Published in Cell on October 04, 2002
Many paths to methyltransfer: a chronicle of convergence. Trends Biochem Sci (2003) 5.65
Structural basis for the product specificity of histone lysine methyltransferases. Mol Cell (2003) 4.42
The SET-domain protein superfamily: protein lysine methyltransferases. Genome Biol (2005) 3.93
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev (2008) 3.90
Structural and sequence motifs of protein (histone) methylation enzymes. Annu Rev Biophys Biomol Struct (2005) 3.17
Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes Dev (2009) 2.66
Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase. Genes Dev (2005) 2.56
Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev (2005) 2.50
In vivo residue-specific histone methylation dynamics. J Biol Chem (2009) 2.33
Histone modification and the control of heterochromatic gene silencing in Drosophila. Chromosome Res (2006) 2.28
Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet. EMBO J (2003) 1.89
Natural history of S-adenosylmethionine-binding proteins. BMC Struct Biol (2005) 1.85
Establishment of the vernalization-responsive, winter-annual habit in Arabidopsis requires a putative histone H3 methyl transferase. Plant Cell (2005) 1.82
Structural origins for the product specificity of SET domain protein methyltransferases. Proc Natl Acad Sci U S A (2008) 1.72
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem (2009) 1.61
How do SET-domain protein lysine methyltransferases achieve the methylation state specificity? Revisited by Ab initio QM/MM molecular dynamics simulations. J Am Chem Soc (2008) 1.48
Comparative analysis of SET domain proteins in maize and Arabidopsis reveals multiple duplications preceding the divergence of monocots and dicots. Plant Physiol (2003) 1.47
Ab initio quantum mechanical/molecular mechanical molecular dynamics simulation of enzyme catalysis: the case of histone lysine methyltransferase SET7/9. J Phys Chem B (2007) 1.40
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase. J Biol Chem (2004) 1.38
Plant SET domain-containing proteins: structure, function and regulation. Biochim Biophys Acta (2007) 1.36
Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B. ACS Chem Biol (2009) 1.33
Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae. Mol Cell Biol (2003) 1.32
Mechanism of histone methylation catalyzed by protein lysine methyltransferase SET7/9 and origin of product specificity. Proc Natl Acad Sci U S A (2007) 1.24
PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function. Blood (2011) 1.21
Structural and functional profiling of the human histone methyltransferase SMYD3. PLoS One (2011) 1.20
A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors. Mol Biosyst (2010) 1.12
The functional diversity of protein lysine methylation. Mol Syst Biol (2014) 1.11
Structural dynamics of protein lysine methylation and demethylation. Mutat Res (2007) 1.08
Identification of three histone methyltransferases in Drosophila: dG9a is a suppressor of PEV and is required for gene silencing. Mol Genet Genomics (2006) 1.07
The SET domain proteins SUVH2 and SUVH9 are required for Pol V occupancy at RNA-directed DNA methylation loci. PLoS Genet (2014) 1.06
Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding. Nucleic Acids Res (2011) 1.04
Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae. Arch Biochem Biophys (2010) 1.04
Lysine-specific modifications of p53: a matter of life and death? Oncotarget (2013) 1.03
Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation. Biochemistry (2012) 1.02
SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J Biol Chem (2010) 1.01
ORTH/VIM proteins that regulate DNA methylation are functional ubiquitin E3 ligases. Plant J (2008) 1.00
Direct evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9. J Biol Chem (2011) 0.99
Arabidopsis Histone Lysine Methyltransferases. Adv Bot Res (2010) 0.98
Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2. J Am Chem Soc (2014) 0.98
Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. Nucleic Acids Res (2011) 0.97
Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors. Mol Biosyst (2011) 0.96
A functional component of the transcriptionally active chromosome complex, Arabidopsis pTAC14, interacts with pTAC12/HEMERA and regulates plastid gene expression. Plant Physiol (2011) 0.95
Assay development for histone methyltransferases. Assay Drug Dev Technol (2013) 0.94
A second protein L-isoaspartyl methyltransferase gene in Arabidopsis produces two transcripts whose products are sequestered in the nucleus. Plant Physiol (2004) 0.93
smyd1 and smyd2 are expressed in muscle tissue in Xenopus laevis. Cytotechnology (2008) 0.92
Crystal structure of a putative methyltransferase from Mycobacterium tuberculosis: misannotation of a genome clarified by protein structural analysis. J Bacteriol (2003) 0.91
A full suite of histone and histone modifying genes are transcribed in the dinoflagellate Lingulodinium. PLoS One (2012) 0.91
Identification of a novel gene, CIA6, required for normal pyrenoid formation in Chlamydomonas reinhardtii. Plant Physiol (2011) 0.91
Avidin plate assay system for enzymatic characterization of a histone lysine methyltransferase. Anal Biochem (2005) 0.90
Rubisco in complex with Rubisco large subunit methyltransferase. Proc Natl Acad Sci U S A (2009) 0.90
Dimerization of a viral SET protein endows its function. Proc Natl Acad Sci U S A (2010) 0.89
SET/MYND Lysine Methyltransferases Regulate Gene Transcription and Protein Activity. Genes (Basel) (2011) 0.88
S-Adenosylmethionine-dependent alkylation reactions: when are radical reactions used? Bioorg Chem (2011) 0.87
Metabolic regulation of histone post-translational modifications. ACS Chem Biol (2015) 0.87
Characterization of chloroplastic fructose 1,6-bisphosphate aldolases as lysine-methylated proteins in plants. J Biol Chem (2012) 0.86
Set2 mediated H3 lysine 36 methylation: regulation of transcription elongation and implications in organismal development. Wiley Interdiscip Rev Dev Biol (2013) 0.86
H3K27me1 is E(z) in animals, but not in plants. Epigenetics (2009) 0.84
Impact of Epigenetic Dietary Components on Cancer through Histone Modifications. Curr Med Chem (2015) 0.82
Characterization of the cofactor-binding site in the SPOUT-fold methyltransferases by computational docking of S-adenosylmethionine to three crystal structures. BMC Bioinformatics (2003) 0.81
Increasing the time step with mass scaling in Born-Oppenheimer ab initio QM/MM molecular dynamics simulations. J Comput Chem (2009) 0.80
Cross-species Analyses Unravel the Complexity of H3K27me3 and H4K20me3 in the Context of Neural Stem Progenitor Cells. Neuroepigenetics (2016) 0.78
SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis. Cell Res (2014) 0.77
Protein and DNA modifications: evolutionary imprints of bacterial biochemical diversification and geochemistry on the provenance of eukaryotic epigenetics. Cold Spring Harb Perspect Biol (2014) 0.77
Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1. PLoS One (2013) 0.77
SETD7 Regulates the Differentiation of Human Embryonic Stem Cells. PLoS One (2016) 0.76
Using 'biased-privileged' scaffolds to identify lysine methyltransferase inhibitors. Bioorg Med Chem (2014) 0.76
Master redox regulator Trx1 upregulates SMYD1 & modulates lysine methylation. Biochim Biophys Acta (2015) 0.76
Crystallization and preliminary X-ray crystallographic studies of O-methyltransferase from Anabaena PCC 7120. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.75
Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites. Sci Rep (2016) 0.75
SETD4 regulates cell quiescence and catalyzes the trimethylation of H4K20 during diapause formation of Artemia. Mol Cell Biol (2016) 0.75
Spatiotemporal expression of Prdm genes during Xenopus development. Cytotechnology (2015) 0.75
Steric Clash in the SET Domain of Histone Methyltransferase NSD1 as a Cause of Sotos Syndrome and Its Genetic Heterogeneity in a Brazilian Cohort. Genes (Basel) (2016) 0.75
dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression. Nucleic Acids Res (2017) 0.75
The winding path of protein methylation research: milestones and new frontiers. Nat Rev Mol Cell Biol (2017) 0.75
How Y357F, Y276F mutants affect the methylation activity of PRDM9: QM/MM MD and free energy simulations. J Mol Model (2015) 0.75
Membrane scission by the ESCRT-III complex. Nature (2009) 4.66
Molecular mechanism of multivesicular body biogenesis by ESCRT complexes. Nature (2010) 4.05
Retromer. Curr Opin Cell Biol (2008) 3.89
Structural mechanism for sterol sensing and transport by OSBP-related proteins. Nature (2005) 3.22
Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. Nat Struct Mol Biol (2006) 2.85
A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. EMBO J (2003) 2.73
Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission. Proc Natl Acad Sci U S A (2011) 2.45
Structural basis for endosomal targeting by the Bro1 domain. Dev Cell (2005) 2.28
Functional architecture of the retromer cargo-recognition complex. Nature (2007) 2.26
Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell (2003) 2.25
Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science (2008) 2.23
Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell (2007) 2.21
Crystal structure and allosteric activation of protein kinase C βII. Cell (2011) 2.19
Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Nat Struct Mol Biol (2008) 2.18
The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nat Struct Mol Biol (2006) 2.09
Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains. Nature (2002) 2.09
Beyond Tsg101: the role of Alix in 'ESCRTing' HIV-1. Nat Rev Microbiol (2007) 2.08
Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides. J Cell Biol (2006) 2.04
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Dev Cell (2010) 1.98
Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. J Virol (2007) 1.90
Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation. EMBO J (2009) 1.88
Structure of a lipid droplet protein; the PAT family member TIP47. Structure (2004) 1.85
Structure of the ESCRT-II endosomal trafficking complex. Nature (2004) 1.80
Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin. Cell (2004) 1.79
Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT. Nat Struct Biol (2003) 1.73
Structural origins for the product specificity of SET domain protein methyltransferases. Proc Natl Acad Sci U S A (2008) 1.72
Structural basis for viral late-domain binding to Alix. Nat Struct Mol Biol (2007) 1.69
Advancing our understanding and capacity to engineer nature's CO2-sequestering enzyme, Rubisco. Plant Physiol (2010) 1.68
Structural and functional organization of the ESCRT-I trafficking complex. Cell (2006) 1.51
Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis. Dev Cell (2009) 1.50
Normalization of nomenclature for peptide motifs as ligands of modular protein domains. FEBS Lett (2002) 1.46
An Alix fragment potently inhibits HIV-1 budding: characterization of binding to retroviral YPXL late domains. J Biol Chem (2006) 1.44
The ESCRT machinery at a glance. J Cell Sci (2009) 1.41
Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. Dev Cell (2008) 1.40
Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. Nat Commun (2010) 1.40
VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo. EMBO J (2010) 1.40
A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy. Proc Natl Acad Sci U S A (2013) 1.37
Two-site recognition of phosphatidylinositol 3-phosphate by PROPPINs in autophagy. Mol Cell (2012) 1.37
The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting. Dev Cell (2007) 1.36
Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3. Nat Struct Biol (2003) 1.36
Phylloplanins of tobacco are defensive proteins deployed on aerial surfaces by short glandular trichomes. Plant Cell (2005) 1.35
The beginnings of mucin biosynthesis: the crystal structure of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1. Proc Natl Acad Sci U S A (2004) 1.28
Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1. Cell (2013) 1.26
A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2. J Virol (2007) 1.25
Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. EMBO J (2012) 1.24
Hybrid structural model of the complete human ESCRT-0 complex. Structure (2009) 1.23
Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy. Proc Natl Acad Sci U S A (2011) 1.22
Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase. Mol Cell (2004) 1.22
SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. Mol Biol Cell (2010) 1.20
In vitro reconstitution of the ordered assembly of the endosomal sorting complex required for transport at membrane-bound HIV-1 Gag clusters. Proc Natl Acad Sci U S A (2012) 1.19
Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9. J Biol Chem (2010) 1.19
Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase. Mol Cell (2005) 1.18
Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins. Proc Natl Acad Sci U S A (2005) 1.16
Kinetic manifestation of processivity during multiple methylations catalyzed by SET domain protein methyltransferases. Biochemistry (2007) 1.16
Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism. Nat Struct Biol (2002) 1.16
Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. EMBO J (2006) 1.09
Proline-rich regions and motifs in trafficking: from ESCRT interaction to viral exploitation. Traffic (2011) 1.08
Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J Biol Chem (2011) 1.07
Solution structure of the ESCRT-I and -II supercomplex: implications for membrane budding and scission. Structure (2012) 1.06
[3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP. Mol Pharmacol (2003) 1.05
Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction. Structure (2010) 1.04
Structural role of the Vps4-Vta1 interface in ESCRT-III recycling. Structure (2010) 1.03
Co- and post-translational modifications in Rubisco: unanswered questions. J Exp Bot (2008) 1.02
Rubisco oligomers composed of linked small and large subunits assemble in tobacco plastids and have higher affinities for CO2 and O2. Plant Physiol (2009) 1.02
The clathrin adaptor complexes as a paradigm for membrane-associated allostery. Protein Sci (2013) 1.02
SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J Biol Chem (2010) 1.01
How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4. Elife (2014) 1.01
Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor. Proc Natl Acad Sci U S A (2003) 1.00
Regulation of protein kinases by lipids. Curr Opin Struct Biol (2011) 0.99
Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases. J Am Chem Soc (2013) 0.97
Calmodulin-mediated signal transduction pathways in Arabidopsis are fine-tuned by methylation. Plant Cell (2013) 0.95
Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3). J Biol Chem (2013) 0.95
Structural basis for membrane targeting by the MVB12-associated β-prism domain of the human ESCRT-I MVB12 subunit. Proc Natl Acad Sci U S A (2012) 0.94
Communication between the maternal testa and the embryo and/or endosperm affect testa attributes in tomato. Plant Physiol (2003) 0.93
Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2. J Biol Chem (2004) 0.92
Subunit folds and maturation pathway of a dsRNA virus capsid. Structure (2013) 0.92
Endosomal sorting complex required for transport (ESCRT) complexes induce phase-separated microdomains in supported lipid bilayers. J Biol Chem (2012) 0.91
Rubisco in complex with Rubisco large subunit methyltransferase. Proc Natl Acad Sci U S A (2009) 0.90
Dynamics of cholesterol exchange in the oxysterol binding protein family. J Mol Biol (2008) 0.90
Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex. J Biol Chem (2013) 0.90
Structural basis for endosomal recruitment of ESCRT-I by ESCRT-0 in yeast. EMBO J (2011) 0.88
Membrane-elasticity model of Coatless vesicle budding induced by ESCRT complexes. PLoS Comput Biol (2012) 0.87
Polypeptide substrate specificity of PsLSMT. A set domain protein methyltransferase. J Biol Chem (2007) 0.87
Insights into the substrate specificity of plant peptide deformylase, an essential enzyme with potential for the development of novel biotechnology applications in agriculture. Biochem J (2008) 0.86
A physical, enzymatic, and genetic characterization of perturbations in the seeds of the brownseed tomato mutants. J Exp Bot (2004) 0.84
Polycistronic expression and purification of the ESCRT-II endosomal trafficking complex. Methods Enzymol (2005) 0.83
Elucidation of New Binding Interactions with the Tumor Susceptibility Gene 101 (Tsg101) Protein Using Modified HIV-1 Gag-p6 Derived Peptide Ligands. ACS Med Chem Lett (2011) 0.83
Leucine in the sky with diamonds. Structure (2003) 0.82
Specificity of chloroplast-localized peptide deformylases as determined with peptide analogs of chloroplast-translated proteins. Arch Biochem Biophys (2002) 0.81