Published in Hybridoma (Larchmt) on December 01, 2006
Alcoholic liver disease and the gut-liver axis. World J Gastroenterol (2010) 2.02
Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci U S A (2012) 1.80
Isolation of monomeric and dimeric secreted MD-2. Endotoxin.sCD14 and Toll-like receptor 4 ectodomain selectively react with the monomeric form of secreted MD-2. J Biol Chem (2008) 1.05
Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling. Blood (2008) 0.94
Free thiol group of MD-2 as the target for inhibition of the lipopolysaccharide-induced cell activation. J Biol Chem (2009) 0.93
Identification of single nucleotide polymorphisms in hematopoietic cell transplant patients affecting early recognition of, and response to, endotoxin. Innate Immun (2013) 0.77
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell (2008) 11.24
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science (2008) 6.28
Current prospects for RNA interference-based therapies. Nat Rev Genet (2011) 3.63
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med (2010) 3.36
Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature (2011) 2.94
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature (2012) 2.94
Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem (2002) 2.66
A novel host defense system of airways is defective in cystic fibrosis. Am J Respir Crit Care Med (2006) 2.61
Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A (2002) 2.56
The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 2.53
Cytokine-mediated regulation of antimicrobial proteins. Nat Rev Immunol (2008) 2.46
Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed. J Clin Invest (2008) 2.21
The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. J Biol Chem (2001) 2.20
Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A (2014) 2.17
T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci U S A (2011) 2.12
Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives. Genome Res (2009) 2.10
The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Sci Transl Med (2011) 2.01
Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. Am J Respir Crit Care Med (2010) 1.94
Ebola virus glycoprotein 1: identification of residues important for binding and postbinding events. J Virol (2007) 1.93
Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms. J Clin Microbiol (2004) 1.91
Correlation between beta-defensin expression and induction profiles in gingival keratinocytes. Mol Immunol (2004) 1.90
Antimicrobial peptides in animals and their role in host defences. Int J Antimicrob Agents (2003) 1.84
[beta]-defensins in lung host defense. Annu Rev Physiol (2002) 1.80
Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2. Am J Physiol Lung Cell Mol Physiol (2004) 1.64
The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. Am J Physiol Lung Cell Mol Physiol (2010) 1.61
Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol (2006) 1.59
Innate immune functions of the airway epithelium. Contrib Microbiol (2008) 1.57
Haemophilus influenzae forms biofilms on airway epithelia: implications in cystic fibrosis. Am J Respir Crit Care Med (2006) 1.56
Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1. Infect Immun (2005) 1.53
Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. J Am Chem Soc (2011) 1.48
Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control. Genome Res (2010) 1.46
miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production. Am J Respir Crit Care Med (2014) 1.45
Lentivirus vectors pseudotyped with filoviral envelope glycoproteins transduce airway epithelia from the apical surface independently of folate receptor alpha. J Virol (2003) 1.45
PLUNC is a novel airway surfactant protein with anti-biofilm activity. PLoS One (2010) 1.44
Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation. Infect Immun (2002) 1.40
piggyBac transposase tools for genome engineering. Proc Natl Acad Sci U S A (2013) 1.35
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. J Clin Invest (2013) 1.30
CCL20 is an inducible product of human airway epithelia with innate immune properties. Am J Respir Cell Mol Biol (2003) 1.28
Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection. J Virol (2014) 1.25
Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun (2006) 1.24
Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins. J Immunol (2003) 1.24
Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. Virology (2011) 1.22
Integration site choice of a feline immunodeficiency virus vector. J Virol (2006) 1.20
Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors. J Virol (2009) 1.20
Measles virus preferentially transduces the basolateral surface of well-differentiated human airway epithelia. J Virol (2002) 1.18
Persistent gene expression in mouse nasal epithelia following feline immunodeficiency virus-based vector gene transfer. J Virol (2005) 1.18
Expression and activity of beta-defensins and LL-37 in the developing human lung. J Immunol (2005) 1.17
In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins. J Virol (2002) 1.16
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. J Virol (2009) 1.15
Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer. Blood (2005) 1.14
ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol (2005) 1.14
Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides. Protein Eng (2002) 1.14
PLUNC is a secreted product of neutrophil granules. J Leukoc Biol (2008) 1.13
Expression of beta-defensins in gingival health and in periodontal disease. J Oral Pathol Med (2004) 1.12
Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth. Proc Natl Acad Sci U S A (2010) 1.12
MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: effect of acylation state. Am J Respir Cell Mol Biol (2008) 1.11
A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A. Mol Ther (2011) 1.11
CFTR DeltaF508 mutation has minimal effect on the gene expression profile of differentiated human airway epithelia. Am J Physiol Lung Cell Mol Physiol (2005) 1.09
SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection. Am J Pathol (2013) 1.08
Advances in cell and gene-based therapies for cystic fibrosis lung disease. Mol Ther (2012) 1.08
Improved protection of mice against lethal respiratory infection with Coccidioides posadasii using two recombinant antigens expressed as a single protein. Vaccine (2006) 1.07
Lentivirus vector can be readministered to nasal epithelia without blocking immune responses. J Virol (2008) 1.07
A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci U S A (2012) 1.07
Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia. Am J Physiol Lung Cell Mol Physiol (2009) 1.06
Viral vector-mediated and cell-based therapies for treatment of cystic fibrosis. Mol Ther (2007) 1.05
Person-to-person spread of the MERS coronavirus--an evolving picture. N Engl J Med (2013) 1.02
Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis. Laryngoscope (2012) 1.02
Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia. Respir Res (2009) 1.02
PLUNC: a multifunctional surfactant of the airways. Biochem Soc Trans (2011) 1.01
Large-scale gene discovery in human airway epithelia reveals novel transcripts. Physiol Genomics (2004) 1.01
Lipopolysaccharide (LPS)-binding protein inhibits responses to cell-bound LPS. J Biol Chem (2003) 0.99
Enhancement of respiratory mucosal antiviral defenses by the oxidation of iodide. Am J Respir Cell Mol Biol (2011) 0.97
Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease. J Virol (2009) 0.96
Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections. J Virol (2012) 0.95
Viscoelastic gel formulations enhance airway epithelial gene transfer with viral vectors. Am J Respir Cell Mol Biol (2005) 0.95
Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola. J Antibiot (Tokyo) (2009) 0.95
Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report. Am J Respir Crit Care Med (2012) 0.94
Developmental expression and distribution of sheep beta-defensin-2. Dev Comp Immunol (2004) 0.94
Enhanced gene expression conferred by stepwise modification of a nonprimate lentiviral vector. Hum Gene Ther (2007) 0.94
A Hyperactive Transposase Promotes Persistent Gene Transfer of a piggyBac DNA Transposon. Mol Ther Nucleic Acids (2012) 0.93
Differential gene expression in human conducting airway surface epithelia and submucosal glands. Am J Respir Cell Mol Biol (2008) 0.92
Post-transcriptional regulation of cystic fibrosis transmembrane conductance regulator expression and function by microRNAs. Am J Respir Cell Mol Biol (2013) 0.92
Dectin-1 is required for resistance to coccidioidomycosis in mice. MBio (2013) 0.92
Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways. Am J Pathol (2012) 0.92
Genetic therapies for cystic fibrosis lung disease. Hum Mol Genet (2011) 0.91
Tracheomalacia is associated with lower FEV1 and Pseudomonas acquisition in children with CF. Pediatr Pulmonol (2013) 0.90
CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia. Am J Physiol Lung Cell Mol Physiol (2012) 0.90
Basolateral entry and release of New and Old World arenaviruses from human airway epithelia. J Virol (2008) 0.90
Increased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity. Am J Respir Cell Mol Biol (2014) 0.90
Gene transfer to respiratory epithelia with lentivirus pseudotyped with Jaagsiekte sheep retrovirus envelope glycoprotein. Hum Gene Ther (2005) 0.89
Lentiviral vector gene transfer to porcine airways. Mol Ther Nucleic Acids (2012) 0.87
Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs. Am J Physiol Lung Cell Mol Physiol (2013) 0.86
Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions. Free Radic Biol Med (2011) 0.86
Pathogenesis of early lung disease in cystic fibrosis: a window of opportunity to eradicate bacteria. Ann Intern Med (2005) 0.86
JunD protects the liver from ischemia/reperfusion injury by dampening AP-1 transcriptional activation. J Biol Chem (2008) 0.85
An activated immune and inflammatory response targets the pancreas of newborn pigs with cystic fibrosis. Pancreatology (2011) 0.85
Endogenous and exogenous glucocorticoid regulation of ENaC mRNA expression in developing kidney and lung. Am J Physiol Cell Physiol (2002) 0.85