Published in Biochem Biophys Res Commun on June 10, 2005
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A (2007) 3.91
Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors. PLoS One (2008) 3.46
Ageing and neuronal vulnerability. Nat Rev Neurosci (2006) 3.36
Mitochondria in neuroplasticity and neurological disorders. Neuron (2008) 3.35
Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proc Natl Acad Sci U S A (2009) 2.33
p53 at a glance. J Cell Sci (2010) 1.88
The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon. EMBO Rep (2009) 1.69
The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. Proc Natl Acad Sci U S A (2007) 1.57
Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin. Mol Biol Cell (2006) 1.51
Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps. Apoptosis (2009) 1.43
Mitochondrial DNA damage and repair in neurodegenerative disorders. DNA Repair (Amst) (2008) 1.31
Delayed treatment with a p53 inhibitor enhances recovery in stroke brain. Ann Neurol (2009) 1.31
Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates. J Neurochem (2008) 1.30
Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. Schizophr Res (2008) 1.29
DNA damage responses in neural cells: Focus on the telomere. Neuroscience (2007) 1.23
Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. Br J Pharmacol (2007) 1.23
Mitochondrial oxidative damage and apoptosis in age-related hearing loss. Mech Ageing Dev (2010) 1.17
Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina. Invest Ophthalmol Vis Sci (2009) 1.15
Multiple transcription factor families regulate axon growth and regeneration. Dev Neurobiol (2011) 1.13
Location, location, location: altered transcription factor trafficking in neurodegeneration. J Neuropathol Exp Neurol (2007) 1.09
Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies. Br J Pharmacol (2012) 1.07
Complement in neuroprotection and neurodegeneration. Trends Mol Med (2010) 1.04
Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress. Mol Cell Biol (2007) 1.03
Oxidative toxicity in neurodegenerative diseases: role of mitochondrial dysfunction and therapeutic strategies. J Toxicol (2011) 0.99
p53 and mitochondrial function in neurons. Biochim Biophys Acta (2014) 0.97
Arginase 2 deletion reduces neuro-glial injury and improves retinal function in a model of retinopathy of prematurity. PLoS One (2011) 0.97
p53 in the CNS: Perspectives on Development, Stem Cells, and Cancer. Genes Cancer (2011) 0.96
Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: how important is BDNF? Br J Pharmacol (2014) 0.96
Role of transcription factors in peripheral nerve regeneration. Front Mol Neurosci (2012) 0.94
Overexpression of human selenoprotein H in neuronal cells ameliorates ultraviolet irradiation-induced damage by modulating cell signaling pathways. Exp Neurol (2009) 0.93
Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration. Neurochem Int (2013) 0.92
Neuronal responses to physiological stress. Front Genet (2012) 0.92
Mechanistic insight into DNA damage and repair in ischemic stroke: exploiting the base excision repair pathway as a model of neuroprotection. Antioxid Redox Signal (2010) 0.91
Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins. J Neurosci (2014) 0.89
Targeting mitochondrially mediated plasticity to develop improved therapeutics for bipolar disorder. Expert Opin Ther Targets (2014) 0.89
Is vitamin E toxic to neuron cells? Cell Mol Neurobiol (2009) 0.86
Role of p53 in neurodegenerative diseases. Neurodegener Dis (2011) 0.86
Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3. PLoS Genet (2015) 0.85
Regulation of p53 function by lysine methylation. Epigenomics (2011) 0.85
Erythropoietin neuroprotection with traumatic brain injury. Pathophysiology (2012) 0.85
Acetylation of the pro-apoptotic factor, p53 in the hippocampus following cerebral ischemia and modulation by estrogen. PLoS One (2011) 0.84
Ischaemic brain damage after stroke: new insights into efficient therapeutic strategies. International Symposium on Neurodegeneration and Neuroprotection. EMBO Rep (2007) 0.83
Inflammatory Response in the CNS: Friend or Foe? Mol Neurobiol (2016) 0.83
APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates. Neurotoxicology (2010) 0.82
Interference of apoptosis in the pathophysiology of subarachnoid hemorrhage. Asian J Neurosurg (2013) 0.81
Experimentally induced diabetes causes glial activation, glutamate toxicity and cellular damage leading to changes in motor function. Front Cell Neurosci (2014) 0.81
Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons. J Neurochem (2010) 0.80
Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression. Cell Death Dis (2013) 0.79
The protective effect of geniposide on human neuroblastoma cells in the presence of formaldehyde. BMC Complement Altern Med (2013) 0.79
Lymphocytes of patients with Alzheimer's disease display different DNA damage repair kinetics and expression profiles of DNA repair and stress response genes. Int J Mol Sci (2013) 0.79
Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury. Exp Neurol (2015) 0.78
No more brain tangles with DeltaNp73. Trends Biochem Sci (2008) 0.78
Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model. Neuroscience (2015) 0.78
The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins. PLoS One (2015) 0.77
Heme oxygenase-1 protects against Alzheimer's amyloid-β(1-42)-induced toxicity via carbon monoxide production. Cell Death Dis (2014) 0.77
Caspase-dependent degradation of MDMx/MDM4 cell cycle regulatory protein in amyloid β-induced neuronal damage. Neurosci Lett (2015) 0.77
Guilty as CHARGED: p53's expanding role in disease. Cell Cycle (2014) 0.77
Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson's disease model. J Neurochem (2016) 0.77
Mouse models of age-related mitochondrial neurosensory hearing loss. Mol Cell Neurosci (2012) 0.77
Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. PLoS One (2013) 0.77
Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease. Neurosci Lett (2011) 0.77
Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury. Brain Sci (2013) 0.77
NF-kappaB activation is associated with homocysteine-induced injury in Neuro2a cells. BMC Neurosci (2008) 0.77
Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. J Alzheimers Dis (2016) 0.76
Activation of p53-regulated pro-apoptotic signaling pathways in PrP-mediated myopathy. BMC Genomics (2009) 0.76
Hck Promotes Neuronal Apoptosis Following Intracerebral Hemorrhage. Cell Mol Neurobiol (2016) 0.76
Large-scale interaction effects reveal missing heritability in schizophrenia, bipolar disorder and posttraumatic stress disorder. Transl Psychiatry (2017) 0.75
Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells. Int J Mol Med (2017) 0.75
Mitochondrial Targeted Antioxidant in Cerebral Ischemia. J Neurol Neurosci (2016) 0.75
Upregulated Expression of SSTR3 is Involved in Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats. Cell Mol Neurobiol (2017) 0.75
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron (2003) 14.03
Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science (2005) 8.86
Superoxide flashes in single mitochondria. Cell (2008) 4.08
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A (2007) 3.91
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci U S A (2004) 3.61
Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem (2002) 3.27
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci (2008) 3.25
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat Neurosci (2008) 3.11
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A (2003) 2.82
"Control" laboratory rodents are metabolically morbid: why it matters. Proc Natl Acad Sci U S A (2010) 2.50
Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease. J Neurochem (2002) 2.45
Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus (2008) 2.44
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev (2008) 2.39
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol (2007) 2.37
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci U S A (2003) 2.35
Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med (2006) 2.32
Calcium orchestrates apoptosis. Nat Cell Biol (2003) 2.27
A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am J Clin Nutr (2007) 2.16
Toll-like receptors in neurodegeneration. Brain Res Rev (2008) 2.15
GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A (2009) 2.15
Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci (2002) 2.14
Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis (2007) 2.08
Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis. Proc Natl Acad Sci U S A (2010) 2.05
Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice. Exp Neurol (2007) 2.04
Acute kidney injury leads to inflammation and functional changes in the brain. J Am Soc Nephrol (2008) 2.03
Toll-like receptor signaling in neural plasticity and disease. Trends Neurosci (2011) 2.01
Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron (2004) 1.99
Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. J Neurochem (2002) 1.99
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med (2011) 1.97
Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin Cancer Res (2006) 1.97
Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Ageing Res Rev (2006) 1.94
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci (2003) 1.91
Modulation of taste sensitivity by GLP-1 signaling. J Neurochem (2008) 1.89
Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia. Ann Neurol (2004) 1.87
Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.86
Evidence for CALM in directing VAMP2 trafficking. Traffic (2007) 1.84
Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. Hippocampus (2009) 1.84
Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med (2006) 1.82
Involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci U S A (2004) 1.77
Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal (2010) 1.77
When neurogenesis encounters aging and disease. Trends Neurosci (2010) 1.73
Membrane properties of rat embryonic multipotent neural stem cells. J Neurochem (2004) 1.73
Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. J Neurochem (2002) 1.71
Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease. Lancet Neurol (2010) 1.71
Age and energy intake interact to modify cell stress pathways and stroke outcome. Ann Neurol (2010) 1.68
Inducible proteopathies. Trends Neurosci (2006) 1.67
Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid beta-peptide: implications for the pathogenesis of Alzheimer's disease. Neuromolecular Med (2002) 1.63
Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. J Neurochem (2007) 1.61
Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis. Ann Neurol (2002) 1.61
hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol (2010) 1.61
Antiparallel β-sheet architecture in Iowa-mutant β-amyloid fibrils. Proc Natl Acad Sci U S A (2012) 1.60
Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess. Endocrinology (2007) 1.59
A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells. Stem Cells (2009) 1.59
Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. Exp Neurol (2008) 1.58
Genome wide profiling of human embryonic stem cells (hESCs), their derivatives and embryonal carcinoma cells to develop base profiles of U.S. Federal government approved hESC lines. BMC Dev Biol (2006) 1.58
beta1 integrin maintains integrity of the embryonic neocortical stem cell niche. PLoS Biol (2009) 1.57
The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women. Br J Nutr (2013) 1.56
Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis. Biochim Biophys Acta (2010) 1.56
Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. J Biol Chem (2008) 1.55
Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia. Ann Neurol (2005) 1.55
Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation. J Neurosci (2008) 1.55
Cardioprotection by intermittent fasting in rats. Circulation (2005) 1.55
An overview of APP processing enzymes and products. Neuromolecular Med (2010) 1.54
Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol (2003) 1.53
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. Neuromolecular Med (2009) 1.53
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res (2008) 1.51
Patterns of laminins and integrins in the embryonic ventricular zone of the CNS. J Comp Neurol (2007) 1.51
Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther (2002) 1.51
Cell-extracellular matrix interactions regulate neural differentiation of human embryonic stem cells. BMC Dev Biol (2008) 1.49
Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron (2011) 1.49
Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res (2007) 1.48
Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. Proc Natl Acad Sci U S A (2007) 1.46
Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res (2003) 1.45
Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors. J Neurochem (2009) 1.45
miR-375 inhibits differentiation of neurites by lowering HuD levels. Mol Cell Biol (2010) 1.43
Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease. Diabetes (2008) 1.42
Recruiting adaptive cellular stress responses for successful brain ageing. Nat Rev Neurosci (2012) 1.42
Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. J Biol Chem (2007) 1.40
Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia. J Neurochem (2009) 1.39
Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease. Pharmacol Rev (2011) 1.38
Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes. Glia (2013) 1.37
Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. FASEB J (2006) 1.36
Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals. J Neurosci (2010) 1.36
GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J Alzheimers Dis (2010) 1.36
Mitochondria and neuroplasticity. ASN Neuro (2010) 1.36
Involvement of notch signaling in wound healing. PLoS One (2007) 1.35
Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender. Genome Biol (2007) 1.35
Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc Natl Acad Sci U S A (2006) 1.35
Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120. J Acquir Immune Defic Syndr (2002) 1.35
Stroke and T-cells. Neuromolecular Med (2005) 1.34
Adverse stress, hippocampal networks, and Alzheimer's disease. Neuromolecular Med (2009) 1.34
Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging. PLoS One (2010) 1.32
A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol Aging (2012) 1.32
Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor. Endocrinology (2003) 1.32
Mitochondrial DNA damage and repair in neurodegenerative disorders. DNA Repair (Amst) (2008) 1.31
Notch: from neural development to neurological disorders. J Neurochem (2008) 1.31
Evidence that nucleocytoplasmic Olig2 translocation mediates brain-injury-induced differentiation of glial precursors to astrocytes. J Neurosci Res (2007) 1.31
Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines. Nat Commun (2012) 1.29