Published in PLoS One on March 12, 2008
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Recent progress in the biology and physiology of sirtuins. Nature (2009) 7.73
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Neural mechanisms of ageing and cognitive decline. Nature (2010) 3.59
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 3.35
How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci (2010) 3.05
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun (2010) 2.97
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. J Clin Invest (2010) 2.92
SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci (2009) 2.80
AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab (2010) 2.40
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
The aging stress response. Mol Cell (2010) 2.19
Energetics, epigenetics, mitochondrial genetics. Mitochondrion (2009) 2.08
SIRT1: recent lessons from mouse models. Nat Rev Cancer (2010) 2.07
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev (2009) 1.97
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest (2010) 1.97
Metabolic reprogramming, caloric restriction and aging. Trends Endocrinol Metab (2009) 1.95
Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91
SIRT1 and other sirtuins in metabolism. Trends Endocrinol Metab (2013) 1.90
Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab (2009) 1.89
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc Natl Acad Sci U S A (2009) 1.89
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85
Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol (2009) 1.85
The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Ageing Res Rev (2009) 1.79
Calorie restriction and sirtuins revisited. Genes Dev (2013) 1.79
TAp63 is a master transcriptional regulator of lipid and glucose metabolism. Cell Metab (2012) 1.77
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) (2010) 1.76
Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J Clin Invest (2011) 1.74
SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci (2010) 1.71
Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A (2010) 1.68
SIRT1 negatively regulates the mammalian target of rapamycin. PLoS One (2010) 1.68
Sirtuin 1 in lipid metabolism and obesity. Ann Med (2011) 1.65
Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation. Endocrinology (2010) 1.65
Regulation of mitochondrial biogenesis. Essays Biochem (2010) 1.58
The SirT3 divining rod points to oxidative stress. Mol Cell (2011) 1.58
The NAD World: a new systemic regulatory network for metabolism and aging--Sirt1, systemic NAD biosynthesis, and their importance. Cell Biochem Biophys (2009) 1.58
Mammalian circadian clock and metabolism - the epigenetic link. J Cell Sci (2010) 1.55
Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. Blood (2011) 1.52
Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation. J Biol Chem (2009) 1.52
Converging pathways in lifespan regulation. Curr Biol (2009) 1.48
SIRT1 contributes to telomere maintenance and augments global homologous recombination. J Cell Biol (2010) 1.48
Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem (2011) 1.47
SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. J Pharmacol Exp Ther (2010) 1.47
The tale of protein lysine acetylation in the cytoplasm. J Biomed Biotechnol (2010) 1.44
Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44
Janus-faced role of SIRT1 in tumorigenesis. Ann N Y Acad Sci (2012) 1.43
Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: a reevaluation. PLoS Biol (2013) 1.40
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab (2015) 1.38
Sirtuins: guardians of mammalian healthspan. Trends Genet (2014) 1.36
Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1. Am J Physiol Heart Circ Physiol (2008) 1.36
Epigenetic targets of bioactive dietary components for cancer prevention and therapy. Clin Epigenetics (2010) 1.33
Small-molecule allosteric activators of sirtuins. Annu Rev Pharmacol Toxicol (2013) 1.31
Association of SIRT1 gene variation with visceral obesity. Hum Genet (2008) 1.29
FoxO1 mediates an autofeedback loop regulating SIRT1 expression. J Biol Chem (2010) 1.27
Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol (2015) 1.24
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy. Clin Sci (Lond) (2013) 1.23
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol (2013) 1.23
Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning. J Cereb Blood Flow Metab (2011) 1.18
Roles of SIRT1 in the acute and restorative phases following induction of inflammation. J Biol Chem (2010) 1.18
Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis. J Biol Chem (2013) 1.18
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
Mammalian sirtuins and energy metabolism. Int J Biol Sci (2011) 1.17
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. Handb Exp Pharmacol (2011) 1.16
Sirtuins and their relevance to the kidney. J Am Soc Nephrol (2010) 1.15
Effect of feeding regimens on circadian rhythms: implications for aging and longevity. Aging (Albany NY) (2010) 1.14
Sirtuin 1, stem cells, aging, and stem cell aging. Curr Opin Hematol (2008) 1.11
NAD⁺ metabolism: a therapeutic target for age-related metabolic disease. Crit Rev Biochem Mol Biol (2013) 1.11
Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction. Proc Natl Acad Sci U S A (2012) 1.10
Calorie restriction effects on silencing and recombination at the yeast rDNA. Aging Cell (2009) 1.10
The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY) (2013) 1.08
Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice. J Gerontol A Biol Sci Med Sci (2012) 1.07
Sirtuin-1 regulation of mammalian metabolism. Trends Mol Med (2011) 1.07
dSir2 mediates the increased spontaneous physical activity in flies on calorie restriction. Aging (Albany NY) (2009) 1.07
Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging. Circ Res (2014) 1.06
SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell (2013) 1.06
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J (2014) 1.06
SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential. Diabetes Metab J (2013) 1.05
A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction. Proc Natl Acad Sci U S A (2011) 1.05
NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise. Am J Physiol Endocrinol Metab (2012) 1.05
Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes. Nutr Metab (Lond) (2009) 1.04
Histone variant macroH2A1 deletion in mice causes female-specific steatosis. Epigenetics Chromatin (2010) 1.03
Maternal protein restriction affects postnatal growth and the expression of key proteins involved in lifespan regulation in mice. PLoS One (2009) 1.03
Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors. Cell Mol Life Sci (2010) 1.00
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). Dose Response (2014) 1.00
Kidney aging--inevitable or preventable? Nat Rev Nephrol (2011) 0.99
The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function. Diabetes (2011) 0.98
Mammalian Sirt1: insights on its biological functions. Cell Commun Signal (2011) 0.98
SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons. J Neurosci (2011) 0.98
Emerging Roles of SIRT1 in Cancer Drug Resistance. Genes Cancer (2013) 0.97
Aging and inflammation: etiological culprits of cancer. Curr Aging Sci (2009) 0.97
SirT1 in muscle physiology and disease: lessons from mouse models. Dis Model Mech (2010) 0.97
ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling. Diabetes (2015) 0.96
The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging (Albany NY) (2012) 0.94
Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes. Clin Exp Nephrol (2011) 0.94
Macronutrients and caloric intake in health and longevity. J Endocrinol (2015) 0.94
SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty. Curr Opin Clin Nutr Metab Care (2009) 0.93
Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance. PLoS One (2013) 0.93
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (2000) 12.98
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A (2004) 9.25
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun (2000) 9.09
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A (2000) 7.92
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell (2007) 6.31
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem (2005) 5.93
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun (1999) 5.83
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev (1995) 5.55
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol (2005) 5.54
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab (2005) 5.39
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37
Increase in activity during calorie restriction requires Sirt1. Science (2005) 4.90
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A (2007) 4.87
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab (2007) 4.75
Biochemical and osmotic properties of skeletal muscle mitochondria. Nature (1954) 4.41
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem (2006) 4.28
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14
Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state. J Membr Biol (1979) 3.95
Extending the lifespan of long-lived mice. Nature (2001) 2.98
Uncoupling: new approaches to an old problem of bioenergetics. Biochim Biophys Acta (1998) 2.70
SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J Biol Chem (2006) 2.42
Sirtuin functions in health and disease. Mol Endocrinol (2007) 2.38
Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Mol Cell Biol (2007) 2.17
Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria. Am J Physiol Endocrinol Metab (2005) 1.77
A quantitative fluorimetric assay for the determination of oxidant production by polymorphonuclear leukocytes: its use in the simultaneous fluorimetric assay of cellular activation processes. Anal Biochem (1984) 1.74
O2 solubility in aqueous media determined by a kinetic method. Anal Biochem (1985) 1.71
Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling. Biochem Soc Trans (2003) 1.57
The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. J Biol Chem (2007) 1.54
Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production. Am J Physiol Endocrinol Metab (2004) 1.30
The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals. Mech Ageing Dev (2005) 1.19
Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. Am J Physiol Endocrinol Metab (2001) 1.03
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell (2008) 5.51
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes (2009) 3.39
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 3.35
Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. Cell Metab (2005) 2.76
A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64
SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol (2005) 2.24
Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell Cycle (2006) 2.17
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter. Cell Metab (2013) 2.15
Sirt1-deficient mice exhibit an altered cartilage phenotype. Joint Bone Spine (2013) 2.06
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. J Clin Invest (2009) 2.02
Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J Clin Invest (2003) 1.97
Uncoupling proteins and the control of mitochondrial reactive oxygen species production. Free Radic Biol Med (2011) 1.91
MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metab (2013) 1.87
The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells. Mol Cancer Res (2003) 1.85
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria. Am J Physiol Endocrinol Metab (2005) 1.77
SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci (2010) 1.71
sirt1-null mice develop an autoimmune-like condition. Exp Cell Res (2008) 1.67
Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3. J Biol Chem (2011) 1.53
Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation. J Biol Chem (2009) 1.52
SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis. Eur Heart J (2010) 1.40
Uncoupling protein-3: clues in an ongoing mitochondrial mystery. FASEB J (2007) 1.38
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe (2008) 1.35
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch Biochem Biophys (2010) 1.34
Uncoupling proteins and thermoregulation. J Appl Physiol (1985) (2002) 1.34
SirT1 fails to affect p53-mediated biological functions. Aging Cell (2006) 1.33
Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria. Am J Physiol Endocrinol Metab (2004) 1.32
Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells. Diabetes (2005) 1.31
Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production. Am J Physiol Endocrinol Metab (2004) 1.30
Percent relative cumulative frequency analysis in indirect calorimetry: application to studies of transgenic mice. Can J Physiol Pharmacol (2004) 1.24
Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. Biochem J (2007) 1.19
Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells. PLoS One (2011) 1.19
Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export. J Biol Chem (2008) 1.19
Thyroid hormone effects on mitochondrial energetics. Thyroid (2008) 1.18
Mitochondrial proticity and ROS signaling: lessons from the uncoupling proteins. Trends Endocrinol Metab (2012) 1.15
Evidence for repeat-induced gene silencing in cultured Mammalian cells: inactivation of tandem repeats of transfected genes. Exp Cell Res (2002) 1.13
Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents. PLoS One (2010) 1.09
Silent information regulator 1 protects the brain against cerebral ischemic damage. Stroke (2013) 1.09
SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell (2013) 1.06
Gene expression profiling in whole blood identifies distinct biological pathways associated with obesity. BMC Med Genomics (2010) 1.05
Sirtuin 1 in immune regulation and autoimmunity. Immunol Cell Biol (2011) 1.05
A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction. Proc Natl Acad Sci U S A (2011) 1.05
Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics. Trends Biochem Sci (2013) 1.04
Long-term high-fat feeding induces greater fat storage in mice lacking UCP3. Am J Physiol Endocrinol Metab (2008) 1.04
Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase. FASEB J (2010) 1.03
Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscle. PLoS One (2007) 1.03
SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol (2011) 1.02
Distinct skeletal muscle fiber characteristics and gene expression in diet-sensitive versus diet-resistant obesity. J Lipid Res (2010) 1.01
Crucial yet divergent roles of mitochondrial redox state in skeletal muscle vs. brown adipose tissue energetics. FASEB J (2011) 1.00
Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. Cancer Res (2010) 1.00
Proton leak and hydrogen peroxide production in liver mitochondria from energy-restricted rats. Am J Physiol Endocrinol Metab (2004) 0.99
Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle. Mech Ageing Dev (2012) 0.99
The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function. Diabetes (2011) 0.98
CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins. Biochem Biophys Res Commun (2003) 0.98
SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons. J Neurosci (2011) 0.98
FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle. Am J Physiol Regul Integr Comp Physiol (2009) 0.97
Poly(D,L lactic-co-glycolic acid) microspheres as biodegradable microcarriers for pluripotent stem cells. Biomaterials (2004) 0.96
Rescue of neurons from ischemic injury by peroxisome proliferator-activated receptor-gamma requires a novel essential cofactor LMO4. J Neurosci (2008) 0.95
NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells. Biochem Biophys Res Commun (2012) 0.95
Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model. Arthritis Rheum (2013) 0.94
Uncoupling proteins: role in insulin resistance and insulin insufficiency. Curr Diabetes Rev (2006) 0.93
Mitochondrial uncoupling as a target in the treatment of obesity. Curr Opin Clin Nutr Metab Care (2007) 0.93
Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice. Am J Physiol Endocrinol Metab (2006) 0.93
Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration. Biochem J (2011) 0.93
Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response. Obesity (Silver Spring) (2007) 0.93
SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice. FASEB J (2011) 0.93
Glutaredoxin-2 is required to control proton leak through uncoupling protein-3. J Biol Chem (2013) 0.92
SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. Am J Physiol Lung Cell Mol Physiol (2014) 0.91
SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183. Future Med Chem (2010) 0.91
Chaotic nature of sepsis and multiple organ failure cannot be explained by linear statistical methods. Crit Care (2008) 0.91
Intrinsic aerobic capacity correlates with greater inherent mitochondrial oxidative and H2O2 emission capacities without major shifts in myosin heavy chain isoform. J Appl Physiol (1985) (2012) 0.91
Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes. Cell Mol Life Sci (2009) 0.89
Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion. J Biol Chem (2012) 0.89
The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome. FASEB J (2013) 0.88