Published in N Engl J Med on May 11, 2006
Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome. Blood (2008) 3.10
The role of the anaphylatoxins in health and disease. Mol Immunol (2009) 2.95
Delayed graft function in the kidney transplant. Am J Transplant (2011) 2.06
Complement in age-related macular degeneration: a focus on function. Eye (Lond) (2011) 1.39
New insights into postrenal transplant hemolytic uremic syndrome. Nat Rev Nephrol (2010) 1.36
The role of complement in the early immune response to transplantation. Nat Rev Immunol (2012) 1.26
Expression of complement components differs between kidney allografts from living and deceased donors. J Am Soc Nephrol (2009) 1.16
Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation. Xenotransplantation (2008) 1.12
Molecular diagnostics in transplantation. Nat Rev Nephrol (2010) 1.01
Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation. Transplantation (2008) 1.00
Complement regulation of T cell immunity. Immunol Res (2012) 0.95
Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease study. PLoS One (2008) 0.95
Complement gene expression in human cardiac allograft biopsies as a correlate of histologic grade of injury. Transplantation (2008) 0.93
Molecules Great and Small: The Complement System. Clin J Am Soc Nephrol (2015) 0.91
Complement as a multifaceted modulator of kidney transplant injury. J Clin Invest (2014) 0.89
Genotypic diversity of complement component C4 does not predict kidney transplant outcome. J Am Soc Nephrol (2010) 0.86
Recombinant complement receptor 2 radiolabeled with [99mTc(CO)3]+: a potential new radiopharmaceutical for imaging activated complement. PLoS One (2011) 0.83
Defining the acute kidney injury and repair transcriptome. Semin Nephrol (2014) 0.83
Gene expression profiling of the donor kidney at the time of transplantation predicts clinical outcomes 2 years after transplantation. Hum Immunol (2010) 0.82
Inflammation in the setting of chronic allograft dysfunction post-kidney transplant: phenotype and genotype. Clin Transplant (2013) 0.82
Complement regulation of T-cell alloimmunity. Semin Nephrol (2013) 0.81
Complement regulation in renal disease models. Semin Nephrol (2013) 0.80
Effects of complement activation on allograft injury. Curr Opin Organ Transplant (2015) 0.79
The genetics of kidney transplantation. Hum Genet (2011) 0.78
Complement regulation of T-cell alloimmunity. Curr Opin Organ Transplant (2011) 0.78
Shift of C3 deposition from localization in the glomerulus into the tubulo-interstitial compartment in the absence of secreted IgM in immune complex glomerulonephritis. Clin Exp Immunol (2007) 0.77
Influence of graft characteristics on the outcome of kidney transplantation. N Engl J Med (2006) 0.77
Complement activation in progressive renal disease. World J Nephrol (2015) 0.77
Rare loss-of-function mutation in complement component C3 provides insight into molecular and pathophysiological determinants of complement activity. J Immunol (2015) 0.76
APT070 (mirococept), a membrane-localizing C3 convertase inhibitor, attenuates early human islet allograft damage in vitro and in vivo in a humanized mouse model. Br J Pharmacol (2016) 0.76
Noninvasive Imaging of Activated Complement in Ischemia-Reperfusion Injury Post-Cardiac Transplant. Am J Transplant (2015) 0.76
New insight into the effects of heparinoids on complement inhibition by C1-inhibitor. Clin Exp Immunol (2016) 0.76
Dialysis or not? A comparative survival study of patients over 75 years with chronic kidney disease stage 5. Nephrol Dial Transplant (2007) 4.99
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science (2002) 4.15
Structures of complement component C3 provide insights into the function and evolution of immunity. Nature (2005) 4.01
Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med (2002) 3.39
Structure of C3b reveals conformational changes that underlie complement activity. Nature (2006) 3.22
Structure of the translocator domain of a bacterial autotransporter. EMBO J (2004) 3.14
Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense. Science (2007) 3.13
Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome. Blood (2008) 3.10
Change in the estimated glomerular filtration rate over time and risk of all-cause mortality. Kidney Int (2013) 3.05
Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nat Immunol (2009) 2.54
Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans. Nat Genet (2007) 2.36
Complement driven by conformational changes. Nat Rev Immunol (2008) 2.21
B-cell diversity decreases in old age and is correlated with poor health status. Aging Cell (2008) 2.15
Short-term change in kidney function and risk of end-stage renal disease. Nephrol Dial Transplant (2012) 2.01
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nat Immunol (2009) 1.98
Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice. J Clin Invest (2008) 1.94
Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade. Nat Med (2003) 1.92
Tracing the origin and history of HIV-1 subtype B' epidemic by near full-length genome analyses. AIDS (2012) 1.89
Toll-like receptor 2 agonists exacerbate accelerated nephrotoxic nephritis. J Am Soc Nephrol (2006) 1.87
C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy. J Am Soc Nephrol (2009) 1.85
Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction. Kidney Int (2010) 1.83
Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. J Biol Chem (2007) 1.71
The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation. Am J Transplant (2004) 1.69
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. Genes Dev (2014) 1.68
Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European consensus conference. Ther Drug Monit (2009) 1.68
Modelling dynamics in protein crystal structures by ensemble refinement. Elife (2012) 1.62
Structures of C3b in complex with factors B and D give insight into complement convertase formation. Science (2010) 1.59
Accuracy of the MDRD (Modification of Diet in Renal Disease) study and CKD-EPI (CKD Epidemiology Collaboration) equations for estimation of GFR in the elderly. Am J Kidney Dis (2012) 1.57
Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype. J Immunol (2006) 1.57
Unique autonomic profile of the pulmonary veins and posterior left atrium. J Am Coll Cardiol (2007) 1.56
Structural insights into the Slit-Robo complex. Proc Natl Acad Sci U S A (2007) 1.54
Crystal structure of Neisserial surface protein A (NspA), a conserved outer membrane protein with vaccine potential. J Biol Chem (2003) 1.54
Molecular mechanisms of complement evasion: learning from staphylococci and meningococci. Nat Rev Microbiol (2010) 1.52
Complement is activated by IgG hexamers assembled at the cell surface. Science (2014) 1.52
Longitudinal evaluation of the pharmacokinetics of cyclosporin microemulsion (Neoral) in pediatric renal transplant recipients and assessment of C2 level as a marker for absorption. Pediatr Transplant (2003) 1.52
Paranoid psychosis and myoclonus: flecainide toxicity in renal failure. Cardiology (2008) 1.48
Arteriovenous fistula in the rat tail: a new model of hemodialysis access dysfunction. Kidney Int (2008) 1.48
The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s. AIDS (2013) 1.48
Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury. J Clin Invest (2016) 1.43
Gigantic cavernous hemangioma of the liver treated by intra-arterial embolization with pingyangmycin-lipiodol emulsion: a multi-center study. Cardiovasc Intervent Radiol (2004) 1.43
Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes. Genome Res (2009) 1.42
Local extravascular pool of C3 is a determinant of postischemic acute renal failure. FASEB J (2006) 1.38
Re: Drugs, driving and sobriety tests. J Clin Forensic Med (2003) 1.38
Crystallography: crystallographic evidence for deviating C3b structure. Nature (2007) 1.38
Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction. Blood (2007) 1.37
Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and P-glycoprotein correlate with dose requirement. Transplantation (2002) 1.33
Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation. Blood (2008) 1.33
Near full-length genomic characterization of a novel HIV type 1 CRF07_ BC/01_AE recombinant in men who have sex with men from Sichuan, China. AIDS Res Hum Retroviruses (2013) 1.30
Mental health and quality of life survey among child survivors of the 2008 Sichuan earthquake. Qual Life Res (2010) 1.30
Factor B structure provides insights into activation of the central protease of the complement system. Nat Struct Mol Biol (2007) 1.27
Toll-like receptor 4 ligation on intrinsic renal cells contributes to the induction of antibody-mediated glomerulonephritis via CXCL1 and CXCL2. J Am Soc Nephrol (2007) 1.27
The role of complement in the early immune response to transplantation. Nat Rev Immunol (2012) 1.26
Structural insights into the central complement component C3. Mol Immunol (2006) 1.25
Dendritic cell function in allostimulation is modulated by C5aR signaling. J Immunol (2009) 1.24
Tacrolimus pharmacogenetics: the CYP3A5*1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians. Transplantation (2005) 1.24
Trajectories of illness in stage 5 chronic kidney disease: a longitudinal study of patient symptoms and concerns in the last year of life. Clin J Am Soc Nephrol (2011) 1.24
Negative regulation of MAVS-mediated innate immune response by PSMA7. J Immunol (2009) 1.24
Protein-induced water 1H MR frequency shifts: contributions from magnetic susceptibility and exchange effects. J Magn Reson (2009) 1.22
The role of anaphylatoxins C3a and C5a in regulating innate and adaptive immune responses. Inflamm Allergy Drug Targets (2009) 1.22
Therapeutic drug monitoring of immunosuppressant drugs in clinical practice. Clin Ther (2002) 1.20
Macrophages from C3-deficient mice have impaired potency to stimulate alloreactive T cells. Blood (2005) 1.19
Characterization of HIV-1 subtype C envelope glycoproteins from perinatally infected children with different courses of disease. Retrovirology (2006) 1.19
Contiguous spread of Mycobacterium ulcerans in Buruli ulcer lesions analysed by histopathology and real-time PCR quantification of mycobacterial DNA. J Pathol (2006) 1.18
Homeostatic proliferation of lymphocytes results in augmented memory-like function and accelerated allograft rejection. J Immunol (2008) 1.17
Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9. Cell Rep (2012) 1.16
Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2006) 1.15
IL-10 genotype analysis in patients with Behçet's disease. Hum Immunol (2006) 1.15
Staphylococcal complement inhibitor: structure and active sites. J Immunol (2007) 1.14
Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex. EMBO J (2009) 1.13
TLR2 stimulation of intrinsic renal cells in the induction of immune-mediated glomerulonephritis. J Immunol (2006) 1.12
The association of the PTPN22 620W polymorphism with Behcet's disease. Ann Rheum Dis (2007) 1.12
Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation. J Synchrotron Radiat (2002) 1.12
One-year change in kidney function is associated with an increased mortality risk. Am J Nephrol (2012) 1.11
Lipopolysaccharide regions involved in the activation of Escherichia coli outer membrane protease OmpT. Eur J Biochem (2002) 1.11
Synthesis of complement protein C3 in the kidney is an important mediator of local tissue injury. FASEB J (2007) 1.11
Phenotypic and genotypic characterization of human immunodeficiency virus type 1 CRF07_BC strains circulating in the Xinjiang Province of China. Retrovirology (2009) 1.10
A pharmacokinetic and clinical review of the potential clinical impact of using different formulations of cyclosporin A. Berlin, Germany, November 19, 2001. Clin Ther (2003) 1.10
Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury. FASEB J (2011) 1.08
Therapeutic strategy with a membrane-localizing complement regulator to increase the number of usable donor organs after prolonged cold storage. J Am Soc Nephrol (2006) 1.08
Complement in organ transplantation. Curr Opin Organ Transplant (2010) 1.08
Evolution of subtype C HIV-1 Env in a slowly progressing Zambian infant. Retrovirology (2005) 1.07
catena-Poly[[heptakis(dimethylformamide-kappaO)di-mu4-oxo-tetra-mu3-oxo-hexadeca-mu2-oxo-tetraoxolanthanum(III)octamolybdenum(IV)]-mu-sodium(I)]. Acta Crystallogr C (2004) 1.07
Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association. EMBO J (2002) 1.07
Common genetic variants in complement genes other than CFH, CD46 and the CFHRs are not associated with aHUS. Mol Immunol (2011) 1.06