Sirtuins in aging and age-related disease.

The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet (2009) 9.68

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97

miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A (2008) 6.24

Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell (2008) 5.51

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell (2010) 5.11

Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00

Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell (2008) 3.38

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 3.35

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci (2010) 3.05

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature (2012) 2.96

Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab (2012) 2.56

Can autophagy promote longevity? Nat Cell Biol (2010) 2.55

Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res (2007) 2.51

Replicative aging in yeast: the means to the end. Annu Rev Cell Dev Biol (2008) 2.49

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev (2008) 2.39

MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components. Mol Immunol (2007) 2.24

Recent developments in yeast aging. PLoS Genet (2007) 2.13

Manifestations and mechanisms of stem cell aging. J Cell Biol (2011) 1.93

Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response. Aging Cell (2007) 1.87

Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes. Mol Cell (2007) 1.77

miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) (2010) 1.76

Age-associated epigenetic drift: implications, and a case of epigenetic thrift? Hum Mol Genet (2013) 1.76

Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. Aging (Albany NY) (2011) 1.74

A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol (2009) 1.73

Chemical mechanisms of histone lysine and arginine modifications. Biochim Biophys Acta (2008) 1.69

Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem (2010) 1.65

Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation. Endocrinology (2010) 1.65

Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation. Proc Natl Acad Sci U S A (2008) 1.62

SIRT6 in DNA repair, metabolism and ageing. J Intern Med (2008) 1.61

Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.61

Mammalian circadian clock and metabolism - the epigenetic link. J Cell Sci (2010) 1.55

NFkappaB promotes inflammation, coagulation, and fibrosis in the aging glomerulus. J Am Soc Nephrol (2010) 1.49

Turning enzymes ON with small molecules. Nat Chem Biol (2010) 1.47

Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. PLoS Biol (2008) 1.47

Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J Biol Chem (2008) 1.46

PGC-1alpha in aging and anti-aging interventions. Biochim Biophys Acta (2009) 1.35

Where in the cell is SIRT3?--functional localization of an NAD+-dependent protein deacetylase. Biochem J (2008) 1.31

T cell replicative senescence in human aging. Curr Pharm Des (2013) 1.31

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol (2013) 1.30

A simple model system for age-dependent DNA damage and cancer. Mech Ageing Dev (2006) 1.29

The circadian clock in cancer development and therapy. Prog Mol Biol Transl Sci (2013) 1.28

Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation. Mol Cells (2009) 1.27

Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J Clin Invest (2010) 1.27

Aging by epigenetics--a consequence of chromatin damage? Exp Cell Res (2008) 1.25

Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells. Int J Biol Sci (2010) 1.24

Resveratrol is a class IA phosphoinositide 3-kinase inhibitor. Biochem J (2007) 1.23

Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem (2008) 1.23

The caloric restriction paradigm: implications for healthy human aging. Am J Hum Biol (2012) 1.22

Structure-based development of novel sirtuin inhibitors. Aging (Albany NY) (2011) 1.19

SIRT3 substrate specificity determined by peptide arrays and machine learning. ACS Chem Biol (2010) 1.17

FOXO transcription factors: their clinical significance and regulation. Biomed Res Int (2014) 1.14

The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span. Proc Natl Acad Sci U S A (2009) 1.14

Nonhuman primate calorie restriction. Antioxid Redox Signal (2010) 1.11

Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism. J Biol Chem (2008) 1.11

Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging. Aging Cell (2014) 1.11

An epigenetic hypothesis of aging-related cognitive dysfunction. Front Aging Neurosci (2010) 1.11

SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. Prev Med (2011) 1.10

NF-kappaB signaling in the aging process. J Clin Immunol (2009) 1.10

Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis. Antioxid Redox Signal (2013) 1.09

Hot topics in epigenetic mechanisms of aging: 2011. Aging Cell (2012) 1.09

Sirtuins at the breaking point: SIRT6 in DNA repair. Aging (Albany NY) (2009) 1.09

Cyclic AMP-dependent protein lysine acylation in mycobacteria regulates fatty acid and propionate metabolism. J Biol Chem (2013) 1.08

Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein. Proc Natl Acad Sci U S A (2007) 1.08

Systems biology of aging in four species. Curr Opin Biotechnol (2007) 1.07

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. Int J Mol Sci (2013) 1.07

The intersection between DNA damage response and cell death pathways. Exp Oncol (2012) 1.06

Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells. Cell Cycle (2009) 1.04

Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans. Proc Natl Acad Sci U S A (2014) 1.04

Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2. Mol Cell Biol (2007) 1.04

Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor. Mol Cell Biol (2010) 1.04

The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. Exp Gerontol (2008) 1.04

Vitamin D and the epigenome. Front Physiol (2014) 1.04

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. J Pineal Res (2010) 1.02

Epigenetic control of aging. Antioxid Redox Signal (2010) 1.02

Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. Cancer Res (2010) 1.00

SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis. Cancer Metab (2014) 1.00

Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model. J Pineal Res (2010) 0.99

Chronological aging in Saccharomyces cerevisiae. Subcell Biochem (2012) 0.98

The Sir2-Sum1 complex represses transcription using both promoter-specific and long-range mechanisms to regulate cell identity and sexual cycle in the yeast Kluyveromyces lactis. PLoS Genet (2009) 0.98

Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer. Biosci Rep (2013) 0.98

The propeptide of yeast cathepsin D inhibits programmed necrosis. Cell Death Dis (2011) 0.98

PMeS: prediction of methylation sites based on enhanced feature encoding scheme. PLoS One (2012) 0.97

Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan. Int J Biochem Cell Biol (2007) 0.97

Age-related changes in redox signaling and VSMC function. Antioxid Redox Signal (2010) 0.97

SirT1 in muscle physiology and disease: lessons from mouse models. Dis Model Mech (2010) 0.97

Targeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implications. Int J Biol Sci (2014) 0.96

Global heterochromatin loss: a unifying theory of aging? Epigenetics (2012) 0.95

Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights. J Nutr Biochem (2011) 0.95

Macronutrients and caloric intake in health and longevity. J Endocrinol (2015) 0.94

SIRT3: as simple as it seems? Gerontology (2013) 0.94

iMethyl-PseAAC: identification of protein methylation sites via a pseudo amino acid composition approach. Biomed Res Int (2014) 0.93

Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms? Biogerontology (2007) 0.93

SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer. Cancer Med (2014) 0.93

The NAD+ synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream target. Cell Cycle (2014) 0.92

Growth factors, nutrient signaling, and cardiovascular aging. Circ Res (2012) 0.91

The p53 Pathway Encounters the MicroRNA World. Curr Genomics (2009) 0.91

Pma1, a P-type proton ATPase, is a determinant of chronological life span in fission yeast. J Biol Chem (2010) 0.91

Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer. Hum Pathol (2014) 0.90

Unique functional roles for class I and class II histone deacetylases in central nervous system development and function. Int J Dev Neurosci (2013) 0.90

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (2005) 11.31

Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev (2006) 6.62

Substrate-specific activation of sirtuins by resveratrol. J Biol Chem (2005) 5.28

LMNA mutations in atypical Werner's syndrome. Lancet (2003) 4.81

Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell (2008) 3.58

Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol (2004) 3.20

A molecular mechanism of chronological aging in yeast. Cell Cycle (2009) 3.12

Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell (2006) 2.95

The TOR pathway comes of age. Biochim Biophys Acta (2009) 2.83

Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nat Rev Mol Cell Biol (2007) 2.56

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res (2008) 2.32

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell (2008) 2.32

A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Proc Natl Acad Sci U S A (2004) 2.17

Recent developments in yeast aging. PLoS Genet (2007) 2.13

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci Transl Med (2012) 1.98

Genes determining yeast replicative life span in a long-lived genetic background. Mech Ageing Dev (2005) 1.96

Progeria syndromes and ageing: what is the connection? Nat Rev Mol Cell Biol (2010) 1.93

Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet (2005) 1.86

When lamins go bad: nuclear structure and disease. Cell (2013) 1.84

A method for high-throughput quantitative analysis of yeast chronological life span. J Gerontol A Biol Sci Med Sci (2008) 1.76

Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC Dev Biol (2008) 1.75

Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes Dev (2006) 1.73

Measuring replicative life span in the budding yeast. J Vis Exp (2009) 1.68

Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell (2013) 1.60

Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. PLoS Genet (2011) 1.52

Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. PLoS One (2008) 1.45

Large-scale identification in yeast of conserved ageing genes. Mech Ageing Dev (2005) 1.43

The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics (2006) 1.36

Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53. Mol Biol Cell (2008) 1.32

Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. Aging Cell (2006) 1.32

Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell (2013) 1.31

Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". Science (2006) 1.27

Yeast hypertrophy: cause or consequence of aging? Reply to Bilinski et al. FEMS Yeast Res (2012) 1.26

Ageing: A midlife longevity drug? Nature (2009) 1.25

Protein translation, 2007. Aging Cell (2007) 1.25

TOR and ageing: a complex pathway for a complex process. Philos Trans R Soc Lond B Biol Sci (2011) 1.25

Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae. Genetics (2012) 1.23

A genomic analysis of chronological longevity factors in budding yeast. Cell Cycle (2011) 1.22

Hot topics in aging research: protein translation and TOR signaling, 2010. Aging Cell (2011) 1.22

Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest. Mol Cell Biol (2006) 1.19

TOR on the brain. Exp Gerontol (2010) 1.18

Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. Cell Metab (2012) 1.18

Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V. Biophys J (2009) 1.16

Genome-wide identification of conserved longevity genes in yeast and worms. Mech Ageing Dev (2006) 1.13

Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. Cell Cycle (2011) 1.13

A-type nuclear lamins act as transcriptional repressors when targeted to promoters. Exp Cell Res (2009) 1.03

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins. Aging Cell (2015) 1.03

The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1. PLoS Genet (2013) 1.02

A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS Genet (2013) 1.02

Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell (2011) 1.01

Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit. Mol Cell Biol (2004) 0.99

Protein translation, 2008. Aging Cell (2008) 0.97

HIV protease inhibitors block adipocyte differentiation independently of lamin A/C. AIDS (2005) 0.95

Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell (2012) 0.94

A-type nuclear lamins, progerias and other degenerative disorders. Mech Ageing Dev (2004) 0.94

Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A. J Gerontol A Biol Sci Med Sci (2009) 0.92

Does resveratrol activate yeast Sir2 in vivo? Aging Cell (2007) 0.92

Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2. PLoS One (2007) 0.91

Cell biology. Rapamycin paradox resolved. Science (2012) 0.91

Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo. Cell Cycle (2013) 0.91

LMNA mutations in progeroid syndromes. Novartis Found Symp (2005) 0.89

Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. Aging Cell (2012) 0.89

Chronological and replicative lifespan in yeast: do they meet in the middle? Cell Cycle (2012) 0.89

Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity. J Clin Invest (2015) 0.88

Cell-extrinsic defective lymphocyte development in Lmna(-/-) mice. PLoS One (2010) 0.88

Integration of multiple nutrient cues and regulation of lifespan by ribosomal transcription factor Ifh1. Cell Rep (2013) 0.87

Rho signaling participates in membrane fluidity homeostasis. PLoS One (2012) 0.87

Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice. Aging Cell (2010) 0.86

Genome-wide analysis of yeast aging. Subcell Biochem (2012) 0.85

Lamin A Δexon9 mutation leads to telomere and chromatin defects but not genomic instability. Nucleus (2013) 0.85

End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging. FEMS Yeast Res (2013) 0.84

Will the real aging Sirtuin please stand up? Cell Res (2012) 0.83

Aging: progeria and the lamin connection. Curr Biol (2006) 0.82

Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects. Exp Cell Res (2012) 0.82

Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice. PLoS One (2012) 0.81

Niche science: the aging stem cell. Cell Cycle (2012) 0.81

Single-gene deletions that restore mating competence to diploid yeast. FEMS Yeast Res (2007) 0.81

Genome-scale studies of aging: challenges and opportunities. Curr Genomics (2012) 0.79

PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae. Age (Dordr) (2015) 0.79

Nuclear tumor suppressors in space and time. Trends Cell Biol (2005) 0.79

The Essence of Aging. Gerontology (2015) 0.78

Cell biology: High-tech yeast ageing. Nature (2012) 0.78

Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1. PLoS One (2011) 0.78

A new chronological survival assay in mammalian cell culture. Cell Cycle (2012) 0.78

Old yeast can't handle the noise. Mol Cell (2010) 0.77

Trinations aging symposium. Mech Ageing Dev (2011) 0.77

Aged worms erase epigenetic history. Cell Metab (2011) 0.76

Elevated MTORC1 signaling and impaired autophagy. Autophagy (2012) 0.76

Aging: one thing leads to another. Curr Biol (2012) 0.76

Sirtuins in yeast: phenotypes and tools. Methods Mol Biol (2013) 0.75

Dialing down SUN1 for laminopathies. Cell (2012) 0.75

Vacuolar dynamics and replicative aging. Cell Cycle (2012) 0.75

Stem Cell Models: A Guide to Understand and Mitigate Aging? Gerontology (2016) 0.75