Evolution of CASK into a Mg2+-sensitive kinase.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 3286871)

Published in Sci Signal on April 27, 2010

Authors

Konark Mukherjee1, Manu Sharma, Reinhard Jahn, Markus C Wahl, Thomas C Südhof

Author Affiliations

1: Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 1050 Arastradero Road, Palo Alto, CA 94304, USA. konark@brandeis.edu

Articles cited by this

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (1988) 35.59

The protein kinase complement of the human genome. Science (2002) 35.36

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J (1995) 14.45

The conformational plasticity of protein kinases. Cell (2002) 11.21

Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell (2004) 6.92

Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol (2007) 6.11

SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science (2002) 5.69

The Trichoplax genome and the nature of placozoans. Nature (2008) 5.56

Protein kinase inhibitors: insights into drug design from structure. Science (2004) 4.86

Emerging roles of pseudokinases. Trends Cell Biol (2006) 4.48

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol (2004) 4.40

Kinetic and catalytic mechanisms of protein kinases. Chem Rev (2001) 3.80

Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera. EMBO J (1994) 3.42

CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10

Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell (2005) 3.08

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. J Neurosci (1996) 2.93

Three protein kinase structures define a common motif. Structure (1994) 2.88

Structural basis for activation of the titin kinase domain during myofibrillogenesis. Nature (1998) 2.80

Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2. Nature (2000) 2.74

Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. J Cell Biol (1998) 2.39

Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum. Nat Genet (2008) 2.16

Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I. Cell (1996) 2.09

Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression. Nat Struct Biol (2001) 2.06

Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses. J Cell Biol (1998) 1.90

Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase. J Biol Chem (2004) 1.80

Detection of genomic copy number changes in patients with idiopathic mental retardation by high-resolution X-array-CGH: important role for increased gene dosage of XLMR genes. Hum Mutat (2007) 1.79

Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme. EMBO J (2001) 1.77

Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A (2007) 1.74

Analysis of the LKB1-STRAD-MO25 complex. J Cell Sci (2004) 1.65

Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. J Phys Chem B (2007) 1.55

How does the cAMP-dependent protein kinase catalyze the phosphorylation reaction: an ab initio QM/MM study. J Am Chem Soc (2005) 1.51

A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility. Structure (1997) 1.51

Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron (2007) 1.30

Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. Biochemistry (1999) 1.29

Haspin-like proteins: a new family of evolutionarily conserved putative eukaryotic protein kinases. Protein Sci (2001) 1.21

TNP-ATP and TNP-ADP as probes of the nucleotide binding site of CheA, the histidine protein kinase in the chemotaxis signal transduction pathway of Escherichia coli. Biochemistry (1998) 1.20

Divalent metal ions influence catalysis and active-site accessibility in the cAMP-dependent protein kinase. Protein Sci (1993) 1.19

Molecular evolution of the MAGUK family in metazoan genomes. BMC Evol Biol (2007) 1.14

Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues. J Biol Chem (1992) 1.11

Purification and characterization of a brain-specific multifunctional calmodulin-dependent protein kinase from rat cerebellum. J Biol Chem (1992) 1.06

The CASK gene harbored in a deletion detected by array-CGH as a potential candidate for a gene causative of X-linked dominant mental retardation. Am J Med Genet A (2008) 1.01

Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole. Protein Sci (2001) 1.00

CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma. Cancer Lett (2002) 0.93

A second magnesium ion is critical for ATP binding in the kinase domain of the oncoprotein v-Fps. Biochemistry (1998) 0.89

Studies on the regulatory domain of Ca2+/calmodulin-dependent protein kinase II. Functional analyses of arginine 283 using synthetic inhibitory peptides and site-directed mutagenesis of the alpha subunit. J Biol Chem (1990) 0.85

The location of human CASK at Xp11.4 identifies this gene as a candidate for X-linked optic atrophy. Genomics (1998) 0.84

A kinetic approach towards understanding substrate interactions and the catalytic mechanism of the serine/threonine protein kinase ERK2: identifying a potential regulatory role for divalent magnesium. Biochim Biophys Acta (2004) 0.82

Articles by these authors

Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76

Molecular anatomy of a trafficking organelle. Cell (2006) 11.47

Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet (2011) 9.10

Membrane fusion. Cell (2003) 7.68

Induction of human neuronal cells by defined transcription factors. Nature (2011) 6.84

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science (2007) 6.64

STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis. Nature (2006) 6.54

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell (2005) 6.31

Video-rate far-field optical nanoscopy dissects synaptic vesicle movement. Science (2008) 5.87

Neuroligins determine synapse maturation and function. Neuron (2006) 5.70

SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science (2002) 5.69

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science (2010) 5.42

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature (2003) 5.19

RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature (2002) 4.37

A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell (2006) 4.36

Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron (2007) 4.32

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet (2012) 4.27

A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. Neuron (2005) 3.93

A dual-Ca2+-sensor model for neurotransmitter release in a central synapse. Nature (2007) 3.91

Three-dimensional structure of the complexin/SNARE complex. Neuron (2002) 3.69

SNCA variants are associated with increased risk for multiple system atrophy. Ann Neurol (2009) 3.55

Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc Natl Acad Sci U S A (2012) 3.52

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study. Lancet Neurol (2011) 3.36

Snares and Munc18 in synaptic vesicle fusion. Nat Rev Neurosci (2002) 3.33

Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (2009) 3.30

RIM1alpha is required for presynaptic long-term potentiation. Nature (2002) 3.28

Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons. Neuron (2007) 3.18

The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR. Nat Struct Mol Biol (2004) 3.16

Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14

CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10

Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release. Neuron (2005) 3.09

Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem (2005) 3.06

Macromolecular-scale resolution in biological fluorescence microscopy. Proc Natl Acad Sci U S A (2006) 3.04

A NusE:NusG complex links transcription and translation. Science (2010) 3.03

Munc18-1 binds directly to the neuronal SNARE complex. Proc Natl Acad Sci U S A (2007) 3.03

Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation. Cell (2005) 2.97

Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A (2009) 2.93

Helical extension of the neuronal SNARE complex into the membrane. Nature (2009) 2.92

RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell (2011) 2.90

Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation. J Neurosci Methods (2006) 2.80

A broken alpha -helix in folded alpha -Synuclein. J Biol Chem (2003) 2.80

Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids. Nat Struct Mol Biol (2007) 2.63

Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A (2004) 2.62

Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord (2009) 2.61

Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc Natl Acad Sci U S A (2007) 2.60

Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. Genomics (2002) 2.58

Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. J Neurosci (2010) 2.57

Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10. Cell (2011) 2.52

Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix. Neuron (2010) 2.52

Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron (2013) 2.51

Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell (2011) 2.49

Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44

Two-color far-field fluorescence nanoscopy. Biophys J (2007) 2.44

Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron (2007) 2.43

Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. Dev Cell (2002) 2.43

The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron (2004) 2.43

Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci (2006) 2.42

SNARE assembly and disassembly exhibit a pronounced hysteresis. Nat Struct Biol (2002) 2.40

Membrane protein sequestering by ionic protein-lipid interactions. Nature (2011) 2.40

Presenilins are essential for regulating neurotransmitter release. Nature (2009) 2.39

Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission. Neuron (2012) 2.35

1.8 A bright-state structure of the reversibly switchable fluorescent protein Dronpa guides the generation of fast switching variants. Biochem J (2007) 2.33

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J Biol Chem (2004) 2.31

How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J (2002) 2.31

Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell (2002) 2.31

LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. Neuron (2009) 2.30

RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone. Neuron (2011) 2.29

Determinants of liposome fusion mediated by synaptic SNARE proteins. Proc Natl Acad Sci U S A (2004) 2.28

Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene. Ann Neurol (2009) 2.21

A complete genetic analysis of neuronal Rab3 function. J Neurosci (2004) 2.21

Structure and mechanism of the reversible photoswitch of a fluorescent protein. Proc Natl Acad Sci U S A (2005) 2.21

Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. Nat Struct Biol (2002) 2.21

Constraints on upward migration of hydraulic fracturing fluid and brine. Ground Water (2013) 2.20

The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged? Annu Rev Cell Dev Biol (2012) 2.19

Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron (2013) 2.18

Munc18-bound syntaxin readily forms SNARE complexes with synaptobrevin in native plasma membranes. PLoS Biol (2006) 2.17

Cell biology of Ca2+-triggered exocytosis. Curr Opin Cell Biol (2010) 2.15

One SNARE complex is sufficient for membrane fusion. Nat Struct Mol Biol (2010) 2.14

The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron (2004) 2.14

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. Proc Natl Acad Sci U S A (2005) 2.13

Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat Cell Biol (2004) 2.11

Structural basis for reversible photoswitching in Dronpa. Proc Natl Acad Sci U S A (2007) 2.08

Imaging direct, dynamin-dependent recapture of fusing secretory granules on plasma membrane lawns from PC12 cells. Proc Natl Acad Sci U S A (2002) 2.03

Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J Neurosci (2007) 2.02

A conformational switch in the Piccolo C2A domain regulated by alternative splicing. Nat Struct Mol Biol (2003) 1.98

Selective capability of SynCAM and neuroligin for functional synapse assembly. J Neurosci (2005) 1.97

A neural circuit for memory specificity and generalization. Science (2013) 1.96

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release. Nat Neurosci (2009) 1.95

CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol (2010) 1.95

Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. EMBO J (2006) 1.93

Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell (2013) 1.92

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J (2012) 1.91