Published in Nat Genet on April 10, 2005
Genetic Predisposition of Coronary Artery Disease -- The COROGENE-Study | NCT00417534
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Am J Hum Genet (2005) 6.61
The immune system in atherosclerosis. Nat Immunol (2011) 6.51
Pathway analysis of seven common diseases assessed by genome-wide association. Genomics (2008) 4.11
The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes Immun (2008) 2.17
Genome-wide association studies and the problem of relatedness among advanced intercross lines and other highly recombinant populations. Genetics (2010) 2.06
Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations. J Med Genet (2008) 1.59
NLR functions beyond pathogen recognition. Nat Immunol (2011) 1.57
Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity. Proc Natl Acad Sci U S A (2010) 1.46
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circ Cardiovasc Genet (2012) 1.35
T cells in rheumatoid arthritis. Arthritis Res Ther (2008) 1.33
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nat Genet (2013) 1.30
P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1. J Immunol (2009) 1.25
Regulation of major histocompatibility complex class II gene expression, genetic variation and disease. Genes Immun (2009) 1.21
The inextricable link between atherosclerosis and prototypical inflammatory diseases rheumatoid arthritis and systemic lupus erythematosus. Arthritis Res Ther (2009) 1.15
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Population genetic tools for dissecting innate immunity in humans. Nat Rev Immunol (2013) 1.08
Cardiovascular complications of rheumatoid arthritis: assessment, prevention, and treatment. Rheum Dis Clin North Am (2010) 1.06
Role of the MHC2TA gene in autoimmune diseases. Ann Rheum Dis (2006) 1.06
The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls. Genome Med (2012) 1.03
The MHC2TA -168A>G gene polymorphism is not associated with rheumatoid arthritis in Austrian patients. Arthritis Res Ther (2006) 1.02
Atherosclerosis in rheumatoid arthritis: is it all about inflammation? Nat Rev Rheumatol (2015) 1.02
CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Hum Mol Genet (2010) 1.01
Statin treatment for rheumatoid arthritis: a promising novel indication. Clin Rheumatol (2007) 1.00
Genetic markers of cardiovascular disease in rheumatoid arthritis. Mediators Inflamm (2012) 0.99
Current concepts in the pathogenesis of early rheumatoid arthritis. Best Pract Res Clin Rheumatol (2009) 0.97
Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK. Mol Biol Cell (2005) 0.96
Molecular genetics of atherosclerosis. Hum Genet (2009) 0.95
MHC2TA is associated with rheumatoid arthritis in Japanese patients. Ann Rheum Dis (2006) 0.94
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Molecular genetics of myocardial infarction. Genomic Med (2008) 0.91
Dyslipidaemia in rheumatological autoimmune diseases. Open Cardiovasc Med J (2011) 0.90
Identification of a novel gene for diabetic traits in rats, mice, and humans. Genetics (2014) 0.89
Infection with human cytomegalovirus alters the MMP-9/TIMP-1 balance in human macrophages. J Virol (2008) 0.89
Patterns of constitutive and IFN-gamma inducible expression of HLA class II molecules in human melanoma cell lines. Immunogenetics (2006) 0.88
The evolutionary landscape of cytosolic microbial sensors in humans. Am J Hum Genet (2012) 0.88
High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis? Arthritis Res Ther (2008) 0.88
Polymorphisms in the inflammatory genes CIITA, CLEC16A and IFNG influence BMD, bone loss and fracture in elderly women. PLoS One (2012) 0.87
The MHC2TA -168A/G polymorphism and risk for rheumatoid arthritis: a meta-analysis of 6861 patients and 9270 controls reveals no evidence for association. Ann Rheum Dis (2007) 0.86
Pathogen-driven selection in the human genome. Int J Evol Biol (2013) 0.85
The PYRIN domain in signal transduction. Curr Protein Pept Sci (2007) 0.85
Interaction analysis between HLA-DRB1 shared epitope alleles and MHC class II transactivator CIITA gene with regard to risk of rheumatoid arthritis. PLoS One (2012) 0.84
From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A. Int J Mol Sci (2013) 0.84
Bone marrow-induced Mef2c deficiency delays B-cell development and alters the expression of key B-cell regulatory proteins. Int Immunol (2012) 0.83
Genetic regulation of microglia activation, complement expression, and neurodegeneration in a rat model of traumatic brain injury. Exp Brain Res (2010) 0.83
Fine mapping of gene regions regulating neurodegeneration. PLoS One (2009) 0.83
CIITA is not associated with risk of developing rheumatoid arthritis. Genes Immun (2011) 0.81
Genetic variability in the rat Aplec C-type lectin gene cluster regulates lymphocyte trafficking and motor neuron survival after traumatic nerve root injury. J Neuroinflammation (2013) 0.81
The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus. Genes Immun (2011) 0.81
Variability in the CIITA gene interacts with HLA in multiple sclerosis. Genes Immun (2014) 0.80
Identification of candidate risk gene variations by whole-genome sequence analysis of four rat strains commonly used in inflammation research. BMC Genomics (2014) 0.79
Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality. PLoS One (2006) 0.79
Naturally occurring variation in the Glutathione-S-Transferase 4 gene determines neurodegeneration after traumatic brain injury. Antioxid Redox Signal (2012) 0.78
Protective effect of A at position - 168 in the type III promoter of the MHCIITA gene in systemic lupus erythematosus. Ann Rheum Dis (2007) 0.78
Asymmetric dimethylarginine as a surrogate marker of endothelial dysfunction and cardiovascular risk in patients with systemic rheumatic diseases. Int J Mol Sci (2012) 0.78
A search for non-chromosome 6 susceptibility loci contributing to rheumatoid arthritis. BMC Proc (2009) 0.78
Lack of association of the CIITA -168A→G promoter SNP with myasthenia gravis and its role in autoimmunity. BMC Med Genet (2010) 0.77
Cardiovascular co-morbidity in patients with rheumatic diseases. Arthritis Res Ther (2011) 0.77
Genetic Variations of NLR family genes in Behcet's Disease. Sci Rep (2016) 0.77
Increased prevalence of multiple sclerosis among COPD patients and their first-degree relatives: a population-based study. Lung (2008) 0.77
Methylation of class II transactivator gene promoter IV is not associated with susceptibility to multiple sclerosis. BMC Med Genet (2008) 0.77
Interaction between Treg apoptosis pathways, Treg function and HLA risk evolves during type 1 diabetes pathogenesis. PLoS One (2012) 0.76
Personalized medicine in coronary artery disease: insights from genomic research. Korean Circ J (2009) 0.76
MHC2TA and FCRL3 genes are not associated with rheumatoid arthritis in Mexican patients. Rheumatol Int (2015) 0.76
Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells. PLoS One (2015) 0.76
Construction of an integrative regulatory element and variation map of the murine Tst locus. BMC Genet (2016) 0.75
On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors. J Negat Results Biomed (2005) 0.75
Nonproteolytic roles of 19S ATPases in transcription of CIITApIV genes. PLoS One (2014) 0.75
DNA methylation and mRNA expression of HLA-DQA1 alleles in type 1 diabetes mellitus. Immunology (2016) 0.75
Sequence and Phylogenetic Analysis of the Untranslated Promoter Regions for HLA Class I Genes. J Immunol (2017) 0.75
Increased incidence of rheumatoid arthritis in multiple sclerosis: A nationwide cohort study. Medicine (Baltimore) (2016) 0.75
Association of EVI5 rs11808092, CD58 rs2300747, and CIITA rs3087456 polymorphisms with multiple sclerosis risk: A meta-analysis. Meta Gene (2016) 0.75
Genetic variants in platelet factor 4 modulate inflammatory and platelet activation biomarkers. Circ Cardiovasc Genet (2012) 0.75
Serum Lipid Alterations in Early Rheumatoid Arthritis Patients on Disease Modifying Anti Rheumatoid Therapy. Indian J Clin Biochem (2016) 0.75
The immunology of atherosclerosis. Nat Rev Nephrol (2017) 0.75
Effects of C2ta genetic polymorphisms on MHC class II expression and autoimmune diseases. Immunology (2016) 0.75
CIITA: a master regulator of adaptive immunity shows its innate side in the bone. J Bone Miner Res (2014) 0.75
Rheumatoid arthritis and atypical cardiovascular disease: inflammation changing the clinical presentation. Can Fam Physician (2013) 0.75
Association between the functional MHC2TA -168 A/G polymorphism and susceptibility to rheumatoid arthritis: a meta-analysis. Clin Rheumatol (2015) 0.75
[How do T-cells become activated in joints?]. Z Rheumatol (2010) 0.75
Population Genetics and Natural Selection in Rheumatic Disease. Rheum Dis Clin North Am (2017) 0.75
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med (2007) 12.24
Prepublication data sharing. Nature (2009) 12.24
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med (2007) 9.80
A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum (2006) 9.52
Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data. Lancet (2012) 9.43
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet (2007) 8.74
Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med (2009) 8.73
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48
Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature (2007) 8.03
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol (2004) 7.17
Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet (2008) 7.07
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet (2007) 6.87
Calculating measures of biological interaction. Eur J Epidemiol (2005) 6.82
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet (2008) 6.72
A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum (2004) 6.63
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Am J Hum Genet (2005) 6.61
Analysis and application of European genetic substructure using 300 K SNP information. PLoS Genet (2008) 6.42
A promoter-level mammalian expression atlas. Nature (2014) 6.25
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
Progress and prospects in rat genetics: a community view. Nat Genet (2008) 6.01
The architecture of gene regulatory variation across multiple human tissues: the MuTHER study. PLoS Genet (2011) 5.95
Complex SNP-related sequence variation in segmental genome duplications. Nat Genet (2004) 5.90
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol (2013) 5.89
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study. Lancet (2002) 5.77
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet (2009) 5.75
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32
European population substructure: clustering of northern and southern populations. PLoS Genet (2006) 5.27
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet (2012) 5.11
Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility. PLoS One (2012) 5.03
Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum (2006) 5.03
Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. Pharmacol Ther (2007) 5.02
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet (2005) 4.80
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet (2007) 4.76
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet (2009) 4.71
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet (2010) 4.65
A recurrent mutation in PALB2 in Finnish cancer families. Nature (2007) 4.64
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial. Arthritis Rheum (2006) 4.61
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet (2012) 4.46