Published in Genes Dev on January 01, 2010
CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set. Cancer Res (2012) 2.57
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease. Cell Death Differ (2013) 2.41
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. Nat Cell Biol (2012) 1.89
MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. Aging Cell (2011) 1.84
Up-regulation of circulating miR-20a is correlated with hepatitis C virus-mediated liver disease progression. Hepatology (2013) 1.79
Apoptotic cell signaling in cancer progression and therapy. Integr Biol (Camb) (2011) 1.22
Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8(+) T cells sensitizing them to apoptotic cell death. Aging Cell (2012) 1.15
Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents. Mol Cell Biol (2014) 1.04
Cancer epigenetics: above and beyond. Toxicol Mech Methods (2011) 0.95
Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis. J Allergy Clin Immunol (2016) 0.93
MicroRNA-19 triggers epithelial-mesenchymal transition of lung cancer cells accompanied by growth inhibition. Lab Invest (2015) 0.87
Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts. J Immunother Cancer (2013) 0.85
Epigenetic silencing of Bim transcription by Spi-1/PU.1 promotes apoptosis resistance in leukaemia. Cell Death Differ (2013) 0.84
PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC. Mol Cancer Res (2014) 0.84
Estrogen-induced upregulation and 3'-UTR shortening of CDC6. Nucleic Acids Res (2012) 0.84
Spi-1, Fli-1 and Fli-3 (miR-17-92) oncogenes contribute to a single oncogenic network controlling cell proliferation in friend erythroleukemia. PLoS One (2012) 0.84
Targeted Disruption of miR-17-92 Impairs Mouse Spermatogenesis by Activating mTOR Signaling Pathway. Medicine (Baltimore) (2016) 0.83
Mechanisms of epigenetic deregulation in lymphoid neoplasms. Blood (2013) 0.83
MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies. ISRN Hematol (2013) 0.80
MicroRNA expression in mouse oligodendrocytes and regulation of proteolipid protein gene expression. J Neurosci Res (2012) 0.79
Blocking the maturation of OncomiRNAs using pri-miRNA-17∼92 aptamer in retinoblastoma. Nucleic Acid Ther (2014) 0.78
BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells. Leukemia (2016) 0.78
miR-20a inhibits TCR-mediated signaling and cytokine production in human naïve CD4+ T cells. PLoS One (2015) 0.77
Genomic instability at the 13q31 locus and somatic mtDNA mutation in the D-loop site correlate with tumor aggressiveness in sporadic Brazilian breast cancer cases. Clinics (Sao Paulo) (2012) 0.76
miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis. Oncotarget (2016) 0.75
Adenomatous polyposis coli (APC) regulates miR17-92 cluster through β-catenin pathway in colorectal cancer. Oncogene (2016) 0.75
MiR-17-5p promotes cancer cell proliferation and tumorigenesis in nasopharyngeal carcinoma by targeting p21. Cancer Med (2016) 0.75
Post-transcriptional Regulation of BRCA2 through Interactions with miR-19a and miR-19b. Front Genet (2016) 0.75
Profiling of microRNAs in AML cells following overexpression or silencing of the VEGF gene. Oncol Lett (2016) 0.75
Prediction of mammalian microRNA targets. Cell (2003) 53.70
A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A (2006) 40.09
The impact of microRNAs on protein output. Nature (2008) 32.39
c-Myc-regulated microRNAs modulate E2F1 expression. Nature (2005) 31.81
Widespread changes in protein synthesis induced by microRNAs. Nature (2008) 31.44
Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet (2009) 16.58
Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. Cell (2005) 15.38
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (1986) 14.56
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res (2005) 10.46
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol (2008) 10.42
Tenets of PTEN tumor suppression. Cell (2008) 8.61
miRiad roles for the miR-17-92 cluster in development and disease. Cell (2008) 8.02
Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. Cancer Res (2004) 7.96
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell (2002) 6.76
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet (2003) 5.82
Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc Natl Acad Sci U S A (2004) 5.55
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell (2008) 5.53
An E2F/miR-20a autoregulatory feedback loop. J Biol Chem (2006) 5.20
MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science (2009) 5.07
miR-19 is a key oncogenic component of mir-17-92. Genes Dev (2009) 4.95
MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol Cell Biol (2008) 4.76
Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem (2006) 4.57
Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes Dev (2009) 4.43
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell (2008) 3.25
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol (2008) 3.02
Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Res (2008) 3.01
Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia. Cancer Res (2007) 2.52
MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression. Br J Cancer (2009) 1.87
Activation of an oncogenic microRNA cistron by provirus integration. Proc Natl Acad Sci U S A (2006) 1.83
Concomitant MYC and microRNA cluster miR-17-92 (C13orf25) amplification in human mantle cell lymphoma. Leuk Lymphoma (2007) 1.46
Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood (2009) 1.29
The microRNA miR-92 increases proliferation of myeloid cells and by targeting p63 modulates the abundance of its isoforms. FASEB J (2009) 1.23
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell (2006) 11.01
A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature (2004) 8.67
Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell (2002) 7.88
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol (2008) 7.86
RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell (2007) 7.06
Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J (2007) 6.26
miR-148 targets human DNMT3b protein coding region. RNA (2008) 4.56
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep (2003) 4.52
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev (2009) 4.15
MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat Rev Cancer (2011) 3.91
eRNAs are required for p53-dependent enhancer activity and gene transcription. Mol Cell (2012) 3.63
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Cell (2005) 3.35
Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res (2008) 3.06
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J (2003) 2.70
A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility. Nat Cell Biol (2010) 2.53
Alternative cleavage and polyadenylation: extent, regulation and function. Nat Rev Genet (2013) 2.37
The tumor-suppressive functions of the human INK4A locus. Cancer Cell (2003) 2.31
The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites. Cell (2012) 2.14
AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. J Biol Chem (2004) 2.07
MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression. Cell Cycle (2011) 2.06
Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation (2011) 1.99
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability. Genes Dev (2005) 1.97
BRD7 is a candidate tumour suppressor gene required for p53 function. Nat Cell Biol (2010) 1.76
Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer. Mol Cancer (2010) 1.69
Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression. Cell Cycle (2009) 1.56
Interplay between microRNAs and RNA-binding proteins determines developmental processes. Cell Cycle (2008) 1.51
Major role for mRNA stability in shaping the kinetics of gene induction. BMC Genomics (2010) 1.46
Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. BMC Neurosci (2002) 1.44
p53 induces transcriptional and translational programs to suppress cell proliferation and growth. Genome Biol (2013) 1.33
The miRNA-192/194 cluster regulates the Period gene family and the circadian clock. FEBS J (2009) 1.27
miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy (2012) 1.25
E2F mediates enhanced alternative polyadenylation in proliferation. Genome Biol (2012) 1.24
Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer. Cell Cycle (2013) 1.23
MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells. Stem Cells Dev (2010) 1.21
p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation. Mol Cell Biol (2005) 1.21
Classifying microRNAs in cancer: the good, the bad and the ugly. Biochim Biophys Acta (2006) 1.20
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity. Nat Commun (2011) 1.20
miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate. Proc Natl Acad Sci U S A (2010) 1.19
The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs. Am J Pathol (2009) 1.17
Noncoding RNAs and cancer. Cell (2013) 1.16
Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein. EMBO J (2004) 1.15
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Adv Exp Med Biol (2007) 1.15
Telomerase-independent regulation of ATR by human telomerase RNA. J Biol Chem (2006) 1.15
Diverse ways to control p27Kip1 function: miRNAs come into play. Cell Cycle (2007) 1.14
miR-21 and miR-214 are consistently modulated during renal injury in rodent models. Am J Pathol (2011) 1.10
MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5. Autophagy (2013) 1.10
Ribosome profiling reveals features of normal and disease-associated mitochondrial translation. Nat Commun (2013) 1.07
Alternative cleavage and polyadenylation during colorectal cancer development. Clin Cancer Res (2012) 1.02
Immense promises for tiny molecules: uncovering miRNA functions. Cell Cycle (2006) 0.97
A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J Exp Med (2007) 0.97
Removal of AU bias from microarray mRNA expression data enhances computational identification of active microRNAs. PLoS Comput Biol (2008) 0.94
Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis. Epigenetics (2013) 0.94
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1. J Clin Invest (2016) 0.94
Ras interference as cancer therapy. Semin Cancer Biol (2003) 0.94
Gene regulation and tumor suppression by the bromodomain-containing protein BRD7. Cell Cycle (2010) 0.90
Knockdown stands up. Trends Biotechnol (2003) 0.88
CDK-dependent stabilization of Cdc6: linking growth and stress signals to activation of DNA replication. Cell Cycle (2005) 0.86
3'UTR-mediated gene silencing of the Mixed Lineage Leukemia (MLL) gene. PLoS One (2011) 0.84
Unraveling human tumor suppressor pathways: a tale of the INK4A locus. Cell Cycle (2004) 0.83
Identification of lethal microRNAs specific for head and neck cancer. Clin Cancer Res (2013) 0.83
shRNA-mediated RNA interference as a tool for genetic synthetic lethality screening in mouse embryo fibroblasts. FEBS Lett (2005) 0.81
eRNAs reach the heart of transcription. Cell Res (2013) 0.80
A PASport to cellular proliferation. Cell (2008) 0.79
A versatile microsatellite instability reporter system in human cells. Nucleic Acids Res (2013) 0.78
Enhancer-associated RNAs as therapeutic targets. Expert Opin Biol Ther (2015) 0.77
Transformation locked in a loop. Cell (2009) 0.76
Lncing protein translation to metastasis. EMBO J (2013) 0.75