Published in DNA Repair (Amst) on April 11, 2013
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Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal. Nucleic Acids Res (2014) 0.75
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Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science (2004) 4.87
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Excess of rare cancers in Werner syndrome (adult progeria). Cancer Epidemiol Biomarkers Prev (1996) 2.76
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol Cell (2004) 2.60
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Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. EMBO J (2001) 2.21
Ku complex interacts with and stimulates the Werner protein. Genes Dev (2000) 2.21
Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1. J Biol Chem (2005) 2.11
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Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82
Telomere dysfunction as a cause of genomic instability in Werner syndrome. Proc Natl Acad Sci U S A (2007) 1.80
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Accumulation of Werner protein at DNA double-strand breaks in human cells. J Cell Sci (2005) 1.59
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat Struct Mol Biol (2006) 1.55
WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations. Hum Genet (2010) 1.50
The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis. Hum Genet (2008) 1.48
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem (2002) 1.39
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein. J Biol Chem (2001) 1.32
Werner protein recruits DNA polymerase delta to the nucleolus. Proc Natl Acad Sci U S A (2000) 1.23
Analysis of helicase gene mutations in Japanese Werner's syndrome patients. Hum Genet (1997) 1.22
Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients. Biochem Biophys Res Commun (1997) 1.12
Enzymatic mechanism of the WRN helicase/nuclease. Methods Enzymol (2006) 1.10
Diagnostic criteria for Werner syndrome based on Japanese nationwide epidemiological survey. Geriatr Gerontol Int (2012) 1.08
The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C. J Biol Chem (2004) 1.08
Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins. BMC Mol Biol (2006) 1.08
Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer. Carcinogenesis (2006) 1.07
Werner syndrome and mutations of the WRN and LMNA genes in France. Hum Mutat (2006) 1.07
Diverged nuclear localization of Werner helicase in human and mouse cells. Oncogene (2001) 1.04
Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair. J Cell Biol (2005) 0.98
A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women. Breast Cancer Res Treat (2009) 0.93
WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3. Aging (Albany NY) (2009) 0.92
Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene. Genetics (2000) 0.90
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells. Cancer Sci (2008) 0.90
RECQL5 plays co-operative and complementary roles with WRN syndrome helicase. Nucleic Acids Res (2012) 0.89
The role of WRN in DNA repair is affected by post-translational modifications. Mech Ageing Dev (2006) 0.87
DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities. Aging (Albany NY) (2012) 0.86
Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM. Carcinogenesis (2009) 0.85
Werner syndrome gene variants in human sarcomas. Mol Carcinog (2010) 0.84
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
LMNA mutations in atypical Werner's syndrome. Lancet (2003) 4.81
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol Cell (2004) 2.60
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J Biol Chem (2002) 2.53
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany NY) (2009) 2.50
The mechanics of base excision repair, and its relationship to aging and disease. DNA Repair (Amst) (2006) 2.43
Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis (2008) 2.42
Prokaryotic nucleotide excision repair: the UvrABC system. Chem Rev (2006) 2.37
No association between telomere length and survival among the elderly and oldest old. Epidemiology (2006) 2.33
The genetics of human longevity. Am J Med (2004) 1.97
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol (2008) 1.95
Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell (2010) 1.84
Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev (2003) 1.84
The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J (2005) 1.84
Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD. PLoS Biol (2008) 1.81
The spectrum of WRN mutations in Werner syndrome patients. Hum Mutat (2006) 1.75
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A (2006) 1.70
Human RecQ helicases in DNA repair, recombination, and replication. Annu Rev Biochem (2014) 1.68
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem (2005) 1.64
Gene expression profiling in Werner syndrome closely resembles that of normal aging. Proc Natl Acad Sci U S A (2003) 1.64
Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes. J Biol Chem (2005) 1.64
Werner syndrome protein contains three structure-specific DNA binding domains. J Biol Chem (2003) 1.62
Accumulation of Werner protein at DNA double-strand breaks in human cells. J Cell Sci (2005) 1.59
Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res (2005) 1.59
Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA. DNA Repair (Amst) (2007) 1.57
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem (2002) 1.56
DNA repair deficiency in neurodegeneration. Prog Neurobiol (2011) 1.55
Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol Aging (2005) 1.52
WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations. Hum Genet (2010) 1.50
The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis. Hum Genet (2008) 1.48
Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res (2007) 1.48
Cockayne syndrome group B cellular and biochemical functions. Am J Hum Genet (2003) 1.46
Human embryonic stem cells have enhanced repair of multiple forms of DNA damage. Stem Cells (2008) 1.43
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med (2012) 1.42
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci (2006) 1.42
'Close-fitting sleeves': DNA damage recognition by the UvrABC nuclease system. Mutat Res (2005) 1.39
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem (2002) 1.39
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. J Biol Chem (2003) 1.39
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. J Biol Chem (2007) 1.38
Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8-hydroxyguanine and 8-hydroxyadenine resulting from oxidative stress. FASEB J (2003) 1.38
Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage. Mol Cell Biol (2003) 1.37
Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. Carcinogenesis (2003) 1.37
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. J Biol Chem (2004) 1.36
The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging. Mech Ageing Dev (2008) 1.36
Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A. Exp Cell Res (2007) 1.36
Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem (2011) 1.35
Junction of RecQ helicase biochemistry and human disease. J Biol Chem (2004) 1.34
Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging. Biogerontology (2008) 1.34
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic Acids Res (2006) 1.34
p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria. Oncogene (2004) 1.33
The pattern of chromosome-specific variations in telomere length in humans is determined by inherited, telomere-near factors and is maintained throughout life. Mech Ageing Dev (2003) 1.33
Mitochondrial DNA damage and repair in neurodegenerative disorders. DNA Repair (Amst) (2008) 1.31
Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress. Mol Cell Biol (2005) 1.31
The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells. Oncogene (2003) 1.30
Structural insights into the first incision reaction during nucleotide excision repair. EMBO J (2005) 1.30
Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells. J Biol Chem (2009) 1.29
Base excision repair capacity in mitochondria and nuclei: tissue-specific variations. FASEB J (2002) 1.27
WRN interacts physically and functionally with the recombination mediator protein RAD52. J Biol Chem (2003) 1.27
Mitochondrial DNA, base excision repair and neurodegeneration. DNA Repair (Amst) (2008) 1.27
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Res (2006) 1.26
Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane. FASEB J (2010) 1.25
Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B. Oncogene (2002) 1.24
WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell (2003) 1.23
Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Mol Cell Biol (2003) 1.23
Pathways and functions of the Werner syndrome protein. Mech Ageing Dev (2005) 1.23
The cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA. J Biol Chem (2002) 1.22
Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference. Hum Genet (2005) 1.22
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem (2002) 1.22
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus. Nucleic Acids Res (2002) 1.22
A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092. J Cell Sci (2002) 1.21
Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein. DNA Repair (Amst) (2002) 1.21
Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis. Aging Cell (2011) 1.20
UvrB domain 4, an autoinhibitory gate for regulation of DNA binding and ATPase activity. J Biol Chem (2006) 1.20
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity. J Biol Chem (2003) 1.19
Aprataxin localizes to mitochondria and preserves mitochondrial function. Proc Natl Acad Sci U S A (2011) 1.19
Mitochondrial DNA repair and association with aging--an update. Exp Gerontol (2010) 1.19
Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice. DNA Repair (Amst) (2008) 1.19
Initiation of repair of DNA-polypeptide cross-links by the UvrABC nuclease. Biochemistry (2005) 1.19
Direct and indirect roles of RECQL4 in modulating base excision repair capacity. Hum Mol Genet (2009) 1.18
Novel DNA mismatch-repair activity involving YB-1 in human mitochondria. DNA Repair (Amst) (2009) 1.18
Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates. Nucleic Acids Res (2007) 1.18
Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1. DNA Repair (Amst) (2010) 1.17
Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells. Nucleic Acids Res (2002) 1.16
Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding. DNA Repair (Amst) (2010) 1.16
Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta. Cancer Res (2006) 1.15
The involvement of human RECQL4 in DNA double-strand break repair. Aging Cell (2010) 1.15