Published in Nat Genet on April 02, 2006
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07
Recent human effective population size estimated from linkage disequilibrium. Genome Res (2007) 6.79
Genetic variation and population structure in native Americans. PLoS Genet (2007) 4.87
Genetic structure of Europeans: a view from the North-East. PLoS One (2009) 3.46
Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe. PLoS One (2008) 3.09
Geographic patterns of genome admixture in Latin American Mestizos. PLoS Genet (2008) 3.07
The genome-wide patterns of variation expose significant substructure in a founder population. Am J Hum Genet (2008) 2.79
Simian immunodeficiency virus SIVmac239 infection of major histocompatibility complex-identical cynomolgus macaques from Mauritius. J Virol (2006) 2.38
Genome-wide association scan for five major dimensions of personality. Mol Psychiatry (2008) 2.29
Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene. Am J Hum Genet (2008) 2.09
Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease. Ann Neurol (2007) 1.92
The impact of divergence time on the nature of population structure: an example from Iceland. PLoS Genet (2009) 1.89
Required sample size and nonreplicability thresholds for heterogeneous genetic associations. Proc Natl Acad Sci U S A (2008) 1.84
Isolated populations and complex disease gene identification. Genome Biol (2008) 1.83
Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population. Proc Natl Acad Sci U S A (2010) 1.64
FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate. Hum Mol Genet (2009) 1.55
Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping. BMC Genet (2008) 1.53
A primary assembly of a bovine haplotype block map based on a 15,036-single-nucleotide polymorphism panel genotyped in holstein-friesian cattle. Genetics (2007) 1.44
Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans. Am J Respir Crit Care Med (2008) 1.43
Genome-wide association study of Tourette's syndrome. Mol Psychiatry (2012) 1.42
Population structure and genome-wide patterns of variation in Ireland and Britain. Eur J Hum Genet (2010) 1.39
Founder population-specific HapMap panel increases power in GWA studies through improved imputation accuracy and CNV tagging. Genome Res (2010) 1.32
Comprehensive testing of positionally cloned asthma genes in two populations. Am J Respir Crit Care Med (2007) 1.32
Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study. Age (Dordr) (2006) 1.31
Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study. BMC Med Genet (2011) 1.29
Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia. Am J Hum Genet (2009) 1.27
Quantification of population structure using correlated SNPs by shrinkage principal components. Hum Hered (2010) 1.24
The genetic basis of colorectal cancer in a population-based incident cohort with a high rate of familial disease. Gut (2010) 1.23
Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. Nicotine Tob Res (2012) 1.22
A genome-wide association study for age-related hearing impairment in the Saami. Eur J Hum Genet (2010) 1.19
The impact of population demography and selection on the genetic architecture of complex traits. PLoS Genet (2014) 1.19
Genetic variation in the Sorbs of eastern Germany in the context of broader European genetic diversity. Eur J Hum Genet (2011) 1.15
Genome-wide linkage scan for prostate cancer susceptibility in Finland: evidence for a novel locus on 2q37.3 and confirmation of signal on 17q21-q22. Int J Cancer (2011) 1.09
Systems biology of the vervet monkey. ILAR J (2013) 1.07
High differentiation among eight villages in a secluded area of Sardinia revealed by genome-wide high density SNPs analysis. PLoS One (2009) 1.06
Linkage disequilibrium compared between five populations of domestic sheep. BMC Genet (2008) 1.06
A non-human primate system for large-scale genetic studies of complex traits. Hum Mol Genet (2012) 1.05
Linkage analysis of adult height in a large pedigree from a Dutch genetically isolated population. Hum Genet (2009) 1.04
Combined effects of thrombosis pathway gene variants predict cardiovascular events. PLoS Genet (2007) 1.03
Genetic markers and population history: Finland revisited. Eur J Hum Genet (2009) 1.02
Multisystem component phenotypes of bipolar disorder for genetic investigations of extended pedigrees. JAMA Psychiatry (2014) 1.02
Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata. PLoS One (2013) 1.02
Association between protective and deleterious HLA alleles with multiple sclerosis in Central East Sardinia. PLoS One (2009) 1.00
A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level. BMC Med Genet (2010) 1.00
An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9. Mol Vis (2010) 0.99
Association between the ACCN1 gene and multiple sclerosis in Central East Sardinia. PLoS One (2007) 0.97
Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample. Mol Psychiatry (2013) 0.96
Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. Hum Mol Genet (2009) 0.96
Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. PLoS One (2010) 0.96
Of founder populations, long QT syndrome, and destiny. Heart Rhythm (2009) 0.95
CNV analysis in Tourette syndrome implicates large genomic rearrangements in COL8A1 and NRXN1. PLoS One (2013) 0.94
Dissecting the genetic make-up of North-East Sardinia using a large set of haploid and autosomal markers. Eur J Hum Genet (2012) 0.94
Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays. BMC Genet (2011) 0.91
Identification of novel susceptibility loci for Guam neurodegenerative disease: challenges of genome scans in genetic isolates. Hum Mol Genet (2009) 0.91
Genome-wide linkage analysis of pulmonary function in families of children with asthma in Costa Rica. Thorax (2006) 0.90
An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders. Biol Psychiatry (2008) 0.90
A role of BRCA1 and BRCA2 germline mutations in breast cancer susceptibility within Sardinian population. BMC Cancer (2009) 0.90
TRIB1 constitutes a molecular link between regulation of sleep and lipid metabolism in humans. Transl Psychiatry (2012) 0.90
Volume measures for linkage disequilibrium. BMC Genet (2006) 0.90
Small effective population size and genetic homogeneity in the Val Borbera isolate. Eur J Hum Genet (2012) 0.89
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun (2016) 0.88
Linkage and linkage disequilibrium scan for autism loci in an extended pedigree from Finland. Hum Mol Genet (2009) 0.88
Replication of association between working memory and Reelin, a potential modifier gene in schizophrenia. Biol Psychiatry (2009) 0.87
Genetic liability to schizophrenia in Oceanic Palau: a search in the affected and maternal generation. Hum Genet (2007) 0.86
Exome-based linkage disequilibrium maps of individual genes: functional clustering and relationship to disease. Hum Genet (2012) 0.86
Extent and distribution of linkage disequilibrium in the Old Order Amish. Genet Epidemiol (2010) 0.86
Association analysis of allelic variants of USF1 in coronary atherosclerosis. Arterioscler Thromb Vasc Biol (2008) 0.84
Simulation of Finnish population history, guided by empirical genetic data, to assess power of rare-variant tests in Finland. Am J Hum Genet (2014) 0.84
A genome-wide analysis of population structure in the Finnish Saami with implications for genetic association studies. Eur J Hum Genet (2010) 0.84
Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD. BMC Genomics (2009) 0.84
HLA Class I and II profiles in São Miguel Island (Azores): genetic diversity and linkage disequilibrium. BMC Res Notes (2010) 0.83
Detecting genetic isolation in human populations: a study of European language minorities. PLoS One (2013) 0.83
Polymorphisms in the GRIA1 gene region in psychotic bipolar disorder. Am J Med Genet B Neuropsychiatr Genet (2009) 0.83
Identity-by-descent estimation and mapping of qualitative traits in large, complex pedigrees. Genetics (2008) 0.82
Genome-wide time-to-event analysis on smoking progression stages in a family-based study. Brain Behav (2016) 0.81
Brain structure-function associations in multi-generational families genetically enriched for bipolar disorder. Brain (2015) 0.81
Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD. Atten Defic Hyperact Disord (2010) 0.81
Linkage disequilibrium and diversity for three genomic regions in Azoreans and mainland Portuguese. Genet Mol Biol (2009) 0.81
Forensic efficiency of microsatellites and single nucleotide polymorphisms on the X chromosome. Int J Legal Med (2007) 0.80
Identification of a founder BRCA2 mutation in Sardinian breast cancer families. Fam Cancer (2007) 0.80
The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants. Eur J Hum Genet (2016) 0.80
Genetic comparison of a Croatian isolate and CEPH European founders. Genet Epidemiol (2010) 0.80
Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom. Eur J Hum Genet (2017) 0.79
Whole genome sequences are required to fully resolve the linkage disequilibrium structure of human populations. BMC Genomics (2015) 0.79
A narrow and highly significant linkage signal for severe bipolar disorder in the chromosome 5q33 region in Latin American pedigrees. Am J Med Genet B Neuropsychiatr Genet (2009) 0.79
Who are the Okinawans? Ancestry, genome diversity, and implications for the genetic study of human longevity from a geographically isolated population. J Gerontol A Biol Sci Med Sci (2014) 0.78
Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans. PLoS One (2013) 0.78
Genome-wide SNP analysis reveals no gain in power for association studies of common variants in the Finnish Saami. Eur J Hum Genet (2009) 0.78
Interaction of early environment, gender and genes of monoamine neurotransmission in the aetiology of depression in a large population-based Finnish birth cohort. BMJ Open (2011) 0.78
Genetic structure of the Newfoundland and Labrador population: founder effects modulate variability. Eur J Hum Genet (2015) 0.77
Privacy protection and public goods: building a genetic database for health research in Newfoundland and Labrador. J Am Med Inform Assoc (2012) 0.77
Genetic similarity of chromosome 6 between patients receiving hematopoietic stem cell transplantation and HLA matched sibling donors. Haematologica (2009) 0.77
HGPGD: the human gene population genetic difference database. PLoS One (2013) 0.77
Genome scan for loci regulating HDL cholesterol levels in Finnish extended pedigrees with early coronary heart disease. Eur J Hum Genet (2009) 0.76
Genome-wide linkage disequilibrium in nine-spined stickleback populations. G3 (Bethesda) (2014) 0.76
Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population. Sci Rep (2015) 0.75
The value of some Corsican sub-populations for genetic association studies. BMC Med Genet (2008) 0.75
Identifying highly conserved and highly differentiated gene ontology categories in human populations. PLoS One (2011) 0.75
Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and major depressive disorder. PLoS One (2014) 0.75
Commercial chicken breeds exhibit highly divergent patterns of linkage disequilibrium. Heredity (Edinb) (2016) 0.75
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron (2011) 18.73
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Variance component model to account for sample structure in genome-wide association studies. Nat Genet (2010) 15.52
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Common variants conferring risk of schizophrenia. Nature (2009) 10.37
Strong association of de novo copy number mutations with sporadic schizophrenia. Nat Genet (2008) 10.19
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science (2002) 9.90
Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet (2002) 9.71
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature (2006) 9.31
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet (2011) 9.10
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Discerning the ancestry of European Americans in genetic association studies. PLoS Genet (2007) 7.81
Identification of a variant associated with adult-type hypolactasia. Nat Genet (2002) 7.49
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Multiple common variants for celiac disease influencing immune gene expression. Nat Genet (2010) 6.90
A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet (2007) 6.87
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet (2003) 6.63
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
A promoter-level mammalian expression atlas. Nature (2014) 6.25
A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. Lancet (2010) 6.07
Aire regulates negative selection of organ-specific T cells. Nat Immunol (2003) 5.85
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77
Network component analysis: reconstruction of regulatory signals in biological systems. Proc Natl Acad Sci U S A (2003) 5.64
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32
Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly. Proc Natl Acad Sci U S A (2002) 5.18
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurol (2012) 5.18
New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med (2009) 4.97
Genetic variation and population structure in native Americans. PLoS Genet (2007) 4.87
Classical twin studies and beyond. Nat Rev Genet (2002) 4.81
Disruption of the neurexin 1 gene is associated with schizophrenia. Hum Mol Genet (2008) 4.78
A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet (2008) 4.75
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
A genomewide admixture map for Latino populations. Am J Hum Genet (2007) 4.71
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet (2004) 4.71
Exome sequencing supports a de novo mutational paradigm for schizophrenia. Nat Genet (2011) 4.67
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62