Published in J Am Chem Soc on February 23, 2007
Biophysical characterization of intrinsically disordered proteins. Curr Opin Struct Biol (2009) 1.98
Residual structure, backbone dynamics, and interactions within the synuclein family. J Mol Biol (2007) 1.43
Sequence feature-based prediction of protein stability changes upon amino acid substitutions. BMC Genomics (2010) 1.13
Allostery in a disordered protein: oxidative modifications to α-synuclein act distally to regulate membrane binding. J Am Chem Soc (2011) 1.08
The role of the lipid bilayer in tau aggregation. Biophys J (2010) 1.08
The intermembrane space domain of Tim23 is intrinsically disordered with a distinct binding region for presequences. Protein Sci (2010) 0.97
p15PAF is an intrinsically disordered protein with nonrandom structural preferences at sites of interaction with other proteins. Biophys J (2014) 0.85
Mechanisms of amyloid formation revealed by solution NMR. Prog Nucl Magn Reson Spectrosc (2015) 0.80
Exploring the accessible conformations of N-terminal acetylated α-synuclein. FEBS Lett (2013) 0.79
Stochastic simulation of structural properties of natively unfolded and denatured proteins. J Mol Model (2012) 0.79
Probing the urea dependence of residual structure in denatured human alpha-lactalbumin. J Biomol NMR (2009) 0.76
A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein. Biochemistry (2014) 0.76
The metastasis suppressor KISS1 is an intrinsically disordered protein slightly more extended than a random coil. PLoS One (2017) 0.75
The loss of inhibitory C-terminal conformations in disease associated P123H β-synuclein. Protein Sci (2015) 0.75
Amyloidogenesis of Tau protein. Protein Sci (2017) 0.75
Structural characterization of flexible proteins using small-angle X-ray scattering. J Am Chem Soc (2007) 6.53
Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. Proc Natl Acad Sci U S A (2005) 3.48
Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A (2008) 2.69
VDAC, a multi-functional mitochondrial protein regulating cell life and death. Mol Aspects Med (2010) 2.36
Identification of slow correlated motions in proteins using residual dipolar and hydrogen-bond scalar couplings. Proc Natl Acad Sci U S A (2005) 2.35
A structural model for unfolded proteins from residual dipolar couplings and small-angle x-ray scattering. Proc Natl Acad Sci U S A (2005) 2.28
Mars -- robust automatic backbone assignment of proteins. J Biomol NMR (2004) 2.22
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A (2008) 2.14
β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons. Ann Neurol (2013) 2.10
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models. EMBO J (2009) 2.09
NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA. Proc Natl Acad Sci U S A (2006) 2.05
Exploring multiple timescale motions in protein GB3 using accelerated molecular dynamics and NMR spectroscopy. J Am Chem Soc (2007) 2.04
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein. J Biol Chem (2008) 1.94
Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings. J Am Chem Soc (2005) 1.75
A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA. J Mol Biol (2008) 1.61
Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol (2009) 1.61
Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem (2009) 1.57
Toward a unified representation of protein structural dynamics in solution. J Am Chem Soc (2009) 1.55
Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions. J Biol Chem (2005) 1.54
Dissociation of amyloid fibrils of alpha-synuclein in supercooled water. Angew Chem Int Ed Engl (2008) 1.51
Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease. Proc Natl Acad Sci U S A (2005) 1.50
Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation. J Am Chem Soc (2007) 1.49
The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli. J Biol Chem (2003) 1.48
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci (2010) 1.46
A thermodynamic switch modulates abscisic acid receptor sensitivity. EMBO J (2011) 1.44
NMR characterization of long-range order in intrinsically disordered proteins. J Am Chem Soc (2010) 1.43
NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation. EMBO J (2004) 1.41
Protein conformational flexibility from structure-free analysis of NMR dipolar couplings: quantitative and absolute determination of backbone motion in ubiquitin. Angew Chem Int Ed Engl (2009) 1.38
Structural properties of pore-forming oligomers of alpha-synuclein. J Am Chem Soc (2009) 1.36
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol (2013) 1.34
Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings. Structure (2009) 1.33
Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation. J Biol Chem (2005) 1.30
Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science (2014) 1.29
Interaction of alpha-synuclein with divalent metal ions reveals key differences: a link between structure, binding specificity and fibrillation enhancement. J Am Chem Soc (2006) 1.28
Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization. J Biol Chem (2005) 1.27
Intrinsic disorder in measles virus nucleocapsids. Proc Natl Acad Sci U S A (2011) 1.27
The "jaws" of the tau-microtubule interaction. J Biol Chem (2007) 1.25
Quantitative description of backbone conformational sampling of unfolded proteins at amino acid resolution from NMR residual dipolar couplings. J Am Chem Soc (2009) 1.24
Flexible-meccano: a tool for the generation of explicit ensemble descriptions of intrinsically disordered proteins and their associated experimental observables. Bioinformatics (2012) 1.22
Describing intrinsically disordered proteins at atomic resolution by NMR. Curr Opin Struct Biol (2013) 1.22
Simultaneous determination of protein backbone structure and dynamics from residual dipolar couplings. J Am Chem Soc (2006) 1.22
Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation. J Mol Biol (2007) 1.21
Domain conformation of tau protein studied by solution small-angle X-ray scattering. Biochemistry (2008) 1.20
Structure of the vesicular stomatitis virus N⁰-P complex. PLoS Pathog (2011) 1.20
Mapping the potential energy landscape of intrinsically disordered proteins at amino acid resolution. J Am Chem Soc (2012) 1.19
Peptide binding induces large scale changes in inter-domain mobility in human Pin1. J Biol Chem (2003) 1.18
Enhanced conformational space sampling improves the prediction of chemical shifts in proteins. J Am Chem Soc (2010) 1.18
Structural characterization of alpha-synuclein in an aggregation prone state. Protein Sci (2009) 1.18
Structural biology: Proteins in dynamic equilibrium. Nature (2010) 1.16
Quantitative conformational analysis of partially folded proteins from residual dipolar couplings: application to the molecular recognition element of Sendai virus nucleoprotein. J Am Chem Soc (2008) 1.15
Defining conformational ensembles of intrinsically disordered and partially folded proteins directly from chemical shifts. J Am Chem Soc (2010) 1.15
Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation. J Am Chem Soc (2008) 1.15
Anisotropic small amplitude Peptide plane dynamics in proteins from residual dipolar couplings. J Am Chem Soc (2004) 1.14
Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork. PLoS Biol (2013) 1.14
pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins. Nucleic Acids Res (2013) 1.13
Sumoylation inhibits alpha-synuclein aggregation and toxicity. J Cell Biol (2011) 1.13
Functional dynamics in the voltage-dependent anion channel. Proc Natl Acad Sci U S A (2010) 1.13
Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules. Biochemistry (2009) 1.12
Solution structure of the C-terminal X domain of the measles virus phosphoprotein and interaction with the intrinsically disordered C-terminal domain of the nucleoprotein. J Mol Recognit (2010) 1.10
Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease. EMBO J (2011) 1.10
Solution structure of the C-terminal nucleoprotein-RNA binding domain of the vesicular stomatitis virus phosphoprotein. J Mol Biol (2008) 1.10
Site-specific measurement of slow motions in proteins. J Am Chem Soc (2011) 1.10
Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy. Chem Rev (2014) 1.08
Imbalance of Hsp70 family variants fosters tau accumulation. FASEB J (2012) 1.07
Conformational distributions of unfolded polypeptides from novel NMR techniques. J Chem Phys (2008) 1.06
High-resolution structure determination of the CylR2 homodimer using paramagnetic relaxation enhancement and structure-based prediction of molecular alignment. J Biomol NMR (2007) 1.06
Structure and dynamics of the nucleocapsid-binding domain of the Sendai virus phosphoprotein in solution. Virology (2004) 1.06
Correlation of amyloid fibril beta-structure with the unfolded state of alpha-synuclein. Chembiochem (2007) 1.06
Phosphorylation drives a dynamic switch in serine/arginine-rich proteins. Structure (2013) 1.05
The native conformation of the human VDAC1 N terminus. Angew Chem Int Ed Engl (2010) 1.05
Automatic assignment of the intrinsically disordered protein Tau with 441-residues. J Am Chem Soc (2010) 1.05
Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem (2010) 1.04
β-Barrel mobility underlies closure of the voltage-dependent anion channel. Structure (2012) 1.04
β-Sheet core of tau paired helical filaments revealed by solid-state NMR. J Am Chem Soc (2012) 1.03
N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits. Acta Neuropathol (2013) 1.03
Intrinsically disordered proteins: from sequence and conformational properties toward drug discovery. Chembiochem (2012) 1.03