Published in Semin Immunol on March 13, 2012
Evidence of innate lymphoid cell redundancy in humans. Nat Immunol (2016) 2.14
Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. ISRN Inflamm (2013) 1.59
IL-7-producing stromal cells are critical for lymph node remodeling. Blood (2012) 1.22
Mechanism of Action of IL-7 and Its Potential Applications and Limitations in Cancer Immunotherapy. Int J Mol Sci (2015) 0.88
Transcription factor networks directing the development, function, and evolution of innate lymphoid effectors. Annu Rev Immunol (2015) 0.87
Mathematical Model of Naive T Cell Division and Survival IL-7 Thresholds. Front Immunol (2013) 0.84
IL-15 sustains IL-7R-independent ILC2 and ILC3 development. Nat Commun (2017) 0.77
New insights into IL-7 signaling pathways during early and late T cell development. Cell Mol Immunol (2013) 0.76
Modulation of peripheral T-cell function by interleukin-7 in rheumatoid arthritis. Arthritis Res Ther (2014) 0.76
Continuous IL-23 stimulation drives ILC3 depletion in the upper GI tract and, in combination with TNFα, induces robust activation and a phenotypic switch of ILC3. PLoS One (2017) 0.75
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature (2010) 15.28
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol (2000) 12.81
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med (2008) 12.68
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity (2007) 12.12
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature (2010) 10.34
Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature (2009) 9.71
SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol (2007) 6.89
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity (2008) 6.49
Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature (1999) 6.23
The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nat Immunol (2010) 6.02
The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol (2007) 5.83
Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature (1988) 5.50
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature (2010) 5.07
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol (2011) 5.05
Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat Immunol (2008) 4.94
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity (2008) 4.67
Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature (2006) 4.51
New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J Immunol (2002) 4.48
A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol (2010) 4.32
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol (2009) 4.31
Lineage relationship analysis of RORgammat+ innate lymphoid cells. Science (2010) 4.12
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med (2008) 3.85
Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol (2003) 3.82
Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity (2004) 3.67
IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell (2011) 3.61
Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes. Immunity (2010) 3.59
Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol (2007) 3.53
Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med (2000) 3.51
IL-7 enhances the survival and maintains the size of naive T cells. J Immunol (2001) 3.39
The role of FoxO in the regulation of metabolism. Oncogene (2008) 3.09
Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J Clin Invest (2009) 2.92
Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol (2008) 2.90
IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors. J Exp Med (2010) 2.87
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med (2007) 2.84
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity (2009) 2.82
Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat Immunol (2011) 2.81
Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis. J Exp Med (2004) 2.78
Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature (2007) 2.65
Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population. Proc Natl Acad Sci U S A (2008) 2.57
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development. Nat Immunol (2008) 2.52
Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol (2008) 2.50
Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. Proc Natl Acad Sci U S A (2007) 2.48
Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling. J Biol Chem (2005) 2.43
Retracted Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat Med (2010) 2.43
Contingent gene regulatory networks and B cell fate specification. Proc Natl Acad Sci U S A (2005) 2.36
Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity. Proc Natl Acad Sci U S A (2010) 2.35
Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol (2011) 2.25
Hepatic interleukin-7 expression regulates T cell responses. Immunity (2009) 2.25
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat Immunol (2010) 2.19
Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J Exp Med (2003) 2.16
Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells. Nat Immunol (2011) 2.12
Notch signaling is necessary for adult, but not fetal, development of RORγt(+) innate lymphoid cells. Nat Immunol (2011) 2.09
Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development. Nat Rev Immunol (2007) 2.07
Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol (2009) 2.05
Transregulation of memory CD8 T-cell proliferation by IL-15Ralpha+ bone marrow-derived cells. Blood (2003) 2.00
The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus. J Exp Med (2003) 1.96
Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice. J Clin Invest (2008) 1.96
Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant (1999) 1.96
Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation. Immunity (2011) 1.96
IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches. Int Immunol (1999) 1.91
Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity (2007) 1.79
Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors. Immunity (1999) 1.75
GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells. Nat Immunol (2004) 1.75
Different cytokines induce surface lymphotoxin-alphabeta on IL-7 receptor-alpha cells that differentially engender lymph nodes and Peyer's patches. Immunity (2002) 1.74
Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo. Proc Natl Acad Sci U S A (2009) 1.72
Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. Science (2007) 1.71
Skint-1 identifies a common molecular mechanism for the development of interferon-γ-secreting versus interleukin-17-secreting γδ T cells. Immunity (2011) 1.62
Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells. J Exp Med (2009) 1.61
Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity (2003) 1.55
Identification of the earliest NK-cell precursor in the mouse BM. Blood (2011) 1.54
Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis. J Exp Med (2001) 1.53
IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development. J Exp Med (2004) 1.52
Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proc Natl Acad Sci U S A (2010) 1.50
Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Invest (2002) 1.47
The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation. Immunity (2001) 1.47
OX40 ligand and CD30 ligand are expressed on adult but not neonatal CD4+CD3- inducer cells: evidence that IL-7 signals regulate CD30 ligand but not OX40 ligand expression. J Immunol (2005) 1.45
Organogenesis of peripheral lymphoid organs. Immunol Rev (2003) 1.38
Increased TSLP availability restores T- and B-cell compartments in adult IL-7 deficient mice. Blood (2007) 1.34
Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1. J Immunol (2008) 1.32
Transient IL-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements. Immunity (2003) 1.31
Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis. Blood (2004) 1.31
Transcriptional regulator Id2 controls survival of hepatic NKT cells. Proc Natl Acad Sci U S A (2009) 1.30
Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice. J Exp Med (2007) 1.28
Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes. Proc Natl Acad Sci U S A (2006) 1.26
{gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci U S A (2005) 1.21
Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation. Immunity (2010) 1.21
A shared gene-expression signature in innate-like lymphocytes. Immunol Rev (2006) 1.19
STAT5 in B cell development and leukemia. Curr Opin Immunol (2010) 1.19
Evidence that gammadelta versus alphabeta T cell fate determination is initiated independently of T cell receptor signaling. J Exp Med (2001) 1.18
Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators. Arthritis Rheum (2010) 1.17
Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol (2005) 1.16
Interleukin 7/interleukin 7 receptor induce c-Fos/c-Jun-dependent vascular endothelial growth factor-D up-regulation: a mechanism of lymphangiogenesis in lung cancer. Eur J Cancer (2009) 1.14
Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells. Blood (2011) 1.14
Growth factor independence-1B expression leads to defects in T cell activation, IL-7 receptor alpha expression, and T cell lineage commitment. J Immunol (2003) 1.12
IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells. Genesis (2009) 1.12
c-Myb is required for pro-B cell differentiation. J Immunol (2009) 1.10
Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. Structure (2009) 1.07
Improved thymic function in exclusively breastfed infants is associated with higher interleukin 7 concentrations in their mothers' breast milk. Am J Clin Nutr (2004) 1.07
Regulation of the interleukin-7 receptor alpha promoter by the Ets transcription factors PU.1 and GA-binding protein in developing B cells. J Biol Chem (2007) 1.06
Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur J Immunol (2003) 5.73
The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development. Nat Immunol (2009) 3.27
Determining disease intervention strategies using spatially resolved simulations. PLoS One (2013) 1.49
Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences. Immunity (2002) 1.40
Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cells. PLoS Pathog (2010) 1.32
Contribution of neural crest-derived cells in the embryonic and adult thymus. J Immunol (2008) 1.30
IL-7-producing stromal cells are critical for lymph node remodeling. Blood (2012) 1.22
IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells. Genesis (2009) 1.12
Spartan: a comprehensive tool for understanding uncertainty in simulations of biological systems. PLoS Comput Biol (2013) 1.09
Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow. Blood (2011) 1.00
Natural killer receptors: the burden of a name. J Exp Med (2010) 0.98
Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice. J Clin Invest (2010) 0.92
Dendritic cell functional properties in a three-dimensional tissue model of human lung mucosa. Am J Physiol Lung Cell Mol Physiol (2011) 0.91
Dendritic cells matured by inflammation induce CD86-dependent priming of naive CD8+ T cells in the absence of their cognate peptide antigen. J Immunol (2009) 0.89
The influence of CD4 T-cell subsets on control of CD4 T-cell-mediated graft-versus-host disease. Immunology (2008) 0.80
Visualisation of lymphoid organ development. Methods Mol Biol (2010) 0.79
Involvement of neurons and retinoic acid in lymphatic development: new insights in increased nuchal translucency. Prenat Diagn (2014) 0.78
Application of tissue engineering to the immune system: development of artificial lymph nodes. Front Immunol (2012) 0.77
Correction: Determining disease intervention strategies using spatially resolved simulations. PLoS One (2015) 0.75
Extending and Applying Spartan to Perform Temporal Sensitivity Analyses for Predicting Changes in Influential Biological Pathways in Computational Models. IEEE/ACM Trans Comput Biol Bioinform (2016) 0.75