Published in IUBMB Life on June 01, 2003
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic Biol Med (2007) 3.48
NOX enzymes as novel targets for drug development. Semin Immunopathol (2008) 1.90
Sources and targets of reactive oxygen species in synaptic plasticity and memory. Antioxid Redox Signal (2007) 1.69
Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. Mol Neurobiol (2010) 1.51
Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury. J Neuroinflammation (2010) 1.40
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase. Semin Immunopathol (2008) 1.37
NADPH oxidase is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1. J Neurochem (2005) 1.21
Neuroprotective and neurorescue effects of a novel polymeric nanoparticle formulation of curcumin (NanoCurc™) in the neuronal cell culture and animal model: implications for Alzheimer's disease. J Alzheimers Dis (2011) 1.14
CK2 is a novel negative regulator of NADPH oxidase and a neuroprotectant in mice after cerebral ischemia. J Neurosci (2009) 1.13
NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease. Antioxid Redox Signal (2012) 1.12
Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia. BMC Neurosci (2011) 1.09
Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration. J Neuroinflammation (2005) 1.09
H2O2: a dynamic neuromodulator. Neuroscientist (2011) 1.07
Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study. J Neuroinflammation (2006) 1.06
Natural compounds as modulators of NADPH oxidases. Oxid Med Cell Longev (2013) 0.94
Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease. Mol Neurobiol (2010) 0.88
Traumatic brain injury and NADPH oxidase: a deep relationship. Oxid Med Cell Longev (2015) 0.85
Effects of chronic low dose rotenone treatment on human microglial cells. Mol Neurodegener (2009) 0.83
Oxidative stress, redox signalling and endothelial dysfunction in ageing-related neurodegenerative diseases: a role of NADPH oxidase 2. Br J Clin Pharmacol (2014) 0.83
Classification of H₂O₂as a neuromodulator that regulates striatal dopamine release on a subsecond time scale. ACS Chem Neurosci (2012) 0.80
Integrating cytosolic phospholipase A₂ with oxidative/nitrosative signaling pathways in neurons: a novel therapeutic strategy for AD. Mol Neurobiol (2012) 0.79
Nutritional status, oxidative stress and dementia: the role of selenium in Alzheimer's disease. Front Aging Neurosci (2014) 0.79
NADPH oxidase in brain injury and neurodegenerative disorders. Mol Neurodegener (2017) 0.78
Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity. J Exp Neurosci (2016) 0.77
FLZ, synthetic squamosamide cyclic derivative, attenuates memory deficit and pathological changes in mice with experimentally induced aging. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.76
Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease. Sci Rep (2017) 0.75
Microwave & magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment. PLoS One (2017) 0.75
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13
NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation. Biochem J (2007) 3.88
Ageing and infection. Lancet Infect Dis (2002) 3.79
Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Res Brain Res Rev (2005) 2.78
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem (2002) 2.41
NOX enzymes in the central nervous system: from signaling to disease. Antioxid Redox Signal (2009) 2.38
NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem (2004) 2.36
Pneumonia in the very old. Lancet Infect Dis (2004) 2.19
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol (2012) 2.17
Decreased blood pressure in NOX1-deficient mice. FEBS Lett (2005) 2.10
Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation. Arterioscler Thromb Vasc Biol (2009) 2.01
NOX enzymes as novel targets for drug development. Semin Immunopathol (2008) 1.90
Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). J Biol Chem (2004) 1.86
Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets. Antioxid Redox Signal (2009) 1.80
A key role for NOX4 in epithelial cell death during development of lung fibrosis. Antioxid Redox Signal (2011) 1.79
The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation. Mol Biol Cell (2006) 1.76
A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells. Stem Cells (2009) 1.71
NOX family NADPH oxidases: not just in mammals. Biochimie (2007) 1.68
Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2007) 1.65
Does dementia predict adverse hospitalization outcomes? A prospective study in aged inpatients. Int J Geriatr Psychiatry (2009) 1.62
Rapid generation of stable transgenic embryonic stem cell lines using modular lentivectors. Stem Cells (2005) 1.48
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase. Semin Immunopathol (2008) 1.37
Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J Neurosci (2008) 1.34
Demented versus non-demented very old inpatients: the same comorbidities but poorer functional and nutritional status. Age Ageing (2007) 1.32
NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Am J Respir Crit Care Med (2009) 1.30
NOX1 deficiency protects from aortic dissection in response to angiotensin II. Hypertension (2007) 1.29
Aging and infectious diseases in the developing world. Clin Infect Dis (2004) 1.29
Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. J Immunol (2005) 1.27
NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon. Mol Cell Biol (2010) 1.25
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun (2012) 1.25
NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? Biochem Soc Trans (2008) 1.20
Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections. Cell Microbiol (2014) 1.18
NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation. Biochimie (2007) 1.17
Involvement of NOX2 in the development of behavioral and pathologic alterations in isolated rats. Biol Psychiatry (2009) 1.17
A pure population of ectodermal cells derived from human embryonic stem cells. Stem Cells (2007) 1.13
Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. Cancer Res (2009) 1.12
Prospective comparison of 6 comorbidity indices as predictors of 1-year post-hospital discharge institutionalization, readmission, and mortality in elderly individuals. J Am Med Dir Assoc (2011) 1.11
Expression and function of alpha-smooth muscle actin during embryonic-stem-cell-derived cardiomyocyte differentiation. J Cell Sci (2006) 1.08
NOX5: from basic biology to signaling and disease. Free Radic Biol Med (2011) 1.08
Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. ALTEX (2010) 1.06
New insights on NOX enzymes in the central nervous system. Antioxid Redox Signal (2014) 1.06
BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase. Oncogene (2005) 1.03
The HIV-1 Nef protein and phagocyte NADPH oxidase activation. J Biol Chem (2002) 1.02
Haplotype-based banking of human pluripotent stem cells for transplantation: potential and limitations. Stem Cells Dev (2012) 1.02
A key role for the microglial NADPH oxidase in APP-dependent killing of neurons. Neurobiol Aging (2005) 1.01
Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries. Circulation (2010) 1.00
Nuclear-cytoplasmic translocation of BARD1 is linked to its apoptotic activity. Oncogene (2004) 0.98
Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress. Antioxid Redox Signal (2013) 0.98
Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis. Int J Cancer (2006) 0.98
NOX family NADPH oxidases: do they have built-in proton channels? J Gen Physiol (2002) 0.97
Calreticulin reveals a critical Ca(2+) checkpoint in cardiac myofibrillogenesis. J Cell Biol (2002) 0.97
Telomere length and ApoE polymorphism in mild cognitive impairment, degenerative and vascular dementia. J Neurol Sci (2010) 0.97
NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion. Diabetes (2012) 0.97
The chemokine receptor CCR5 in the central nervous system. Prog Neurobiol (2010) 0.96
Detection of reactive oxygen species derived from the family of NOX NADPH oxidases. Free Radic Biol Med (2012) 0.96
Geriatrics index of comorbidity was the most accurate predictor of death in geriatric hospital among six comorbidity scores. J Clin Epidemiol (2010) 0.96
Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow. Blood (2011) 0.96
Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation. Hum Mutat (2009) 0.95
The NADPH oxidase NOX2 controls glutamate release: a novel mechanism involved in psychosis-like ketamine responses. J Neurosci (2010) 0.95
Targeting NOX enzymes in the central nervous system: therapeutic opportunities. Cell Mol Life Sci (2012) 0.95
Calnexin deficiency leads to dysmyelination. J Biol Chem (2010) 0.94
Comprehensive metagenomic analysis of glioblastoma reveals absence of known virus despite antiviral-like type I interferon gene response. Int J Cancer (2014) 0.94
Severe life stress and oxidative stress in the brain: from animal models to human pathology. Antioxid Redox Signal (2012) 0.94
Regulation of NOX1 expression by GATA, HNF-1alpha, and Cdx transcription factors. Free Radic Biol Med (2007) 0.94
The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy. ALTEX (2008) 0.93
Hyperinflammation of chronic granulomatous disease is abolished by NOX2 reconstitution in macrophages and dendritic cells. J Pathol (2012) 0.93
Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development. Am J Hum Genet (2008) 0.93
Neural progenitors derived from human embryonic stem cells are targeted by allogeneic T and natural killer cells. J Cell Mol Med (2009) 0.93
NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action. Br J Pharmacol (2011) 0.92
NOX-4 is expressed in thickened pulmonary arteries in idiopathic pulmonary fibrosis. Nat Med (2011) 0.92
NADPH oxidase 1 deficiency alters caveolin phosphorylation and angiotensin II-receptor localization in vascular smooth muscle. Antioxid Redox Signal (2009) 0.91
Booster vaccination and 1-year follow-up of 4-8-year-old children with a reduced-antigen-content dTpa-IPV vaccine. Eur J Pediatr (2007) 0.91
Telomere length is not predictive of dementia or MCI conversion in the oldest old. Neurobiol Aging (2008) 0.90
Dissemination of intraperitoneal ovarian cancer: Discussion of mechanisms and demonstration of lymphatic spreading in ovarian cancer model. Crit Rev Oncol Hematol (2009) 0.90
Test systems of developmental toxicity: state-of-the art and future perspectives. Arch Toxicol (2013) 0.90
Expression of mRNA for ROS-generating NADPH oxidases in the aging stomach. Exp Gerontol (2005) 0.89
Phenazopyridine induces and synchronizes neuronal differentiation of embryonic stem cells. J Cell Mol Med (2009) 0.89
Evolution of the ferric reductase domain (FRD) superfamily: modularity, functional diversification, and signature motifs. PLoS One (2013) 0.89
The NADPH oxidase NOX2 plays a role in periodontal pathologies. Semin Immunopathol (2008) 0.87
Cellular diversity within embryonic stem cells: pluripotent clonal sublines show distinct differentiation potential. J Cell Mol Med (2012) 0.86
Pax6-induced alteration of cell fate: shape changes, expression of neuronal alpha tubulin, postmitotic phenotype, and cell migration. J Neurobiol (2006) 0.86
Isoform- and dose-sensitive feedback interactions between paired box 6 gene and delta-catenin in cell differentiation and death. Exp Cell Res (2010) 0.85
Prospective comparison of six co-morbidity indices as predictors of 5 years post hospital discharge survival in the elderly. Rejuvenation Res (2010) 0.84
BARD1 expression during spermatogenesis is associated with apoptosis and hormonally regulated. Biol Reprod (2004) 0.84
NOX4 expression in human microglia leads to constitutive generation of reactive oxygen species and to constitutive IL-6 expression. J Innate Immun (2009) 0.83
Pluripotent stem cells as new drugs? The example of Parkinson's disease. Int J Pharm (2009) 0.83
Engineering of midbrain organoids containing long-lived dopaminergic neurons. Stem Cells Dev (2014) 0.83
Embryonic stem cell-based screen for small molecules: cluster analysis reveals four response patterns in developing neural cells. Curr Med Chem (2013) 0.82
Cerebrospinal fluid tau and Abeta42 concentrations in healthy subjects: delineation of reference intervals and their limitations. Clin Chem Lab Med (2004) 0.82
Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways. J Pathol (2014) 0.82
HIV-1 Tat C modulates NOX2 and NOX4 expressions through miR-17 in a human microglial cell line. J Neurochem (2014) 0.81
Quinone compounds regulate the level of ROS production by the NADPH oxidase Nox4. Biochem Pharmacol (2013) 0.81
NOX1 NADPH oxidase regulation by the NOXA1 SH3 domain. Free Radic Biol Med (2007) 0.81
Chemokine-induced cell death in CCR5-expressing neuroblastoma cells. J Neuroimmunol (2003) 0.80
Nanoscale liquid chromatography and capillary electrophoresis coupled to electrospray mass spectrometry for the detection of amyloid-beta peptide related to Alzheimer's disease. J Chromatogr A (2002) 0.80
Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties. Arterioscler Thromb Vasc Biol (2013) 0.80
Regulation of calreticulin expression during induction of differentiation in human myeloid cells. Evidence for remodeling of the endoplasmic reticulum. J Biol Chem (2002) 0.80