Finding distal regulatory elements in the human genome.

Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13

A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron (2011) 6.93

Transcription factors: from enhancer binding to developmental control. Nat Rev Genet (2012) 5.00

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J (2010) 4.78

Genome-wide MyoD binding in skeletal muscle cells: a potential for broad cellular reprogramming. Dev Cell (2010) 4.50

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature (2013) 3.93

The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Annu Rev Biochem (2012) 3.61

A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol Cell (2012) 3.04

Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers. Nat Genet (2014) 2.58

Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell (2011) 2.53

Mapping human epigenomes. Cell (2013) 2.44

Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab (2010) 2.21

Genomic views of STAT function in CD4+ T helper cell differentiation. Nat Rev Immunol (2011) 2.09

A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. Nat Genet (2010) 1.94

Identification of {beta}-catenin binding regions in colon cancer cells using ChIP-Seq. Nucleic Acids Res (2010) 1.81

H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells. BMC Genomics (2012) 1.73

Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions. Genome Res (2013) 1.69

RFECS: a random-forest based algorithm for enhancer identification from chromatin state. PLoS Comput Biol (2013) 1.66

Coding exons function as tissue-specific enhancers of nearby genes. Genome Res (2012) 1.64

Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation. PLoS Genet (2014) 1.59

Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans. Nephrol Dial Transplant (2013) 1.56

Transcription: Enhancers make non-coding RNA. Nature (2010) 1.54

Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Blood (2011) 1.43

Minireview: PPARγ as the target of obesogens. J Steroid Biochem Mol Biol (2011) 1.40

Expression of Terminal Effector Genes in Mammalian Neurons Is Maintained by a Dynamic Relay of Transient Enhancers. Neuron (2016) 1.37

Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells. Mol Cell Biol (2011) 1.34

Discover regulatory DNA elements using chromatin signatures and artificial neural network. Bioinformatics (2010) 1.29

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus. Genome Biol (2013) 1.12

Identification of biologically relevant enhancers in human erythroid cells. J Biol Chem (2013) 1.03

DEEP: a general computational framework for predicting enhancers. Nucleic Acids Res (2014) 1.01

Transcriptional networks driving enhancer function in the CFTR gene. Biochem J (2012) 1.00

Developmental regulation of chromatin conformation by Hox proteins in Drosophila. Cell Rep (2012) 1.00

Genetic, epigenetic, and environmental contributions to neural tube closure. Annu Rev Genet (2014) 0.99

DNA methylation and differentiation: silencing, upregulation and modulation of gene expression. Epigenomics (2013) 0.97

Required enhancer-matrin-3 network interactions for a homeodomain transcription program. Nature (2014) 0.96

Complex genomic interactions in the dynamic regulation of transcription by the glucocorticoid receptor. Mol Cell Endocrinol (2013) 0.95

Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia. PLoS One (2011) 0.91

Epigenomics: the science of no-longer-junk DNA. Why study it in chronic kidney disease? Semin Nephrol (2013) 0.90

Transcriptional competence in pluripotency. Genes Dev (2009) 0.89

Enhancing myogenic differentiation of pluripotent stem cells with small molecule inducers. Cell Biosci (2013) 0.88

Stepwise acetyltransferase association and histone acetylation at the Myod1 locus during myogenic differentiation. Sci Rep (2013) 0.87

Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens. Proc Natl Acad Sci U S A (2014) 0.87

Using epigenetic mechanisms to understand the impact of common disease causing alleles. Curr Opin Immunol (2012) 0.87

Imaging Specific Genomic DNA in Living Cells. Annu Rev Biophys (2016) 0.86

Linking genome to epigenome. Wiley Interdiscip Rev Syst Biol Med (2012) 0.85

HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells. Elife (2015) 0.84

Identifying and characterizing regulatory sequences in the human genome with chromatin accessibility assays. Genes (Basel) (2012) 0.83

GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27. Biochim Biophys Acta (2014) 0.83

Effects of gene regulatory reprogramming on gene expression in human and mouse developing hearts. Philos Trans R Soc Lond B Biol Sci (2013) 0.82

Progress and challenges in bioinformatics approaches for enhancer identification. Brief Bioinform (2015) 0.82

Identification of an enhancer that increases miR-200b~200a~429 gene expression in breast cancer cells. PLoS One (2013) 0.82

Distant cis-regulatory elements in human skeletal muscle differentiation. Genomics (2011) 0.82

Identification of epigenetic modifications that contribute to pathogenesis in therapy-related AML: Effective integration of genome-wide histone modification with transcriptional profiles. BMC Med Genomics (2015) 0.81

Network analysis of microRNAs and their regulation in human ovarian cancer. BMC Syst Biol (2011) 0.81

Chromosomal organization at the level of gene complexes. Cell Mol Life Sci (2010) 0.80

Enhancer alterations in cancer: a source for a cell identity crisis. Genome Med (2014) 0.80

Cell-Type Specific Determinants of NRAMP1 Expression in Professional Phagocytes. Biology (Basel) (2013) 0.79

Cell specific CD44 expression in breast cancer requires the interaction of AP-1 and NFκB with a novel cis-element. PLoS One (2012) 0.79

Retinoic acid and histone deacetylases regulate epigenetic changes in embryonic stem cells. J Biol Chem (2014) 0.79

lncRNA and gene looping: what's the connection? Transcription (2014) 0.78

Hi-C Chromatin Interaction Networks Predict Co-expression in the Mouse Cortex. PLoS Comput Biol (2015) 0.78

Single nucleotide polymorphisms with cis-regulatory effects on long non-coding transcripts in human primary monocytes. PLoS One (2014) 0.78

A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element. PLoS One (2017) 0.77

De novo prediction of cis-regulatory elements and modules through integrative analysis of a large number of ChIP datasets. BMC Genomics (2014) 0.77

Chromatin signatures of active enhancers. Nucleus (2012) 0.77

DENdb: database of integrated human enhancers. Database (Oxford) (2015) 0.77

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins. Int J Mol Sci (2016) 0.77

PEDLA: predicting enhancers with a deep learning-based algorithmic framework. Sci Rep (2016) 0.77

AGE-RAGE signal generates a specific NF-κB RelA "barcode" that directs collagen I expression. Sci Rep (2016) 0.76

DNA fragments binding CTCF in vitro and in vivo are capable of blocking enhancer activity. BMC Res Notes (2012) 0.76

EP-DNN: A Deep Neural Network-Based Global Enhancer Prediction Algorithm. Sci Rep (2016) 0.75

Unraveling the score of the enhancer symphony. Proc Natl Acad Sci U S A (2010) 0.75

Genome-Wide Identification of Regulatory Sequences Undergoing Accelerated Evolution in the Human Genome. Mol Biol Evol (2016) 0.75

Discriminative identification of transcriptional responses of promoters and enhancers after stimulus. Nucleic Acids Res (2016) 0.75

Opening up the blackbox: an interpretable deep neural network-based classifier for cell-type specific enhancer predictions. BMC Syst Biol (2016) 0.75

ESE-1 in Early Development: Approaches for the Future. Front Cell Dev Biol (2016) 0.75

DNA Hypomethylation in Intragenic and Intergenic Enhancer Chromatin of Muscle-Specific Genes Usually Correlates with their Expression. Yale J Biol Med (2016) 0.75

ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children. Pharmacogenomics J (2016) 0.75

Beyond the bolus: transgenic tools for investigating the neurophysiology of learning and memory. Learn Mem (2014) 0.75

Construction of gene/transcription regulatory networks. Brief Funct Genomics (2010) 0.75

Quantitative genetics of circulating Dickkopf-related protein 1 (DKK1) in community-based sample of UK twins. Osteoporos Int (2016) 0.75

Mining the Unknown: Assigning Function to Noncoding Single Nucleotide Polymorphisms. Trends Genet (2016) 0.75

SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development (2017) 0.75

Initial sequencing and analysis of the human genome. Nature (2001) 212.86

The sequence of the human genome. Science (2001) 101.55

High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

The language of covalent histone modifications. Nature (2000) 44.92

Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature (1997) 44.55

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41

Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29

Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41

TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic Acids Res (2006) 22.20

JASPAR: an open-access database for eukaryotic transcription factor binding profiles. Nucleic Acids Res (2004) 19.32

ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38

Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66

Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. Genome Res (2006) 13.32

Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature (2008) 12.01

The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev (2000) 11.65

Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). Nat Genet (2006) 11.02

Transcriptional activation by recruitment. Nature (1997) 10.44

The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell (1999) 9.74

Active genes dynamically colocalize to shared sites of ongoing transcription. Nat Genet (2004) 9.57

Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev (2001) 9.54

A census of human transcription factors: function, expression and evolution. Nat Rev Genet (2009) 9.19

Diversity and complexity in DNA recognition by transcription factors. Science (2009) 9.07

Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nat Genet (2006) 8.99

Transcriptional activation: a complex puzzle with few easy pieces. Cell (1994) 8.63

Controlling the double helix. Nature (2003) 8.61

Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Nat Biotechnol (2006) 8.38

Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell (2008) 7.93

CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1. Science (2006) 7.68

Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41

Transcriptional regulatory elements in the human genome. Annu Rev Genomics Hum Genet (2006) 7.18

Interchromosomal interactions and olfactory receptor choice. Cell (2006) 6.93

UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. Nucleic Acids Res (2008) 6.83

Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter. Cell (1999) 6.83

Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays. Nat Genet (2004) 6.33

Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev (2006) 6.32

Transcription of eukaryotic protein-coding genes. Annu Rev Genet (2000) 6.12

Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature (2009) 5.96

CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95

Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome. PLoS Genet (2007) 5.93

ATP-dependent remodeling and acetylation as regulators of chromatin fluidity. Genes Dev (1999) 5.90

Orchestrated response: a symphony of transcription factors for gene control. Genes Dev (2000) 5.86

We gather together: insulators and genome organization. Curr Opin Genet Dev (2007) 5.81

Insulators and boundaries: versatile regulatory elements in the eukaryotic genome. Science (2001) 5.37

Insulators: many functions, many mechanisms. Genes Dev (2002) 5.36

Exploring the DNA-binding specificities of zinc fingers with DNA microarrays. Proc Natl Acad Sci U S A (2001) 5.08

Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites. Proc Natl Acad Sci U S A (2007) 4.91

Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation. Science (2002) 4.57

Concern Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules. Proc Natl Acad Sci U S A (2008) 4.31

Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell (2008) 3.96

The RNA polymerase II core promoter: a key component in the regulation of gene expression. Genes Dev (2002) 3.87

Mediator of transcriptional regulation. Annu Rev Biochem (2000) 3.51

Dynamics of enhancer-promoter communication during differentiation-induced gene activation. Mol Cell (2002) 2.94

Long-range chromosomal interactions and gene regulation. Mol Biosyst (2008) 2.56

Modifying gene expression programs by altering core promoter chromatin architecture. Cell (2002) 2.22

The gateway to transcription: identifying, characterizing and understanding promoters in the eukaryotic genome. Cell Mol Life Sci (2007) 2.20

Genome-wide scanning of HoxB1-associated loci in mouse ES cells using an open-ended Chromosome Conformation Capture methodology. Chromosome Res (2006) 2.13

Chromatin boundaries and chromatin domains. Cold Spring Harb Symp Quant Biol (2004) 2.08

CTCF-dependent enhancer-blocking by alternative chromatin loop formation. Proc Natl Acad Sci U S A (2008) 1.90

How cohesin and CTCF cooperate in regulating gene expression. Chromosome Res (2009) 1.62

A closer look at long-range chromosomal interactions. Trends Biochem Sci (2003) 1.50

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

Transcriptional regulatory networks in Saccharomyces cerevisiae. Science (2002) 43.52

Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41

Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41

A high-resolution map of active promoters in the human genome. Nature (2005) 24.35

ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38

Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature (2012) 18.23

Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66

The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94

Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39

Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74

A map of the cis-regulatory sequences in the mouse genome. Nature (2012) 8.74

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc Natl Acad Sci U S A (2003) 7.30

Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell (2012) 7.09

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00

Genome-wide analysis of protein-DNA interactions. Annu Rev Genomics Hum Genet (2006) 6.47

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature (2011) 6.25

Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome. PLoS Genet (2007) 5.93

Next-generation genomics: an integrative approach. Nat Rev Genet (2010) 5.88

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell (2011) 5.27

A high-resolution map of the three-dimensional chromatin interactome in human cells. Nature (2013) 5.18

A cis-regulatory map of the Drosophila genome. Nature (2011) 4.80

ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet (2010) 4.32

An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biol (2012) 4.15

Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08

Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome. Cell (2012) 4.00

Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81

An assessment of histone-modification antibody quality. Nat Struct Mol Biol (2010) 3.72

Direct isolation and identification of promoters in the human genome. Genome Res (2005) 3.68

Discovery and annotation of functional chromatin signatures in the human genome. PLoS Comput Biol (2009) 3.61

ChromaSig: a probabilistic approach to finding common chromatin signatures in the human genome. PLoS Comput Biol (2008) 3.46

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature (2012) 3.38

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res (2011) 3.36

Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A (2014) 3.35

Predictive chromatin signatures in the mammalian genome. Hum Mol Genet (2009) 3.25

Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet (2011) 2.87

Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells. Proc Natl Acad Sci U S A (2013) 2.71

Mapping human epigenomes. Cell (2013) 2.44

Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues. Nat Genet (2013) 2.41

ChIP-chip: data, model, and analysis. Biometrics (2007) 2.27

Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation. J Biol Chem (2008) 2.17

Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs. Genome Res (2007) 2.16

Fine tuning of craniofacial morphology by distant-acting enhancers. Science (2013) 2.16

Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. Am J Hum Genet (2007) 2.08

Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing. Nat Biotechnol (2013) 2.05

Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev (2011) 1.86

Genome-wide prediction of transcription factor binding sites using an integrated model. Genome Biol (2010) 1.84

HiCNorm: removing biases in Hi-C data via Poisson regression. Bioinformatics (2012) 1.77

Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency. Cell Res (2011) 1.72

The transcriptional regulatory code of eukaryotic cells--insights from genome-wide analysis of chromatin organization and transcription factor binding. Curr Opin Cell Biol (2006) 1.71

Genome-wide mapping of allele-specific protein-DNA interactions in human cells. Nat Methods (2008) 1.69

RFECS: a random-forest based algorithm for enhancer identification from chromatin state. PLoS Comput Biol (2013) 1.66

Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine. Nat Protoc (2012) 1.66

Bayesian inference of spatial organizations of chromosomes. PLoS Comput Biol (2013) 1.66

Prediction of regulatory elements in mammalian genomes using chromatin signatures. BMC Bioinformatics (2008) 1.64

Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis. Elife (2013) 1.64

Genome organization and long-range regulation of gene expression by enhancers. Curr Opin Cell Biol (2013) 1.63

Unraveling epigenetic regulation in embryonic stem cells. Cell Stem Cell (2008) 1.57

Transcription: Enhancers make non-coding RNA. Nature (2010) 1.54

PU.1 and C/EBP(alpha) synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers. Proc Natl Acad Sci U S A (2011) 1.30

Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. Immunity (2013) 1.27

beta-Catenin activates the growth factor endothelin-1 in colon cancer cells. Oncogene (2005) 1.21

Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II. Mol Cell (2012) 1.18

An integrated approach to identifying cis-regulatory modules in the human genome. PLoS One (2009) 1.16

Relative roles of genetic background and variation in PspA in the ability of antibodies to PspA to protect against capsular type 3 and 4 strains of Streptococcus pneumoniae. Infect Immun (2003) 1.15

Vaccine-induced human antibodies to PspA augment complement C3 deposition on Streptococcus pneumoniae. Microb Pathog (2007) 1.13

Positive inter-regulation between beta-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells. Mol Pharmacol (2005) 1.13

ChIP-chip for genome-wide analysis of protein binding in mammalian cells. Curr Protoc Mol Biol (2007) 1.11

CBX3 regulates efficient RNA processing genome-wide. Genome Res (2012) 1.10

Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet (2012) 1.07

Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1. Proc Natl Acad Sci U S A (2014) 1.04

Enhancers: multi-dimensional signal integrators. Transcription (2012) 1.02

Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencing. Genome Biol (2010) 1.01

Developmental biology. Enhancing pluripotency and lineage specification. Science (2013) 0.99

Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing. Nat Commun (2013) 0.99

Genome-wide location analysis: insights on transcriptional regulation. Hum Mol Genet (2006) 0.96

Comparative annotation of functional regions in the human genome using epigenomic data. Nucleic Acids Res (2013) 0.94

Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression. Cancer Res (2006) 0.94

Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML. Blood (2012) 0.92

Distinct patterns of somatic alterations in a lymphoblastoid and a tumor genome derived from the same individual. Nucleic Acids Res (2011) 0.88

p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells. Aging Cell (2010) 0.88

[Continuous veno-venous hemofiltration in treatment of acute severe hyponatremia: a report of 6 cases]. Zhonghua Nei Ke Za Zhi (2003) 0.84

Programmed Death-Ligand 1 Expression Is Common in Gastric Cancer Associated With Epstein-Barr Virus or Microsatellite Instability. Am J Surg Pathol (2016) 0.83

Mapping higher order structure of chromatin domains. Nat Genet (2011) 0.83

Histone acetyltransferase cofactor Trrap maintains self-renewal and restricts differentiation of embryonic stem cells. Stem Cells (2013) 0.83

Clinical observation on removal of small foreign bodies touching the optic nerve in the deep orbital region: a case series. Orbit (2014) 0.82

Global identification of transcriptional regulators of pluripotency and differentiation in embryonic stem cells. Nucleic Acids Res (2012) 0.80

Systematic mapping of occluded genes by cell fusion reveals prevalence and stability of cis-mediated silencing in somatic cells. Genome Res (2013) 0.79

STAR: an integrated solution to management and visualization of sequencing data. Bioinformatics (2013) 0.78

Corrigendum: Human body epigenome maps reveal noncanonical DNA methylation variation. Nature (2015) 0.77

Effects of aminoguanidine on retinal apoptosis in mice with oxygen-induced retinopathy. Int J Ophthalmol (2013) 0.76

Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease. Proc Natl Acad Sci U S A (2014) 0.76

SERPINB13 is a novel RUNX1 target gene. Biochem Biophys Res Commun (2011) 0.76

Effects of minocycline on expression of bcl-2, bax in early retinal neuropathy of diabetes in rats. Int J Ophthalmol (2011) 0.75

Comparative study of modified and conventional secondary hydroxyapatite orbital implantations. Int J Ophthalmol (2013) 0.75

[Near-infrared spectroscopy analysis of adenosine and water in fermentation cordyceps powder and wavelength assignment]. Guang Pu Xue Yu Guang Pu Fen Xi (2012) 0.75

An all-round view of eukaryotic transcription. Genome Biol (2006) 0.75

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