Published in Biochemistry on September 12, 2006
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Molecular dynamics guided study of salt bridge length dependence in both fluorinated and non-fluorinated parallel dimeric coiled-coils. Proteins (2009) 0.86
Characterization of the cofactor-induced folding mechanism of a zinc-binding peptide using computationally designed mutants. J Mol Biol (2009) 0.85
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Structural basis for the function and inhibition of an influenza virus proton channel. Nature (2008) 5.69
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Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science (2003) 3.22
Foldamers as versatile frameworks for the design and evolution of function. Nat Chem Biol (2007) 2.79
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus. Proc Natl Acad Sci U S A (2010) 2.43
Helix formation via conformation diffusion search. Proc Natl Acad Sci U S A (2002) 2.34
Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel. Proc Natl Acad Sci U S A (2009) 2.32
Using nitrile-derivatized amino acids as infrared probes of local environment. J Am Chem Soc (2003) 2.30
Computational design of peptides that target transmembrane helices. Science (2007) 2.28
De novo design of biomimetic antimicrobial polymers. Proc Natl Acad Sci U S A (2002) 1.95
Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus. Proc Natl Acad Sci U S A (2009) 1.93
Amphiphilic polymethacrylate derivatives as antimicrobial agents. J Am Chem Soc (2005) 1.84
Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers. Proc Natl Acad Sci U S A (2003) 1.82
Protein-protein interactions in the membrane: sequence, structural, and biological motifs. Structure (2008) 1.75
Computational de novo design, and characterization of an A(2)B(2) diiron protein. J Mol Biol (2002) 1.71
Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes. J Biol Chem (2004) 1.65
Determining the orientation of uniaxially rotating membrane proteins using unoriented samples: a 2H, 13C, AND 15N solid-state NMR investigation of the dynamics and orientation of a transmembrane helical bundle. J Am Chem Soc (2007) 1.63
The hydration of amides in helices; a comprehensive picture from molecular dynamics, IR, and NMR. Protein Sci (2003) 1.62
Computational design and characterization of a monomeric helical dinuclear metalloprotein. J Mol Biol (2003) 1.60
De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers. Proc Natl Acad Sci U S A (2009) 1.58
Ultrafast folding of alpha3D: a de novo designed three-helix bundle protein. Proc Natl Acad Sci U S A (2003) 1.57
Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus. Curr Opin Struct Biol (2011) 1.56
Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor. J Am Chem Soc (2005) 1.52
A new method for determining the local environment and orientation of individual side chains of membrane-binding peptides. J Am Chem Soc (2004) 1.51
pH-induced conformational change of the influenza M2 protein C-terminal domain. Biochemistry (2008) 1.48
Computational design of virus-like protein assemblies on carbon nanotube surfaces. Science (2011) 1.45
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrob Agents Chemother (2010) 1.42
Cholesterol-dependent phase separation in cell-derived giant plasma-membrane vesicles. Biochem J (2009) 1.40
Understanding the key factors that control the rate of beta-hairpin folding. Proc Natl Acad Sci U S A (2004) 1.40
Trp zipper folding kinetics by molecular dynamics and temperature-jump spectroscopy. Proc Natl Acad Sci U S A (2004) 1.39
Salt bridges: geometrically specific, designable interactions. Proteins (2011) 1.39
Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein. Proc Natl Acad Sci U S A (2002) 1.39
The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. Structure (2008) 1.38
An artificial di-iron oxo-protein with phenol oxidase activity. Nat Chem Biol (2009) 1.37
Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2. J Am Chem Soc (2011) 1.37
Site-Specific Spectroscopic Reporters of the Local Electric Field, Hydration, Structure, and Dynamics of Biomolecules. J Phys Chem Lett (2011) 1.36
Structural basis for proton conduction and inhibition by the influenza M2 protein. Protein Sci (2012) 1.36
Conformational distribution of a 14-residue peptide in solution: a fluorescence resonance energy transfer study. J Phys Chem B (2005) 1.35
Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function. J Mol Biol (2005) 1.35
Design of a switchable eliminase. Proc Natl Acad Sci U S A (2011) 1.34
Long-range interactions stabilize the fold of a non-natural oligomer. J Am Chem Soc (2002) 1.33
Consensus motif for integrin transmembrane helix association. Proc Natl Acad Sci U S A (2009) 1.33
Computational design of water-soluble analogues of the potassium channel KcsA. Proc Natl Acad Sci U S A (2004) 1.31
Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy. J Am Chem Soc (2011) 1.30
De novo designed synthetic mimics of antimicrobial peptides. Curr Opin Biotechnol (2008) 1.30
De novo design of a single-chain diphenylporphyrin metalloprotein. J Am Chem Soc (2007) 1.28
Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. J Am Chem Soc (2009) 1.28
Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy. Proc Natl Acad Sci U S A (2011) 1.27
A novel fluorescent probe for protein binding and folding studies: p-cyano-phenylalanine. Biopolymers (2006) 1.27
Nontoxic membrane-active antimicrobial arylamide oligomers. Angew Chem Int Ed Engl (2004) 1.26
Ultrafast folding of a computationally designed Trp-cage mutant: Trp2-cage. J Phys Chem B (2006) 1.26
Proton and cation transport activity of the M2 proton channel from influenza A virus. Proc Natl Acad Sci U S A (2010) 1.24
Computational design of a protein crystal. Proc Natl Acad Sci U S A (2012) 1.23
Probing the folding transition state structure of the villin headpiece subdomain via side chain and backbone mutagenesis. J Am Chem Soc (2009) 1.23
Infrared study of the effect of hydration on the amide I band and aggregation properties of helical peptides. J Phys Chem B (2007) 1.21
Site-specific hydration status of an amphipathic peptide in AOT reverse micelles. Langmuir (2007) 1.21
5-Cyanotryptophan as an Infrared Probe of Local Hydration Status of Proteins. Chem Phys Lett (2009) 1.21
Empirical lipid propensities of amino acid residues in multispan alpha helical membrane proteins. Proteins (2005) 1.19
Structural organization and interactions of transmembrane domains in tetraspanin proteins. BMC Struct Biol (2005) 1.19
Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy. Biochemistry (2002) 1.18
Using an amino acid fluorescence resonance energy transfer pair to probe protein unfolding: application to the villin headpiece subdomain and the LysM domain. Biochemistry (2008) 1.18
Development of α-helical calpain probes by mimicking a natural protein-protein interaction. J Am Chem Soc (2012) 1.18
Residue-specific vibrational echoes yield 3D structures of a transmembrane helix dimer. Science (2011) 1.17
Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer. Proc Natl Acad Sci U S A (2006) 1.17
Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell Host Microbe (2012) 1.16
Functional analysis of the transmembrane domain in paramyxovirus F protein-mediated membrane fusion. J Mol Biol (2008) 1.16
NMR analysis of the alphaIIb beta3 cytoplasmic interaction suggests a mechanism for integrin regulation. Proc Natl Acad Sci U S A (2010) 1.16
The Two Dimensional Vibrational Echo of a Nitrile Probe of the Villin HP35 Protein. J Phys Chem Lett (2010) 1.15
Divalent cation-induced cluster formation by polyphosphoinositides in model membranes. J Am Chem Soc (2012) 1.14
Transmembrane orientation and possible role of the fusogenic peptide from parainfluenza virus 5 (PIV5) in promoting fusion. Proc Natl Acad Sci U S A (2011) 1.14
Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles. Biochemistry (2003) 1.14
Energy and electron transfer in enhanced two-photon-absorbing systems with triplet cores. J Phys Chem A (2007) 1.14
Effect of dehydration on the aggregation kinetics of two amyloid peptides. J Phys Chem B (2009) 1.14
Amino acid propensities are position-dependent throughout the length of alpha-helices. J Mol Biol (2004) 1.13
Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. Proc Natl Acad Sci U S A (2009) 1.13
Infrared study of the stability and folding kinetics of a 15-residue beta-hairpin. J Am Chem Soc (2003) 1.12
Artificial diiron proteins: from structure to function. Biopolymers (2005) 1.12
Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5. Proc Natl Acad Sci U S A (2011) 1.12
Preorganization of molecular binding sites in designed diiron proteins. Proc Natl Acad Sci U S A (2003) 1.12
Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins. Nat Chem (2012) 1.11
Spectroscopic studies of protein folding: linear and nonlinear methods. Protein Sci (2011) 1.10
A hierarchic approach to the design of hexameric helical barrels. J Mol Biol (2002) 1.10
Using two fluorescent probes to dissect the binding, insertion, and dimerization kinetics of a model membrane peptide. J Am Chem Soc (2009) 1.09
Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization. Biophys J (2004) 1.09
Nanosecond folding dynamics of a three-stranded beta-sheet. J Am Chem Soc (2006) 1.09
Noncovalent self-assembly of a heterotetrameric diiron protein. Proc Natl Acad Sci U S A (2002) 1.08
Folding kinetics of a naturally occurring helical peptide: implication of the folding speed limit of helical proteins. J Phys Chem B (2008) 1.08
Probing the kinetics of membrane-mediated helix folding. J Phys Chem B (2006) 1.08
Role of helix nucleation in the kinetics of binding of mastoparan X to phospholipid bilayers. Biochemistry (2007) 1.08