Published in Proteomics on August 01, 2006
Addressing accuracy and precision issues in iTRAQ quantitation. Mol Cell Proteomics (2010) 3.10
Cytosolic Ca2+ buffers. Cold Spring Harb Perspect Biol (2010) 1.42
Quantification of the synaptosomal proteome of the rat cerebellum during post-natal development. Genome Res (2007) 1.39
A comparison of the accuracy of iTRAQ quantification by nLC-ESI MSMS and nLC-MALDI MSMS methods. J Proteomics (2010) 1.20
Extracellular matrix plasticity and GABAergic inhibition of prefrontal cortex pyramidal cells facilitates relapse to heroin seeking. Neuropsychopharmacology (2010) 1.17
Identification of differentially expressed proteins in experimental autoimmune encephalomyelitis (EAE) by proteomic analysis of the spinal cord. J Proteome Res (2007) 1.11
Elucidation of thioredoxin target protein networks in mouse. Mol Cell Proteomics (2009) 1.11
Isobaric labeling-based relative quantification in shotgun proteomics. J Proteome Res (2014) 1.09
Type 1 equilibrative nucleoside transporter regulates ethanol drinking through accumbal N-methyl-D-aspartate receptor signaling. Biol Psychiatry (2011) 1.08
Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiation. Glia (2011) 0.98
Molecular alterations in the cerebellum of the plasma membrane calcium ATPase 2 (PMCA2)-null mouse indicate abnormalities in Purkinje neurons. Mol Cell Neurosci (2006) 0.98
A multiplexed proteomics approach to differentiate neurite outgrowth patterns. J Neurosci Methods (2006) 0.96
Charge prediction machine: tool for inferring precursor charge states of electron transfer dissociation tandem mass spectra. Anal Chem (2009) 0.94
Quantitative Proteomic Analysis of Formalin Fixed Paraffin Embedded Oral HPV Lesions from HIV Patients. Open Proteomics J (2008) 0.90
Post-translational modifications in the rat lumbar spinal cord in experimental autoimmune encephalomyelitis. J Proteome Res (2007) 0.90
Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy in db/db Mice by Quantitative Proteomics. J Diabetes Res (2013) 0.89
Reduced expression of the Ca(2+) transporter protein PMCA2 slows Ca(2+) dynamics in mouse cerebellar Purkinje neurones and alters the precision of motor coordination. J Physiol (2010) 0.89
Quantitative proteomics analysis of the nuclear fraction of human CD4+ cells in the early phases of IL-4-induced Th2 differentiation. Mol Cell Proteomics (2010) 0.87
Interconnected network motifs control podocyte morphology and kidney function. Sci Signal (2014) 0.87
Altered proteolytic events in experimental autoimmune encephalomyelitis discovered by iTRAQ shotgun proteomics analysis of spinal cord. Proteome Sci (2009) 0.86
Proteomic identification of immunoproteasome accumulation in formalin-fixed rodent spinal cords with experimental autoimmune encephalomyelitis. J Proteome Res (2012) 0.85
Defining, comparing, and improving iTRAQ quantification in mass spectrometry proteomics data. Mol Cell Proteomics (2013) 0.82
A comparison of relative quantification with isobaric tags on a subset of the murine hepatic proteome using electrospray ionization quadrupole time-of-flight and matrix-assisted laser desorption/ionization tandem time-of-flight. Rapid Commun Mass Spectrom (2008) 0.81
Microwave & magnetic (M2) proteomics reveals CNS-specific protein expression waves that precede clinical symptoms of experimental autoimmune encephalomyelitis. Sci Rep (2014) 0.80
Quantitative phosphokinome analysis of the Met pathway activated by the invasin internalin B from Listeria monocytogenes. Mol Cell Proteomics (2009) 0.80
Identification of putative biomarkers for HIV-associated neurocognitive impairment in the CSF of HIV-infected patients under cART therapy determined by mass spectrometry. J Neurovirol (2014) 0.79
Recent advances in neuroproteomics. Curr Opin Mol Ther (2007) 0.79
iTRAQ-based shotgun neuroproteomics. Methods Mol Biol (2009) 0.78
Proteomic mechanisms of cardioprotection during mammalian hibernation in woodchucks, Marmota monax. J Proteome Res (2013) 0.77
Hippocampal Transcriptomic and Proteomic Alterations in the BTBR Mouse Model of Autism Spectrum Disorder. Front Physiol (2015) 0.77
Master redox regulator Trx1 upregulates SMYD1 & modulates lysine methylation. Biochim Biophys Acta (2015) 0.76
CSF-Based Analysis for Identification of Potential Serum Biomarkers of Neural Tube Defects. Neurosci Bull (2017) 0.75
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
A simple method for displaying the hydropathic character of a protein. J Mol Biol (1982) 150.65
Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics (2003) 100.88
DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol (2003) 84.79
EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet (2000) 69.26
Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol Cell Proteomics (2004) 19.05
Microarray data analysis: from disarray to consolidation and consensus. Nat Rev Genet (2006) 16.12
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome. J Proteome Res (2003) 11.96
Design issues for cDNA microarray experiments. Nat Rev Genet (2002) 5.69
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Mol Cell Proteomics (2005) 4.33
Validation and development of fluorescence two-dimensional differential gel electrophoresis proteomics technology. Proteomics (2001) 3.02
Mass spectrometry and the age of the proteome. J Mass Spectrom (1998) 2.59
An introduction to quadrupole-time-of-flight mass spectrometry. J Mass Spectrom (2001) 2.30
Search for cancer markers from endometrial tissues using differentially labeled tags iTRAQ and cICAT with multidimensional liquid chromatography and tandem mass spectrometry. J Proteome Res (2005) 2.22
Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. J Biol Chem (1998) 2.10
Proteomic mapping of brain plasma membrane proteins. Mol Cell Proteomics (2005) 1.96
Characterization of the mouse brain proteome using global proteomic analysis complemented with cysteinyl-peptide enrichment. J Proteome Res (2006) 1.93
Whole proteome pI values correlate with subcellular localizations of proteins for organisms within the three domains of life. Genome Res (2001) 1.75
Genetic analysis of the mouse brain proteome. Nat Genet (2002) 1.73
Quantifying reproducibility for differential proteomics: noise analysis for protein liquid chromatography-mass spectrometry of human serum. Bioinformatics (2004) 1.57
Organellar proteomics: analysis of pancreatic zymogen granule membranes. Mol Cell Proteomics (2005) 1.49
Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells. Mol Cell Proteomics (2005) 1.42
Quantitative analysis of protein expression using amine-specific isobaric tags in Escherichia coli cells expressing rhsA elements. Proteomics (2005) 1.40
Mutational analysis of dendritic Ca2+ kinetics in rodent Purkinje cells: role of parvalbumin and calbindin D28k. J Physiol (2003) 1.32
Assessing the effects of diurnal variation on the composition of human parotid saliva: quantitative analysis of native peptides using iTRAQ reagents. Anal Chem (2005) 1.18
Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury. FASEB J (2004) 1.15
Global analysis of the cortical neuron proteome. Mol Cell Proteomics (2004) 1.14
The continuing evolution of shotgun proteomics. Drug Discov Today (2005) 1.12
Proteomics in molecular medicine: applications in central nervous systems disorders. Electrophoresis (2000) 1.04
Proteomics in brain research: potentials and limitations. Prog Neurobiol (2003) 1.01
Recent advancements in differential proteomics based on stable isotope coding. Brief Funct Genomic Proteomic (2005) 1.00
Large-scale evaluation of quantitative reproducibility and proteome coverage using acid cleavable isotope coded affinity tag mass spectrometry for proteomic profiling. Proteomics (2005) 1.00
Proteomics in postgenomic neuroscience: the end of the beginning. Nat Neurosci (2004) 1.00
Proteomic analysis of the fetal brain. Proteomics (2002) 1.00
Plasma membrane Ca(2+)-ATPase isoforms: distribution of mRNAs in rat brain by in situ hybridization. Brain Res Mol Brain Res (1992) 0.94
Proteomics in neuropsychiatric disorders. Int J Neuropsychopharmacol (2001) 0.93
Analysis of the mouse proteome. (I) Brain proteins: separation by two-dimensional electrophoresis and identification by mass spectrometry and genetic variation. Electrophoresis (1999) 0.93
The rat brain hippocampus proteome. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 0.89
Preliminary analysis of the mouse cerebellum proteome. Brain Res Mol Brain Res (2002) 0.88
The role of the extracellular signal-regulated kinase pathway in cerebellar abnormalities in schizophrenia. Cerebellum (2004) 0.85
Toward a global analysis of the human pituitary proteome by multiple gel-based technology. Anal Chem (2005) 0.84
Proteomic profiling of human hippocampus. Electrophoresis (2004) 0.84
Role of calcium binding proteins in the control of cerebellar granule cell neuronal excitability: experimental and modeling studies. Prog Brain Res (2005) 0.83
Analysis of the proteome in the human pituitary. Proteomics (2002) 0.82
Cerebellar protein expression in three different mouse strains and their relevance for motor performance. Neurochem Int (2005) 0.81
Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature (2012) 18.23
The Genome sequence of the SARS-associated coronavirus. Science (2003) 16.68
Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA (2003) 16.08
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature (2010) 10.66
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature (2007) 10.40
Modelling schizophrenia using human induced pluripotent stem cells. Nature (2011) 7.41
Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes. Genes Dev (2008) 7.09
A distinct lineage of influenza A virus from bats. Proc Natl Acad Sci U S A (2012) 6.27
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04
Trends in survival after in-hospital cardiac arrest. N Engl J Med (2012) 5.67
Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis (2002) 5.64
Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med (2003) 5.45
Functional profiling of a human cytomegalovirus genome. Proc Natl Acad Sci U S A (2003) 5.21
Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study. Lancet (2007) 5.21
A high-resolution map of the three-dimensional chromatin interactome in human cells. Nature (2013) 5.18
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science (2006) 4.71
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell (2009) 4.47
Human illness from avian influenza H7N3, British Columbia. Emerg Infect Dis (2004) 4.29
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med (2010) 4.23
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: final results of a phase III randomized clinical trial. Ann Surg Oncol (2011) 4.16
New world bats harbor diverse influenza A viruses. PLoS Pathog (2013) 4.10
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina). J Am Coll Cardiol (2013) 3.90
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell (2005) 3.89
Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada. PLoS Med (2010) 3.85
Long-term outcomes in elderly survivors of in-hospital cardiac arrest. N Engl J Med (2013) 3.85
Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature (2012) 3.83
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
Interaction of the Cas6 riboendonuclease with CRISPR RNAs: recognition and cleavage. Structure (2011) 3.58
Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung. Nat Biotechnol (2007) 3.54
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol (2003) 3.51
Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol (2010) 3.49
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. Science (2008) 3.44
Single-layer MoS2 phototransistors. ACS Nano (2011) 3.43
Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study. Hypertension (2006) 3.42
A universal method to produce low-work function electrodes for organic electronics. Science (2012) 3.33
Human Bocavirus infection, Canada. Emerg Infect Dis (2006) 3.30
The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev (2004) 3.29
Pre-existing AAV capsid-specific CD8+ T cells are unable to eliminate AAV-transduced hepatocytes. Mol Ther (2007) 3.26
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature (2004) 3.24
A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants. Cell Host Microbe (2007) 3.15
The scale of population structure in Arabidopsis thaliana. PLoS Genet (2010) 3.12
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol (2014) 3.12
Triple reassortant H3N2 influenza A viruses, Canada, 2005. Emerg Infect Dis (2006) 3.05
Label-free, normalized quantification of complex mass spectrometry data for proteomic analysis. Nat Biotechnol (2009) 3.01
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature (2013) 3.00
Identification of a novel astrovirus (astrovirus VA1) associated with an outbreak of acute gastroenteritis. J Virol (2009) 2.96
Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol (2012) 2.91
Novel avian influenza H7N3 strain outbreak, British Columbia. Emerg Infect Dis (2004) 2.90
Masked hypertension in diabetes mellitus: treatment implications for clinical practice. Hypertension (2013) 2.89
Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr Biol (2007) 2.84
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell (2008) 2.84
Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease. Diabetes Care (2012) 2.84
Anterior chamber width measurement by high-speed optical coherence tomography. Ophthalmology (2005) 2.77
Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J Neurosci (2004) 2.76
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. EMBO J (2011) 2.71
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat Med (2013) 2.70
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet (2005) 2.68
Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC Neurosci (2006) 2.68
Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res (2010) 2.65
Prognostic value of reading-to-reading blood pressure variability over 24 hours in 8938 subjects from 11 populations. Hypertension (2010) 2.64
Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. Nat Med (2010) 2.62
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Nat Biotechnol (2004) 2.60
Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study. Lancet Neurol (2010) 2.60
Component-specific effectiveness of trivalent influenza vaccine as monitored through a sentinel surveillance network in Canada, 2006-2007. J Infect Dis (2009) 2.59
Modeling desertification change in Minqin County, China. Environ Monit Assess (2005) 2.56
Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells. Kidney Int (2004) 2.55
Structure and function of archaeal box C/D sRNP core proteins. Nat Struct Biol (2003) 2.55
A decade's studies on metastasis of hepatocellular carcinoma. J Cancer Res Clin Oncol (2003) 2.50
Effectiveness of AS03 adjuvanted pandemic H1N1 vaccine: case-control evaluation based on sentinel surveillance system in Canada, autumn 2009. BMJ (2011) 2.50
Correlation of IHC and FISH for ALK gene rearrangement in non-small cell lung carcinoma: IHC score algorithm for FISH. J Thorac Oncol (2011) 2.50
miR-301a as an NF-κB activator in pancreatic cancer cells. EMBO J (2010) 2.47
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell (2008) 2.47
Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. Nat Immunol (2002) 2.46
A coastal cline in sodium accumulation in Arabidopsis thaliana is driven by natural variation of the sodium transporter AtHKT1;1. PLoS Genet (2010) 2.45
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke. J Biol Chem (2005) 2.44
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor. Nature (2011) 2.43
Prevention of stroke and myocardial infarction by amlodipine and Angiotensin receptor blockers: a quantitative overview. Hypertension (2007) 2.43
Reference values for continuous glucose monitoring in Chinese subjects. Diabetes Care (2009) 2.41
BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. J Cell Biol (2002) 2.40
Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett (2009) 2.40
Two calcium-dependent protein kinases, CPK4 and CPK11, regulate abscisic acid signal transduction in Arabidopsis. Plant Cell (2007) 2.40
The interferon-inducible MxB protein inhibits HIV-1 infection. Cell Host Microbe (2013) 2.39
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nat Biotechnol (2011) 2.37
Efficient formulation of the stochastic simulation algorithm for chemically reacting systems. J Chem Phys (2004) 2.36
A new class of Solvent-in-Salt electrolyte for high-energy rechargeable metallic lithium batteries. Nat Commun (2013) 2.33
Ambulatory blood pressure monitoring in 9357 subjects from 11 populations highlights missed opportunities for cardiovascular prevention in women. Hypertension (2011) 2.33
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell (2002) 2.33
Novel, chimpanzee serotype 68-based adenoviral vaccine carrier for induction of antibodies to a transgene product. J Virol (2002) 2.31
Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of Eurasian H7N7 viruses isolated from humans. J Virol (2007) 2.30
Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations. J Hypertens (2010) 2.28
A transforming metal nanocomposite with large elastic strain, low modulus, and high strength. Science (2013) 2.28
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol (2003) 2.26
A cross-sectional study of the microeconomic impact of cardiovascular disease hospitalization in four low- and middle-income countries. PLoS One (2011) 2.23
Positional cloning of the murine flavivirus resistance gene. Proc Natl Acad Sci U S A (2002) 2.22
Slc26a11, a chloride transporter, localizes with the vacuolar H(+)-ATPase of A-intercalated cells of the kidney. Kidney Int (2011) 2.21
A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone. Nat Protoc (2010) 2.20