Published in Immunol Rev on June 01, 2005
Aging of the immune system: how much can the adaptive immune system adapt? Immunity (2006) 4.30
CD28(-) T cells: their role in the age-associated decline of immune function. Trends Immunol (2009) 2.66
T cell subset-specific susceptibility to aging. Clin Immunol (2008) 2.42
Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells. Immunity (2009) 2.11
IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28+ CD8 memory T cells throughout the adult age span. J Leukoc Biol (2009) 1.55
Gain and loss of T cell subsets in old age--age-related reshaping of the T cell repertoire. J Clin Immunol (2011) 1.48
Inflammaging as a prodrome to Alzheimer's disease. J Neuroinflammation (2008) 1.29
Immune aging and autoimmunity. Cell Mol Life Sci (2012) 1.19
Signaling pathways in aged T cells - a reflection of T cell differentiation, cell senescence and host environment. Semin Immunol (2012) 1.18
Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines. J Immunol (2006) 1.16
The pharmacology of second-generation chimeric antigen receptors. Nat Rev Drug Discov (2015) 1.09
A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia. Blood (2008) 1.07
CD8 T cell persistence in treated HIV infection. Curr Opin HIV AIDS (2014) 0.97
T cell aging: a review of the transcriptional changes determined from genome-wide analysis. Front Immunol (2013) 0.96
Gene expression and generation of CD28-CD8 T cells mediated by interleukin 15. Exp Gerontol (2007) 0.88
Finding Balance: T cell Regulatory Receptor Expression during Aging. Aging Dis (2011) 0.86
Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing. Immun Ageing (2015) 0.85
Age and CD161 expression contribute to inter-individual variation in interleukin-23 response in CD8+ memory human T cells. PLoS One (2013) 0.81
Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity. Blood (2014) 0.80
Convergence of Innate and Adaptive Immunity during Human Aging. Front Immunol (2016) 0.79
Skin-resident effector memory CD8+CD28- T cells exhibit a pro-fibrotic phenotype in patients with systemic sclerosis. J Invest Dermatol (2016) 0.78
Oxidative stress and age-related changes in T cells: is thalassemia a model of accelerated immune system aging? Cent Eur J Immunol (2016) 0.75
Unusual CD4(+)CD28(-) T Cells and Their Pathogenic Role in Chronic Inflammatory Disorders. Immune Netw (2016) 0.75
Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection. Front Microbiol (2016) 0.75
Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful Aging. Front Immunol (2016) 0.75
Low expression of CD39 and CD73 genes in centenarians compared with octogenarians. Immun Ageing (2017) 0.75
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med (2011) 18.99
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med (2011) 12.58
The genetic association database. Nat Genet (2004) 11.29
Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med (2014) 8.21
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med (2014) 7.64
Analysis of microarray data using Z score transformation. J Mol Diagn (2003) 6.82
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood (2010) 5.79
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
LincRNA-p21 suppresses target mRNA translation. Mol Cell (2012) 3.87
Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proc Natl Acad Sci U S A (2002) 3.71
Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer. Nat Med (2005) 3.65
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron (2003) 3.58
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet (2011) 3.56
Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet (2006) 3.34
Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells. Sci Transl Med (2012) 3.29
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
White spot syndromes of the retina: a hypothesis based on the common genetic hypothesis of autoimmune/inflammatory disease. Am J Ophthalmol (2003) 2.97
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma. Blood (2013) 2.91
L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood (2004) 2.90
Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma. N Engl J Med (2015) 2.77
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor. Cancer Res (2010) 2.64
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood (2004) 2.63
MicroRNA expression and identification of putative miRNA targets in ovarian cancer. PLoS One (2008) 2.60
Application of z-score transformation to Affymetrix data. Appl Bioinformatics (2003) 2.56
A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation. Blood (2005) 2.39
In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood (2004) 2.28
Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion. Cancer Res (2007) 2.25
Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability. BMC Genomics (2005) 2.18
Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity. Sci Transl Med (2011) 2.14
Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells. Immunity (2009) 2.11
Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells. Sci Transl Med (2013) 2.07
Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation. Psychosom Med (2010) 2.06
The PDL1-PD1 axis converts human TH1 cells into regulatory T cells. Sci Transl Med (2011) 2.04
Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol (2009) 2.00
Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells. Mol Ther (2009) 1.97
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci U S A (2009) 1.91
CD28 costimulation is essential for human T regulatory expansion and function. J Immunol (2008) 1.86
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res (2012) 1.85
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load. Mol Ther (2004) 1.80
Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study. Schizophr Res (2002) 1.76
Rapid default transition of CD4 T cell effectors to functional memory cells. J Exp Med (2007) 1.69
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. J Clin Invest (2008) 1.68
Genetic and environmental pathways to complex diseases. BMC Syst Biol (2009) 1.67
Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV. Blood (2012) 1.64
Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. J Virol (2008) 1.63
Adoptive immunotherapy for cancer or viruses. Annu Rev Immunol (2014) 1.61
Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess. Endocrinology (2007) 1.59
Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information. BMC Med Genomics (2010) 1.57
Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J (2009) 1.52
Rule-based human gene normalization in biomedical text with confidence estimation. Comput Syst Bioinformatics Conf (2007) 1.51
Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies. Mol Ther (2008) 1.47
Stability regulation of mRNA and the control of gene expression. Ann N Y Acad Sci (2005) 1.46
A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients. Virology (2008) 1.45
Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B). J Immunol (2008) 1.44
4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies. Hum Gene Ther (2010) 1.40
Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system. Blood (2005) 1.40
Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells. Clin Cancer Res (2009) 1.38
Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes. Glia (2013) 1.37
Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer. Oncoimmunology (2013) 1.37
VENNTURE--a novel Venn diagram investigational tool for multiple pharmacological dataset analysis. PLoS One (2012) 1.36
Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia. Blood (2009) 1.35
Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1. PLoS Biol (2010) 1.35
Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender. Genome Biol (2007) 1.35
Age-related changes in microRNA levels in serum. Aging (Albany NY) (2013) 1.35
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation. J Exp Med (2010) 1.33
CD28-mediated regulation of multiple myeloma cell proliferation and survival. Blood (2007) 1.31
The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells. Oncogene (2003) 1.30
Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates. J Neurochem (2008) 1.30
Regulatory considerations for novel gene therapy products: a review of the process leading to the first clinical lentiviral vector. Hum Gene Ther (2005) 1.30
Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8(+) T-cell response. Blood (2006) 1.26
Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma. Blood (2010) 1.23
Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice. Neurobiol Aging (2008) 1.22
Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation. EMBO J (2011) 1.21
Enhanced translation by Nucleolin via G-rich elements in coding and non-coding regions of target mRNAs. Nucleic Acids Res (2011) 1.21
Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissue. Pediatr Res (2003) 1.21
Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway. Proc Natl Acad Sci U S A (2009) 1.18
Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cell differentiation. Biol Blood Marrow Transplant (2007) 1.18
HER-2 pulsed dendritic cell vaccine can eliminate HER-2 expression and impact ductal carcinoma in situ. Cancer (2012) 1.18
Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elements. Mol Cell Biol (2011) 1.17
A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development. J Pathol (2014) 1.17
iTRAQ analysis of complex proteome alterations in 3xTgAD Alzheimer's mice: understanding the interface between physiology and disease. PLoS One (2008) 1.16
FACS purification of immunolabeled cell types from adult rat brain. J Neurosci Methods (2011) 1.15
Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells. Curr Biol (2008) 1.14
T cells expressing chimeric antigen receptors can cause anaphylaxis in humans. Cancer Immunol Res (2013) 1.14
Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5. Hum Gene Ther (2013) 1.14