Published in Genes Dev on September 15, 2004
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J (2004) 3.57
RNAi in budding yeast. Science (2009) 3.32
On the origin and functions of RNA-mediated silencing: from protists to man. Curr Genet (2006) 3.05
RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production. Proc Natl Acad Sci U S A (2004) 2.88
The Argonaute protein family. Genome Biol (2008) 2.83
Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing. EMBO J (2007) 2.79
HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTR. BMC Mol Biol (2007) 2.20
Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter. Nucleic Acids Res (2010) 1.74
siRNA-mediated heterochromatin establishment requires HP1 and is associated with antisense transcription. Mol Cell (2008) 1.74
RNA interference in protozoan parasites: achievements and challenges. Eukaryot Cell (2011) 1.42
Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe. Nat Struct Mol Biol (2010) 1.30
A double-stranded-RNA response program important for RNA interference efficiency. Mol Cell Biol (2007) 1.29
Retracted Identification of an RNA-dependent RNA polymerase in Drosophila involved in RNAi and transposon suppression. Proc Natl Acad Sci U S A (2009) 1.27
The Tetrahymena argonaute-binding protein Giw1p directs a mature argonaute-siRNA complex to the nucleus. Cell (2010) 1.25
RNA interference (RNAi)-dependent and RNAi-independent association of the Chp1 chromodomain protein with distinct heterochromatic loci in fission yeast. Mol Cell Biol (2005) 1.24
Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast. EMBO Rep (2010) 1.17
Analysis of small RNA in fission yeast; centromeric siRNAs are potentially generated through a structured RNA. EMBO J (2009) 1.14
Functional specialization of Piwi proteins in Paramecium tetraurelia from post-transcriptional gene silencing to genome remodelling. Nucleic Acids Res (2011) 1.13
Determinants of heterochromatic siRNA biogenesis and function. Mol Cell (2013) 1.10
Characterizing the role of RNA silencing components in Cryptococcus neoformans. Fungal Genet Biol (2010) 1.09
Heterochromatin assembly: a new twist on an old model. Chromosome Res (2006) 1.08
A potential link between transgene silencing and poly(A) tails. RNA (2005) 1.02
Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others? Biochem J (2005) 1.02
The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells. Mol Cell Biol (2006) 1.01
RITS-connecting transcription, RNA interference, and heterochromatin assembly in fission yeast. Wiley Interdiscip Rev RNA (2011) 1.00
Programmed fluctuations in sense/antisense transcript ratios drive sexual differentiation in S. pombe. Mol Syst Biol (2011) 0.99
Transgene-induced silencing of the zoosporogenesis-specific NIFC gene cluster of Phytophthora infestans involves chromatin alterations. Eukaryot Cell (2007) 0.95
Identification of microRNA-like RNAs in mycelial and yeast phases of the thermal dimorphic fungus Penicillium marneffei. PLoS Negl Trop Dis (2013) 0.93
RNA interference and heterochromatin assembly. Cold Spring Harb Perspect Biol (2011) 0.93
pHg/pSILBAγ vector system for efficient gene silencing in homobasidiomycetes: optimization of ihpRNA - triggering in the mycorrhizal fungus Laccaria bicolor. Microb Biotechnol (2009) 0.89
Replication competent HIV-1 viruses that express intragenomic microRNA reveal discrete RNA-interference mechanisms that affect viral replication. Cell Biosci (2011) 0.87
Small RNAs, big impact: small RNA pathways in transposon control and their effect on the host stress response. Chromosome Res (2013) 0.86
Characterization of RNA silencing components in the plant pathogenic fungus Fusarium graminearum. Sci Rep (2015) 0.86
Molecular cloning and expression profiles of Argonaute proteins in Schistosoma japonicum. Parasitol Res (2010) 0.85
Expansion of genes encoding piRNA-associated argonaute proteins in the pea aphid: diversification of expression profiles in different plastic morphs. PLoS One (2011) 0.85
The RNA-induced transcriptional silencing complex targets chromatin exclusively via interacting with nascent transcripts. Genes Dev (2016) 0.82
Phylogenetic comparison of small RNA-triggered transcriptional gene silencing. J Biol Chem (2011) 0.79
Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus. World J Virol (2015) 0.79
The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1. Mol Cell (2017) 0.75
Silencing in trans: position matters in fission yeast. EMBO Rep (2010) 0.75
Molecular biology: RNA interference hangs by a thread. Nature (2015) 0.75
Two sets of RNAi components are required for heterochromatin formation in trans triggered by truncated transgenes. Nucleic Acids Res (2016) 0.75
Probing Evolutionary Biography of MicroRNAs and Associated Factors. Curr Genomics (2012) 0.75
The inhibition of microRNAs by HIV-1 Tat suppresses beta catenin activity in astrocytes. Retrovirology (2016) 0.75
Analysis of hairpin RNA transgene-induced gene silencing in Fusarium oxysporum. Silence (2013) 0.75
Ablation of RNA interference and retrotransposons accompany acquisition and evolution of transposases to heterochromatin protein CENPB. Mol Biol Cell (2017) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (1998) 72.56
Identification of novel genes coding for small expressed RNAs. Science (2001) 44.44
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science (2001) 44.16
Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75
An extensive class of small RNAs in Caenorhabditis elegans. Science (2001) 34.17
Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol (1991) 33.90
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell (2001) 25.86
A microRNA in a multiple-turnover RNAi enzyme complex. Science (2002) 23.36
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature (2000) 23.17
RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell (2000) 20.32
A species of small antisense RNA in posttranscriptional gene silencing in plants. Science (1999) 19.34
Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast (1998) 18.47
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science (2002) 17.04
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell (2004) 16.10
Argonaute2, a link between genetic and biochemical analyses of RNAi. Science (2001) 15.32
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell (2002) 14.37
Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell (2004) 13.51
The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell (1999) 13.48
Crystal structure of Argonaute and its implications for RISC slicer activity. Science (2004) 12.48
Genetic and functional diversification of small RNA pathways in plants. PLoS Biol (2004) 12.21
A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science (2001) 11.86
An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus. Cell (2000) 10.42
ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell (2001) 10.20
ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science (2003) 9.54
Thiamine-repressible expression vectors pREP and pRIP for fission yeast. Gene (1993) 9.36
Establishment and maintenance of a heterochromatin domain. Science (2002) 9.34
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev (2004) 9.32
RNAi-mediated targeting of heterochromatin by the RITS complex. Science (2004) 8.73
EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans. Curr Biol (2000) 7.16
Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline. Curr Biol (2001) 7.06
The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development. Genes Dev (2004) 6.69
Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science (2004) 6.35
Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase. Nature (1999) 6.02
Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena. Cell (2002) 5.78
Fertile hypomorphic ARGONAUTE (ago1) mutants impaired in post-transcriptional gene silencing and virus resistance. Plant Cell (2002) 5.39
The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell (2002) 5.07
AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals. Proc Natl Acad Sci U S A (2000) 5.03
RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol Cell (2002) 4.90
RISC assembly defects in the Drosophila RNAi mutant armitage. Cell (2004) 4.88
Total silencing by intron-spliced hairpin RNAs. Nature (2000) 4.78
Retracted Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing. Science (2003) 3.98
Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain. Trends Biochem Sci (2000) 3.96
Whole-genome microarrays of fission yeast: characteristics, accuracy, reproducibility, and processing of array data. BMC Genomics (2003) 3.30
Distinct protein interaction domains and protein spreading in a complex centromere. Genes Dev (2000) 3.09
ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos. Proc Natl Acad Sci U S A (2002) 3.09
Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa. Proc Natl Acad Sci U S A (1997) 2.69
RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E. Genes Dev (2002) 2.61
Heterochromatin: silence is golden. Curr Biol (2003) 2.22
Involvement of small RNAs and role of the qde genes in the gene silencing pathway in Neurospora. Genes Dev (2002) 2.19
Redundancy of the two dicer genes in transgene-induced posttranscriptional gene silencing in Neurospora crassa. Mol Cell Biol (2004) 2.10
RNAi in Dictyostelium: the role of RNA-directed RNA polymerases and double-stranded RNase. Mol Biol Cell (2002) 1.92
PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of C. elegans. Curr Biol (2002) 1.91
Argonaute protein in the early divergent eukaryote Trypanosoma brucei: control of small interfering RNA accumulation and retroposon transcript abundance. Mol Cell Biol (2004) 1.76
Application of the chromatin immunoprecipitation method to identify in vivo protein-DNA associations in fission yeast. Sci STKE (2000) 0.98
Double-stranded RNA-mediated gene silencing in fission yeast. Nucleic Acids Res (2003) 0.95
Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nat Biotechnol (2011) 53.86
A microRNA in a multiple-turnover RNAi enzyme complex. Science (2002) 23.36
Asymmetry in the assembly of the RNAi enzyme complex. Cell (2003) 22.18
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
A distinct small RNA pathway silences selfish genetic elements in the germline. Science (2006) 11.63
A biochemical framework for RNA silencing in plants. Genes Dev (2003) 9.95
Perspective: machines for RNAi. Genes Dev (2005) 9.37
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell (2005) 9.35
Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells. Science (2008) 8.62
microPrimer: the biogenesis and function of microRNA. Development (2005) 8.19
Sequence-specific inhibition of small RNA function. PLoS Biol (2004) 7.98
A protein sensor for siRNA asymmetry. Science (2004) 7.77
Kinetic analysis of the RNAi enzyme complex. Nat Struct Mol Biol (2004) 7.26
Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein. PLoS Biol (2005) 7.23
Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol Cell (2002) 6.43
MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region. EMBO J (2004) 6.27
RNAi: nature abhors a double-strand. Curr Opin Genet Dev (2002) 5.74
The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr Biol (2007) 5.35
Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell (2007) 5.26
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell (2010) 5.22
RISC assembly defects in the Drosophila RNAi mutant armitage. Cell (2004) 4.88
Sorting of Drosophila small silencing RNAs. Cell (2007) 4.67
Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell (2009) 4.39
Modular recognition of RNA by a human pumilio-homology domain. Cell (2002) 4.17
Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies. Curr Biol (2008) 4.07
Target RNA-directed trimming and tailing of small silencing RNAs. Science (2010) 3.98
Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol (2013) 3.80
The RNA-induced silencing complex is a Mg2+-dependent endonuclease. Curr Biol (2004) 3.68
Basic methods for fission yeast. Yeast (2006) 3.37
Designing siRNA that distinguish between genes that differ by a single nucleotide. PLoS Genet (2006) 3.23
Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway. RNA (2009) 3.19
The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell (2009) 3.13
MicroRNA biogenesis: drosha can't cut it without a partner. Curr Biol (2005) 2.85
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res (2010) 2.56
Why do miRNAs live in the miRNP? Genes Dev (2002) 2.41
DNA replication origins fire stochastically in fission yeast. Mol Biol Cell (2005) 2.35
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol Cell (2013) 2.23
In vitro analysis of RNA interference in Drosophila melanogaster. Methods (2003) 2.20
Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients. Curr Biol (2009) 2.19
Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell (2012) 2.07
Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis. Aging Cell (2003) 1.88
Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains. Mol Cell (2011) 1.79
Adaptation to P element transposon invasion in Drosophila melanogaster. Cell (2011) 1.76
Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nat Methods (2012) 1.67
The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Curr Biol (2011) 1.66
Beginning to understand microRNA function. Cell Res (2007) 1.59
Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing. RNA (2011) 1.59
Dicer partner proteins tune the length of mature miRNAs in flies and mammals. Cell (2012) 1.57
A role for microRNAs in the Drosophila circadian clock. Genes Dev (2009) 1.56
In vivo labeling of fission yeast DNA with thymidine and thymidine analogs. Methods (2004) 1.54
UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery. Cell (2012) 1.53
The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint. Mol Cell Biol (2003) 1.45
Modeling genome-wide replication kinetics reveals a mechanism for regulation of replication timing. Mol Syst Biol (2010) 1.42
Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells. Nat Protoc (2008) 1.38
Evolutionary divergence of intrinsic and trans-regulated nucleosome positioning sequences reveals plastic rules for chromatin organization. Genome Res (2011) 1.37
MicroRNAs: regulating a change of heart. Circulation (2009) 1.37
Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease. Mol Cell (2011) 1.36
MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression. Mol Ther (2010) 1.30
Rethinking the microprocessor. Cell (2006) 1.29
The Hsk1(Cdc7) replication kinase regulates origin efficiency. Mol Biol Cell (2008) 1.29
Argonaute proteins. Curr Biol (2011) 1.26
Linking SNPs to CAG repeat length in Huntington's disease patients. Nat Methods (2008) 1.19
Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins. RNA (2010) 1.19
The DNA replication checkpoint directly regulates MBF-dependent G1/S transcription. Mol Cell Biol (2008) 1.18
Small silencing RNAs. Curr Biol (2007) 1.18
Genome-wide identification and characterization of replication origins by deep sequencing. Genome Biol (2012) 1.18
Replication timing and its emergence from stochastic processes. Trends Genet (2012) 1.12
RNA silencing: genomic defence with a slice of pi. Nature (2007) 1.12
A 5'-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation. Silence (2011) 1.08
Sustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles. Mol Ther (2012) 1.07
Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection. Silence (2012) 1.07
MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis. J Clin Invest (2015) 1.03
Rapid and specific purification of Argonaute-small RNA complexes from crude cell lysates. RNA (2012) 1.00
Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks. Mol Cell Biol (2010) 0.98
Cnidarian microRNAs frequently regulate targets by cleavage. Genome Res (2014) 0.96
Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint. Mol Biol Cell (2008) 0.95
Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin. EMBO J (2014) 0.91
Biochemical dissection of RNA silencing in plants. Methods Mol Biol (2004) 0.91
Regulation of DNA replication by the S-phase DNA damage checkpoint. Cell Div (2009) 0.90
The role of MRN in the S-phase DNA damage checkpoint is independent of its Ctp1-dependent roles in double-strand break repair and checkpoint signaling. Mol Biol Cell (2009) 0.90
Huntington's disease: silencing a brutal killer. Exp Neurol (2009) 0.89
Cdc2 tyrosine phosphorylation is not required for the S-phase DNA damage checkpoint in fission yeast. Cell Cycle (2006) 0.87
Small RNA-directed silencing: the fly finds its inner fission yeast? Curr Biol (2013) 0.84
Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain. EMBO J (2014) 0.84
The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress. PLoS One (2009) 0.84
SnapShot: Fly piRNAs, PIWI proteins, and the ping-pong cycle. Cell (2009) 0.81
Defining piRNA primary transcripts. Cell Cycle (2013) 0.80
The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint. Genetics (2010) 0.79
SnapShot: mouse piRNAs, PIWI proteins, and the ping-pong cycle. Cell (2009) 0.78
siRNAs knock down hepatitis. Nat Med (2003) 0.78
Checkpoint regulation of replication forks: global or local? Biochem Soc Trans (2013) 0.77
Studying G2 DNA damage checkpoints using the fission yeast Schizosaccharomyces pombe. Methods Mol Biol (2011) 0.77
Studying S-phase DNA damage checkpoints using the fission yeast Schizosaccharomyces pombe. Methods Mol Biol (2011) 0.76
Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides. Cell (2016) 0.75
Corrigendum: Replication timing is regulated by the number of MCMs loaded at origins. Genome Res (2016) 0.75
Nucleus and gene expression. Curr Opin Cell Biol (2009) 0.75