Published in J Cell Sci on June 01, 2003
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev (2005) 5.50
Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication. Genes Dev (2006) 5.15
Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription. Genes Dev (2004) 5.11
The site-specific installation of methyl-lysine analogs into recombinant histones. Cell (2007) 4.22
Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism. Microbiol Mol Biol Rev (2004) 3.67
Mouse centric and pericentric satellite repeats form distinct functional heterochromatin. J Cell Biol (2004) 3.65
Structural and sequence motifs of protein (histone) methylation enzymes. Annu Rev Biophys Biomol Struct (2005) 3.17
The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell (2008) 3.05
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature (2010) 2.91
In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases. J Biol Chem (2004) 2.86
Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences. Mol Cell Biol (2006) 2.68
Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation? Cell Cycle (2007) 2.55
Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev (2005) 2.50
The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions. J Exp Med (2008) 2.50
Loss-of-function mutations in euchromatin histone methyl transferase 1 (EHMT1) cause the 9q34 subtelomeric deletion syndrome. Am J Hum Genet (2006) 2.31
Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications. Nucleic Acids Res (2004) 2.28
Histone modification and the control of heterochromatic gene silencing in Drosophila. Chromosome Res (2006) 2.28
Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294. J Biol Chem (2010) 2.23
Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc Natl Acad Sci U S A (2007) 2.11
Functional dynamics of H3K9 methylation during meiotic prophase progression. EMBO J (2007) 1.96
Footprinting of mammalian promoters: use of a CpG DNA methyltransferase revealing nucleosome positions at a single molecule level. Nucleic Acids Res (2005) 1.94
Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release. Cell (2013) 1.87
K4, K9 and K18 in human histone H3 are targets for biotinylation by biotinidase. FEBS J (2005) 1.84
ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease. Proc Natl Acad Sci U S A (2006) 1.82
Methylation: lost in hydroxylation? EMBO Rep (2005) 1.77
Epigenetics in the placenta. Am J Reprod Immunol (2009) 1.77
Epigenetics as a mechanism driving polygenic clinical drug resistance. Br J Cancer (2006) 1.77
14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation. EMBO J (2007) 1.69
Histone code modifications on pluripotential nuclei of reprogrammed somatic cells. Mol Cell Biol (2004) 1.67
The X and Y chromosomes assemble into H2A.Z-containing [corrected] facultative heterochromatin [corrected] following meiosis. Mol Cell Biol (2006) 1.64
A conserved chromatin architecture marks and maintains the restricted germ cell lineage in worms and flies. Dev Cell (2003) 1.63
Disruption of the gene Euchromatin Histone Methyl Transferase1 (Eu-HMTase1) is associated with the 9q34 subtelomeric deletion syndrome. J Med Genet (2005) 1.60
HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance. Oncogene (2008) 1.59
Mapping global histone methylation patterns in the coding regions of human genes. Mol Cell Biol (2005) 1.55
DNA methylation-dependent regulation of BORIS/CTCFL expression in ovarian cancer. Cancer Immun (2007) 1.53
Automethylation of G9a and its implication in wider substrate specificity and HP1 binding. Nucleic Acids Res (2007) 1.52
Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation. EMBO J (2006) 1.47
Partitioning of the maize epigenome by the number of methyl groups on histone H3 lysines 9 and 27. Genetics (2006) 1.47
Global loss of Set1-mediated H3 Lys4 trimethylation is associated with silencing defects in Saccharomyces cerevisiae. J Biol Chem (2005) 1.46
Epigenetic mechanisms of facioscapulohumeral muscular dystrophy. Mutat Res (2008) 1.45
Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin. EMBO J (2006) 1.44
Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol (2010) 1.42
Histone modifications and nuclear architecture: a review. J Histochem Cytochem (2008) 1.42
Epigenetic mechanisms regulate Mallory Denk body formation in the livers of drug-primed mice. Exp Mol Pathol (2008) 1.41
Prokaryotic BirA ligase biotinylates K4, K9, K18 and K23 in histone H3. BMB Rep (2008) 1.40
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase. J Biol Chem (2004) 1.38
The FMR1 gene and fragile X-associated tremor/ataxia syndrome. Am J Med Genet B Neuropsychiatr Genet (2009) 1.37
Epigenetic transcriptional repression of cellular genes by a viral SET protein. Nat Cell Biol (2008) 1.34
Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells. PLoS Genet (2011) 1.33
PfGCN5-mediated histone H3 acetylation plays a key role in gene expression in Plasmodium falciparum. Eukaryot Cell (2007) 1.31
Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells. Cancer Res (2008) 1.30
BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression. Arch Biochem Biophys (2005) 1.30
CCR4/NOT complex associates with the proteasome and regulates histone methylation. Proc Natl Acad Sci U S A (2007) 1.30
Differential dynamics of histone H3 methylation at positions K4 and K9 in the mouse zygote. BMC Dev Biol (2004) 1.30
Methylation of histone H3 lysine 36 is required for normal development in Neurospora crassa. Eukaryot Cell (2005) 1.29
Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem (2007) 1.28
Epigenetics and its role in male infertility. J Assist Reprod Genet (2012) 1.27
KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev (2010) 1.26
Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates. EMBO Rep (2008) 1.25
Regulation of cancer germline antigen gene expression: implications for cancer immunotherapy. Future Oncol (2010) 1.25
Deregulation of H3K27 methylation in cancer. Nat Genet (2010) 1.23
Histone lysine methyltransferases and demethylases in Plasmodium falciparum. Int J Parasitol (2008) 1.22
Epigenetic alterations in aging. J Appl Physiol (1985) (2010) 1.20
Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia. Mol Pain (2010) 1.19
H3K9 methylation regulates growth and development in Aspergillus fumigatus. Eukaryot Cell (2008) 1.19
Altered memory capacities and response to stress in p300/CBP-associated factor (PCAF) histone acetylase knockout mice. Neuropsychopharmacology (2007) 1.18
Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4. Proc Natl Acad Sci U S A (2012) 1.16
Epigenetics of beta-globin gene regulation. Mutat Res (2008) 1.15
Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells. Mol Cancer Res (2009) 1.15
Genetics and epigenetics of obesity. Maturitas (2011) 1.14
Vernalization, competence, and the epigenetic memory of winter. Plant Cell (2004) 1.13
RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes. EMBO J (2007) 1.12
Differences in centromere positioning of cycling and postmitotic human cell types. Chromosoma (2004) 1.12
Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus. Cancer Res (2010) 1.10
Analysis methods for studying the 3D architecture of the genome. Genome Biol (2015) 1.09
Structural dynamics of protein lysine methylation and demethylation. Mutat Res (2007) 1.08
A minimal CENP-A core is required for nucleation and maintenance of a functional human centromere. EMBO J (2007) 1.08
dSETDB1 and SU(VAR)3-9 sequentially function during germline-stem cell differentiation in Drosophila melanogaster. PLoS One (2008) 1.08
Epigenetic mechanisms in lupus. Curr Opin Rheumatol (2010) 1.07
Identification of three histone methyltransferases in Drosophila: dG9a is a suppressor of PEV and is required for gene silencing. Mol Genet Genomics (2006) 1.07
DDM1 binds Arabidopsis methyl-CpG binding domain proteins and affects their subnuclear localization. Plant Cell (2005) 1.06
Monomethyl histone H3 lysine 4 as an epigenetic mark for silenced euchromatin in Chlamydomonas. Plant Cell (2005) 1.06
The Drosophila G9a gene encodes a multi-catalytic histone methyltransferase required for normal development. Nucleic Acids Res (2006) 1.06
Controlling histone methylation via trans-histone pathways. Epigenetics (2008) 1.06
H3K9 histone acetylation predicts pluripotency and reprogramming capacity of ES cells. Nucleus (2011) 1.04
Epigenetic regulation of mammalian stem cells. Stem Cells Dev (2008) 1.04
Facioscapulohumeral muscular dystrophy (FSHD): an enigma unravelled? Hum Genet (2011) 1.04
Histone lysine methylation patterns in human cell types are arranged in distinct three-dimensional nuclear zones. Histochem Cell Biol (2005) 1.04
Promoter analysis reveals globally differential regulation of human long non-coding RNA and protein-coding genes. PLoS One (2014) 1.03
Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation. Mol Cell Biol (2007) 1.03
Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts. Exp Cell Res (2008) 1.03
HDAC inhibition and graft versus host disease. Mol Med (2011) 1.02
Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elements. J Biol Chem (2009) 1.01
Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential. Am J Transl Res (2013) 1.01
CpG methylation plays a vital role in determining tissue- and cell-specific expression of the human cell-death-inducing DFF45-like effector A gene through the regulation of Sp1/Sp3 binding. Nucleic Acids Res (2007) 1.01
Beta-globin intergenic transcription and histone acetylation dependent on an enhancer. Mol Cell Biol (2007) 1.00
Telomeres, histone code, and DNA damage response. Cytogenet Genome Res (2009) 0.98
Epigenetic modifications and diabetic retinopathy. Biomed Res Int (2013) 0.97
Inheritance of epigenetic chromatin silencing. J Theor Biol (2008) 0.97
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell (2003) 11.33
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol (2003) 9.13
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45
Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell (2003) 7.11
The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J (2005) 7.10
The many faces of histone lysine methylation. Curr Opin Cell Biol (2002) 6.01
Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component. Nat Genet (2002) 5.86
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J (2002) 5.70
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell (2007) 5.49
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J (2002) 5.33
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science (2003) 4.74
p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53
Repression of p53 activity by Smyd2-mediated methylation. Nature (2006) 4.51
A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol (2004) 4.23
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J (2006) 4.16
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol (2007) 3.89
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci U S A (2006) 3.86
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet (2003) 3.64
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res (2006) 3.59
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J (2004) 3.51
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat Genet (2001) 3.46
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev (2006) 3.24
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell (2007) 3.16
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome. Genome Res (2008) 3.09
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev (2004) 3.08
Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma (2004) 3.00
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development (2003) 2.91
In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases. PLoS Genet (2012) 2.70
Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome. Mol Cell (2007) 2.69
Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27. EMBO J (2006) 2.68
Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol Cell (2007) 2.66
G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol (2005) 2.27
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol (2007) 2.24
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab (2011) 2.22
TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature (2011) 2.17
A transcription factor-based mechanism for mouse heterochromatin formation. Nat Struct Mol Biol (2012) 2.15
Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos. Curr Biol (2003) 2.14
Generation and characterization of methyl-lysine histone antibodies. Methods Enzymol (2004) 2.09
Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis. EMBO J (2005) 2.04
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem (2009) 2.02
Histone modification patterns associated with the human X chromosome. EMBO Rep (2006) 1.99
DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2. Cancer Res (2007) 1.96
EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells. J Biol Chem (2005) 1.93
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol (2010) 1.91
Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins. Mol Cell Biol (2002) 1.85
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell (2012) 1.78
Arabidopsis REF6 is a histone H3 lysine 27 demethylase. Nat Genet (2011) 1.74
The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem (2006) 1.67
Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes Dev (2009) 1.67
Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence. Cancer Cell (2010) 1.53
Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO J (2004) 1.49
Formation of facultative heterochromatin in the absence of HP1. EMBO J (2003) 1.45
Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation. Curr Biol (2002) 1.36
A crack in histone lysine methylation. Cell (2004) 1.33
Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells. Mol Cell (2014) 1.28
Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. EMBO J (2010) 1.25
Mammalian Su(var) genes in chromatin control. Annu Rev Cell Dev Biol (2010) 1.22
Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. Development (2007) 1.16
Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage. J Biol Chem (2008) 1.09
Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte. EMBO Rep (2005) 1.05
PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse. EMBO Rep (2008) 1.04
MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output. EMBO J (2010) 1.03
The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA. J Immunol (2006) 1.00
Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development (2006) 0.99
The indexing potential of histone lysine methylation. Novartis Found Symp (2004) 0.94