Published in J Biol Chem on June 19, 2006
Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med (2012) 6.15
Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patients. J Immunol (2007) 3.20
Healthy aging and disease: role for telomere biology? Clin Sci (Lond) (2011) 2.10
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet (2012) 1.77
Transforming growth factor-β and the hallmarks of cancer. Cell Signal (2010) 1.66
Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc. J Biol Chem (2008) 1.34
Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol (2010) 1.27
Telomeres and immunological diseases of aging. Gerontology (2009) 1.22
Telomeres-structure, function, and regulation. Exp Cell Res (2012) 1.11
Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene. Protein Cell (2010) 1.07
Molecular mechanisms involved in the aging of the T-cell immune response. Curr Genomics (2012) 1.05
Telomere dynamics in keloids. Eplasty (2011) 0.95
Generation of human induced pluripotent stem (Ips) cells in serum- and feeder-free defined culture and TGF-Β1 regulation of pluripotency. PLoS One (2014) 0.92
SMAD3 functions as a transcriptional repressor of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc. J Bone Miner Res (2008) 0.91
Systemic Problems: A perspective on stem cell aging and rejuvenation. Aging (Albany NY) (2015) 0.88
Therapeutic targeting of redox signaling in myofibroblast differentiation and age-related fibrotic disease. Oxid Med Cell Longev (2012) 0.85
Redox signaling as a therapeutic target to inhibit myofibroblast activation in degenerative fibrotic disease. Biomed Res Int (2014) 0.84
The MAPK pathway signals telomerase modulation in response to isothiocyanate-induced DNA damage of human liver cancer cells. PLoS One (2013) 0.84
Regeneration in pig livers by compensatory hyperplasia induces high levels of telomerase activity. Comp Hepatol (2007) 0.83
KLF17 empowers TGF-β/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression. Cell Death Dis (2015) 0.82
Tumor suppressors p53, p63TAα, p63TAy, p73α, and p73β use distinct pathways to repress telomerase expression. J Biol Chem (2012) 0.80
Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene. Genes (Basel) (2016) 0.79
Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. Carcinogenesis (2015) 0.77
Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs. J Biol Chem (2015) 0.77
The role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignancies. JAKSTAT (2013) 0.77
TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence. Protein Cell (2016) 0.75
Concomitant underexpression of TGFBR2 and overexpression of hTERT are associated with poor prognosis in cervical cancer. Sci Rep (2017) 0.75
Telomerase: The Devil Inside. Genes (Basel) (2016) 0.75
Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res (2011) 2.39
Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab Rev (2009) 2.16
ATF3 transcription factor and its emerging roles in immunity and cancer. J Mol Med (Berl) (2009) 2.08
Evidence for activation of tissue factor by an allosteric disulfide bond. Biochemistry (2006) 1.99
Platelet physiology and thrombosis. Thromb Res (2004) 1.90
High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood (2010) 1.75
Piezoresistive strain sensors made from carbon nanotubes based polymer nanocomposites. Sensors (Basel) (2011) 1.73
Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense. Immunity (2012) 1.62
Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation. EMBO J (2005) 1.52
The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface. J Biol Chem (2003) 1.49
Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood (2005) 1.47
Establishment, immortalisation and characterisation of pteropid bat cell lines. PLoS One (2009) 1.45
Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa. Blood (2011) 1.44
A miR-19 regulon that controls NF-κB signaling. Nucleic Acids Res (2012) 1.43
CD4(+)CD25(+)CD127(low/-) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression. Clin Immunol (2009) 1.39
Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. J Biol Chem (2002) 1.39
Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner. Clin Immunol (2009) 1.39
Recent advances in molecular imprinting technology: current status, challenges and highlighted applications. Chem Soc Rev (2011) 1.37
P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface. Blood (2003) 1.34
Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc. J Biol Chem (2008) 1.34
Apoptosis of lung carcinoma cells induced by a flexible optical fiber-based cold microplasma. Biosens Bioelectron (2011) 1.31
TERT regulates cell survival independent of telomerase enzymatic activity. Oncogene (2002) 1.31
Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery: influence of the synthesis parameters on transfection efficiency. Biomaterials (2006) 1.30
The immediate economic impact of maternal deaths on rural Chinese households. PLoS One (2012) 1.28
Infrared photodetectors based on CVD-grown graphene and PbS quantum dots with ultrahigh responsivity. Adv Mater (2012) 1.27
Extracellular matrix-mediated signaling by dentin phosphophoryn involves activation of the Smad pathway independent of bone morphogenetic protein. J Biol Chem (2005) 1.26
TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages. J Immunol (2008) 1.25
ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodeling of the actin cytoskeleton. Cancer Res (2013) 1.25
15-μm-sized single-cellular-level and cell-manipulatable microplasma jet in cancer therapies. Biosens Bioelectron (2010) 1.24
Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo. Blood (2006) 1.22
Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner. Blood (2005) 1.21
Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family. Ann N Y Acad Sci (2007) 1.21
A critical role for 14-3-3zeta protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications. Blood (2005) 1.20
Hormones and growth factors regulate telomerase activity in ageing and cancer. Mol Cell Endocrinol (2005) 1.16
Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated aging. J Infect Dis (2013) 1.16
Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. Drug Metab Rev (2010) 1.15
Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood (2008) 1.11
GAPDH: a common enzyme with uncommon functions. Clin Exp Pharmacol Physiol (2012) 1.10
Deletion of the ftsZ-like gene results in the production of superparamagnetic magnetite magnetosomes in Magnetospirillum gryphiswaldense. J Bacteriol (2009) 1.10
Diversity analysis of magnetotactic bacteria in Lake Miyun, northern China, by restriction fragment length polymorphism. Syst Appl Microbiol (2009) 1.10
Glomerular endothelial cell injury and damage precedes that of podocytes in adriamycin-induced nephropathy. PLoS One (2013) 1.10
Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase. Blood (2002) 1.09
Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta). J Biol Chem (2002) 1.09
Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V. Arthritis Rheum (2006) 1.09
Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation. J Pathol (2012) 1.06
Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIa. Blood (2007) 1.06
Does capillary racetrack-based enrichment reflect the diversity of uncultivated magnetotactic cocci in environmental samples? FEMS Microbiol Lett (2007) 1.05
Newly isolated but uncultivated magnetotactic bacterium of the phylum Nitrospirae from Beijing, China. Appl Environ Microbiol (2011) 1.04
Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase. Blood (2004) 1.04
Molecular imprinting: perspectives and applications. Chem Soc Rev (2016) 1.04
The promyelocytic leukemia zinc finger protein: two decades of molecular oncology. Front Oncol (2012) 1.03
Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor. J Biol Chem (2006) 1.03
Bernard-Soulier syndrome. Haematologica (2011) 1.00
Single-cell-level microplasma cancer therapy. Small (2011) 1.00
Platelet adhesion: a game of catch and release. J Clin Invest (2008) 1.00
Telomerase activation causes vascular smooth muscle cell proliferation in genetic hypertension. FASEB J (2002) 1.00
Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha. Blood (2004) 0.99
Dentin matrix protein 1 (DMP1) signals via cell surface integrin. J Biol Chem (2011) 0.99
Biofunctionalization of a titanium surface with a nano-sawtooth structure regulates the behavior of rat bone marrow mesenchymal stem cells. Int J Nanomedicine (2012) 0.99
Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets. Thromb Haemost (2005) 0.98
Combined treatment of dendritoma vaccine and low-dose interleukin-2 in stage IV renal cell carcinoma patients induced clinical response: A pilot study. Oncol Rep (2007) 0.98
HDACi: molecular mechanisms and therapeutic implications in the innate immune system. Immunol Cell Biol (2011) 0.97
Isolation and characterization of a marine magnetotactic spirillum axenic culture QH-2 from an intertidal zone of the China Sea. Res Microbiol (2010) 0.96
The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large. J Biol Chem (2004) 0.96
High diversity of magnetotactic deltaproteobacteria in a freshwater niche. Appl Environ Microbiol (2013) 0.96
Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. Circ Res (2008) 0.95
A regulatory gene induces trichome formation and embryo lethality in tomato. Proc Natl Acad Sci U S A (2011) 0.95
Increased CD45RA+ FoxP3(low) regulatory T cells with impaired suppressive function in patients with systemic lupus erythematosus. PLoS One (2012) 0.95
Single-cell-level cancer therapy using a hollow optical fiber-based microplasma. Small (2010) 0.94
Grooming reciprocity in female tibetan macaques macaca thibetana. Am J Primatol (2012) 0.93
Amplified voltammetric detection of DNA hybridization via oxidation of ferrocene caps on gold nanoparticle/streptavidin conjugates. Anal Chem (2003) 0.93
Betaglycan is required for the establishment of nephron endowment in the mouse. PLoS One (2011) 0.93
Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor gamma-chain. J Biol Chem (2003) 0.93
Herbal interactions with anticancer drugs: mechanistic and clinical considerations. Curr Med Chem (2010) 0.93
Platelet receptor proteolysis: a mechanism for downregulating platelet reactivity. Arterioscler Thromb Vasc Biol (2007) 0.92
The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation. Arterioscler Thromb Vasc Biol (2012) 0.92
Telomere protein complexes and interactions with telomerase in telomere maintenance. Front Biosci (Landmark Ed) (2011) 0.92
Visible-light responsive photocatalytic fuel cell based on WO(3)/W photoanode and Cu(2)O/Cu photocathode for simultaneous wastewater treatment and electricity generation. Environ Sci Technol (2012) 0.92
Potential roles for estrogen regulation of telomerase activity in aging. Ann N Y Acad Sci (2007) 0.92
Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood. J Biol Chem (2012) 0.92
Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor. J Biol Chem (2008) 0.92
Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789. Am J Physiol Cell Physiol (2008) 0.91
Effects of a hybrid micro/nanorod topography-modified titanium implant on adhesion and osteogenic differentiation in rat bone marrow mesenchymal stem cells. Int J Nanomedicine (2013) 0.91
Dehydroepiandrosterone inhibits human vascular smooth muscle cell proliferation independent of ARs and ERs. J Clin Endocrinol Metab (2002) 0.91
Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo. Protein Cell (2011) 0.90
Mechanisms of action of TGF-beta in cancer: evidence for Smad3 as a repressor of the hTERT gene. Ann N Y Acad Sci (2007) 0.90
Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study. Xenobiotica (2010) 0.90
Molecular regulation of telomerase activity in aging. Protein Cell (2011) 0.90
A STAY-GREEN protein SlSGR1 regulates lycopene and β-carotene accumulation by interacting directly with SlPSY1 during ripening processes in tomato. New Phytol (2013) 0.89
Bone morphogenetic protein-7 inhibits telomerase activity, telomere maintenance, and cervical tumor growth. Cancer Res (2008) 0.89
Platelet receptor redox regulation. Platelets (2008) 0.88
The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities. Drug Discov Today (2006) 0.88
Synergistic anti-tumor effect of glycosylphosphatidylinositol-anchored IL-2 and IL-12. J Gene Med (2004) 0.88
LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis. Blood (2013) 0.88
Niemann-Pick Disease Type C: from molecule to clinic. Clin Exp Pharmacol Physiol (2009) 0.88
Role of carbonic anhydrase IV in corneal endothelial HCO3- transport. Invest Ophthalmol Vis Sci (2008) 0.88
Genetic modulation of TLR8 response following bacterial phagocytosis. Hum Mutat (2010) 0.88