Type I interferon dependence of plasmacytoid dendritic cell activation and migration.

PubWeight™: 2.53‹?› | Rank: Top 2%

🔗 View Article (PMC 2213121)

Published in J Exp Med on March 28, 2005

Authors

Carine Asselin-Paturel1, Géraldine Brizard, Karine Chemin, Andre Boonstra, Anne O'Garra, Alain Vicari, Giorgio Trinchieri

Author Affiliations

1: Laboratory for Immunological Research, Schering-Plough Research Institute, Dardilly 69571, France.

Articles citing this

Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant. J Exp Med (2009) 4.27

Pathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion. J Virol (2006) 3.15

Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I. Nat Immunol (2008) 2.82

The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids. Nat Immunol (2013) 2.66

Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol Rev (2010) 2.55

Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections. Cell Host Microbe (2008) 2.18

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase. Proc Natl Acad Sci U S A (2008) 2.18

Production of type I interferons: plasmacytoid dendritic cells and beyond. J Exp Med (2005) 2.14

Control of adaptive immunity by the innate immune system. Nat Immunol (2015) 2.04

HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2007) 2.01

Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood (2008) 1.94

Deficiency of the type I interferon receptor protects mice from experimental lupus. Arthritis Rheum (2007) 1.80

Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo. J Virol (2007) 1.77

Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history. Cytokine Growth Factor Rev (2008) 1.68

Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J Exp Med (2007) 1.68

Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J Clin Invest (2012) 1.66

TAM receptor signaling and autoimmune disease. Curr Opin Immunol (2010) 1.63

NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med (2007) 1.57

Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease. J Immunol (2009) 1.55

Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors. Trends Immunol (2009) 1.49

Differential activation of human monocyte-derived and plasmacytoid dendritic cells by West Nile virus generated in different host cells. J Virol (2007) 1.48

Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation. J Immunol (2008) 1.45

Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo. Proc Natl Acad Sci U S A (2008) 1.44

Dynamics of immature subsets of dendritic cells during antiviral therapy in HLA-A24-positive chronic hepatitis C patients. J Gastroenterol (2006) 1.44

Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration. J Exp Med (2011) 1.41

Dual signaling of MyD88 and TRIF is critical for maximal TLR4-induced dendritic cell maturation. J Immunol (2008) 1.41

Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo. J Exp Med (2011) 1.39

Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection. J Immunol (2008) 1.39

Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of breast cancer cells. J Immunol (2012) 1.36

PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon. Proc Natl Acad Sci U S A (2008) 1.33

The role of type I interferon production by dendritic cells in host defense. Biochimie (2007) 1.33

Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus. PLoS Pathog (2008) 1.32

Interferon alpha in systemic lupus erythematosus. J Biomed Biotechnol (2010) 1.31

Adhesive mechanisms governing interferon-producing cell recruitment into lymph nodes. J Exp Med (2005) 1.29

Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? Nat Rev Immunol (2011) 1.23

CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy. Eur J Immunol (2008) 1.22

Molecular control of steady-state dendritic cell maturation and immune homeostasis. Annu Rev Immunol (2013) 1.13

Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC. J Exp Med (2008) 1.11

Emerging therapies for systemic lupus erythematosus--focus on targeting interferon-alpha. Clin Immunol (2012) 1.09

Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system. Int J Nanomedicine (2012) 1.09

IL-1R1 is required for dendritic cell-mediated T cell reactivation within the CNS during West Nile virus encephalitis. J Exp Med (2013) 1.09

Evaluation of TLR agonists as potential mucosal adjuvants for HIV gp140 and tetanus toxoid in mice. PLoS One (2012) 1.04

Anti-IFN-α/β receptor antibody treatment ameliorates disease in lupus-predisposed mice. J Immunol (2012) 1.03

Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity. J Immunol (2009) 1.02

Plasmacytoid dendritic cell dichotomy: identification of IFN-α producing cells as a phenotypically and functionally distinct subset. J Immunol (2010) 1.02

Lymph node hypertrophy following Leishmania major infection is dependent on TLR9. J Immunol (2011) 1.00

Type I interferon inhibition and dendritic cell activation during gammaherpesvirus respiratory infection. J Virol (2007) 1.00

Type I Interferons are essential for the efficacy of replicase-based DNA vaccines. Vaccine (2006) 0.99

Role of toll-like receptors in immune activation and tolerance in the liver. Front Immunol (2014) 0.96

Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells. J Immunol (2013) 0.95

Production of interferon α by human immunodeficiency virus type 1 in human plasmacytoid dendritic cells is dependent on induction of autophagy. J Infect Dis (2012) 0.95

Type I interferons: diversity of sources, production pathways and effects on immune responses. Curr Opin Virol (2011) 0.95

CD1a expression defines an interleukin-12 producing population of human dendritic cells. Clin Exp Immunol (2009) 0.94

Spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via TLR9-dependent crosstalk with myeloid dendritic cells. PLoS One (2012) 0.93

Cell-cell fusion induced by measles virus amplifies the type I interferon response. J Virol (2007) 0.92

Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells. J Exp Med (2013) 0.92

Measure and countermeasure: type I IFN (IFN-alpha/beta) antiviral response against West Nile virus. J Innate Immun (2009) 0.92

Type I interferon-dependent CD86(high) marginal zone precursor B cells are potent T cell costimulators in mice. Arthritis Rheum (2011) 0.91

A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors. J Exp Med (2013) 0.91

An intranasally delivered Toll-like receptor 7 agonist elicits robust systemic and mucosal responses to Norwalk virus-like particles. Clin Vaccine Immunol (2010) 0.91

Tumour-derived prostaglandin E and transforming growth factor-beta synergize to inhibit plasmacytoid dendritic cell-derived interferon-alpha. Immunology (2009) 0.90

STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response. J Biomed Sci (2009) 0.89

Local administration of TLR ligands rescues the function of tumor-infiltrating CD8 T cells and enhances the antitumor effect of lentivector immunization. J Immunol (2013) 0.89

ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2. J Exp Med (2014) 0.88

Immune plexins and semaphorins: old proteins, new immune functions. Protein Cell (2013) 0.88

Cytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease. Discov Med (2011) 0.86

Binding mode of CpG oligodeoxynucleotides to nanoparticles regulates bifurcated cytokine induction via Toll-like receptor 9. Sci Rep (2012) 0.85

TLR7/9 versus TLR3/MDA5 signaling during virus infections and diabetes. J Leukoc Biol (2011) 0.84

Tickling the TLR7 to cure viral hepatitis. J Transl Med (2014) 0.83

Dysregulated cytokine production by dendritic cells modulates B cell responses in the NZM2410 mouse model of lupus. PLoS One (2014) 0.83

Foot-and-mouth disease virus replicates only transiently in well-differentiated porcine nasal epithelial cells. J Virol (2010) 0.83

Human plasmacytoid dendritic cell accumulation amplifies their type 1 interferon production. Clin Immunol (2010) 0.83

Self-priming determines high type I IFN production by plasmacytoid dendritic cells. Eur J Immunol (2014) 0.82

Post-transcriptional regulation of interferons and their signaling pathways. J Interferon Cytokine Res (2014) 0.82

TLR tolerance reduces IFN-alpha production despite plasmacytoid dendritic cell expansion and anti-nuclear antibodies in NZB bicongenic mice. PLoS One (2012) 0.81

Immunostimulatory effects of three classes of CpG oligodeoxynucleotides on PBMC from HCV chronic carriers. J Immune Based Ther Vaccines (2008) 0.81

A role for IFNgamma in differential superantigen stimulation of conventional versus plasmacytoid DCs. Cell Immunol (2006) 0.81

Identification of dendritic cell subsets responding to genital infection by Chlamydia muridarum. FEMS Immunol Med Microbiol (2009) 0.81

EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells. PLoS One (2013) 0.79

Role of G protein-coupled receptors in control of dendritic cell migration. Biomed Res Int (2014) 0.79

Vitamin K deficiency leads to exacerbation of murine dextran sulfate sodium-induced colitis. J Gastroenterol (2015) 0.78

Flow cytometric gating for spleen monocyte and DC subsets: differences in autoimmune NOD mice and with acute inflammation. J Immunol Methods (2015) 0.78

Plasmacytoid dendritic cells in allogeneic hematopoietic cell transplantation: benefit or burden? Bone Marrow Transplant (2015) 0.78

CD8(+) T Cells Orchestrate pDC-XCR1(+) Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming. Immunity (2017) 0.78

Host STAT2/type I interferon axis controls tumor growth. Int J Cancer (2014) 0.77

c-FLIP-Short reduces type I interferon production and increases viremia with coxsackievirus B3. PLoS One (2014) 0.77

Monitoring Therapeutic Treatments against Burkholderia Infections Using Imaging Techniques. Pathogens (2013) 0.77

Expression of TLR-7, MyD88, NF-kB, and INF-α in B Lymphocytes of Mayan Women with Systemic Lupus Erythematosus in Mexico. Front Immunol (2016) 0.76

The Ebola Interferon Inhibiting Domains Attenuate and Dysregulate Cell-Mediated Immune Responses. PLoS Pathog (2016) 0.76

Type I Interferons as Regulators of Lung Inflammation. Front Immunol (2017) 0.75

Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses. Nat Commun (2017) 0.75

STING-Licensed Macrophages Prime Type I IFN Production by Plasmacytoid Dendritic Cells in the Bone Marrow during Severe Plasmodium yoelii Malaria. PLoS Pathog (2016) 0.75

IgE-mediated enhancement of CD4(+) T cell responses requires antigen presentation by CD8α(-) conventional dendritic cells. Sci Rep (2016) 0.75

Analysis of Transcriptional Signatures in Response to Listeria monocytogenes Infection Reveals Temporal Changes That Result from Type I Interferon Signaling. PLoS One (2016) 0.75

FcγRIIB prevents inflammatory type I IFN production from plasmacytoid dendritic cells during a viral memory response. J Immunol (2015) 0.75

Distinct oxysterol requirements for positioning naïve and activated dendritic cells in the spleen. Sci Immunol (2017) 0.75

Articles cited by this

Dendritic cells and the control of immunity. Nature (1998) 56.54

Toll-like receptors and innate immunity. Nat Rev Immunol (2001) 16.50

Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell (2001) 13.24

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell (1999) 12.50

The nature of the principal type 1 interferon-producing cells in human blood. Science (1999) 10.90

Mouse and human dendritic cell subtypes. Nat Rev Immunol (2002) 10.01

Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A (2004) 9.00

Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat Immunol (2001) 8.31

Reciprocal control of T helper cell and dendritic cell differentiation. Science (1999) 7.28

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26

In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med (1997) 6.53

The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med (2000) 5.74

CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J Exp Med (2001) 4.82

Interferons alpha and beta as immune regulators--a new look. Immunity (2001) 4.75

Dendritic cells in the T-cell areas of lymphoid organs. Immunol Rev (1997) 4.41

Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol (2001) 4.23

Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation. J Exp Med (2003) 3.41

Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines. Eur J Immunol (2003) 3.39

Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci U S A (2003) 3.29

Type I IFNs enhance the terminal differentiation of dendritic cells. J Immunol (1998) 3.19

Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunol Rev (2000) 3.18

Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J Immunol (2003) 3.17

Immune defence in mice lacking type I and/or type II interferon receptors. Immunol Rev (1995) 2.97

Does Toll-like receptor 3 play a biological role in virus infections? Virology (2004) 2.73

Type I interferons produced by dendritic cells promote their phenotypic and functional activation. Blood (2002) 2.59

Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice. Blood (2001) 2.25

Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation. Int Immunol (2002) 2.23

A leukocyte subset bearing HLA-DR antigens is responsible for in vitro alpha interferon production in response to viruses. Nat Immun Cell Growth Regul (1985) 2.17

Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res (1998) 2.04

Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules. Int Immunol (2004) 1.85

IFN-alpha2a induces IP-10/CXCL10 and MIG/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cells. J Leukoc Biol (2002) 1.82

Cutting edge: selective usage of chemokine receptors by plasmacytoid dendritic cells. J Immunol (2001) 1.82

Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c- type 2 dendritic cell precursors and CD11c+ dendritic cells to produce type I IFN. J Immunol (2001) 1.74

Dendritic and natural killer cells cooperate in the control/switch of innate immunity. J Exp Med (2002) 1.68

The inducible CXCR3 ligands control plasmacytoid dendritic cell responsiveness to the constitutive chemokine stromal cell-derived factor 1 (SDF-1)/CXCL12. J Exp Med (2003) 1.63

Requirement for HLA-DR+ accessory cells in natural killing of cytomegalovirus-infected fibroblasts. J Exp Med (1986) 1.63

Differential migration behavior and chemokine production by myeloid and plasmacytoid dendritic cells. Hum Immunol (2002) 1.62

Splenic marginal metallophilic macrophages and marginal zone macrophages are the major interferon-alpha/beta producers in mice upon intravenous challenge with herpes simplex virus. Scand J Immunol (1999) 1.52

Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells. J Leukoc Biol (2004) 1.47

IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation. J Immunol (2002) 1.36

Dendritic cells directly modulate B cell growth and differentiation. J Leukoc Biol (1999) 1.26

Myd88-dependent in vivo maturation of splenic dendritic cells induced by Leishmania donovani and other Leishmania species. Infect Immun (2004) 1.14

The Toll of herpes simplex virus infection. Trends Microbiol (2004) 0.94

Articles by these authors

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature (2010) 10.37

The regulation of IL-10 production by immune cells. Nat Rev Immunol (2010) 9.18

Plasmacytoid dendritic cells in immunity. Nat Immunol (2004) 9.11

In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med (2002) 5.28

Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science (2013) 5.09

Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat Immunol (2006) 5.00

Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med (2002) 4.67

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature (2012) 4.41

Compartmentalized control of skin immunity by resident commensals. Science (2012) 4.19

Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol (2005) 4.01

The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J Exp Med (2002) 3.91

Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo. J Exp Med (2002) 3.86

Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46. Proc Natl Acad Sci U S A (2007) 3.60

A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J Exp Med (2005) 3.59

Interferon-γ links ultraviolet radiation to melanomagenesis in mice. Nature (2011) 3.56

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J Exp Med (2008) 3.50

IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. J Immunol (2004) 3.46

Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation. J Exp Med (2003) 3.41

Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J Immunol (2003) 3.17

Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest (2005) 2.94

Cancer classification using the Immunoscore: a worldwide task force. J Transl Med (2012) 2.88

Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev (2002) 2.86

Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res (2005) 2.83

The immune score as a new possible approach for the classification of cancer. J Transl Med (2012) 2.79

Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity. Nat Immunol (2005) 2.72

Plasmacytoid dendritic cells mediate oral tolerance. Immunity (2008) 2.66

Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Immunity (2006) 2.62

Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity (2009) 2.61

Innate immune mechanisms of colitis and colitis-associated colorectal cancer. Nat Rev Immunol (2010) 2.58

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J Exp Med (2010) 2.57

Strategies for use of IL-10 or its antagonists in human disease. Immunol Rev (2008) 2.52

Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers. Clin Cancer Res (2011) 2.44

The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions. J Immunol (2005) 2.43

Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells. J Exp Med (2008) 2.41

Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals. J Immunol (2002) 2.37

Further checkpoints in Th1 development. Immunity (2002) 2.31

Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody. J Exp Med (2002) 2.25

SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. Nat Med (2003) 2.20

Production of type I interferons: plasmacytoid dendritic cells and beyond. J Exp Med (2005) 2.14

Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts. Cancer Res (2010) 2.13

Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals. J Immunol (2006) 2.11

A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure. Immunity (2002) 2.09

Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J Immunol (2005) 2.05

Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH. J Biol Chem (2005) 2.03

Neutrophils in tuberculosis: friend or foe? Trends Immunol (2011) 1.94

MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo. J Immunol (2005) 1.92

IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. J Clin Invest (2011) 1.90

Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers. PLoS One (2013) 1.86

Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung. Eur J Immunol (2010) 1.84

NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection. Immunity (2012) 1.84

A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers". J Transl Med (2008) 1.77

TGF-β signaling in myeloid cells is required for tumor metastasis. Cancer Discov (2013) 1.76

Tripartite-motif proteins and innate immune regulation. Curr Opin Immunol (2010) 1.73

Cancer and inflammation: promise for biologic therapy. J Immunother (2010) 1.72

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines. Nat Immunol (2012) 1.70

Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement. J Immunol (2004) 1.69

Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy. PLoS One (2012) 1.68

Type I interferon-dependent and -independent expression of tripartite motif proteins in immune cells. Eur J Immunol (2008) 1.67

The inducible CXCR3 ligands control plasmacytoid dendritic cell responsiveness to the constitutive chemokine stromal cell-derived factor 1 (SDF-1)/CXCL12. J Exp Med (2003) 1.63

GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells. J Immunol (2006) 1.59

Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1β production in human macrophages. J Immunol (2011) 1.58

TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells. J Exp Med (2009) 1.58

Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection. J Infect Dis (2005) 1.56

IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J Immunol (2011) 1.56

Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans. Immunol Rev (2008) 1.54

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages. J Cell Sci (2008) 1.52

Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies. J Clin Invest (2015) 1.51

Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells. J Exp Med (2012) 1.50

Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells. J Exp Med (2006) 1.49

Force generation upon T cell receptor engagement. PLoS One (2011) 1.49

IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis. J Exp Med (2012) 1.48

Breakpoints in immunoregulation required for Th1 cells to induce diabetes. Eur J Immunol (2006) 1.48

Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells. Eur J Immunol (2011) 1.45

Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces. Eur J Immunol (2002) 1.44

Assessment of the effect of ribavirin on myeloid and plasmacytoid dendritic cells during interferon-based therapy of chronic hepatitis B patients. Mol Immunol (2012) 1.41

CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production. Int Immunol (2005) 1.40

Tumour escape from immune surveillance through dendritic cell inactivation. Semin Cancer Biol (2002) 1.38

Identification of a macrophage-specific chromatin signature in the IL-10 locus. J Immunol (2005) 1.37

The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas. Cancer Cell (2013) 1.36

Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection. J Immunol (2012) 1.35

Regulation of dendritic cell recruitment by chemokines. Transplantation (2002) 1.31

ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses. Nat Immunol (2006) 1.31

The Ets-1 transcription factor controls the development and function of natural regulatory T cells. J Exp Med (2010) 1.30

Relevance of KIR gene polymorphisms in bone marrow transplantation outcome. Hum Immunol (2002) 1.28

Differentiation of human T(H)-17 cells does require TGF-beta! Nat Immunol (2008) 1.27

The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells. Eur J Immunol (2012) 1.27

The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma. Cancer Res (2012) 1.27

Interleukin-10 in viral diseases and cancer: exiting the labyrinth? Immunol Rev (2004) 1.26

Twenty-first century Foxp3. Nat Immunol (2003) 1.25