Published in Am J Hum Genet on November 07, 2013
Rare-variant association analysis: study designs and statistical tests. Am J Hum Genet (2014) 3.42
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet (2014) 2.53
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo. Cell (2015) 2.31
Pooled ChIP-Seq Links Variation in Transcription Factor Binding to Complex Disease Risk. Cell (2016) 1.54
A Whole-Genome Analysis Framework for Effective Identification of Pathogenic Regulatory Variants in Mendelian Disease. Am J Hum Genet (2016) 1.52
Natural selection and infectious disease in human populations. Nat Rev Genet (2014) 1.48
Identifying causal variants at loci with multiple signals of association. Genetics (2014) 1.41
GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation. PLoS Genet (2014) 1.29
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nat Genet (2015) 1.23
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. Nat Commun (2014) 1.19
Radiogenomics: radiobiology enters the era of big data and team science. Int J Radiat Oncol Biol Phys (2014) 1.10
Systematic Functional Dissection of Common Genetic Variation Affecting Red Blood Cell Traits. Cell (2016) 1.09
Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite. Nat Genet (2015) 1.08
Explaining additional genetic variation in complex traits. Trends Genet (2014) 1.08
Prediction of Causal Candidate Genes in Coronary Artery Disease Loci. Arterioscler Thromb Vasc Biol (2015) 1.08
The association analysis of lncRNA HOTAIR genetic variants and gastric cancer risk in a Chinese population. Oncotarget (2015) 1.07
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism. Nature (2015) 1.07
Non-coding genetic variants in human disease. Hum Mol Genet (2015) 1.04
Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1. Am J Hum Genet (2014) 1.00
Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome. Epigenetics Chromatin (2015) 0.99
The importance of p53 pathway genetics in inherited and somatic cancer genomes. Nat Rev Cancer (2016) 0.98
The bright side of dark matter: lncRNAs in cancer. J Clin Invest (2016) 0.94
Applying compressed sensing to genome-wide association studies. Gigascience (2014) 0.94
Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era. BMC Med Genomics (2014) 0.93
On the identification of potential regulatory variants within genome wide association candidate SNP sets. BMC Med Genomics (2014) 0.93
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nat Genet (2016) 0.92
Fine-mapping additive and dominant SNP effects using group-LASSO and fractional resample model averaging. Genet Epidemiol (2014) 0.91
Approaches to Investigating Complex Genetic Traits in a Large-Scale Inbred Mouse Aging Study. Vet Pathol (2016) 0.91
Molecular basis and genetic predisposition to intracranial aneurysm. Ann Med (2014) 0.90
Vision from next generation sequencing: multi-dimensional genome-wide analysis for producing gene regulatory networks underlying retinal development, aging and disease. Prog Retin Eye Res (2015) 0.90
Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans. Genome Res (2015) 0.90
Recent genetic findings in schizophrenia and their therapeutic relevance. J Psychopharmacol (2014) 0.88
TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits. PLoS One (2015) 0.88
Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials. ILAR J (2014) 0.88
Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2. Hum Mol Genet (2015) 0.88
The many faces of long noncoding RNAs. FEBS J (2014) 0.87
Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. Hum Mol Genet (2014) 0.87
Update on abdominal aortic aneurysm research: from clinical to genetic studies. Scientifica (Cairo) (2014) 0.85
Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis. Ann Rheum Dis (2014) 0.85
Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility. World J Diabetes (2014) 0.85
Fine mapping of genetic susceptibility loci for melanoma reveals a mixture of single variant and multiple variant regions. Int J Cancer (2014) 0.84
Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites. Clin Transl Med (2015) 0.84
Use of genome-wide association studies for cancer research and drug repositioning. PLoS One (2015) 0.84
Non-coding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival. Oncotarget (2015) 0.84
Chasing Mendel: five questions for personalized medicine. J Physiol (2014) 0.83
The genomic origins of asthma. Thorax (2014) 0.83
Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2. Am J Hum Genet (2016) 0.83
The Genetic Architecture of Gene Expression in Peripheral Blood. Am J Hum Genet (2016) 0.83
Re-sequencing data for refining candidate genes and polymorphisms in QTL regions affecting adiposity in chicken. PLoS One (2014) 0.82
Using the ENCODE Resource for Functional Annotation of Genetic Variants. Cold Spring Harb Protoc (2015) 0.82
3D genome organization in health and disease: emerging opportunities in cancer translational medicine. Nucleus (2015) 0.81
Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions. Hum Mol Genet (2015) 0.81
What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit. Mol Psychiatry (2014) 0.81
Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus. PLoS Genet (2016) 0.81
Genetic Variants Underlying Risk of Intracranial Aneurysms: Insights from a GWAS in Portugal. PLoS One (2015) 0.80
Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women. Genes Immun (2015) 0.80
Genetics of Combined Pituitary Hormone Deficiency: Roadmap into the Genome Era. Endocr Rev (2016) 0.80
Genetic architectures of seropositive and seronegative rheumatic diseases. Nat Rev Rheumatol (2015) 0.79
dcVar: a method for identifying common variants that modulate differential correlation structures in gene expression data. Front Genet (2015) 0.79
Genomic approaches for understanding the genetics of complex disease. Genome Res (2015) 0.79
In vitro clinical trials: the future of cell-based profiling. Front Pharmacol (2014) 0.78
Polymorphisms involving gain or loss of CpG sites are significantly enriched in trait-associated SNPs. Oncotarget (2015) 0.78
Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors. Hum Mol Genet (2015) 0.78
FGFR2 risk SNPs confer breast cancer risk by augmenting oestrogen responsiveness. Carcinogenesis (2016) 0.78
Combined QTL and selective sweep mappings with coding SNP annotation and cis-eQTL analysis revealed PARK2 and JAG2 as new candidate genes for adiposity regulation. G3 (Bethesda) (2015) 0.78
Removing reference mapping biases using limited or no genotype data identifies allelic differences in protein binding at disease-associated loci. BMC Med Genomics (2015) 0.78
Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci. BMC Genomics (2015) 0.78
Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression. Nat Commun (2016) 0.78
Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits. Am J Hum Genet (2017) 0.78
Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting. Nat Commun (2017) 0.78
Schizophrenia genetics: building the foundations of the future. Schizophr Bull (2014) 0.77
Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits. Dis Model Mech (2017) 0.77
Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry. Nat Genet (2016) 0.77
From GWAS to function: lessons from blood cells. ISBT Sci Ser (2015) 0.77
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. Breast Cancer Res (2016) 0.77
Kidney disease: new technologies translate mechanisms to cure. J Clin Invest (2014) 0.77
Genetic variation in HTR4 and lung function: GWAS follow-up in mouse. FASEB J (2014) 0.77
Genetics of Tinnitus: Still in its Infancy. Front Neurosci (2017) 0.77
Genetic variation and cognitive dysfunction in opioid-treated patients with cancer. Brain Behav (2016) 0.76
Systematic fine-mapping of association with BMI and type 2 diabetes at the FTO locus by integrating results from multiple ethnic groups. PLoS One (2014) 0.76
Several Critical Cell Types, Tissues, and Pathways Are Implicated in Genome-Wide Association Studies for Systemic Lupus Erythematosus. G3 (Bethesda) (2016) 0.76
Enhancer scanning to locate regulatory regions in genomic loci. Nat Protoc (2015) 0.76
The evolution of the human genome. Curr Opin Genet Dev (2015) 0.76
Gene regulatory effects of disease-associated variation in the NRF2 network. Curr Opin Toxicol (2016) 0.76
The roles of RNA processing in translating genotype to phenotype. Nat Rev Mol Cell Biol (2016) 0.75
Transcriptomics in type 2 diabetes: Bridging the gap between genotype and phenotype. Genom Data (2015) 0.75
ADAMTS7 locus confers high cross-race risk for development of coronary atheromatous plaque. Mol Genet Genomics (2015) 0.75
Combining Multiple Hypothesis Testing with Machine Learning Increases the Statistical Power of Genome-wide Association Studies. Sci Rep (2016) 0.75
Translating Genetic Risk Loci Into Molecular Risk Mechanisms for Schizophrenia. Schizophr Bull (2015) 0.75
Multivariate Methods for Genetic Variants Selection and Risk Prediction in Cardiovascular Diseases. Front Cardiovasc Med (2016) 0.75
Functional Analysis of SNPs in the ERCC5 Promoter in Advanced Colorectal Cancer Patients Treated With Oxaliplatin-Based Chemotherapy. Medicine (Baltimore) (2016) 0.75
A Common Variant at the 14q32 Endometrial Cancer Risk Locus Activates AKT1 through YY1 Binding. Am J Hum Genet (2016) 0.75
Computational Characterization of Osteoporosis Associated SNPs and Genes Identified by Genome-Wide Association Studies. PLoS One (2016) 0.75
An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression. Hum Mol Genet (2016) 0.75
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. Hum Mol Genet (2014) 0.75
Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing. Arterioscler Thromb Vasc Biol (2016) 0.75
Multicentric Genome-Wide Association Study for Primary Spontaneous Pneumothorax. PLoS One (2016) 0.75
Integrating Diverse Types of Genomic Data to Identify Genes that Underlie Adverse Pregnancy Phenotypes. PLoS One (2015) 0.75
Decoding transcriptional enhancers: Evolving from annotation to functional interpretation. Semin Cell Dev Biol (2016) 0.75
Study of exonic variation identifies incremental information regarding lipid-related and coronary heart disease genes. Circ Res (2014) 0.75
Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23
MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
Finding the missing heritability of complex diseases. Nature (2009) 67.95
An integrated map of genetic variation from 1,092 human genomes. Nature (2012) 59.82
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
The language of covalent histone modifications. Nature (2000) 44.92
Genome-wide association studies for common diseases and complex traits. Nat Rev Genet (2005) 33.96
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature (2012) 31.78
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Genetic analysis of genome-wide variation in human gene expression. Nature (2004) 27.28
A TALE nuclease architecture for efficient genome editing. Nat Biotechnol (2010) 26.47
Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet (1999) 25.93
Capturing chromosome conformation. Science (2002) 23.93
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature (2012) 20.47
Genome editing with engineered zinc finger nucleases. Nat Rev Genet (2010) 18.88
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature (2007) 18.38
Linkage disequilibrium in the human genome. Nature (2001) 17.24
Systematic localization of common disease-associated variation in regulatory DNA. Science (2012) 14.47
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat Biotechnol (2013) 14.28
Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. Genome Res (2006) 13.32
An oestrogen-receptor-alpha-bound human chromatin interactome. Nature (2009) 12.16
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
A survey of genetic human cortical gene expression. Nat Genet (2007) 12.04
DNA methylation and human disease. Nat Rev Genet (2005) 12.00
Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28
Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet (2010) 10.75
The long-range interaction landscape of gene promoters. Nature (2012) 9.20
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74
Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell (2012) 8.41
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet (2010) 7.62
Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. PLoS One (2010) 7.48
Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet (2013) 7.13
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet (2009) 6.99
Analysing biological pathways in genome-wide association studies. Nat Rev Genet (2010) 6.63
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56
CTCF-mediated functional chromatin interactome in pluripotent cells. Nat Genet (2011) 6.55
Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data. Nat Rev Genet (2011) 6.52
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet (2011) 6.36
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature (2011) 6.25
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
The architecture of gene regulatory variation across multiple human tissues: the MuTHER study. PLoS Genet (2011) 5.95
Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst (2008) 5.82
Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet (2008) 5.66
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat Genet (2009) 5.65
Patterns of cis regulatory variation in diverse human populations. PLoS Genet (2012) 5.28
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Knockout mice created by TALEN-mediated gene targeting. Nat Biotechnol (2013) 4.31
Targeted RNA sequencing reveals the deep complexity of the human transcriptome. Nat Biotechnol (2011) 4.18
Genetics of human gene expression: mapping DNA variants that influence gene expression. Nat Rev Genet (2009) 4.05
Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature (2010) 4.04
Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells. Nat Struct Mol Biol (2004) 4.00
Regulation of RNA polymerase II transcription by sequence-specific DNA binding factors. Cell (2004) 3.82
Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature (2010) 3.77
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. PLoS Genet (2011) 3.65
Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell (2007) 3.58
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet (2011) 3.56
Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer. PLoS Biol (2008) 3.49
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet (2013) 3.42
8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc Natl Acad Sci U S A (2010) 3.37
Drug-sensitive FGFR2 mutations in endometrial carcinoma. Proc Natl Acad Sci U S A (2008) 3.30
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C. Nat Genet (2009) 3.03
Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression. Nat Genet (2012) 2.86
Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells. Mol Cell Biol (2010) 2.80
An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science (2013) 2.71
FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation. Hum Mol Genet (2009) 2.62
Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors. Science (2012) 2.58
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am J Hum Genet (2009) 2.56
Integrative eQTL-based analyses reveal the biology of breast cancer risk loci. Cell (2013) 2.56
Long-range enhancers on 8q24 regulate c-Myc. Proc Natl Acad Sci U S A (2010) 2.54
Use of genome-wide association studies for drug repositioning. Nat Biotechnol (2012) 2.51
Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression. PLoS Genet (2010) 2.39
Differential microRNA regulation of HLA-C expression and its association with HIV control. Nature (2011) 2.36
Variation and genetic control of protein abundance in humans. Nature (2013) 2.32
Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression. PLoS Genet (2012) 2.29
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression. Nat Genet (2012) 2.25
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet (2013) 2.24
Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization. Cell Res (2012) 2.09
The extent of linkage disequilibrium in four populations with distinct demographic histories. Am J Hum Genet (2000) 2.03
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proc Natl Acad Sci U S A (2009) 1.93
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One (2010) 1.93
The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type. Proc Natl Acad Sci U S A (2012) 1.92
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes. Genome Biol (2013) 1.71
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression. PLoS Genet (2013) 1.59
Genomic interactions: chromatin loops and gene meeting points in transcriptional regulation. Semin Cell Dev Biol (2009) 1.58
Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut (2013) 1.58
RNA sequencing reveals the role of splicing polymorphisms in regulating human gene expression. Genome Res (2010) 1.58
Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5'UTR. Cancer Cell (2011) 1.56
Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res (2011) 1.50
Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet (2012) 1.47
Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis. Gut (2013) 1.43
Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet (2011) 1.42
Fine scale mapping of the breast cancer 16q12 locus. Hum Mol Genet (2010) 1.39
Genetic architecture of microRNA expression: implications for the transcriptome and complex traits. Am J Hum Genet (2012) 1.36
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med (2009) 10.88
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet (2010) 7.62
A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet (2007) 7.35
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet (2008) 6.22
Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst (2008) 5.82
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet (2013) 5.58
Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet (2010) 4.51
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet (2009) 4.38
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet (2010) 3.86
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
Association studies for finding cancer-susceptibility genetic variants. Nat Rev Cancer (2004) 3.64
Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet (2008) 3.41
Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20
A common 8q24 variant in prostate and breast cancer from a large nested case-control study. Cancer Res (2007) 3.08
Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study. Lancet Oncol (2011) 3.04
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature (2011) 2.96
Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. J Natl Cancer Inst (2009) 2.88
The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. Ann Intern Med (2006) 2.74
Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Hum Mol Genet (2011) 2.72
FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation. Hum Mol Genet (2009) 2.62
Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One (2011) 2.61
A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Hum Mol Genet (2012) 2.45
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet (2013) 2.39
Telomere length in prospective and retrospective cancer case-control studies. Cancer Res (2010) 2.30
Genome-wide association study identifies three new melanoma susceptibility loci. Nat Genet (2011) 2.29
Association between common variation in 120 candidate genes and breast cancer risk. PLoS Genet (2007) 2.27
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet (2013) 2.24
Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes. JAMA (2004) 2.20
Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers. Hum Mol Genet (2009) 2.13
Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype. Nat Rev Cancer (2009) 2.13
Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer. Hum Mol Genet (2005) 2.05
SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer. RNA (2011) 2.03
Effect of germ-line genetic variation on breast cancer survival in a population-based study. Cancer Res (2002) 1.95
Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene. Proc Natl Acad Sci U S A (2008) 1.93
Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. Cancer Res (2007) 1.92
Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction. Cancer Res (2010) 1.90
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet (2013) 1.88
Genome-wide association study identifies a common variant associated with risk of endometrial cancer. Nat Genet (2011) 1.84
Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women. Cancer Res (2007) 1.82
19p13.1 is a triple-negative-specific breast cancer susceptibility locus. Cancer Res (2012) 1.81
A role for common genomic variants in the assessment of familial breast cancer. J Clin Oncol (2012) 1.80
Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. Hum Mol Genet (2013) 1.78
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun (2013) 1.73
Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study. PLoS Med (2006) 1.68
Genetic variation in the HSD17B1 gene and risk of prostate cancer. PLoS Genet (2005) 1.67
Common breast cancer susceptibility loci are associated with triple-negative breast cancer. Cancer Res (2011) 1.65
No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: results from the RAPPER study. Radiother Oncol (2010) 1.63
IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer. Hum Mol Genet (2005) 1.62
ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas. Gynecol Oncol (2013) 1.61
Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer. Cancer Res (2009) 1.59
Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium. Hum Mol Genet (2011) 1.56
Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors. PLoS Genet (2013) 1.56
A combined analysis of genome-wide association studies in breast cancer. Breast Cancer Res Treat (2010) 1.54
A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet (2013) 1.52
Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study. Breast Cancer Res (2010) 1.51
Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers. Hum Mol Genet (2011) 1.51
HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer. Breast Cancer Res (2010) 1.48
Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients. Clin Cancer Res (2011) 1.47
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". PLoS Genet (2010) 1.47
Polymorphisms in DNA repair genes and epithelial ovarian cancer risk. Int J Cancer (2005) 1.44
Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study. Hum Mol Genet (2009) 1.42
Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst (2010) 1.41
No association between TERT-CLPTM1L single nucleotide polymorphism rs401681 and mean telomere length or cancer risk. Cancer Epidemiol Biomarkers Prev (2010) 1.40
Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1. Am J Hum Genet (2013) 1.39
Fine scale mapping of the breast cancer 16q12 locus. Hum Mol Genet (2010) 1.39
Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet (2013) 1.38
Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast Cancer Res (2012) 1.38
Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis. J Natl Cancer Inst (2008) 1.36
ABCB1 (MDR 1) polymorphisms and progression-free survival among women with ovarian cancer following paclitaxel/carboplatin chemotherapy. Clin Cancer Res (2008) 1.33
CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen. Breast Cancer Res (2010) 1.31
Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Proc Natl Acad Sci U S A (2007) 1.29
Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium. Cancer Res (2007) 1.29
Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev (2009) 1.29
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer. J Clin Oncol (2012) 1.29
11q13 is a susceptibility locus for hormone receptor positive breast cancer. Hum Mutat (2012) 1.26
The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study. Breast Cancer Res Treat (2007) 1.24
Genetic variants in epigenetic genes and breast cancer risk. Carcinogenesis (2006) 1.24
Life stress, emotional health, and mean telomere length in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study. J Gerontol A Biol Sci Med Sci (2011) 1.24
Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populations. Hum Mol Genet (2007) 1.24