Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth.

PubWeight™: 1.55‹?› | Rank: Top 4%

🔗 View Article (PMC 2745954)

Published in J Neurosci on April 26, 2006

Authors

Justine Masson1, Michèle Darmon, Agnès Conjard, Nao Chuhma, Nicole Ropert, Muriel Thoby-Brisson, Arthur S Foutz, Sandrine Parrot, Gretchen M Miller, Renée Jorisch, Jonathan Polan, Michel Hamon, René Hen, Stephen Rayport

Author Affiliations

1: Unité Mixte de Recherche U677, NeuroPsychoPharmacologie, Faculté de Médecine Pitié-Salpêtrière, 75634 Paris Cedex 13, France. jumasson@ext.jussieu.fr

Articles citing this

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab (2012) 4.80

Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES). Biochem J (2007) 2.52

Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation. J Immunol (2010) 2.31

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition. Blood (2015) 1.79

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. J Clin Invest (2015) 1.67

Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability. Neuron (2012) 1.27

Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J Med Chem (2012) 1.27

Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia. Neuropsychopharmacology (2009) 1.20

Glutamate production by HIV-1 infected human macrophage is blocked by the inhibition of glutaminase. J Neurochem (2007) 1.13

Therapeutic strategies impacting cancer cell glutamine metabolism. Future Med Chem (2013) 1.12

In vitro glutaminase regulation and mechanisms of glutamate generation in HIV-1-infected macrophage. J Neurochem (2009) 1.08

Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders. J Neurosci (2011) 1.06

Fast homeostatic plasticity of inhibition via activity-dependent vesicular filling. PLoS One (2008) 1.05

A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release. Neuron (2014) 1.04

Vesicular and plasma membrane transporters for neurotransmitters. Cold Spring Harb Perspect Biol (2012) 1.02

Glutamatergic or GABAergic neuron-specific, long-term expression in neocortical neurons from helper virus-free HSV-1 vectors containing the phosphate-activated glutaminase, vesicular glutamate transporter-1, or glutamic acid decarboxylase promoter. Brain Res (2007) 0.98

Effects of glucose and glutamine concentration in the formulation of the artificial cerebrospinal fluid (ACSF). Brain Res (2008) 0.98

Loss of function mutation in glutamic pyruvate transaminase 2 (GPT2) causes developmental encephalopathy. J Inherit Metab Dis (2015) 0.93

Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice. J Neurosci (2010) 0.93

Cortical metabolism in pyruvate dehydrogenase deficiency revealed by ex vivo multiplet (13)C NMR of the adult mouse brain. Neurochem Int (2012) 0.92

How high-resolution basal-state functional imaging can guide the development of new pharmacotherapies for schizophrenia. Schizophr Bull (2009) 0.85

Glutamine fuels proliferation but not migration of endothelial cells. EMBO J (2017) 0.84

Synaptic vesicles are capable of synthesizing the VGLUT substrate glutamate from α-ketoglutarate for vesicular loading. J Neurochem (2012) 0.84

Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons. PLoS One (2008) 0.84

Synaptic underpinnings of altered hippocampal function in glutaminase-deficient mice during maturation. Hippocampus (2012) 0.83

Diphenylarsinic acid promotes degradation of glutaminase C by mitochondrial Lon protease. J Biol Chem (2012) 0.83

Brain slices from glutaminase-deficient mice metabolize less glutamine: a cellular metabolomic study with carbon 13 NMR. J Cereb Blood Flow Metab (2012) 0.82

Modeling resilience to schizophrenia in genetically modified mice: a novel approach to drug discovery. Expert Rev Neurother (2012) 0.81

Network of brain protein level changes in glutaminase deficient fetal mice. J Proteomics (2013) 0.79

Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice. Front Syst Neurosci (2016) 0.79

Vesicular release of glutamate from hippocampal neurons in culture: an immunocytochemical assay. Exp Brain Res (2007) 0.78

Glutaminase 1 is essential for the differentiation, proliferation, and survival of human neural progenitor cells. Stem Cells Dev (2014) 0.76

Brain proteomics supports the role of glutamate metabolism and suggests other metabolic alterations in protein l-isoaspartyl methyltransferase (PIMT)-knockout mice. J Proteome Res (2013) 0.76

VGLUTs and Glutamate Synthesis-Focus on DRG Neurons and Pain. Biomolecules (2015) 0.75

Good housekeeping. Neuron (2014) 0.75

Presynaptic Molecular Determinants of Quantal Size. Front Synaptic Neurosci (2016) 0.75

Wnt signaling and cellular metabolism in osteoblasts. Cell Mol Life Sci (2016) 0.75

Dopamine neuron dependent behaviorsmediated by glutamate cotransmission. Elife (2017) 0.75

Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA1 Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity. Front Mol Neurosci (2017) 0.75

Articles cited by this

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol (2001) 31.56

Glutamate uptake. Prog Neurobiol (2001) 13.59

Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci U S A (1992) 9.19

Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science (1991) 8.26

Respiratory control by ventral surface chemoreceptor neurons in rats. Nat Neurosci (2004) 4.87

Temporal binding and the neural correlates of sensory awareness. Trends Cogn Sci (2001) 4.29

Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science (2000) 3.68

Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters. Physiol Rev (1995) 3.45

Regulation of glutaminase activity and glutamine metabolism. Annu Rev Nutr (1995) 3.40

A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons. J Neurosci (2002) 2.71

Dopamine neurons make glutamatergic synapses in vitro. J Neurosci (1998) 2.33

Models of respiratory rhythm generation in the pre-Bötzinger complex. II. Populations Of coupled pacemaker neurons. J Neurophysiol (1999) 2.23

Cellular mechanisms underlying modulation of breathing pattern in mammals. Ann N Y Acad Sci (1989) 2.16

Generation and transmission of respiratory oscillations in medullary slices: role of excitatory amino acids. J Neurophysiol (1993) 2.07

The distribution of glutaminase isoenzymes in the various structures of the nephron in normal, acidotic, and alkalotic rat kidney. J Biol Chem (1973) 2.01

The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons. J Neurosci (2004) 1.82

Effect of zolpidem on miniature IPSCs and occupancy of postsynaptic GABAA receptors in central synapses. J Neurosci (1999) 1.65

Astrocytes: glutamate producers for neurons. J Neurosci Res (1999) 1.62

Cloning and functional identification of a neuronal glutamine transporter. J Biol Chem (2000) 1.60

The glutamine commute: take the N line and transfer to the A. J Cell Biol (2002) 1.56

Reorganization of pontine rhythmogenic neuronal networks in Krox-20 knockout mice. Neuron (1996) 1.49

Postnatal changes in the mammalian respiratory network as revealed by the transverse brainstem slice of mice. J Physiol (1996) 1.43

Models of respiratory rhythm generation in the pre-Bötzinger complex. III. Experimental tests of model predictions. J Neurophysiol (2001) 1.39

Sex genes for genomic analysis in human brain: internal controls for comparison of probe level data extraction. BMC Bioinformatics (2003) 1.36

Metabolic compartmentation of glutamate and glutamine: morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum. Neuroscience (1992) 1.36

A single packet of transmitter does not saturate postsynaptic glutamate receptors. Neuron (2002) 1.33

Cre-loxP biochemistry. Methods (2002) 1.31

Molecular and functional analysis of a novel neuronal vesicular glutamate transporter. J Biol Chem (2001) 1.25

Early postnatal maturation of GABAA-mediated inhibition in the brainstem respiratory rhythm-generating network of the mouse. Eur J Neurosci (2000) 1.23

Quantal currents at single-site central synapses. J Physiol (2000) 1.22

Brain amino acid requirements and toxicity: the example of leucine. J Nutr (2005) 1.14

Expression of functional tyrosine kinase B receptors by rhythmically active respiratory neurons in the pre-Bötzinger complex of neonatal mice. J Neurosci (2003) 1.14

Intercellular metabolic compartmentation in the brain: past, present and future. Neurochem Int (2004) 1.13

Offspring-induced nurturance: animal-human parallels. Dev Psychobiol (1997) 1.11

Postembedding immunogold labelling reveals subcellular localization and pathway-specific enrichment of phosphate activated glutaminase in rat cerebellum. Neuroscience (1999) 1.08

Branched-chain amino acids and neurotransmitter metabolism: expression of cytosolic branched-chain aminotransferase (BCATc) in the cerebellum and hippocampus. J Comp Neurol (2004) 1.04

Glutamatergic neuronal projections from the marginal layer of the rostral ventral medulla to the respiratory centers in rats. J Comp Neurol (2004) 1.02

Neuropharmacology of control of respiratory rhythm and pattern in mature mammals. Pharmacol Ther (2000) 1.01

Glutamate immunoreactivity in rat cerebral cortex is reversibly abolished by 6-diazo-5-oxo-L-norleucine (DON), an inhibitor of phosphate-activated glutaminase. J Histochem Cytochem (1994) 1.00

Role of inspiratory pacemaker neurons in mediating the hypoxic response of the respiratory network in vitro. J Neurosci (2000) 0.98

Phosphate-activated glutaminase and mitochondrial glutamine transport in the brain. Neurochem Res (2000) 0.96

Immunohistochemical study of glutaminase-containing neurons in the cerebral cortex and thalamus of the rat. J Comp Neurol (1988) 0.96

Utilization of glutamine and of TCA cycle constituents as precursors for transmitter glutamate and GABA. Dev Neurosci (1993) 0.95

Role of mitochondrial glutaminase in rat renal glutamine metabolism. J Nutr (2001) 0.93

The essential amino acid lysine acts as precursor of glutamate in the mammalian central nervous system. FEBS Lett (2001) 0.91

Metabolic flux analysis as a tool for the elucidation of the metabolism of neurotransmitter glutamate. Metab Eng (2003) 0.91

In vivo simultaneous monitoring of gamma-aminobutyric acid, glutamate, and L-aspartate using brain microdialysis and capillary electrophoresis with laser-induced fluorescence detection: Analytical developments and in vitro/in vivo validations. Electrophoresis (2003) 0.90

Properties and localization of glutamate transporters. Prog Brain Res (1998) 0.90

Isolation of a cDNA for rat brain glutaminase. Brain Res (1988) 0.89

Role of glutamine and neuronal glutamate uptake in glutamate homeostasis and synthesis during vesicular release in cultured glutamatergic neurons. Neurochem Int (2005) 0.89

Effect of starvation on glutamine ammoniagenesis and gluconeogenesis in isolated mouse kidney tubules. Biochem J (2002) 0.86

Glutamate immunoreactive terminals in the lateral amygdaloid nucleus: a possible substrate for emotional memory. Brain Res (1992) 0.86

Development of rats' maternally directed orienting behaviors from birth to day 2. Dev Psychobiol (2002) 0.85

Dominant role of the cytosolic C-terminal domain of the rat 5-HT1B receptor in axonal-apical targeting. J Neurosci (2000) 0.83

Glutaminase inhibition and the release of neurotransmitter glutamate from synaptosomes. Brain Res (1989) 0.80

Endogenous glutamate involvement in pulsatile secretion of gonadotropin-releasing hormone: evidence from effect of glutamine and developmental changes. Endocrinology (1995) 0.78

Colocalization of fixative-modified glutamate and glutaminase but not GAD in rubrospinal neurons. J Comp Neurol (1988) 0.77

Release of endogenous amino acids from striatal neurons in primary culture. J Neurochem (1986) 0.77

Articles by these authors

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science (2003) 16.14

Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc Natl Acad Sci U S A (2006) 5.83

Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron (2009) 5.20

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature (2011) 5.17

Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science (2004) 4.31

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature (2002) 3.92

Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful faces. Neuron (2004) 3.26

Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science (2013) 3.26

Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci (2008) 3.13

Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment. Nat Neurosci (2006) 3.00

Hippocampal neurogenesis: regulation by stress and antidepressants. Biol Psychiatry (2006) 2.94

Targeted gene expression in dopamine and serotonin neurons of the mouse brain. J Neurosci Methods (2004) 2.80

Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron (2010) 2.75

5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron (2010) 2.75

Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron (2013) 2.74

Different data from different labs: lessons from studies of gene-environment interaction. J Neurobiol (2003) 2.68

Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology (2009) 2.63

Pattern separation: a common function for new neurons in hippocampus and olfactory bulb. Neuron (2011) 2.54

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (2006) 2.49

Dopamine neurons mediate a fast excitatory signal via their glutamatergic synapses. J Neurosci (2004) 2.45

Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal. Biol Psychiatry (2008) 2.35

Hindbrain interneurons and axon guidance signaling critical for breathing. Nat Neurosci (2010) 2.34

Fear erasure in mice requires synergy between antidepressant drugs and extinction training. Science (2011) 2.25

5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. J Neurosci (2009) 2.21

Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc Natl Acad Sci U S A (2003) 2.19

Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat Neurosci (2012) 2.15

Behavioral effects of chronic fluoxetine in BALB/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptor. Neuropsychopharmacology (2007) 2.11

Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension. Circ Res (2006) 2.10

Paradoxical influence of hippocampal neurogenesis on working memory. Proc Natl Acad Sci U S A (2007) 1.96

Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice. Biol Psychiatry (2003) 1.94

Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertension. Circ Res (2004) 1.92

Dendritic inhibition in the hippocampus supports fear learning. Science (2014) 1.92

Functional connectome of the striatal medium spiny neuron. J Neurosci (2011) 1.89

Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia. Circulation (2006) 1.79

Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation. J Neurosci (2006) 1.68

Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus. Hippocampus (2010) 1.67

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. J Clin Invest (2015) 1.67

Neurogenesis and affective disorders. Eur J Neurosci (2011) 1.64

Role of adult hippocampal neurogenesis in persistent pain. Pain (2016) 1.56

Adult-born hippocampal neurons promote cognitive flexibility in mice. Hippocampus (2012) 1.50

Corticosteroid-serotonin interactions in the neurobiological mechanisms of stress-related disorders. Neurosci Biobehav Rev (2008) 1.50

Krüppel-like factor 9 is necessary for late-phase neuronal maturation in the developing dentate gyrus and during adult hippocampal neurogenesis. J Neurosci (2009) 1.50

Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression. Proc Natl Acad Sci U S A (2003) 1.48

4- to 6-week-old adult-born hippocampal neurons influence novelty-evoked exploration and contextual fear conditioning. Hippocampus (2011) 1.47

Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons. J Neurosci (2009) 1.45

Neurodevelopmental origins of depressive disorders. Curr Opin Pharmacol (2006) 1.44

Genetics of affective and anxiety disorders. Annu Rev Psychol (2006) 1.40

Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats. Circulation (2005) 1.40

Mitral cells in the olfactory bulb are mainly excited through a multistep signaling path. J Neurosci (2012) 1.38

Breathing without CO(2) chemosensitivity in conditional Phox2b mutants. J Neurosci (2011) 1.36

Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease. Circulation (2003) 1.34

VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety. J Neurosci (2010) 1.29

Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension. Am J Respir Crit Care Med (2006) 1.29

Constitutive activation drives compartment-selective endocytosis and axonal targeting of type 1 cannabinoid receptors. J Neurosci (2006) 1.28

Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety. J Neurosci (2011) 1.27

Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression. Biol Psychiatry (2012) 1.25

Increased fear response to contextual cues in mice lacking the 5-HT1A receptor. Neuropsychopharmacology (2006) 1.24

NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination. J Neurosci (2012) 1.22

Direct Immunohistochemical Evidence of the Existence of 5-HT1A Autoreceptors on Serotoninergic Neurons in the Midbrain Raphe Nuclei. Eur J Neurosci (1990) 1.21

Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia. Neuropsychopharmacology (2009) 1.20

Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice. Pain (2007) 1.19

Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression. Neuropsychopharmacology (2013) 1.16

Differential modulation of neural network and pacemaker activity underlying eupnea and sigh-breathing activities. J Neurophysiol (2008) 1.16

Impact of D2 receptor internalization on binding affinity of neuroimaging radiotracers. Neuropsychopharmacology (2009) 1.15

Acute treatment with the antidepressant fluoxetine internalizes 5-HT1A autoreceptors and reduces the in vivo binding of the PET radioligand [18F]MPPF in the nucleus raphe dorsalis of rat. J Neurosci (2004) 1.15

Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons. Mol Ther (2005) 1.14

3,4-methylenedioxymethamphetamine self-administration is abolished in serotonin transporter knockout mice. Biol Psychiatry (2007) 1.14

Selective cortical interneuron and GABA deficits in cyclin D2-null mice. Development (2007) 1.12

Cannabinoid CB1 receptors are involved in motivational effects of nicotine in rats. Psychopharmacology (Berl) (2005) 1.12

Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice. J Neurosci (2002) 1.11

The antimigraine 5-HT 1B/1D receptor agonists, sumatriptan, zolmitriptan and dihydroergotamine, attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain. Br J Pharmacol (2002) 1.10

Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice. J Neurosci (2004) 1.10

Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter. Am J Physiol Gastrointest Liver Physiol (2002) 1.08

Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension. Am J Respir Crit Care Med (2003) 1.08

Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system. Cell Rep (2012) 1.08

5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain (2008) 1.07

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism. Proc Natl Acad Sci U S A (2011) 1.07

Serotonin receptor expression along the dorsal-ventral axis of mouse hippocampus. Philos Trans R Soc Lond B Biol Sci (2012) 1.07

Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens. Proc Natl Acad Sci U S A (2007) 1.06

Lentiviral-mediated targeted NF-kappaB blockade in dorsal spinal cord glia attenuates sciatic nerve injury-induced neuropathic pain in the rat. Mol Ther (2007) 1.04

Adult neurogenesis in the mammalian hippocampus: why the dentate gyrus? Learn Mem (2013) 1.04

Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences. Neuropsychopharmacology (2011) 1.03

Developmental gene control of brainstem function: views from the embryo. Prog Biophys Mol Biol (2004) 1.03

Neuronal plasticity and antidepressant actions. Trends Neurosci (2013) 1.03

Role of the C-terminal di-leucine motif of 5-HT1A and 5-HT1B serotonin receptors in plasma membrane targeting. J Cell Sci (2006) 1.02

Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification. PLoS One (2012) 1.02

Neurochemical and behavioral alterations in glucocorticoid receptor-impaired transgenic mice after chronic mild stress. J Neurosci (2004) 1.02

TrkB inhibition as a therapeutic target for CNS-related disorders. Prog Neurobiol (2012) 1.02

Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter. J Neurosci (2006) 1.01

Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. Int J Neuropsychopharmacol (2007) 1.01