Published in Nature on September 01, 2002
Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol (2009) 8.85
Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu Rev Biochem (2009) 8.83
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Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature (2010) 5.08
Complete subunit architecture of the proteasome regulatory particle. Nature (2012) 4.41
Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med (2011) 4.09
Identification of aneuploidy-tolerating mutations. Cell (2010) 3.73
Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Proc Natl Acad Sci U S A (2012) 3.42
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev (2009) 3.23
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature (2008) 3.11
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J (2005) 2.99
For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection. EMBO J (2003) 2.82
Molecular mechanisms of proteasome assembly. Nat Rev Mol Cell Biol (2009) 2.82
A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. EMBO J (2006) 2.69
The ubiquitylation machinery of the endoplasmic reticulum. Nature (2009) 2.66
AMSH is an endosome-associated ubiquitin isopeptidase. J Cell Biol (2004) 2.58
Structural organization of the 19S proteasome lid: insights from MS of intact complexes. PLoS Biol (2006) 2.56
JAMM: a metalloprotease-like zinc site in the proteasome and signalosome. PLoS Biol (2003) 2.56
Endoproteolytic activity of the proteasome. Science (2002) 2.56
MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function. BMC Biochem (2002) 2.43
hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J (2006) 2.35
Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell Stem Cell (2012) 2.35
Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes. Mol Biol Cell (2005) 2.31
Ubiquitin depletion as a key mediator of toxicity by translational inhibitors. Mol Cell Biol (2003) 2.29
Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. Mol Biol Cell (2007) 2.28
ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome. Mol Cell (2006) 2.26
Targeting proteins for degradation. Nat Chem Biol (2009) 2.22
K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. EMBO J (2009) 2.17
Inhibition of p97-dependent protein degradation by Eeyarestatin I. J Biol Chem (2008) 2.07
Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution. Proc Natl Acad Sci U S A (2010) 2.05
Near-atomic resolution structural model of the yeast 26S proteasome. Proc Natl Acad Sci U S A (2012) 2.04
Molecular architecture and assembly of the eukaryotic proteasome. Annu Rev Biochem (2013) 2.04
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. Mol Cell (2007) 1.98
The biology of proteostasis in aging and disease. Annu Rev Biochem (2015) 1.96
The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology. Physiol Rev (2012) 1.95
Conformational switching of the 26S proteasome enables substrate degradation. Nat Struct Mol Biol (2013) 1.90
Otubains: a new family of cysteine proteases in the ubiquitin pathway. EMBO Rep (2003) 1.90
Proteasomal dysfunction in aging and Huntington disease. Neurobiol Dis (2010) 1.85
A proteasome for all occasions. FEBS Lett (2007) 1.84
Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1. J Mol Biol (2009) 1.82
PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes. BMC Biol (2005) 1.82
Ubiquitin-like small archaeal modifier proteins (SAMPs) in Haloferax volcanii. Nature (2010) 1.80
Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol Cell Proteomics (2010) 1.79
Multiple interactions of rad23 suggest a mechanism for ubiquitylated substrate delivery important in proteolysis. Mol Biol Cell (2004) 1.78
The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics (2012) 1.73
Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Mol Cell Biol (2008) 1.69
The mycobacterial Mpa-proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminus. EMBO J (2010) 1.67
Role of proteasomes in disease. BMC Biochem (2007) 1.65
Structure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation. Nat Struct Mol Biol (2014) 1.63
Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS One (2011) 1.62
Proteasome activators. Mol Cell (2011) 1.62
Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate. EMBO J (2003) 1.61
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proc Natl Acad Sci U S A (2004) 1.59
Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13. Mol Cell (2009) 1.57
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11. Proc Natl Acad Sci U S A (2014) 1.57
Regulation of proteasome activity in health and disease. Biochim Biophys Acta (2013) 1.52
Integration of clearance mechanisms: the proteasome and autophagy. Cold Spring Harb Perspect Biol (2010) 1.52
Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexes. BMC Bioinformatics (2005) 1.49
Substrate degradation by the proteasome: a single-molecule kinetic analysis. Science (2015) 1.47
The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome. Mol Biol Cell (2006) 1.46
The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response. EMBO J (2012) 1.44
Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. RNA (2006) 1.43
Regulation of proteolysis by human deubiquitinating enzymes. Biochim Biophys Acta (2013) 1.42
Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. J Am Chem Soc (2005) 1.40
Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase. Nat Struct Mol Biol (2013) 1.40
The lysine 48 and lysine 63 ubiquitin conjugates are processed differently by the 26 s proteasome. J Biol Chem (2009) 1.39
Subcomplexes of PA700, the 19 S regulator of the 26 S proteasome, reveal relative roles of AAA subunits in 26 S proteasome assembly and activation and ATPase activity. J Biol Chem (2009) 1.38
Polyubiquitin binding and disassembly by deubiquitinating enzymes. Chem Rev (2009) 1.36
Reverse the curse--the role of deubiquitination in cell cycle control. Curr Opin Cell Biol (2008) 1.31
Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome. Nat Struct Mol Biol (2009) 1.30
Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J Biol Chem (2005) 1.26
Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants. Protein Sci (2007) 1.25
Crystal structure of human otubain 2. EMBO Rep (2004) 1.24
The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments. J Biol Chem (2010) 1.22
Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development. Mol Cell Biol (2007) 1.21
Toward an integrated structural model of the 26S proteasome. Mol Cell Proteomics (2010) 1.19
Participation of the proteasomal lid subunit Rpn11 in mitochondrial morphology and function is mapped to a distinct C-terminal domain. Biochem J (2004) 1.18
An atlas of altered expression of deubiquitinating enzymes in human cancer. PLoS One (2011) 1.17
Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells. Nat Commun (2013) 1.16
Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome. J Biol Chem (2012) 1.15
Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget (2015) 1.15
NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes. J Biol Chem (2011) 1.14
Protein targeting to ATP-dependent proteases. Curr Opin Struct Biol (2008) 1.14
Specificity of the BRISC deubiquitinating enzyme is not due to selective binding to Lys63-linked polyubiquitin. J Biol Chem (2009) 1.13
Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex. J Biol Chem (2010) 1.12
Perilous journey: a tour of the ubiquitin-proteasome system. Trends Cell Biol (2014) 1.11
Mapping the structural topology of the yeast 19S proteasomal regulatory particle using chemical cross-linking and probabilistic modeling. Mol Cell Proteomics (2012) 1.10
Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. Mol Cell (2013) 1.10
The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development. Plant Cell (2004) 1.10
Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. Mol Cell Biol (2005) 1.09
Gates, Channels, and Switches: Elements of the Proteasome Machine. Trends Biochem Sci (2015) 1.09
A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. PLoS Biol (2010) 1.08
Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1. Proc Natl Acad Sci U S A (2013) 1.08
Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13. Mol Cell Biol (2003) 1.08
Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome. J Biol Chem (2009) 1.08
Dissection of the carboxyl-terminal domain of the proteasomal subunit Rpn11 in maintenance of mitochondrial structure and function. Mol Biol Cell (2008) 1.05
Mechanisms for countering oxidative stress and damage in retinal pigment epithelium. Int Rev Cell Mol Biol (2012) 1.05
A conserved late endosome-targeting signal required for Doa4 deubiquitylating enzyme function. J Cell Biol (2006) 1.04
Ubiquitin receptors and protein quality control. J Mol Cell Cardiol (2012) 1.04
Proteasomes and their kin: proteases in the machine age. Nat Rev Mol Cell Biol (2004) 5.14
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33
Designing superoleophobic surfaces. Science (2007) 3.56
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol (2006) 3.14
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J (2005) 2.99
Robust omniphobic surfaces. Proc Natl Acad Sci U S A (2008) 2.41
Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80. Mol Cell (2009) 2.39
Noncarious cervical lesions and abfractions: a re-evaluation. J Am Dent Assoc (2003) 2.28
K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. EMBO J (2009) 2.17
The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J Biol Chem (2008) 2.09
The etiology and prevalence of gingival recession. J Am Dent Assoc (2003) 2.06
Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1. J Mol Biol (2009) 1.82
Structural insights into the assembly and function of the SAGA deubiquitinating module. Science (2010) 1.74
Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Mol Cell (2008) 1.71
Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling. Nat Methods (2012) 1.62
Antibacterial properties of Ag nanoparticle loaded multilayers and formation of magnetically directed antibacterial microparticles. Langmuir (2005) 1.52
Poly-ubiquitin binding by the polyglutamine disease protein ataxin-3 links its normal function to protein surveillance pathways. J Biol Chem (2003) 1.44
Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domains. Nat Struct Mol Biol (2009) 1.35
Transparent superhydrophobic films based on silica nanoparticles. Langmuir (2007) 1.34
The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling. Oncogene (2005) 1.33
Controlled drug release from porous polyelectrolyte multilayers. Biomacromolecules (2006) 1.33
Patterned superhydrophobic surfaces: toward a synthetic mimic of the Namib Desert beetle. Nano Lett (2006) 1.29
Nanotextured silica surfaces with robust superhydrophobicity and omnidirectional broadband supertransmissivity. ACS Nano (2012) 1.27
All-nanoparticle thin-film coatings. Nano Lett (2006) 1.23
Durable antifog films from layer-by-layer molecularly blended hydrophilic polysaccharides. Langmuir (2010) 1.20
Relationships between water wettability and ice adhesion. ACS Appl Mater Interfaces (2010) 1.16
Specificity of the BRISC deubiquitinating enzyme is not due to selective binding to Lys63-linked polyubiquitin. J Biol Chem (2009) 1.13
Surface functionalization of living cells with multilayer patches. Nano Lett (2008) 1.13
Myosin V attachment to cargo requires the tight association of two functional subdomains. J Cell Biol (2005) 1.11
Mixed-linkage ubiquitin chains send mixed messages. Structure (2013) 1.09
Two-level antibacterial coating with both release-killing and contact-killing capabilities. Langmuir (2006) 1.06
A modified Cassie-Baxter relationship to explain contact angle hysteresis and anisotropy on non-wetting textured surfaces. J Colloid Interface Sci (2009) 1.06
Optimal design of permeable fiber network structures for fog harvesting. Langmuir (2013) 1.06
Nanoporosity-driven superhydrophilicity: a means to create multifunctional antifogging coatings. Langmuir (2006) 1.03
Collagen as an implantable material in medicine and dentistry. J Oral Implantol (2002) 1.03
Exploiting topographical texture to impart icephobicity. ACS Nano (2010) 1.00
Treatment of gingival recession. J Am Dent Assoc (2002) 0.99
Structural color in porous, superhydrophilic, and self-cleaning SiO2/TiO2 Bragg stacks. Small (2007) 0.97
Cell-based drug delivery devices using phagocytosis-resistant backpacks. Adv Mater (2011) 0.96
Freely suspended cellular "backpacks" lead to cell aggregate self-assembly. Biomacromolecules (2010) 0.95
Synthesis of free and proliferating cell nuclear antigen-bound polyubiquitin chains by the RING E3 ubiquitin ligase Rad5. J Biol Chem (2009) 0.94
pH-induced hysteretic gating of track-etched polycarbonate membranes: swelling/deswelling behavior of polyelectrolyte multilayers in confined geometry. J Am Chem Soc (2006) 0.94
Tooth wear: attrition, erosion, and abrasion. Quintessence Int (2003) 0.93
Heterostructured magnetic nanotubes. Langmuir (2007) 0.92
Analysis of host responses and risk for disease progression. Periodontol 2000 (2004) 0.91
Orientation-specific attachment of polymeric microtubes on cell surfaces. Adv Mater (2013) 0.91
Esthetic management of peripheral giant cell granuloma. J Periodontol (2004) 0.91
Toothbrushing and gingival recession. Int Dent J (2003) 0.89
Large area two-dimensional B cell arrays for sensing and cell-sorting applications. Biomacromolecules (2004) 0.88
Creating effective refractive index gradients within polyelectrolyte multilayer films: molecularly assembled rugate filters. Langmuir (2004) 0.88
An assessment of stress analyses in the theory of abfraction. Biomed Mater Eng (2004) 0.88
Depth-profiling X-ray photoelectron spectroscopy (XPS) analysis of interlayer diffusion in polyelectrolyte multilayers. Proc Natl Acad Sci U S A (2013) 0.87
Wear reduction of orthopaedic bearing surfaces using polyelectrolyte multilayer nanocoatings. Biomaterials (2005) 0.87
The effect of an 810-nm diode laser on postoperative pain and tissue response after modified Widman flap surgery: a pilot study in humans. J Periodontol (2012) 0.86
Fluoroalkylated silicon-containing surfaces-estimation of solid-surface energy. ACS Appl Mater Interfaces (2010) 0.85
Quantification of feather structure, wettability and resistance to liquid penetration. J R Soc Interface (2014) 0.85
Zwitter-wettability and antifogging coatings with frost-resisting capabilities. ACS Nano (2013) 0.85
Influence of bisphosphonates on alveolar bone loss around osseointegrated implants. J Oral Implantol (2010) 0.84
Collagen: an overview. Implant Dent (2002) 0.84
Position paper: periodontal maintenance. J Periodontol (2003) 0.83
Hollow silica nanoparticles in UV-visible antireflection coatings for poly(methyl methacrylate) substrates. ACS Nano (2010) 0.82
Bioinert solution-cross-linked hydrogen-bonded multilayers on colloidal particles. Langmuir (2004) 0.82
Spray-layer-by-layer assembly can more rapidly produce optical-quality multistack heterostructures. Langmuir (2011) 0.81
The effect of EDTA in attachment gain and root coverage. Compend Contin Educ Dent (2006) 0.80
Layer-by-layer deposition of all-nanoparticle multilayers in confined geometries. ACS Appl Mater Interfaces (2011) 0.80
Creating patterned carbon nanotube catalysts through the microcontact printing of block copolymer micellar thin films. Langmuir (2006) 0.79
Wedged cervical lesions produced by toothbrushing. Am J Dent (2004) 0.79
Assessing the accuracy of contact angle measurements for sessile drops on liquid-repellent surfaces. Langmuir (2011) 0.79
The significance of epithelial rests of Malassez in the periodontal ligament. J Endod (2013) 0.79
Cellular inflammatory response to porcine collagen membranes. J Periodontal Res (2003) 0.78
Scale dependence of omniphobic mesh surfaces. Langmuir (2010) 0.78
pH-responsive reversibly swellable nanotube arrays. Langmuir (2009) 0.78
Bioactive polyelectrolyte multilayers: hyaluronic acid mediated B lymphocyte adhesion. Biomacromolecules (2010) 0.78
Hydrothermal treatment of nanoparticle thin films for enhanced mechanical durability. Langmuir (2008) 0.78
Application of supramolecular nanostamping to the replication of DNA nanoarrays. Nano Lett (2007) 0.78
Multifunctional inverted nanocone arrays for non-wetting, self-cleaning transparent surface with high mechanical robustness. Small (2014) 0.77
Block copolymer micelles as nanocontainers for controlled release of proteins from biocompatible oil phases. Biomacromolecules (2009) 0.77
Toothbrush abrasions and noncarious cervical lesions: evolving concepts. Compend Contin Educ Dent (2005) 0.77
Multilayers of oppositely charged SiO2 nanoparticles: effect of surface charge on multilayer assembly. Langmuir (2007) 0.76
Sugar-mediated disassembly of mucin/lectin multilayers and their use as pH-Tolerant, on-demand sacrificial layers. Biomacromolecules (2014) 0.76
Targeted functionalization of nanoparticle thin films via capillary condensation. Nano Lett (2009) 0.76
Geometrically controlled mechanically responsive polyelectrolyte tube arrays. Adv Mater (2011) 0.76
Designing Robust Hierarchically Textured Oleophobic Fabrics. Langmuir (2015) 0.76
The effect of root modification and biomodification on periodontal therapy. Compend Contin Educ Dent (2003) 0.76
Utilizing dynamic tensiometry to quantify contact angle hysteresis and wetting state transitions on nonwetting surfaces. Langmuir (2013) 0.75
The effects of thyroid hormone abnormalities on periodontal disease status. J Int Acad Periodontol (2011) 0.75
Hydrate-phobic surfaces: fundamental studies in clathrate hydrate adhesion reduction. Phys Chem Chem Phys (2012) 0.75
Inflammatory response to dental polishing and prophylaxis materials in rats. J Int Acad Periodontol (2011) 0.75
Drug-induced gingival enlargement: an overview. Compend Contin Educ Dent (2013) 0.75
Phenotypic characterization of mononuclear inflammatory cells following equine hydroxyapatite/collagen block grafting in rats. Biomed Mater (2012) 0.75
Non-drug induced gingival enlargement. Gen Dent (2013) 0.75
Layer-by-layer-assembled high-performance broadband antireflection coatings. ACS Appl Mater Interfaces (2010) 0.75
Effect of local nifedipine administration on rat gingiva. J Int Acad Periodontol (2012) 0.75
Superoleophobic surfaces through control of sprayed-on stochastic topography. Langmuir (2012) 0.75
Thermal annealing treatment to achieve switchable and reversible oleophobicity on fabrics. Langmuir (2009) 0.75
Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase. Mol Cell (2016) 0.75
Ubiquitin-ovomucoid fusion proteins as model substrates for monitoring degradation and deubiquitination by proteasomes. Methods Enzymol (2005) 0.75
Tuning the properties of mucin via layer-by-layer assembly. Biomacromolecules (2014) 0.75
Templated nanopores for robust functional surface porosity in poly(methyl methacrylate). Langmuir (2012) 0.75
Design and fabrication of zwitter-wettable nanostructured films. ACS Appl Mater Interfaces (2014) 0.75