Published in Mol Biol Cell on September 12, 2012
Mechanism-based corrector combination restores ΔF508-CFTR folding and function. Nat Chem Biol (2013) 1.76
Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression. Sci Transl Med (2014) 1.64
Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect. PLoS Biol (2016) 1.42
The secret life of CFTR as a calcium-activated chloride channel. J Physiol (2013) 1.01
An unexpected effect of TNF-α on F508del-CFTR maturation and function. F1000Res (2015) 0.98
Cigarette smoke and CFTR: implications in the pathogenesis of COPD. Am J Physiol Lung Cell Mol Physiol (2013) 0.96
Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy. Mol Pharmacol (2014) 0.94
Current progress of genetically engineered pig models for biomedical research. Biores Open Access (2014) 0.84
Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion. Proc Natl Acad Sci U S A (2014) 0.84
Normal CFTR inhibits epidermal growth factor receptor-dependent pro-inflammatory chemokine production in human airway epithelial cells. PLoS One (2013) 0.82
Quantitative proteomics reveals an altered cystic fibrosis in vitro bronchial epithelial secretome. Am J Respir Cell Mol Biol (2015) 0.81
TMEM16A overexpression contributes to tumor invasion and poor prognosis of human gastric cancer through TGF-β signaling. Oncotarget (2015) 0.80
Potentiators of Defective ΔF508-CFTR Gating that Do Not Interfere with Corrector Action. Mol Pharmacol (2015) 0.80
Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker. Br J Pharmacol (2016) 0.79
Epithelial Anion Transport as Modulator of Chemokine Signaling. Mediators Inflamm (2016) 0.75
Creation and characterization of an airway epithelial cell line for stable expression of CFTR variants. J Cyst Fibros (2015) 0.75
The Contribution of the Airway Epithelial Cell to Host Defense. Mediators Inflamm (2015) 0.75
New use for an old drug: COX-independent anti-inflammatory effects of sulindac in models of cystic fibrosis. Br J Pharmacol (2016) 0.75
Differential Contribution of the Aryl-Hydrocarbon Receptor and Toll-Like Receptor Pathways to IL-8 Expression in Normal and Cystic Fibrosis Airway Epithelial Cells Exposed to Pseudomonas aeruginosa. Front Cell Dev Biol (2016) 0.75
Correctors and Potentiators Rescue Function of the Truncated W1282X-CFTR Translation Product. J Biol Chem (2016) 0.75
Epithelial Chloride Transport by CFTR Requires TMEM16A. Sci Rep (2017) 0.75
Increased TMEM16A Involved in Alveolar Fluid Clearance After Lipopolysaccharide Stimulation. Inflammation (2016) 0.75
A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science (1989) 40.22
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A (1992) 35.45
TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science (2008) 8.74
TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature (2008) 8.40
Cystic fibrosis. N Engl J Med (2005) 8.09
Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell (2008) 7.79
Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell (1998) 6.72
Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell (1993) 6.25
Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med (2005) 6.13
Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice. Nat Med (2004) 5.24
Cystic fibrosis. Lancet (2003) 5.00
Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest (2002) 4.97
Well-differentiated human airway epithelial cell cultures. Methods Mol Med (2005) 4.66
PerlPrimer: cross-platform, graphical primer design for standard, bisulphite and real-time PCR. Bioinformatics (2004) 3.44
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med (2010) 3.36
Cystic fibrosis: genotypic and phenotypic variations. Annu Rev Genet (1995) 3.27
Peripheral protein quality control removes unfolded CFTR from the plasma membrane. Science (2010) 2.92
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. J Cell Biol (2004) 2.74
TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem (2010) 2.66
Integral and peripheral protein composition of the apical and basolateral membrane domains in MDCK cells. J Membr Biol (1989) 2.65
CFTR inhibition mimics the cystic fibrosis inflammatory profile. Am J Physiol Lung Cell Mol Physiol (2006) 2.54
Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis. J Clin Invest (2010) 2.45
The CF salt controversy: in vivo observations and therapeutic approaches. Mol Cell (2001) 2.42
Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur Respir J (2005) 2.37
Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers. Am J Respir Crit Care Med (2006) 2.34
Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A (2009) 2.33
Regulation by ATP and ADP of CFTR chloride channels that contain mutant nucleotide-binding domains. Science (1992) 2.18
Regulation of TMEM16A chloride channel properties by alternative splicing. J Biol Chem (2009) 2.16
Endotoxin activity and inflammatory markers in the airways of young patients with cystic fibrosis. Am J Respir Crit Care Med (2002) 1.94
Lower airway inflammation in infants with cystic fibrosis detected by newborn screening. Pediatr Pulmonol (2005) 1.90
Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration. FASEB J (2011) 1.79
Salmonella typhimurium induces epithelial IL-8 expression via Ca(2+)-mediated activation of the NF-kappaB pathway. J Clin Invest (2000) 1.74
Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea. FASEB J (2010) 1.71
Airway inflammation in cystic fibrosis. Chest (2008) 1.70
Innate immune response in CF airway epithelia: hyperinflammatory? Am J Physiol Cell Physiol (2006) 1.69
Epigenetic regulation of airway inflammation. Curr Opin Immunol (2007) 1.66
Lung inflammation early in cystic fibrosis: bugs are indicted, but the defense is guilty. Am J Respir Crit Care Med (2002) 1.53
Neutrophils in cystic fibrosis. Thorax (2009) 1.51
Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J (2011) 1.45
Macromolecular complexes of cystic fibrosis transmembrane conductance regulator and its interacting partners. Pharmacol Ther (2005) 1.45
Development of a novel trans-lentiviral vector that affords predictable safety. Mol Ther (2000) 1.42
Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)- (2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis. J Pharmacol Exp Ther (2002) 1.40
Do airway epithelium air-liquid cultures represent the in vivo airway epithelium transcriptome? Am J Respir Cell Mol Biol (2010) 1.40
Chronic airway infection/inflammation induces a Ca2+i-dependent hyperinflammatory response in human cystic fibrosis airway epithelia. J Biol Chem (2005) 1.37
Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1. J Biol Chem (2008) 1.33
Pathways for cytokine secretion. Physiology (Bethesda) (2010) 1.33
Response to acute lung infection with mucoid Pseudomonas aeruginosa in cystic fibrosis mice. Am J Respir Crit Care Med (2005) 1.33
Regulation of hypoxia-inducible factors during inflammation. Methods Enzymol (2007) 1.29
Revisiting the role of cystic fibrosis transmembrane conductance regulator and counterion permeability in the pH regulation of endocytic organelles. Mol Biol Cell (2009) 1.29
Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J Med Chem (2011) 1.25
Novel human bronchial epithelial cell lines for cystic fibrosis research. Am J Physiol Lung Cell Mol Physiol (2008) 1.24
Effects of cystic fibrosis transmembrane conductance regulator and DeltaF508CFTR on inflammatory response, ER stress, and Ca2+ of airway epithelia. Am J Physiol Lung Cell Mol Physiol (2007) 1.19
Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium. J Biol Chem (2010) 1.19
Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem (2009) 1.17
Towards an in vitro model of cystic fibrosis small airway epithelium: characterisation of the human bronchial epithelial cell line CFBE41o-. Cell Tissue Res (2005) 1.15
Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. Am J Physiol Lung Cell Mol Physiol (2009) 1.14
Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2. J Biol Chem (2008) 1.14
Inhalation of Moli1901 in patients with cystic fibrosis. Chest (2007) 1.13
Regulation of receptor protein-tyrosine phosphatase alpha by oxidative stress. EMBO J (2002) 1.11
TLR-4-mediated innate immunity is reduced in cystic fibrosis airway cells. Am J Respir Cell Mol Biol (2009) 1.08
Expression of wild-type CFTR suppresses NF-kappaB-driven inflammatory signalling. PLoS One (2010) 1.08
Peripheral airway cell differentiation in human lung cancer cell lines. Cancer Res (1990) 1.07
Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching. FASEB J (2011) 1.07
Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation. J Biol Chem (2005) 1.04
Down-regulation of the anti-inflammatory protein annexin A1 in cystic fibrosis knock-out mice and patients. Mol Cell Proteomics (2005) 1.00
Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition. J Pharmacol Exp Ther (2010) 0.99
G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling. Cardiovasc Res (2010) 0.94
Hypoxia-inducible factor 1alpha induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2 transcription. J Biol Chem (2009) 0.93
What's new in CF airway inflammation: an update. Paediatr Respir Rev (2006) 0.91
Denufosol tetrasodium in patients with cystic fibrosis and normal to mildly impaired lung function. Am J Respir Crit Care Med (2010) 0.91
Cystic fibrosis transmembrane conductance regulator does not affect neutrophil migration across cystic fibrosis airway epithelial monolayers. Am J Pathol (2000) 0.91
Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motif. Mol Cell Biol (2003) 0.89
Agonist-induced phosphorylation and desensitization of the P2Y2 nucleotide receptor. Mol Cell Biochem (2005) 0.89
Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways. J Immunol (2011) 0.89
Inflammation, HIF-1, and the epigenetics that follows. Mediators Inflamm (2010) 0.87
An activated immune and inflammatory response targets the pancreas of newborn pigs with cystic fibrosis. Pancreatology (2011) 0.85
Reduced surface toll-like receptor-4 expression and absent interferon-γ-inducible protein-10 induction in cystic fibrosis airway cells. Exp Lung Res (2011) 0.84
Cell-to-cell variation in store-operated calcium entry in HEK-293 cells and its impact on the interpretation of data from stable clones expressing exogenous calcium channels. Cell Calcium (2000) 0.83
Duramycin increases intracellular calcium in airway epithelium. Membr Biochem (1993) 0.83
Calcium dependent and independent cytokine synthesis by air pollution particle-exposed human bronchial epithelial cells. Toxicol Appl Pharmacol (2007) 0.83
The cystic fibrosis transmembrane recruiter the alter ego of CFTR as a multi-kinase anchor. Pflugers Arch (2007) 0.82
P. aeruginosa drives CXCL8 synthesis via redundant toll-like receptors and NADPH oxidase in CFTR∆F508 airway epithelial cells. J Cyst Fibros (2010) 0.82
Extracellular pH in restricted domains as a gating signal for ion channels involved in transepithelial transport. Biol Pharm Bull (2011) 0.80
N-acetylcysteine inhibits Na+ absorption across human nasal epithelial cells. J Cell Physiol (2004) 0.80
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med (2005) 10.39
TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science (2008) 8.74
Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol (2004) 6.35
Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med (2000) 6.27
Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest (2002) 4.97
Tracking of single fluorescent particles in three dimensions: use of cylindrical optics to encode particle position. Biophys J (1994) 4.77
Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus. J Cell Biol (1997) 4.53
Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem (2003) 4.40
Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature (2005) 4.20
Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening. J Clin Invest (2005) 4.19
Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain (2010) 3.95
Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J (2004) 3.80
Green fluorescent protein as a noninvasive intracellular pH indicator. Biophys J (1998) 3.61
Determinants of the translational mobility of a small solute in cell cytoplasm. J Cell Biol (1993) 3.46
Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest (1997) 3.45
Size-dependent DNA mobility in cytoplasm and nucleus. J Biol Chem (2000) 3.29
Chloride channels as drug targets. Nat Rev Drug Discov (2008) 3.22
The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR. Nat Struct Mol Biol (2004) 3.16
Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol (2004) 3.10
Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem (1998) 3.00
Crowding effects on diffusion in solutions and cells. Annu Rev Biophys (2008) 3.00
Peripheral protein quality control removes unfolded CFTR from the plasma membrane. Science (2010) 2.92
Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. J Biol Chem (1999) 2.91
Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis. Kidney Int (2006) 2.89
Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. J Biol Chem (1994) 2.85
Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein. Cell Stress Chaperones (1996) 2.80
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. J Cell Biol (2004) 2.74
Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice. Proc Natl Acad Sci U S A (1998) 2.73
Low viscosity in the aqueous domain of cell cytoplasm measured by picosecond polarization microfluorimetry. J Cell Biol (1991) 2.73
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol (2009) 2.70
TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem (2010) 2.66
Diffusion of green fluorescent protein in the aqueous-phase lumen of endoplasmic reticulum. Biophys J (1999) 2.59
Aquaporin 4 and neuromyelitis optica. Lancet Neurol (2012) 2.58
Water and glycerol permeabilities of aquaporins 1-5 and MIP determined quantitatively by expression of epitope-tagged constructs in Xenopus oocytes. J Biol Chem (1997) 2.56
Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues. J Cell Sci (1995) 2.55
Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci (2005) 2.48
Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Ann Neurol (2012) 2.45
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science (2004) 2.39
Green fluorescent protein-based halide indicators with improved chloride and iodide affinities. FEBS Lett (2001) 2.38
Mechanism and cellular applications of a green fluorescent protein-based halide sensor. J Biol Chem (2000) 2.38
Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes. Proc Natl Acad Sci U S A (1995) 2.37
Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers. Am J Respir Crit Care Med (2006) 2.34
Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis. Am J Physiol Cell Physiol (2005) 2.32
Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating. J Biol Chem (2003) 2.25
Localization of the CHIP28 water channel in rat kidney. Am J Physiol (1992) 2.17
Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol (2002) 2.16
The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cells. J Biol Chem (1996) 2.16
Regulation of TMEM16A chloride channel properties by alternative splicing. J Biol Chem (2009) 2.16
Rapid diffusion of green fluorescent protein in the mitochondrial matrix. J Cell Biol (1998) 2.12
Submucosal gland secretions in airways from cystic fibrosis patients have normal [Na(+)] and pH but elevated viscosity. Proc Natl Acad Sci U S A (2001) 2.10
Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. J Biol Chem (2005) 2.08
Increased migration and metastatic potential of tumor cells expressing aquaporin water channels. FASEB J (2006) 2.07
Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis. J Cell Biol (2007) 2.07
Lung fluid transport in aquaporin-5 knockout mice. J Clin Invest (2000) 2.07
Aquaporins and cell migration. Pflugers Arch (2007) 2.02
Water and urea permeability properties of Xenopus oocytes: expression of mRNA from toad urinary bladder. Am J Physiol (1991) 2.01
Monte Carlo analysis of obstructed diffusion in three dimensions: application to molecular diffusion in organelles. Biophys J (1998) 2.00
Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds. J Biol Chem (2001) 1.99
CFTR: folding, misfolding and correcting the ΔF508 conformational defect. Trends Mol Med (2011) 1.99
Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method. Am J Physiol Cell Physiol (2003) 1.99
Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays. J Biol Chem (2011) 1.98
K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator. Nat Methods (2005) 1.98
Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in Mammalian cells. Traffic (2006) 1.96
Analysis of fluorophore diffusion by continuous distributions of diffusion coefficients: application to photobleaching measurements of multicomponent and anomalous diffusion. Biophys J (1998) 1.95
Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proc Natl Acad Sci U S A (2000) 1.94
Identification of a NBD1-binding pharmacological chaperone that corrects the trafficking defect of F508del-CFTR. Chem Biol (2011) 1.92
In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching. J Neurosci (2004) 1.90
High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. J Biol Chem (2002) 1.89
Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Am J Physiol Lung Cell Mol Physiol (2005) 1.87
Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones. J Clin Invest (1998) 1.87
Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung. Proc Natl Acad Sci U S A (1998) 1.85
Functional reconstitution of the isolated erythrocyte water channel CHIP28. J Biol Chem (1992) 1.85
Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol Pharmacol (2007) 1.85
Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study. J Cell Biol (1993) 1.84
Three-dimensional organization of a human water channel. Nature (1997) 1.83
Salt and water transport across alveolar and distal airway epithelia in the adult lung. Am J Physiol (1996) 1.82
Noninvasive in vivo fluorescence measurement of airway-surface liquid depth, salt concentration, and pH. J Clin Invest (2001) 1.80
Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol Pharmacol (2005) 1.80
Cytoplasmic viscosity near the cell plasma membrane: translational diffusion of a small fluorescent solute measured by total internal reflection-fluorescence photobleaching recovery. Biophys J (1996) 1.79
Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J Biol Chem (2002) 1.79
Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4. J Cell Sci (1997) 1.78
Mechanism-based corrector combination restores ΔF508-CFTR folding and function. Nat Chem Biol (2013) 1.76
Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides. Bioorg Med Chem (2008) 1.75
A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways. FASEB J (2004) 1.75
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Mol Biol Cell (2006) 1.74
Second messengers regulate endosomal acidification in Swiss 3T3 fibroblasts. J Cell Biol (1992) 1.74
Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function. Cell (2012) 1.73
Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury. FASEB J (2006) 1.72
Mapping of fluorescence anisotropy in living cells by ratio imaging. Application to cytoplasmic viscosity. Biophys J (1990) 1.72