Stable insertion of Alzheimer Abeta peptide into the ER membrane strongly correlates with its length.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 2000821)

Published in FEBS Lett on July 19, 2007

Authors

Carolina Lundin1, Sofia Johansson, Arthur E Johnson, Jan Näslund, Gunnar von Heijne, IngMarie Nilsson

Author Affiliations

1: Stockholm Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 12, SE-106 91 Stockholm, Sweden.

Articles cited by this

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07

Alzheimer's disease: genes, proteins, and therapy. Physiol Rev (2001) 19.19

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol (2007) 17.69

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science (1999) 13.19

Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature (2005) 7.72

Preparation of microsomal membranes for cotranslational protein translocation. Methods Enzymol (1983) 6.94

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science (1994) 5.10

Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci (1997) 4.57

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem (1998) 3.83

Determination of the distance between the oligosaccharyltransferase active site and the endoplasmic reticulum membrane. J Biol Chem (1993) 3.02

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J Neurosci (2005) 2.48

Membrane-protein integration and the role of the translocation channel. Trends Cell Biol (2004) 2.03

Cotranslational membrane protein biogenesis at the endoplasmic reticulum. J Biol Chem (2004) 1.70

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. J Biol Chem (2006) 1.66

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain. J Biol Chem (2005) 1.61

Turns in transmembrane helices: determination of the minimal length of a "helical hairpin" and derivation of a fine-grained turn propensity scale. J Mol Biol (1999) 1.36

Asn- and Asp-mediated interactions between transmembrane helices during translocon-mediated membrane protein assembly. EMBO Rep (2006) 1.33

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42. Biochemistry (2004) 1.32

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein. J Biol Chem (2004) 1.30

Mutations in APP have independent effects on Abeta and CTFgamma generation. Neurobiol Dis (2004) 1.29

Proline-induced disruption of a transmembrane alpha-helix in its natural environment. J Mol Biol (1998) 1.26

DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase. Biochemistry (2006) 1.12

Segregation of a missense mutation in the amyloid beta-protein precursor gene with familial Alzheimer's disease. J Alzheimers Dis (2006) 0.99

Inter-helical hydrogen bond formation during membrane protein integration into the ER membrane. J Mol Biol (2003) 0.92

Abeta 11-40/42 production without gamma-secretase epsilon-site cleavage. Biochem Biophys Res Commun (2006) 0.91

Articles by these authors

Improved prediction of signal peptides: SignalP 3.0. J Mol Biol (2004) 48.40

SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat Methods (2011) 33.90

Locating proteins in the cell using TargetP, SignalP and related tools. Nat Protoc (2007) 19.50

Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature (2005) 7.72

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol (2005) 4.91

Molecular code for transmembrane-helix recognition by the Sec61 translocon. Nature (2007) 4.60

Global topology analysis of the Escherichia coli inner membrane proteome. Science (2005) 4.11

Functional reconstitution of ESCRT-III assembly and disassembly. Cell (2009) 3.52

Membrane insertion of a potassium-channel voltage sensor. Science (2005) 3.30

Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14

Reliability measures for membrane protein topology prediction algorithms. J Mol Biol (2003) 3.13

Identification and evolution of dual-topology membrane proteins. Nat Struct Mol Biol (2006) 3.12

Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins. Cell (2004) 3.03

Emulating membrane protein evolution by rational design. Science (2007) 2.96

Interface connections of a transmembrane voltage sensor. Proc Natl Acad Sci U S A (2005) 2.92

Coping with cold: the genome of the versatile marine Antarctica bacterium Pseudoalteromonas haloplanktis TAC125. Genome Res (2005) 2.89

Prediction of membrane-protein topology from first principles. Proc Natl Acad Sci U S A (2008) 2.55

LUMA (LUminometric Methylation Assay)--a high throughput method to the analysis of genomic DNA methylation. Exp Cell Res (2006) 2.48

Central functions of the lumenal and peripheral thylakoid proteome of Arabidopsis determined by experimentation and genome-wide prediction. Plant Cell (2002) 2.48

Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein. Nat Struct Mol Biol (2005) 2.33

Control of membrane protein topology by a single C-terminal residue. Science (2010) 2.28

The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells. Blood (2008) 2.24

Membrane protein structure: prediction versus reality. Annu Rev Biochem (2007) 2.21

Rapid topology mapping of Escherichia coli inner-membrane proteins by prediction and PhoA/GFP fusion analysis. Proc Natl Acad Sci U S A (2002) 2.17

High-throughput fluorescent-based optimization of eukaryotic membrane protein overexpression and purification in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2007) 2.15

Membrane topology of the Drosophila OR83b odorant receptor. FEBS Lett (2007) 2.11

SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites. Cell (2008) 2.09

GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae. Nat Protoc (2008) 2.06

How translocons select transmembrane helices. Annu Rev Biophys (2008) 2.03

Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin. Nat Struct Biol (2002) 1.96

Fluorescence mapping of mitochondrial TIM23 complex reveals a water-facing, substrate-interacting helix surface. Cell (2008) 1.94

Importin-alpha-16 is a translocon-associated protein involved in sorting membrane proteins to the nuclear envelope. Nat Struct Mol Biol (2006) 1.90

Stepwise insertion and inversion of a type II signal anchor sequence in the ribosome-Sec61 translocon complex. Cell (2011) 1.86

Prediction of the human membrane proteome. Proteomics (2010) 1.85

Redefining cholesterol's role in the mechanism of the cholesterol-dependent cytolysins. Proc Natl Acad Sci U S A (2003) 1.79

N-linked glycans direct the cotranslational folding pathway of influenza hemagglutinin. Mol Cell (2003) 1.79

Translation arrest requires two-way communication between a nascent polypeptide and the ribosome. Mol Cell (2006) 1.74

Using LUMA: a Luminometric-based assay for global DNA-methylation. Epigenetics (2006) 1.74

Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens. J Biol Chem (2003) 1.71

Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit beta-strand alignment. Nat Struct Mol Biol (2004) 1.71

Cotranslational membrane protein biogenesis at the endoplasmic reticulum. J Biol Chem (2004) 1.70

Protein complexes of the Escherichia coli cell envelope. J Biol Chem (2005) 1.69

A study of the membrane-water interface region of membrane proteins. J Mol Biol (2004) 1.68

Evidence for a protein transported through the secretory pathway en route to the higher plant chloroplast. Nat Cell Biol (2005) 1.66

Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface. Proc Natl Acad Sci U S A (2010) 1.66

Transmembrane helices before, during, and after insertion. Curr Opin Struct Biol (2005) 1.64

Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin. J Biol Chem (2002) 1.62

Biogenesis of inner membrane proteins in Escherichia coli. Annu Rev Microbiol (2005) 1.61

Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA (2005) 1.59

Assembly and topography of the prepore complex in cholesterol-dependent cytolysins. J Biol Chem (2003) 1.58

Arginine in membranes: the connection between molecular dynamics simulations and translocon-mediated insertion experiments. J Membr Biol (2010) 1.58

The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene. Genetics (2004) 1.57

Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions. Proc Natl Acad Sci U S A (2007) 1.57

Comparative analysis of amino acid distributions in integral membrane proteins from 107 genomes. Proteins (2005) 1.57

Photocross-linking of nascent chains to the STT3 subunit of the oligosaccharyltransferase complex. J Cell Biol (2003) 1.54

Partial purification and characterization of gamma-secretase from post-mortem human brain. J Biol Chem (2003) 1.54

The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum. J Cell Biol (2005) 1.52

A nine-transmembrane domain topology for presenilin 1. J Biol Chem (2005) 1.52

The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation. Proc Natl Acad Sci U S A (2005) 1.52

A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel. Proc Natl Acad Sci U S A (2009) 1.49

Minimal acupuncture is not a valid placebo control in randomised controlled trials of acupuncture: a physiologist's perspective. Chin Med (2009) 1.49

Membrane topology of the human seipin protein. FEBS Lett (2006) 1.48

A global topology map of the Saccharomyces cerevisiae membrane proteome. Proc Natl Acad Sci U S A (2006) 1.45

Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system. Cell (2007) 1.44

Cotranslational protein integration into the ER membrane is mediated by the binding of nascent chains to translocon proteins. Mol Cell (2003) 1.44

Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin. J Biol Chem (2007) 1.44

Molecular recognition of a single sphingolipid species by a protein's transmembrane domain. Nature (2012) 1.42

Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions. J Biol Chem (2003) 1.40

Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding. Biochemistry (2009) 1.39

The machinery of membrane protein assembly. Curr Opin Struct Biol (2004) 1.34

Asn- and Asp-mediated interactions between transmembrane helices during translocon-mediated membrane protein assembly. EMBO Rep (2006) 1.33

Insertion of short transmembrane helices by the Sec61 translocon. Proc Natl Acad Sci U S A (2009) 1.31

A new role for BiP: closing the aqueous translocon pore during protein integration into the ER membrane. J Cell Biol (2002) 1.30

PONGO: a web server for multiple predictions of all-alpha transmembrane proteins. Nucleic Acids Res (2006) 1.29

Fluorescence resonance energy transfer analysis of protein translocase. SecYE from Thermus thermophilus HB8 forms a constitutive oligomer in membranes. J Biol Chem (2003) 1.28

Sequence-based feature prediction and annotation of proteins. Genome Biol (2009) 1.28

Bax forms an oligomer via separate, yet interdependent, surfaces. J Biol Chem (2010) 1.27

A biphasic pulling force acts on transmembrane helices during translocon-mediated membrane integration. Nat Struct Mol Biol (2012) 1.24

Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+ channel voltage sensor domain. Proc Natl Acad Sci U S A (2007) 1.24

Molecular code for protein insertion in the endoplasmic reticulum membrane is similar for N(in)-C(out) and N(out)-C(in) transmembrane helices. Proc Natl Acad Sci U S A (2008) 1.21

In silico prediction of the peroxisomal proteome in fungi, plants and animals. J Mol Biol (2003) 1.21

Determination of N- and C-terminal borders of the transmembrane domain of integrin subunits. J Biol Chem (2004) 1.21

Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax. J Biol Chem (2004) 1.20

How interaction of perfringolysin O with membranes is controlled by sterol structure, lipid structure, and physiological low pH: insights into the origin of perfringolysin O-lipid raft interaction. J Biol Chem (2007) 1.20

Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system. PLoS One (2007) 1.19

A sensitive and quantitative assay for measuring cleavage of presenilin substrates. J Biol Chem (2001) 1.19

Functionality of the voltage-gated proton channel truncated in S4. Proc Natl Acad Sci U S A (2009) 1.18

Amyloid beta pathology in Alzheimer's disease and schizophrenia. Am J Psychiatry (2003) 1.17

Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation. J Biol Chem (2005) 1.17

Evidence for the "dock, lock, and latch" ligand binding mechanism of the staphylococcal microbial surface component recognizing adhesive matrix molecules (MSCRAMM) SdrG. J Biol Chem (2007) 1.16

Phenotypic effects of membrane protein overexpression in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2006) 1.15

Is placebo acupuncture what it is intended to be? Evid Based Complement Alternat Med (2011) 1.14

The Emperors sham - wrong assumption that sham needling is sham. Acupunct Med (2008) 1.14