Published in Aging Cell on February 01, 2006
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Sirtuins in mammals: insights into their biological function. Biochem J (2007) 7.60
Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell (2012) 2.96
SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci (2009) 2.80
SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell Stem Cell (2008) 2.67
SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell (2007) 2.42
SIRT1: recent lessons from mouse models. Nat Rev Cancer (2010) 2.07
SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts. PLoS One (2008) 1.58
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J Biol Chem (2008) 1.46
The dual role of sirtuins in cancer. Genes Cancer (2011) 1.45
C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis. Genes Dev (2008) 1.41
Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. Biochem J (2007) 1.19
Biochemical effects of SIRT1 activators. Biochim Biophys Acta (2009) 1.16
Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells. Cell Cycle (2009) 1.04
Sirtuins, metabolism, and cancer. Front Pharmacol (2012) 0.91
Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells. Br J Haematol (2011) 0.89
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress. Genes Cancer (2013) 0.89
Dual role of SIRT1 in UVB-induced skin tumorigenesis. Oncogene (2014) 0.89
SIRTain regulators of premature senescence and accelerated aging. Protein Cell (2015) 0.82
Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle. Exerc Sport Sci Rev (2013) 0.81
The apoptotic effects of sirtuin1 inhibitor on the MCF-7 and MRC-5 cell lines. Res Pharm Sci (2013) 0.80
SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of "cancer cells with neural stemness" in a p53-dependent manner. Neuro Oncol (2014) 0.79
The Benefits of Calorie Restriction and Calorie Restriction Mimetics as Related to the Eye. Open Longev Sci (2009) 0.77
Combination of Salermide and Cholera Toxin B Induce Apoptosis in MCF-7 but Not in MRC-5 Cell Lines. Int J Prev Med (2013) 0.76
Anticancer Effects of a New SIRT Inhibitor, MHY2256, against Human Breast Cancer MCF-7 Cells via Regulation of MDM2-p53 Binding. Int J Biol Sci (2016) 0.75
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell (2008) 5.51
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One (2008) 3.66
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes (2009) 3.39
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 3.35
A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64
SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol (2005) 2.24
Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell Cycle (2006) 2.17
Sirt1-deficient mice exhibit an altered cartilage phenotype. Joint Bone Spine (2013) 2.06
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. J Clin Invest (2009) 2.02
The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells. Mol Cancer Res (2003) 1.85
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci (2010) 1.71
sirt1-null mice develop an autoimmune-like condition. Exp Cell Res (2008) 1.67
SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis. Eur Heart J (2010) 1.40
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe (2008) 1.35
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch Biochem Biophys (2010) 1.34
Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. Biochem J (2007) 1.19
Evidence for repeat-induced gene silencing in cultured Mammalian cells: inactivation of tandem repeats of transfected genes. Exp Cell Res (2002) 1.13
Silent information regulator 1 protects the brain against cerebral ischemic damage. Stroke (2013) 1.09
SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell (2013) 1.06
Sirtuin 1 in immune regulation and autoimmunity. Immunol Cell Biol (2011) 1.05
A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction. Proc Natl Acad Sci U S A (2011) 1.05
Transcriptome analysis of stem development in the tumourous stem mustard Brassica juncea var. tumida Tsen et Lee by RNA sequencing. BMC Plant Biol (2012) 1.05
SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol (2011) 1.02
Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. Cancer Res (2010) 1.00
Enhanced external counterpulsation inhibits intimal hyperplasia by modifying shear stress responsive gene expression in hypercholesterolemic pigs. Circulation (2007) 0.99
CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins. Biochem Biophys Res Commun (2003) 0.98
SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons. J Neurosci (2011) 0.98
Analysis of sea-island cotton and upland cotton in response to Verticillium dahliae infection by RNA sequencing. BMC Genomics (2013) 0.96
Poly(D,L lactic-co-glycolic acid) microspheres as biodegradable microcarriers for pluripotent stem cells. Biomaterials (2004) 0.96
NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells. Biochem Biophys Res Commun (2012) 0.95
Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model. Arthritis Rheum (2013) 0.94
Isolation and biological characteristics of chicken adipose-derived progenitor cells. DNA Cell Biol (2011) 0.93
SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice. FASEB J (2011) 0.93
SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. Am J Physiol Lung Cell Mol Physiol (2014) 0.91
SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183. Future Med Chem (2010) 0.91
Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes. Cell Mol Life Sci (2009) 0.89
The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome. FASEB J (2013) 0.88
Gene expression profiling during gland morphogenesis of a mutant and a glandless upland cotton. Mol Biol Rep (2009) 0.87
Lovastatin induces neuronal differentiation and apoptosis of embryonal carcinoma and neuroblastoma cells: enhanced differentiation and apoptosis in combination with dbcAMP. Mol Cell Biochem (2010) 0.85
SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. PLoS One (2010) 0.84
SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol (2013) 0.84
WldS enhances insulin transcription and secretion via a SIRT1-dependent pathway and improves glucose homeostasis. Diabetes (2011) 0.84
SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer. PLoS One (2013) 0.84
Increased proton leak and SOD2 expression in myotubes from obese non-diabetic subjects with a family history of type 2 diabetes. Biochim Biophys Acta (2013) 0.82
A selectable and excisable marker system for the rapid creation of recombinant poxviruses. PLoS One (2011) 0.82
Enhanced external counterpulsation attenuates atherosclerosis progression through modulation of proinflammatory signal pathway. Arterioscler Thromb Vasc Biol (2010) 0.82
Mapping quantitative trait loci associated with chlorophyll a fluorescence parameters in soybean (Glycine max (L.) Merr.). Planta (2010) 0.81
Genomewide mapping reveals a combination of different genetic effects causing the genetic basis of heterosis in two elite rice hybrids. J Genet (2015) 0.80
Pseudomonas chengduensis sp. nov., isolated from landfill leachate. Int J Syst Evol Microbiol (2013) 0.77
Effect of organic carbon on nitrification efficiency and community composition of nitrifying biofilms. J Environ Sci (China) (2009) 0.77
The direct electrocatalysis of phenazine-1-carboxylic acid excreted by Pseudomonas alcaliphila under alkaline condition in microbial fuel cells. Bioresour Technol (2011) 0.77
Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration. Mol Endocrinol (2014) 0.76
Ultrasound microbubble contrast agent-mediated suicide gene transfection in the treatment of hepatic cancer. Oncol Lett (2012) 0.76
Disruption of Igfbp1 fails to rescue the phenotype of Sirt1-/- mice. Exp Cell Res (2010) 0.75
Isolation and biological characteristics of beijing Fatty chicken skeletal muscle satellite cells. Cell Commun Adhes (2012) 0.75
Sample Processing Effect on BK Virus Detection by Real-Time PCR in Urine Samples. Clin Lab (2016) 0.75
[Reduction of selenite to elemental red selenium under aerobic condition by Pseudomonas alcaliphila MBR]. Wei Sheng Wu Xue Bao (2010) 0.75
Nitrogen removal from landfill leachate via ex situ nitrification and sequential in situ denitrification. Waste Manag (2008) 0.75
[Isolation, culture and differentiation of skeletal muscle satellite cells of Luxi cattle embryo]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2013) 0.75
Enhanced transgene expression in embryonal carcinoma stem cells: transcription through introns and exons increases gene copy numbers and forestalls silencing. Exp Cell Res (2003) 0.75
Primer effect in the detection of mtDNA heteroplasmy: insights from horse Cytochrome b gene. Mitochondrial DNA (2014) 0.75
Effect of acetate on nitrite oxidation in mixed-population biofilms. J Biosci Bioeng (2008) 0.75