoprotein and phosphoprotein of Hendra virus. PLoS Pathog 2013 0.83
75 The influence of nitrogen-15 proton-driven spin diffusion on the measurement of nitrogen-15 longitudinal relaxation times. J Magn Reson 2006 0.82
76 Ultrahigh-resolution backbone structure of perdeuterated protein GB1 using residual dipolar couplings from two alignment media. Angew Chem Int Ed Engl 2006 0.82
77 Long-range correlated dynamics in intrinsically disordered proteins. J Am Chem Soc 2014 0.82
78 Characterization of the interactions between the nucleoprotein and the phosphoprotein of Henipavirus. J Biol Chem 2011 0.82
79 On the origin of NMR dipolar waves in transient helical elements of partially folded proteins. J Am Chem Soc 2008 0.82
80 Characterization of protein dynamics from residual dipolar couplings using the three dimensional Gaussian axial fluctuation model. Proteins 2008 0.81
81 Modulation of the intrinsic helix propensity of an intrinsically disordered protein reveals long-range helix-helix interactions. J Am Chem Soc 2013 0.81
82 Modulation of structure and dynamics by disulfide bond formation in unfolded states. J Am Chem Soc 2012 0.81
83 Residual dipolar couplings in short peptides reveal systematic conformational preferences of individual amino acids. J Am Chem Soc 2006 0.81
84 Structural disorder within sendai virus nucleoprotein and phosphoprotein: insight into the structural basis of molecular recognition. Protein Pept Lett 2010 0.80
85 Conformational and thermodynamic changes of the repressor/DNA operator complex upon monomerization shed new light on regulation mechanisms of bacterial resistance against beta-lactam antibiotics. Nucleic Acids Res 2007 0.80
86 Ensemble structure of the modular and flexible full-length vesicular stomatitis virus phosphoprotein. J Mol Biol 2012 0.80
87 Biophysical characterization of the MerP-like amino-terminal extension of the mercuric reductase from Ralstonia metallidurans CH34. J Biol Inorg Chem 2003 0.79
88 Mapping protein conformational energy landscapes using NMR and molecular simulation. Chemphyschem 2013 0.79
89 Reactivity, secondary structure, and molecular topology of the Escherichia coli sulfite reductase flavodoxin-like domain. Biochemistry 2002 0.79
90 Charge-induced molecular alignment of intrinsically disordered proteins. Angew Chem Int Ed Engl 2006 0.78
91 Investigating protein conformational energy landscapes and atomic resolution dynamics from NMR dipolar couplings: a review. Rep Prog Phys 2015 0.78
92 Measurement and analysis of NMR residual dipolar couplings for the study of intrinsically disordered proteins. Methods Mol Biol 2012 0.78
93 Direct structure determination using residual dipolar couplings: reaction-site conformation of methionine sulfoxide reductase in solution. J Am Chem Soc 2002 0.78
94 Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications. PLoS One 2013 0.77
95 The role of (15)N CSA and CSA/dipole cross-correlation in (15)N relaxation in solid proteins. J Magn Reson 2007 0.77
96 Mapping the conformational mobility of multidomain proteins. Biophys J 2010 0.76
97 Characterizing weak protein-protein complexes by NMR residual dipolar couplings. Eur Biophys J 2011 0.76
98 Ligand-dependent dynamics of the active-site lid in bacterial dimethylarginine dimethylaminohydrolase. Biochemistry 2014 0.76
99 Disentangling the coil: modulation of conformational and dynamic properties by site-directed mutation in the non-native state of hen egg white lysozyme. Biochemistry 2012 0.76
100 Quantitative modelfree analysis of urea binding to unfolded ubiquitin using a combination of small angle X-ray and neutron scattering. J Am Chem Soc 2009 0.76
101 Structural biology turned on its head. Chembiochem 2015 0.75
102 Side chain orientation from methyl 1H-1H residual dipolar couplings measured in highly deuterated proteins. J Am Chem Soc 2002 0.75
103 Residual dipolar couplings measured in unfolded proteins are sensitive to amino-acid-specific geometries as well as local conformational sampling. Biochem Soc Trans 2012 0.75
104 Direct prediction of NMR residual dipolar couplings from the primary sequence of unfolded proteins. Angew Chem Int Ed Engl 2012 0.75
105 NMR study of the interaction between Zn(II) ligated bleomycin and Streptoalloteichus hindustanus bleomycin resistance protein. Biochemistry 2003 0.75
106 Effect of the solvent on the conformation of a depsipeptide: NMR-derived solution structure of hormaomycin in DMSO from residual dipolar couplings in a novel DMSO-compatible alignment medium. Chembiochem 2006 0.75