Published in J Cell Biol on October 01, 1991
High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A (1993) 2.78
Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene. J Cell Biol (1996) 2.46
Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region. EMBO J (1993) 1.99
Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression. Proc Natl Acad Sci U S A (1993) 1.45
Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment. Proc Natl Acad Sci U S A (1993) 1.44
Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells. Proc Natl Acad Sci U S A (1993) 1.38
Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism. Mol Cell Biol (1995) 1.38
RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon. Proc Natl Acad Sci U S A (1992) 1.27
Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells. Mol Cell Biol (1997) 1.21
Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment. EMBO J (1997) 1.19
Functional significance of a family of protein kinases encoded at the shaggy locus in Drosophila. EMBO J (1993) 1.18
Phosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation. EMBO J (2002) 1.18
Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types. Proc Natl Acad Sci U S A (1995) 1.11
A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias. EMBO J (1996) 1.08
The cellular retinoic acid binding protein I is dispensable. Proc Natl Acad Sci U S A (1994) 1.05
Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells. J Cell Biol (1997) 1.03
Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1, Oct-2, and retinoic acid receptor. J Exp Med (1994) 0.89
A G-tract element in apoptotic agents-induced alternative splicing. Nucleic Acids Res (2008) 0.88
Terminal differentiation in keratinocytes involves positive as well as negative regulation by retinoic acid receptors and retinoid X receptors at retinoid response elements. Mol Cell Biol (1992) 0.88
Characterization of the AB (AF-1) region in the muscle-specific retinoid X receptor-gamma: evidence that the AF-1 region functions in a cell-specific manner. Nucleic Acids Res (1996) 0.85
Characterization and purification of human retinoic acid receptor-gamma 1 overexpressed in the baculovirus-insect cell system. Biochem J (1992) 0.78
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
The steroid and thyroid hormone receptor superfamily. Science (1988) 25.68
A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system. Nucleic Acids Res (1981) 24.41
Gene regulation by steroid hormones. Cell (1989) 12.96
Production of monoclonal antibodies: strategy and tactics. J Immunol Methods (1980) 9.28
A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature (1988) 9.07
Identification of a receptor for the morphogen retinoic acid. Nature (1988) 8.32
Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. Cell (1990) 8.11
Protein kinase recognition sequence motifs. Trends Biochem Sci (1990) 7.49
Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation. Cell (1988) 7.06
Nuclear receptors enhance our understanding of transcription regulation. Trends Genet (1988) 5.95
Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature (1990) 5.50
Identification of a second human retinoic acid receptor. Nature (1988) 5.11
A third human retinoic acid receptor, hRAR-gamma. Proc Natl Acad Sci U S A (1989) 3.74
Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature (1989) 3.72
Identification and spatial distribution of retinoids in the developing chick limb bud. Nature (1987) 3.49
A new retinoic acid receptor identified from a hepatocellular carcinoma. Nature (1988) 3.33
The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen. EMBO J (1991) 3.27
Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene. Proc Natl Acad Sci U S A (1990) 3.17
Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid. EMBO J (1991) 2.84
Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing. EMBO J (1991) 2.68
Murine isoforms of retinoic acid receptor gamma with specific patterns of expression. Proc Natl Acad Sci U S A (1990) 2.42
Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB. Mol Cell Biol (1991) 2.27
Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site. EMBO J (1990) 2.21
Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos. Development (1991) 2.15
Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis. Development (1990) 2.11
Regulated phosphorylation and dephosphorylation of GAL4, a transcriptional activator. Genes Dev (1989) 1.90
Vitamin A and pattern formation in the regenerating limb. Nature (1982) 1.90
Regulation of progesterone receptor-mediated transcription by phosphorylation. Science (1990) 1.82
Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse. Nature (1989) 1.79
The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon. EMBO J (1989) 1.75
Identification of phosphorylated sites in the mouse glucocorticoid receptor. J Biol Chem (1991) 1.54
General repression of enhanson activity by the adenovirus-2 E1A proteins. Genes Dev (1990) 1.42
Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo. Mol Cell Biol (1990) 1.38
Activation of protein kinase C or cAMP-dependent protein kinase increases phosphorylation of the c-erbA-encoded thyroid hormone receptor and of the v-erbA-encoded protein. EMBO J (1988) 1.37
Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis. Development (1990) 1.33
The late retinoic acid induction of laminin B1 gene transcription involves RAR binding to the responsive element. EMBO J (1991) 1.33
Down-regulation and phosphorylation of glucocorticoid receptors in cultured cells. Investigations with a monospecific antiserum against a bacterially expressed receptor fragment. J Biol Chem (1989) 1.28
The distribution of two hnRNP-associated proteins defined by a monoclonal antibody is altered in heat-shocked HeLa cells. Exp Cell Res (1988) 1.13
Hormone-dependent phosphorylation of the glucocorticoid receptor occurs mainly in the amino-terminal transactivation domain. J Biol Chem (1990) 1.10
The c-erbA alpha-encoded thyroid hormone receptor is phosphorylated in its amino terminal domain by casein kinase II. Oncogene (1989) 1.10
Antibodies specific to the retinoic acid human nuclear receptors alpha and beta. Proc Natl Acad Sci U S A (1989) 1.07
Phosphorylation of the 1,25-dihydroxyvitamin D3 receptor. A primary event in 1,25-dihydroxyvitamin D3 action. J Biol Chem (1990) 1.06
Phosphorylation of steroid receptors. J Steroid Biochem (1989) 0.98
Hormonal regulation and identification of chicken progesterone receptor phosphorylation sites. J Biol Chem (1990) 0.93
Phosphorylation at serine 89 induces a shift in gel mobility but has little effect on the function of adenovirus type 5 E1A proteins. J Virol (1989) 0.90
Organization and expression of eucaryotic split genes coding for proteins. Annu Rev Biochem (1981) 49.46
In vivo sequence requirements of the SV40 early promotor region. Nature (1981) 25.00
The nuclear receptor superfamily: the second decade. Cell (1995) 24.99
Isolation of high-molecular-weight DNA from mammalian cells. Eur J Biochem (1973) 24.38
Promoter sequences of eukaryotic protein-coding genes. Science (1980) 19.96
The ovalbumin gene-sequence of putative control regions. Nucleic Acids Res (1980) 18.04
A reliable method for the recovery of DNA fragments from agarose and acrylamide gels. Anal Biochem (1981) 15.38
The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants. Nucleic Acids Res (1981) 15.12
Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc Natl Acad Sci U S A (1978) 14.82
Good behavior game: effects of individual contingencies for group consequences on disruptive behavior in a classroom. J Appl Behav Anal (1969) 11.76
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature (1986) 11.35
Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence. Proc Natl Acad Sci U S A (1980) 10.27
Specific in vitro initiation of transcription on conalbumin and ovalbumin genes and comparison with adenovirus-2 early and late genes. Nature (1980) 10.22
DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. Science (1993) 9.94
Folding of the DNA double helix in chromatin-like structures from simian virus 40. Proc Natl Acad Sci U S A (1975) 9.70
Organisation and sequences at the 5' end of a cloned complete ovalbumin gene. Nature (1979) 9.30
A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature (1988) 9.07
Electron microscopic and biochemical evidence that chromatin structure is a repeating unit. Cell (1975) 8.90
Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem Biophys Res Commun (1997) 7.87
Deletions covering the putative promoter region of early mRNAs of simian virus 40 do not abolish T-antigen expression. Proc Natl Acad Sci U S A (1980) 7.77
Multiple sequence motifs are involved in SV40 enhancer function. EMBO J (1986) 7.76
Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequences. Nature (1983) 7.22
Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription. Nature (1985) 7.14
Ovalbumin gene is split in chicken DNA. Nature (1977) 7.05
The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell (1988) 6.59
Functional domains of the human estrogen receptor. Cell (1987) 6.52
Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci U S A (1996) 6.48
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science (1995) 6.37
Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res (1999) 6.35
The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell (1989) 6.24
A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Mol Cell (2000) 6.14
Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor. EMBO J (1986) 6.08
Nuclear receptors enhance our understanding of transcription regulation. Trends Genet (1988) 5.95
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell (1992) 5.87
The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements. Cell (1983) 5.67
Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science (1996) 5.55
Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor. Nature (1987) 5.47
The SV40 early region TATA box is required for accurate in vitro initiation of transcription. Nature (1981) 5.43
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature (1995) 5.40
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat Genet (1999) 5.31
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A (1997) 5.24
Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Res (1982) 5.14
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Nature (1991) 5.13
Identification of a second human retinoic acid receptor. Nature (1988) 5.11
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J (1990) 5.05
Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development (2000) 5.03
Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions. Science (1985) 5.00
TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J (1996) 4.96
The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter. Nucleic Acids Res (1983) 4.93
DNA methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes. Nucleic Acids Res (1979) 4.81
Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. Nature (1995) 4.79
Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter. Nature (1986) 4.77
The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J (1995) 4.72
A canonical structure for the ligand-binding domain of nuclear receptors. Nat Struct Biol (1996) 4.69
A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J (1996) 4.65
Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell (1995) 4.64
The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation. Nat Genet (1993) 4.57
The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors. EMBO J (1986) 4.47
Organization and sequence studies of the 17-piece chicken conalbumin gene. Nature (1979) 4.36
Sequences upstream from the T-A-T-A box are required in vivo and in vitro for efficient transcription from the adenovirus serotype 2 major late promoter. Proc Natl Acad Sci U S A (1982) 4.30
Stimulation of in vitro transcription from the SV40 early promoter by the enhancer involves a specific trans-acting factor. EMBO J (1984) 4.28
The yeast UASG is a transcriptional enhancer in human HeLa cells in the presence of the GAL4 trans-activator. Cell (1988) 4.22
The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell (1988) 4.17
Alpha-amanitin: a specific inhibitor of one of two DNA-pendent RNA polymerase activities from calf thymus. Biochem Biophys Res Commun (1970) 4.16
Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J Biol Chem (2000) 4.15
The ovalbumin gene family: structure of the X gene and evolution of duplicated split genes. Cell (1980) 4.14
Cooperativity and hierarchical levels of functional organization in the SV40 enhancer. Cell (1988) 4.03
A trans-acting factor is responsible for the simian virus 40 enhancer activity in vitro. Nature (1985) 4.01
Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. Proc Natl Acad Sci U S A (1995) 3.94
Distinct classes of transcriptional activating domains function by different mechanisms. Cell (1990) 3.75
A third human retinoic acid receptor, hRAR-gamma. Proc Natl Acad Sci U S A (1989) 3.74
Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature (1989) 3.72
Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1. Cell (1991) 3.71
Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins. Mol Cell (2001) 3.70
Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements. Nature (1984) 3.68
The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J (1998) 3.64
Multiplicity generates diversity in the retinoic acid signalling pathways. Trends Biochem Sci (1992) 3.63
Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J (1990) 3.59
Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development (1994) 3.53
Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell (1991) 3.53
Steroid hormone receptors compete for factors that mediate their enhancer function. Cell (1989) 3.50
Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor. Cell (1994) 3.46
The HeLa cell protein TEF-1 binds specifically and cooperatively to two SV40 enhancer motifs of unrelated sequence. Cell (1988) 3.41
Isolation by molecular cloning of a fragment in the split ovalbumin gene. Nature (1978) 3.40
The human oestrogen receptor functions in yeast. Nature (1988) 3.32
Molecular cloning of extensive sequences of the in vitro synthesized chicken ovalbumin structural gene. Nucleic Acids Res (1977) 3.32
Cell-type specific protein binding to the enhancer of simian virus 40 in nuclear extracts. Nature (1986) 3.25
Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7. Proc Natl Acad Sci U S A (1984) 3.25
The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties. EMBO J (1989) 3.23
Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell (1994) 3.16
Frataxin is reduced in Friedreich ataxia patients and is associated with mitochondrial membranes. Hum Mol Genet (1997) 3.11