Published in Genome Res on May 02, 2008
A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell (2014) 8.79
Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD). PLoS Genet (2009) 2.90
RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy. Hum Mol Genet (2009) 2.51
Widespread plasticity in CTCF occupancy linked to DNA methylation. Genome Res (2012) 2.45
Analysis of the largest tandemly repeated DNA families in the human genome. BMC Genomics (2008) 1.43
The D4Z4 macrosatellite repeat acts as a CTCF and A-type lamins-dependent insulator in facio-scapulo-humeral dystrophy. PLoS Genet (2009) 1.37
Bipartite structure of the inactive mouse X chromosome. Genome Biol (2015) 1.10
Expression, tandem repeat copy number variation and stability of four macrosatellite arrays in the human genome. BMC Genomics (2010) 1.08
The macrosatellite DXZ4 mediates CTCF-dependent long-range intrachromosomal interactions on the human inactive X chromosome. Hum Mol Genet (2012) 1.06
DNA replication timing is maintained genome-wide in primary human myoblasts independent of D4Z4 contraction in FSH muscular dystrophy. PLoS One (2011) 1.01
The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation. Genome Biol (2015) 0.98
A repetitive elements perspective in Polycomb epigenetics. Front Genet (2012) 0.97
Characterization of DXZ4 conservation in primates implies important functional roles for CTCF binding, array expression and tandem repeat organization on the X chromosome. Genome Biol (2011) 0.97
D4Z4 as a prototype of CTCF and lamins-dependent insulator in human cells. Nucleus (2011) 0.93
Genome-wide analysis of macrosatellite repeat copy number variation in worldwide populations: evidence for differences and commonalities in size distributions and size restrictions. BMC Genomics (2013) 0.93
YY1 associates with the macrosatellite DXZ4 on the inactive X chromosome and binds with CTCF to a hypomethylated form in some male carcinomas. Nucleic Acids Res (2011) 0.92
Asymmetric bidirectional transcription from the FSHD-causing D4Z4 array modulates DUX4 production. PLoS One (2012) 0.90
Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture. Proc Natl Acad Sci U S A (2016) 0.90
Macrosatellite epigenetics: the two faces of DXZ4 and D4Z4. Chromosoma (2009) 0.90
Facioscapulohumeral muscular dystrophy: consequences of chromatin relaxation. Curr Opin Neurol (2012) 0.88
Vertebrate Protein CTCF and its Multiple Roles in a Large-Scale Regulation of Genome Activity. Curr Genomics (2009) 0.87
Variation in array size, monomer composition and expression of the macrosatellite DXZ4. PLoS One (2011) 0.87
Facioscapulohumeral muscular dystrophy as a model for epigenetic regulation and disease. Antioxid Redox Signal (2014) 0.86
The mouse DXZ4 homolog retains Ctcf binding and proximity to Pls3 despite substantial organizational differences compared to the primate macrosatellite. Genome Biol (2012) 0.85
Loss of WSTF results in spontaneous fluctuations of heterochromatin formation and resolution, combined with substantial changes to gene expression. BMC Genomics (2013) 0.81
Structural aspects of the inactive X chromosome. Philos Trans R Soc Lond B Biol Sci (2017) 0.81
Epigenetic regulation of the X-chromosomal macrosatellite repeat encoding for the cancer/testis gene CT47. Eur J Hum Genet (2011) 0.80
The X chromosome in space. Nat Rev Genet (2017) 0.79
Epigenetics and autoimmune diseases: the X chromosome-nucleolus nexus. Front Genet (2015) 0.79
Small RNA expression from the human macrosatellite DXZ4. G3 (Bethesda) (2014) 0.79
Function and evolution of local repeats in the Firre locus. Nat Commun (2016) 0.78
Genome-Wide Analysis of Transposon and Retroviral Insertions Reveals Preferential Integrations in Regions of DNA Flexibility. G3 (Bethesda) (2016) 0.78
Two novel DXZ4-associated long noncoding RNAs show developmental changes in expression coincident with heterochromatin formation at the human (Homo sapiens) macrosatellite repeat. Chromosome Res (2015) 0.76
X-chromosome inactivation and escape. J Genet (2015) 0.76
A region of euchromatin coincides with an extensive tandem repeat on the mouse (Mus musculus) inactive X chromosome. Chromosome Res (2014) 0.76
PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice. Genome Biol (2017) 0.75
YY1 binding association with sex-biased transcription revealed through X-linked transcript levels and allelic binding analyses. Sci Rep (2016) 0.75
Polycomb Repressive Complex 1 provides a molecular explanation for repeat copy number dependency in FSHD muscular dystrophy. Hum Mol Genet (2016) 0.75
A novel tRNA variable number tandem repeat at human chromosome 1q23.3 is implicated as a boundary element based on conservation of a CTCF motif in mouse. Nucleic Acids Res (2014) 0.75
An enigmatic satellite. Genome Biol (2011) 0.75
The "lnc" between 3D chromatin structure and X chromosome inactivation. Semin Cell Dev Biol (2016) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
A high-resolution map of active promoters in the human genome. Nature (2005) 24.35
Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature (1961) 23.98
RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science (2007) 18.59
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science (2002) 17.04
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature (2000) 14.91
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature (2000) 12.97
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell (1999) 9.74
Establishment and maintenance of a heterochromatin domain. Science (2002) 9.34
RNAi-mediated targeting of heterochromatin by the RITS complex. Science (2004) 8.73
The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J (2005) 7.10
Noncoding RNAs and gene silencing. Cell (2007) 5.99
Small RNAs correspond to centromere heterochromatic repeats. Science (2002) 5.96
Dicer is essential for formation of the heterochromatin structure in vertebrate cells. Nat Cell Biol (2004) 5.92
Bisulfite genomic sequencing: systematic investigation of critical experimental parameters. Nucleic Acids Res (2001) 5.89
An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol Cell Biol (1996) 5.74
Sequence organization of the human genome. Cell (1975) 5.67
Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive. Curr Biol (2000) 5.34
Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy. Nat Genet (1992) 5.12
Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells. Nat Struct Mol Biol (2006) 4.93
L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells. Nat Struct Mol Biol (2006) 4.80
Genomic and genetic definition of a functional human centromere. Science (2001) 4.28
FSHD associated DNA rearrangements are due to deletions of integral copies of a 3.2 kb tandemly repeated unit. Hum Mol Genet (1993) 4.21
Dosage compensation in mammals: fine-tuning the expression of the X chromosome. Genes Dev (2006) 4.17
Transcription and RNA interference in the formation of heterochromatin. Nature (2007) 4.08
Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF. Mol Cell (2005) 4.07
Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nat Genet (2001) 3.63
Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nat Genet (2004) 3.56
Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. Dev Cell (2005) 3.32
CTCF maintains differential methylation at the Igf2/H19 locus. Nat Genet (2002) 3.15
CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms. Mol Cell Biol (1993) 3.08
Genetics and epigenetics of the multifunctional protein CTCF. Curr Top Dev Biol (2008) 3.01
Transgenic RNAi reveals essential function for CTCF in H19 gene imprinting. Science (2004) 2.98
CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus. Nat Genet (2001) 2.93
The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide. Genome Res (2004) 2.78
Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell (2007) 2.69
Analysis of the tandem repeat locus D4Z4 associated with facioscapulohumeral muscular dystrophy. Hum Mol Genet (1994) 2.60
CTCF, a candidate trans-acting factor for X-inactivation choice. Science (2001) 2.59
Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein. Nat Genet (2007) 2.35
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance. Mol Cell Biol (2004) 2.24
So much "junk" DNA in our genome. Brookhaven Symp Biol (1972) 2.09
CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide. Mol Cell Biol (2007) 2.07
Human centromeric DNAs. Hum Genet (1997) 1.94
Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome. Proc Natl Acad Sci U S A (2004) 1.80
CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus. Hum Mol Genet (2006) 1.72
Differential effect of zinc finger deletions on the binding of CTCF to the promoter of the amyloid precursor protein gene. Nucleic Acids Res (2000) 1.59
Structural and functional dynamics of human centromeric chromatin. Annu Rev Genomics Hum Genet (2006) 1.55
The 5' flank of mouse H19 in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication. Curr Biol (2000) 1.55
Heterochromatin and satellite DNA in man: properties and prospects. Am J Hum Genet (1979) 1.39
Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome. J Cell Biol (2002) 1.36
Chromatin of the Barr body: histone and non-histone proteins associated with or excluded from the inactive X chromosome. Hum Mol Genet (2003) 1.28
Variation in Xi chromatin organization and correlation of the H3K27me3 chromatin territories to transcribed sequences by microarray analysis. Chromosoma (2006) 1.25
Noninactivation of a selectable human X-linked gene that complements a murine temperature-sensitive cell cycle defect. Am J Hum Genet (1989) 1.22
Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice. Mol Cell Biol (2006) 1.20
High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer. Nucleic Acids Res (2006) 1.16
A novel GC-rich human macrosatellite VNTR in Xq24 is differentially methylated on active and inactive X chromosomes. Nat Genet (1992) 1.05
The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter. Genomics (2000) 1.04
Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene. Hum Genet (2002) 1.03
A novel tandem repeat sequence located on human chromosome 4p: isolation and characterization. Genomics (1997) 0.98
Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation. Genomics (1998) 0.90