Published in Proc Natl Acad Sci U S A on November 17, 2006
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development (2009) 2.82
Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations. J Invest Dermatol (2011) 1.64
Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline. Development (2013) 1.41
p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J Cell Biol (2011) 1.39
Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle. FASEB J (2010) 1.21
Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development (2011) 1.15
Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals. Proc Natl Acad Sci U S A (2007) 1.14
Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling. Mol Biol Cell (2007) 1.14
Building epithelial tissues from skin stem cells. Cold Spring Harb Symp Quant Biol (2008) 1.12
Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling. Proc Natl Acad Sci U S A (2013) 1.10
Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways. Am J Pathol (2009) 1.04
MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes. J Cell Sci (2011) 1.01
Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair. PLoS One (2010) 1.01
Wnt signaling in skin organogenesis. Organogenesis (2008) 1.00
Disruption of Smad4 in mouse epidermis leads to depletion of follicle stem cells. Mol Biol Cell (2008) 0.94
Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. J Invest Dermatol (2012) 0.93
BMP signaling induces cell-type-specific changes in gene expression programs of human keratinocytes and fibroblasts. J Invest Dermatol (2009) 0.93
p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells. Development (2014) 0.92
Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration. J Invest Dermatol (2013) 0.89
Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. J Cell Biol (2015) 0.88
Earlier-born secondary hair follicles exhibit phenotypic plasticity. Exp Dermatol (2015) 0.88
MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway. J Cell Biol (2014) 0.87
The dermal papilla: an instructive niche for epithelial stem and progenitor cells in development and regeneration of the hair follicle. Cold Spring Harb Perspect Med (2014) 0.84
Modulating hair follicle size with Wnt10b/DKK1 during hair regeneration. Exp Dermatol (2014) 0.83
Genome-wide association study and ancestral origins of the slick-hair coat in tropically adapted cattle. Front Genet (2014) 0.82
A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning. Elife (2017) 0.82
Identification of hair shaft progenitors that create a niche for hair pigmentation. Genes Dev (2017) 0.82
Mutations in the cholesterol transporter gene ABCA5 are associated with excessive hair overgrowth. PLoS Genet (2014) 0.81
Proliferative and non-proliferative lesions of the rat and mouse integument. J Toxicol Pathol (2013) 0.80
A pair of transmembrane receptors essential for the retention and pigmentation of hair. Genesis (2012) 0.79
Complex changes in the apoptotic and cell differentiation programs during initiation of the hair follicle response to chemotherapy. J Invest Dermatol (2014) 0.77
Skin as a living coloring book: how epithelial cells create patterns of pigmentation. Pigment Cell Melanoma Res (2014) 0.75
Whole-transcriptome gene expression profiling in an epidermolysis bullosa simplex Dowling-Meara model keratinocyte cell line uncovered novel, potential therapeutic targets and affected pathways. BMC Res Notes (2015) 0.75
The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family. PLoS One (2016) 0.75
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell (1996) 8.41
Size control in animal development. Cell (1999) 6.39
Controls of hair follicle cycling. Physiol Rev (2001) 5.49
Dynamics of global gene expression changes during mouse preimplantation development. Dev Cell (2004) 4.97
Getting under the skin of epidermal morphogenesis. Nat Rev Genet (2002) 4.54
Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol (2005) 4.27
Molecular mechanisms regulating hair follicle development. J Invest Dermatol (2002) 4.16
BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev (2005) 3.97
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46
Characterization and isolation of stem cell-enriched human hair follicle bulge cells. J Clin Invest (2006) 3.41
FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell (1994) 3.10
Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99
A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis. J Invest Dermatol (1999) 2.92
Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol (2003) 2.65
At the roots of a never-ending cycle. Dev Cell (2001) 2.23
Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Dev Cell (2005) 2.21
Self-organization of periodic patterns by dissociated feather mesenchymal cells and the regulation of size, number and spacing of primordia. Development (1999) 2.20
Igf-I signalling controls the hair growth cycle and the differentiation of hair shafts. J Invest Dermatol (2005) 2.18
Transformation of tooth type induced by inhibition of BMP signaling. Science (1998) 2.16
Regulation of mammalian tooth cusp patterning by ectodin. Science (2005) 2.05
Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle. EMBO J (2000) 2.01
Noggin is required for induction of the hair follicle growth phase in postnatal skin. FASEB J (2001) 1.95
Hair follicle predetermination. J Cell Sci (2001) 1.92
Hair follicle renewal: organization of stem cells in the matrix and the role of stereotyped lineages and behaviors. Development (2005) 1.88
Stimulation of ectodermal organ development by Ectodysplasin-A1. Dev Biol (2003) 1.88
Morpho-regulation of ectodermal organs: integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathway. Am J Pathol (2004) 1.72
'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation. Development (2003) 1.70
Characterization of a bone morphogenetic protein-responsive Smad-binding element. Mol Biol Cell (2000) 1.66
Geometric relationships between the matrix of the hair bulb and its dermal papilla in normal and alopecic scalp. J Invest Dermatol (1958) 1.56
Mechanisms of size control. Curr Opin Genet Dev (2001) 1.54
Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development (2004) 1.53
Molecular characterization of melanocyte stem cells in their niche. Development (2005) 1.53
Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: implications for the control of hair follicle size and androgen responses. J Invest Dermatol (1999) 1.40
Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity. Evol Dev (2005) 1.38
Molecular control of epithelial-mesenchymal interactions during hair follicle cycling. J Investig Dermatol Symp Proc (2003) 1.33
Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation. EMBO J (2003) 1.27
BMP antagonists: their roles in development and involvement in pathophysiology. Cytokine Growth Factor Rev (2005) 1.26
Essential roles of BMPR-IA signaling in differentiation and growth of hair follicles and in skin tumorigenesis. Genesis (2004) 1.22
Molecular cloning and characterization of the human p27Kip1 gene promoter. FEBS Lett (1997) 1.18
BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice. Development (2004) 1.18
Segmental Igfbp5 expression is specifically associated with the bent structure of zigzag hairs. Mech Dev (2005) 1.11
Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway. Proc Natl Acad Sci U S A (2004) 1.10
Epithelial stem cells: stepping out of their niche. Cell (2004) 0.98
FGF signals specifically regulate the structure of hair shaft medulla via IGF-binding protein 5. Development (2005) 0.96
The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling. J Invest Dermatol (2004) 0.92
Ectodysplasin regulates pattern formation in the mammalian hair coat. Genesis (2003) 0.90
Igfbp3 modulates cell proliferation in the hair follicle. J Invest Dermatol (2005) 0.90
Krox20, a novel candidate for the regulatory hierarchy that controls hair shaft bending. Mech Dev (2006) 0.82
Cell mass, hair type and expression of the agouti gene. Nature (1969) 0.79
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev (2006) 3.72
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol (2003) 3.51
Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell (2012) 2.75
Impact of normalization on miRNA microarray expression profiling. RNA (2009) 2.63
Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. Genes Dev (2007) 2.61
Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points. Am J Surg Pathol (2006) 2.55
Variation in the detection of serrated polyps in an average risk colorectal cancer screening cohort. Am J Gastroenterol (2010) 2.44
The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nat Immunol (2008) 2.34
The clinical significance of serrated polyps. Am J Gastroenterol (2010) 2.21
Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Dev Cell (2005) 2.21
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev (2005) 2.17
Sertoli cells from non-obstructive azoospermia and obstructive azoospermia patients show distinct morphology, Raman spectrum and biochemical phenotype. Hum Reprod (2013) 2.06
Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev (2002) 1.97
Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin. J Invest Dermatol (2009) 1.96
EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nat Cell Biol (2008) 1.88
IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev Cell (2002) 1.79
High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism. Dev Cell (2004) 1.78
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J (2004) 1.78
Dedicated epithelial recipient cells determine pigmentation patterns. Cell (2007) 1.78
Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature (2010) 1.57
Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans. Cancer Res (2007) 1.56
Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata). J Invest Dermatol (2007) 1.54
Remodeling of three-dimensional organization of the nucleus during terminal keratinocyte differentiation in the epidermis. J Invest Dermatol (2013) 1.51
Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion. J Cell Biol (2002) 1.48
Genome organizing function of SATB1 in tumor progression. Semin Cancer Biol (2012) 1.45
Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death. J Biol Chem (2005) 1.42
p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J Cell Biol (2011) 1.39
RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Curr Biol (2006) 1.37
IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes. EMBO J (2011) 1.33
Epigenetic regulation of gene expression in keratinocytes. J Invest Dermatol (2012) 1.32
Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype. Am J Surg Pathol (2004) 1.30
Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression. Semin Cancer Biol (2004) 1.29
Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation. EMBO J (2003) 1.27
Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis. Genes Dev (2010) 1.25
ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. J Biol Chem (2008) 1.21
'Srcasm: a novel Src activating and signaling molecule. J Biol Chem (2001) 1.21
The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response. EMBO J (2008) 1.20
Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway. Am J Gastroenterol (2004) 1.20
Developmental timing of hair follicle and dorsal skin innervation in mice. J Comp Neurol (2002) 1.20
p75 Neurotrophin receptor antagonist retards apoptosis-driven hair follicle involution (catagen). J Invest Dermatol (2003) 1.16
Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development (2011) 1.15
An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. Blood (2010) 1.14
An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer. Mol Cell Biol (2006) 1.13
The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling. Am J Pathol (2002) 1.11
Multifocal epithelial tumors and field cancerization: stroma as a primary determinant. J Clin Invest (2014) 1.10
Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway. Proc Natl Acad Sci U S A (2004) 1.10
CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity. Cancer Res (2010) 1.09
A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. J Clin Invest (2009) 1.09
Pathobiology of chemotherapy-induced hair loss. Lancet Oncol (2013) 1.08
Cancer network disruption by a single molecule inhibitor targeting both histone deacetylase activity and phosphatidylinositol 3-kinase signaling. Clin Cancer Res (2012) 1.08
Medical hyperspectral imaging to facilitate residual tumor identification during surgery. Cancer Biol Ther (2007) 1.05
Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways. Am J Pathol (2009) 1.04
Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes. PLoS One (2010) 1.03
Role of the nude gene in epithelial terminal differentiation. J Invest Dermatol (2002) 1.03
CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy. Clin Cancer Res (2009) 1.02
Immunohistochemistry with a mutation-specific monoclonal antibody as a screening tool for the BRAFV600E mutational status in primary cutaneous malignant melanoma. Mod Pathol (2012) 1.02
Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype. Cancer Res (2007) 1.02
MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes. J Cell Sci (2011) 1.01
Involvement of the Edar signaling in the control of hair follicle involution (catagen). Am J Pathol (2006) 1.01
Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1). Proc Natl Acad Sci U S A (2002) 0.99
CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models. Cancer Res (2003) 0.98
Kit is expressed by epithelial cells in vivo. J Invest Dermatol (2003) 0.98
Fate of melanocytes during development of the hair follicle pigmentary unit. J Investig Dermatol Symp Proc (2003) 0.97
A dynamic model of keratinocyte stem cell renewal and differentiation: role of the p21WAF1/Cip1 and Notch1 signaling pathways. J Investig Dermatol Symp Proc (2004) 0.96
Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer. Trends Cell Biol (2013) 0.94
Potential advantages of CUDC-101, a multitargeted HDAC, EGFR, and HER2 inhibitor, in treating drug resistance and preventing cancer cell migration and invasion. Mol Cancer Ther (2013) 0.93
BMP signaling induces cell-type-specific changes in gene expression programs of human keratinocytes and fibroblasts. J Invest Dermatol (2009) 0.93
p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells. Development (2014) 0.92
Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer. J Clin Invest (2014) 0.92
Generation of male germ cells from induced pluripotent stem cells (iPS cells): an in vitro and in vivo study. Asian J Androl (2012) 0.92