Published in Arch Gen Psychiatry on March 01, 2007
Mu Opioid Receptor Genes, Remifentanil, and Pain Sensitivity | NCT01878006
An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry (2008) 4.91
A genetic determinant of the striatal dopamine response to alcohol in men. Mol Psychiatry (2010) 2.02
The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction. Psychopharmacology (Berl) (2012) 1.96
Pharmacogenetic approaches to the treatment of alcohol addiction. Nat Rev Neurosci (2011) 1.74
Medications development to treat alcohol dependence: a vision for the next decade. Addict Biol (2012) 1.56
Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates. Proc Natl Acad Sci U S A (2008) 1.56
OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models. Drug Alcohol Depend (2010) 1.55
Mu-opioid receptor (OPRM1) variation, oxytocin levels and maternal attachment in free-ranging rhesus macaques Macaca mulatta. Behav Neurosci (2011) 1.54
CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression. Mol Psychiatry (2012) 1.42
Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism. Subst Use Misuse (2010) 1.39
Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes. Addict Biol (2010) 1.38
Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues. Neurosci Biobehav Rev (2009) 1.18
The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review. Alcohol Clin Exp Res (2011) 1.18
Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the micro-opioid receptor gene locus. Biol Psychiatry (2010) 1.14
Subjective response to alcohol among alcohol-dependent individuals: effects of the μ-opioid receptor (OPRM1) gene and alcoholism severity. Alcohol Clin Exp Res (2012) 1.12
CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques. Arch Gen Psychiatry (2008) 1.09
The genetics of the opioid system and specific drug addictions. Hum Genet (2012) 1.04
Initial evidence of an association between OPRM1 and adolescent alcohol misuse. Alcohol Clin Exp Res (2009) 1.00
A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys. Drug Alcohol Depend (2010) 0.98
Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes. Alcohol Clin Exp Res (2012) 0.95
OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques. Psychoneuroendocrinology (2011) 0.94
Gender differences in predictors of treatment attrition with high dose naltrexone in cocaine and alcohol dependence. Am J Addict (2008) 0.93
Proton magnetic resonance spectroscopy in alcohol use disorders: a potential new endophenotype? Alcohol Clin Exp Res (2008) 0.93
Child μ-opioid receptor gene variant influences parent-child relations. Neuropsychopharmacology (2011) 0.92
Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences. Alcohol (2010) 0.87
Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults. Addict Biol (2014) 0.86
Large-scale polymorphism discovery in macaque G-protein coupled receptors. BMC Genomics (2013) 0.84
Subjective response to alcohol and associated craving in heavy drinkers vs. alcohol dependents: an examination of Koob's allostatic model in humans. Drug Alcohol Depend (2014) 0.84
The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: potential roles in genetic selection and gene × environment interactions. Dev Psychopathol (2012) 0.82
The value of extended pedigrees for next-generation analysis of complex disease in the rhesus macaque. ILAR J (2013) 0.82
Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability. Neuroscience (2008) 0.82
DRD1 5'UTR variation, sex and early infant stress influence ethanol consumption in rhesus macaques. Genes Brain Behav (2009) 0.81
Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans. PLoS One (2011) 0.81
Limited effects of beta-endorphin compared to loperamide or fentanyl in a neuroendocrine biomarker assay in non-human primates. Psychoneuroendocrinology (2008) 0.81
Pharmacogenetic approaches in the treatment of alcohol use disorders: addressing clinical utility and implementation thresholds. Addict Sci Clin Pract (2014) 0.79
Interactive effects of OPRM1 and DAT1 genetic variation on subjective responses to alcohol. Alcohol Alcohol (2014) 0.79
Genetic and environmental determinants of stress responding. Alcohol Res (2012) 0.77
[High-dose buprenorphine for outpatient palliative pain therapy]. Schmerz (2009) 0.77
Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype. Neuropsychopharmacology (2016) 0.76
Opioid pharmacogenetics of alcohol addiction. Cold Spring Harb Perspect Med (2013) 0.76
Comparative genetic approaches to the evolution of human brain and behavior. Am J Hum Biol (2010) 0.76
Strategies for performing genotype-phenotype association studies in nonhuman primates. Methods (2009) 0.75
OPRM1 genotype interacts with serotonin system dysfunction to predict alcohol-heightened aggression in primates. Addict Biol (2016) 0.75
A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology. Transl Psychiatry (2016) 0.75
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell (2003) 12.50
Serotonin transporter genetic variation and the response of the human amygdala. Science (2002) 9.31
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet (2006) 6.27
Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet (2004) 5.87
An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry (2008) 4.91
COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science (2003) 4.72
1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial. Lancet (2003) 4.41
An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res (2005) 3.94
Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry (2006) 3.44
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med (2006) 3.38
Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol Alcohol (2008) 3.13
A stepped care strategy using buprenorphine and methadone versus conventional methadone maintenance in heroin dependence: a randomized controlled trial. Am J Psychiatry (2007) 3.10
Neonatal imitation in rhesus macaques. PLoS Biol (2006) 3.10
Neurobiological mechanisms in the transition from drug use to drug dependence. Neurosci Biobehav Rev (2004) 2.97
Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry (2003) 2.82
Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain (2006) 2.75
Conditioned withdrawal drives heroin consumption and decreases reward sensitivity. J Neurosci (2006) 2.74
Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet (2004) 2.71
Genetic variation in human NPY expression affects stress response and emotion. Nature (2008) 2.65
A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet (2002) 2.60
A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry (2002) 2.51
Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biol Psychiatry (2004) 2.49
Capuchin monkeys, inequity aversion, and the frustration effect. J Comp Psychol (2006) 2.45
Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain (2010) 2.41
Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders. Trends Pharmacol Sci (2003) 2.37
Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry (2006) 2.31
Reciprocal face-to-face communication between rhesus macaque mothers and their newborn infants. Curr Biol (2009) 2.30
Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. FASEB J (2002) 2.29
The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med (2009) 2.20
Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain (2004) 2.17
Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch Gen Psychiatry (2004) 2.12
Capuchin monkeys display affiliation toward humans who imitate them. Science (2009) 2.09
Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry (2006) 2.09
Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci (2005) 2.04
A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature (2010) 2.00
Using ancestry-informative markers to define populations and detect population stratification. J Psychopharmacol (2006) 1.98
Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. Arch Gen Psychiatry (2004) 1.98
Requirement of central ghrelin signaling for alcohol reward. Proc Natl Acad Sci U S A (2009) 1.82
Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys. Biol Psychiatry (2005) 1.81
Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol (2009) 1.81
Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function. Biol Psychiatry (2008) 1.79
Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample size. Anesthesiology (2004) 1.78
Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science (2008) 1.77
Pharmacogenetic approaches to the treatment of alcohol addiction. Nat Rev Neurosci (2011) 1.74
Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proc Natl Acad Sci U S A (2004) 1.71
Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort. Am J Psychiatry (2009) 1.70
Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. Am J Psychiatry (2002) 1.70
Genetic approaches to addiction: genes and alcohol. Addiction (2008) 1.70
A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction. Proc Natl Acad Sci U S A (2010) 1.70
Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide. Neuropsychopharmacology (2010) 1.68
Problem drinking and alcoholism: diagnosis and treatment. Am Fam Physician (2002) 1.67
Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology (2005) 1.66
Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. J Neurosci (2012) 1.65
Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism. Psychiatr Genet (2003) 1.64
Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. Am J Med Genet B Neuropsychiatr Genet (2006) 1.64
Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse. Pharmacol Ther (2010) 1.62
Oxytocin gene polymorphisms influence human dopaminergic function in a sex-dependent manner. Biol Psychiatry (2012) 1.61
Interaction between childhood trauma and serotonin transporter gene variation in suicide. Neuropsychopharmacology (2007) 1.60
Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Hum Mol Genet (2008) 1.60
Expansion of the human mu-opioid receptor gene architecture: novel functional variants. Hum Mol Genet (2008) 1.59
Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series. Drug Alcohol Depend (2008) 1.57
An assessment of memory awareness in tufted capuchin monkeys (Cebus apella). Anim Cogn (2008) 1.57
Medications development to treat alcohol dependence: a vision for the next decade. Addict Biol (2012) 1.56
Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates. Proc Natl Acad Sci U S A (2008) 1.56
Long-term effects of neonatal medial temporal ablations on socioemotional behavior in monkeys (Macaca mulatta). Behav Neurosci (2010) 1.55
Fluoxetine administered to juvenile monkeys: effects on the serotonin transporter and behavior. Am J Psychiatry (2014) 1.54
The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. J Neurosci (2012) 1.51
MECP2 structural and 3'-UTR variants in schizophrenia, autism and other psychiatric diseases: a possible association with autism. Am J Med Genet B Neuropsychiatr Genet (2004) 1.51
Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet (2006) 1.50
A stereo music system as environmental enrichment for captive chimpanzees. Lab Anim (NY) (2003) 1.50
The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination. Ann Hum Genet (2004) 1.49
Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms. Hepatology (2015) 1.48
Early-life stress induces long-term morphologic changes in primate brain. Arch Gen Psychiatry (2009) 1.46
Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates. PLoS One (2011) 1.45
Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress. Alcohol Clin Exp Res (2003) 1.43
Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia. Neuropsychopharmacology (2008) 1.43
Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. Alcohol Clin Exp Res (2008) 1.41
DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients. Am J Psychiatry (2006) 1.41
GABRG1 and GABRA2 as independent predictors for alcoholism in two populations. Neuropsychopharmacology (2008) 1.41
Features associated with excessive exercise in women with eating disorders. Int J Eat Disord (2006) 1.40
Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior. Neurosci Biobehav Rev (2004) 1.39
[Researchers and psychiatrists defending Gillberg's research on ADDH: Karfve's campaign is a form of personal persecution and scientific basis is missing]. Lakartidningen (2003) 1.39