| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
|
N Engl J Med
|
2013
|
19.87
|
|
2
|
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.
|
Cancer Cell
|
2010
|
16.12
|
|
3
|
Integrated genomic characterization of endometrial carcinoma.
|
Nature
|
2013
|
14.29
|
|
4
|
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.
|
Nat Genet
|
2006
|
13.63
|
|
5
|
The somatic genomic landscape of glioblastoma.
|
Cell
|
2013
|
11.73
|
|
6
|
Absolute quantification of somatic DNA alterations in human cancer.
|
Nat Biotechnol
|
2012
|
10.87
|
|
7
|
Epigenetic stem cell signature in cancer.
|
Nat Genet
|
2006
|
9.62
|
|
8
|
Pan-cancer patterns of somatic copy number alteration.
|
Nat Genet
|
2013
|
7.73
|
|
9
|
Analysis of repetitive element DNA methylation by MethyLight.
|
Nucleic Acids Res
|
2005
|
6.49
|
|
10
|
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.
|
Genome Res
|
2010
|
6.03
|
|
11
|
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
|
N Engl J Med
|
2015
|
5.71
|
|
12
|
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains.
|
Nat Genet
|
2011
|
5.70
|
|
13
|
Genome-scale analysis of aberrant DNA methylation in colorectal cancer.
|
Genome Res
|
2011
|
4.84
|
|
14
|
Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis.
|
J Mol Diagn
|
2006
|
4.68
|
|
15
|
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.
|
Nat Biotechnol
|
2011
|
3.97
|
|
16
|
Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium.
|
J Mol Cell Cardiol
|
2002
|
3.79
|
|
17
|
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements.
|
Mol Cell Biol
|
2002
|
3.61
|
|
18
|
DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons.
|
PLoS One
|
2007
|
3.30
|
|
19
|
Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen.
|
Cancer Res
|
2004
|
3.23
|
|
20
|
Interplay between the cancer genome and epigenome.
|
Cell
|
2013
|
3.05
|
|
21
|
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
|
N Engl J Med
|
2015
|
3.00
|
|
22
|
Inferring tumour purity and stromal and immune cell admixture from expression data.
|
Nat Commun
|
2013
|
2.94
|
|
23
|
Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns.
|
Hum Mol Genet
|
2009
|
2.85
|
|
24
|
Cigarette smoking and colorectal cancer risk by molecularly defined subtypes.
|
J Natl Cancer Inst
|
2010
|
2.38
|
|
25
|
Low-level processing of Illumina Infinium DNA Methylation BeadArrays.
|
Nucleic Acids Res
|
2013
|
2.19
|
|
26
|
Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.
|
Cancer Epidemiol Biomarkers Prev
|
2008
|
2.12
|
|
27
|
Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.
|
Cancer Prev Res (Phila)
|
2008
|
2.04
|
|
28
|
DNA methylation as a biomarker for cardiovascular disease risk.
|
PLoS One
|
2010
|
2.04
|
|
29
|
Bis-SNP: combined DNA methylation and SNP calling for Bisulfite-seq data.
|
Genome Biol
|
2012
|
2.02
|
|
30
|
Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer.
|
Cancer Res
|
2006
|
1.99
|
|
31
|
Epigenetic analysis of KSHV latent and lytic genomes.
|
PLoS Pathog
|
2010
|
1.94
|
|
32
|
A comparison of cluster analysis methods using DNA methylation data.
|
Bioinformatics
|
2004
|
1.94
|
|
33
|
Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling.
|
PLoS One
|
2009
|
1.90
|
|
34
|
DNA hypomethylation and ovarian cancer biology.
|
Cancer Res
|
2004
|
1.75
|
|
35
|
Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice.
|
Cancer Res
|
2002
|
1.73
|
|
36
|
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.
|
Nat Commun
|
2013
|
1.73
|
|
37
|
The landscape of microsatellite instability in colorectal and endometrial cancer genomes.
|
Cell
|
2013
|
1.68
|
|
38
|
DNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines.
|
PLoS One
|
2010
|
1.65
|
|
39
|
Sensitive detection of DNA methylation.
|
Ann N Y Acad Sci
|
2003
|
1.65
|
|
40
|
Hypomethylation and hypermethylation of DNA in Wilms tumors.
|
Oncogene
|
2002
|
1.59
|
|
41
|
Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells.
|
Gastroenterology
|
2007
|
1.56
|
|
42
|
Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm.
|
PLoS One
|
2007
|
1.55
|
|
43
|
Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice.
|
Cancer Res
|
2006
|
1.52
|
|
44
|
Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells.
|
Stem Cells
|
2010
|
1.50
|
|
45
|
Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue.
|
Cancer Res
|
2010
|
1.47
|
|
46
|
Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships.
|
Hum Genet
|
2012
|
1.47
|
|
47
|
Discovery of multi-dimensional modules by integrative analysis of cancer genomic data.
|
Nucleic Acids Res
|
2012
|
1.46
|
|
48
|
MethyLight.
|
Methods Mol Biol
|
2009
|
1.45
|
|
49
|
Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine.
|
Oncotarget
|
2013
|
1.44
|
|
50
|
DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight.
|
Nucleic Acids Res
|
2008
|
1.42
|
|
51
|
An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma.
|
J Natl Cancer Inst
|
2013
|
1.42
|
|
52
|
Distinct methylation profiles of glioma subtypes.
|
Int J Cancer
|
2003
|
1.38
|
|
53
|
Hierarchical clustering of lung cancer cell lines using DNA methylation markers.
|
Cancer Epidemiol Biomarkers Prev
|
2002
|
1.38
|
|
54
|
Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines.
|
Cancer Res
|
2008
|
1.36
|
|
55
|
Sex differential in methylation patterns of selected genes in Singapore Chinese.
|
Hum Genet
|
2005
|
1.35
|
|
56
|
DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis.
|
Lab Invest
|
2007
|
1.34
|
|
57
|
Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function.
|
Circulation
|
2002
|
1.32
|
|
58
|
Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma.
|
Am J Surg Pathol
|
2006
|
1.29
|
|
59
|
Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer.
|
Mol Cancer
|
2008
|
1.24
|
|
60
|
Combined bisulfite restriction analysis (COBRA).
|
Methods Mol Biol
|
2002
|
1.20
|
|
61
|
Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels.
|
Hum Genet
|
2002
|
1.19
|
|
62
|
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair.
|
Mol Cell Biol
|
2002
|
1.18
|
|
63
|
Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells.
|
Nucleic Acids Res
|
2004
|
1.17
|
|
64
|
Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer.
|
PLoS One
|
2012
|
1.14
|
|
65
|
Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma.
|
Mol Cancer
|
2007
|
1.14
|
|
66
|
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.
|
Int J Cancer
|
2009
|
1.14
|
|
67
|
DNA methylation profile of 28 potential marker loci in malignant mesothelioma.
|
Lung Cancer
|
2007
|
1.11
|
|
68
|
Ovarian cancer early detection claims are biased.
|
Clin Cancer Res
|
2008
|
1.10
|
|
69
|
The role of DNA methylation in the development and progression of lung adenocarcinoma.
|
Dis Markers
|
2007
|
1.09
|
|
70
|
The mutagenic potential of duodenoesophageal reflux.
|
Ann Surg
|
2005
|
1.08
|
|
71
|
Rapid and quantitative method of allele-specific DNA methylation analysis.
|
Biotechniques
|
2006
|
1.08
|
|
72
|
Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung.
|
Lung Cancer
|
2005
|
1.06
|
|
73
|
Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon.
|
J Nutr
|
2007
|
1.04
|
|
74
|
DNA hypermethylation of ESR1 and PGR in breast cancer: pathologic and epidemiologic associations.
|
Cancer Epidemiol Biomarkers Prev
|
2009
|
1.04
|
|
75
|
Frequency of deletions of EPCAM (TACSTD1) in MSH2-associated Lynch syndrome cases.
|
J Mol Diagn
|
2010
|
1.04
|
|
76
|
Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study.
|
Nutr Cancer
|
2012
|
1.03
|
|
77
|
Gene-specific methylation and subsequent risk of colorectal adenomas among participants of the polyp prevention trial.
|
Cancer Epidemiol Biomarkers Prev
|
2005
|
1.01
|
|
78
|
Analysis of complex methylation data.
|
Methods
|
2002
|
1.00
|
|
79
|
Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers.
|
Neoplasia
|
2010
|
0.99
|
|
80
|
Associations between colorectal cancer molecular markers and pathways with clinicopathologic features in older women.
|
Gastroenterology
|
2013
|
0.98
|
|
81
|
Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.
|
PLoS One
|
2010
|
0.95
|
|
82
|
Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older women.
|
Gut
|
2011
|
0.94
|
|
83
|
In epigenetic therapy, less is more.
|
Cell Stem Cell
|
2012
|
0.93
|
|
84
|
Hormone therapy, DNA methylation and colon cancer.
|
Carcinogenesis
|
2010
|
0.91
|
|
85
|
Sensitivity and reproducibility of standardized-competitive RT-PCR for transcript quantification and its comparison with real time RT-PCR.
|
Mol Cancer
|
2004
|
0.89
|
|
86
|
Diet, cancer and aging in DNA mismatch repair deficient mice.
|
Carcinogenesis
|
2002
|
0.89
|
|
87
|
Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women.
|
Cancer Prev Res (Phila)
|
2011
|
0.88
|
|
88
|
Locking in on the human methylome.
|
Nat Biotechnol
|
2009
|
0.88
|
|
89
|
2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1.
|
Cancer Lett
|
2008
|
0.88
|
|
90
|
Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry.
|
Cancer Prev Res (Phila)
|
2011
|
0.88
|
|
91
|
Gene dysregulation by histone variant H2A.Z in bladder cancer.
|
Epigenetics Chromatin
|
2013
|
0.88
|
|
92
|
Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia.
|
Cancer Epidemiol Biomarkers Prev
|
2007
|
0.88
|
|
93
|
Clinical applications of DNA methylation biomarkers in colorectal cancer.
|
Epigenomics
|
2013
|
0.88
|
|
94
|
A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force.
|
Cancer Res
|
2012
|
0.87
|
|
95
|
Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis.
|
Cancer Prev Res (Phila)
|
2011
|
0.87
|
|
96
|
Genome-scale screen for DNA methylation-based detection markers for ovarian cancer.
|
PLoS One
|
2011
|
0.87
|
|
97
|
Tumor Budding in Colorectal Carcinoma: Confirmation of Prognostic Significance and Histologic Cutoff in a Population-based Cohort.
|
Am J Surg Pathol
|
2015
|
0.84
|
|
98
|
Cluster analysis for DNA methylation profiles having a detection threshold.
|
BMC Bioinformatics
|
2006
|
0.80
|
|
99
|
Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice.
|
Carcinogenesis
|
2011
|
0.80
|
|
100
|
Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors.
|
PLoS One
|
2011
|
0.80
|
|
101
|
Promoter hypermethylation: a new therapeutic target emerges in urothelial cancer.
|
J Clin Oncol
|
2005
|
0.79
|
|
102
|
Epigenomics-based diagnostics.
|
Clin Chem
|
2010
|
0.79
|
|
103
|
Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model.
|
Urology
|
2013
|
0.78
|
|
104
|
γ-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells.
|
Genes Nutr
|
2014
|
0.77
|
|
105
|
Repeated assessment by high-throughput assay demonstrates that sperm DNA methylation levels are highly reproducible.
|
Fertil Steril
|
2011
|
0.76
|
|
106
|
Modeling exposures for DNA methylation profiles.
|
Cancer Epidemiol Biomarkers Prev
|
2006
|
0.76
|
|
107
|
Non-specific filtering of beta-distributed data.
|
BMC Bioinformatics
|
2014
|
0.75
|
|
108
|
Modeling measurement error in tumor characterization studies.
|
BMC Bioinformatics
|
2011
|
0.75
|
|
109
|
Abstract 31: DNA methylation analysis of radiated skin reveals chonic inflammation with a predominance of polymorphonuclear granulocytes.
|
Plast Reconstr Surg
|
2014
|
0.75
|
|
110
|
Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles.
|
Cell Rep
|
2017
|
0.75
|