PubRank

Erol Fikrig

Author PubWeight™ 220.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 2009 7.88
2 Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med 2004 7.49
3 RNA interference screen for human genes associated with West Nile virus infection. Nature 2008 4.93
4 STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A 2003 3.46
5 The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity 2012 3.43
6 OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. J Clin Invest 2004 3.38
7 Essential role for OspA/B in the life cycle of the Lyme disease spirochete. J Exp Med 2004 3.02
8 The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature 2005 2.82
9 Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med 2002 2.77
10 Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity 2009 2.66
11 Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol 2010 2.63
12 TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi. Cell 2004 2.62
13 Molecular adaptation of Borrelia burgdorferi in the murine host. J Exp Med 2002 2.49
14 Crystal structure of west nile virus envelope glycoprotein reveals viral surface epitopes. J Virol 2006 2.20
15 Age-associated defect in human TLR-1/2 function. J Immunol 2007 2.20
16 A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector. Cell Host Microbe 2007 2.17
17 Rab 5 is required for the cellular entry of dengue and West Nile viruses. J Virol 2007 2.12
18 Human Borrelia miyamotoi infection in the United States. N Engl J Med 2013 2.11
19 IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection. J Immunol 2003 2.03
20 Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol 2009 2.00
21 Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J Virol 2008 1.93
22 Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. J Virol 2006 1.84
23 Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses. Infect Immun 2004 1.82
24 West Nile virus: a growing concern? J Clin Invest 2004 1.77
25 Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation. Immunity 2002 1.75
26 A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. Lancet 2013 1.73
27 Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus. J Virol 2005 1.72
28 Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine 2009 1.72
29 A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity. J Infect Dis 2007 1.68
30 Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination. J Clin Microbiol 2003 1.65
31 Detection of human anti-flavivirus antibodies with a west nile virus recombinant antigen microsphere immunoassay. J Clin Microbiol 2004 1.59
32 Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. J Clin Invest 2007 1.57
33 Disruption of Ixodes scapularis anticoagulation by using RNA interference. Proc Natl Acad Sci U S A 2004 1.56
34 Repression of rac2 mRNA expression by Anaplasma phagocytophila is essential to the inhibition of superoxide production and bacterial proliferation. J Immunol 2002 1.52
35 Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection. Infect Immun 2004 1.52
36 Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity. Infect Immun 2006 1.52
37 Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain. J Virol 2008 1.49
38 Salivating for knowledge: potential pharmacological agents in tick saliva. PLoS Med 2008 1.46
39 A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent. Cell Host Microbe 2011 1.44
40 The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks. Mol Microbiol 2006 1.44
41 Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. PLoS Pathog 2008 1.43
42 Examination of the Borrelia burgdorferi transcriptome in Ixodes scapularis during feeding. J Bacteriol 2002 1.43
43 Adaptation of Borrelia burgdorferi in the vector and vertebrate host. Microbes Infect 2003 1.41
44 Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell 2011 1.39
45 Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15. J Immunol 2006 1.39
46 West Nile Virus: biology, transmission, and human infection. Clin Microbiol Rev 2012 1.38
47 Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. J Infect Dis 2011 1.38
48 A paradoxical role for neutrophils in the pathogenesis of West Nile virus. J Infect Dis 2010 1.37
49 IL-10 signaling blockade controls murine West Nile virus infection. PLoS Pathog 2009 1.35
50 Invasion and survival strategies of Anaplasma phagocytophilum. Cell Microbiol 2003 1.35
51 Tick-host-pathogen interactions in Lyme borreliosis. Trends Parasitol 2007 1.34
52 A recombinant envelope protein vaccine against West Nile virus. Vaccine 2005 1.31
53 Association of linear plasmid 28-1 with an arthritic phenotype of Borrelia burgdorferi. Infect Immun 2005 1.30
54 Protective niche for Borrelia burgdorferi to evade humoral immunity. Am J Pathol 2004 1.29
55 Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis. J Exp Med 2007 1.29
56 West Nile virus envelope protein inhibits dsRNA-induced innate immune responses. J Immunol 2007 1.26
57 Borrelia burgdorferi transcriptome in the central nervous system of non-human primates. Proc Natl Acad Sci U S A 2003 1.26
58 DNA microarray assessment of putative Borrelia burgdorferi lipoprotein genes. Infect Immun 2002 1.25
59 Use of RNA interference to prevent lethal murine west nile virus infection. J Infect Dis 2005 1.24
60 Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks. PLoS Pathog 2007 1.24
61 Alterations in the Aedes aegypti transcriptome during infection with West Nile, dengue and yellow fever viruses. PLoS Pathog 2011 1.22
62 Differential expression of the p44 gene family in the agent of human granulocytic ehrlichiosis. Infect Immun 2002 1.21
63 Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display. PLoS One 2011 1.21
64 Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold. J Clin Invest 2010 1.21
65 CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosis. Clin Diagn Lab Immunol 2004 1.20
66 Adaptation of Borrelia burgdorferi in the tick and the mammalian host. FEMS Microbiol Rev 2003 1.19
67 Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent. Cell Host Microbe 2009 1.19
68 Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice. J Immunol 2006 1.18
69 Structurally distinct requirements for binding of P-selectin glycoprotein ligand-1 and sialyl Lewis x to Anaplasma phagocytophilum and P-selectin. J Biol Chem 2003 1.18
70 An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands. J Exp Med 2006 1.17
71 A C-type lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile virus infection of mosquitoes. Cell 2010 1.17
72 Icam-1 participates in the entry of west nile virus into the central nervous system. J Virol 2008 1.16
73 Immunity to West Nile virus. Curr Opin Immunol 2004 1.16
74 Inhibition of neutrophil function by two tick salivary proteins. Infect Immun 2009 1.16
75 Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. J Immunol 2008 1.13
76 Borrelia miyamotoi sensu lato seroreactivity and seroprevalence in the northeastern United States. Emerg Infect Dis 2014 1.13
77 Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the lyme disease agent. PLoS Pathog 2010 1.12
78 Comparative reactivity of human sera to recombinant VlsE and other Borrelia burgdorferi antigens in class-specific enzyme-linked immunosorbent assays for Lyme borreliosis. J Med Microbiol 2002 1.11
79 Immunity against Ixodes scapularis salivary proteins expressed within 24 hours of attachment thwarts tick feeding and impairs Borrelia transmission. PLoS One 2007 1.11
80 A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks. J Infect Dis 2008 1.11
81 Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Blood 2003 1.11
82 ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection. J Immunol 2007 1.10
83 TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. J Immunol 2010 1.09
84 Fucosylation enhances colonization of ticks by Anaplasma phagocytophilum. Cell Microbiol 2010 1.09
85 Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells. Immunology 2011 1.08
86 Mechanisms of evasion of neutrophil killing by Anaplasma phagocytophilum. Curr Opin Hematol 2006 1.08
87 Antiviral peptides targeting the west nile virus envelope protein. J Virol 2006 1.08
88 Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks. J Exp Med 2010 1.08
89 Modulation of NB4 promyelocytic leukemic cell machinery by Anaplasma phagocytophilum. Genomics 2005 1.08
90 Anaplasma phagocytophilum specifically induces tyrosine phosphorylation of ROCK1 during infection. Cell Microbiol 2007 1.08
91 Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of human granulocytic anaplasmosis. J Infect Dis 2012 1.06
92 Fusion loop peptide of the West Nile virus envelope protein is essential for pathogenesis and is recognized by a therapeutic cross-reactive human monoclonal antibody. J Immunol 2009 1.05
93 Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host. J Virol 2013 1.05
94 Anaplasma phagocytophilum modulates gp91phox gene expression through altered interferon regulatory factor 1 and PU.1 levels and binding of CCAAT displacement protein. Infect Immun 2005 1.05
95 Molecular interactions that enable movement of the Lyme disease agent from the tick gut into the hemolymph. PLoS Pathog 2011 1.05
96 Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nat Immunol 2010 1.04
97 Role of outer surface protein D in the Borrelia burgdorferi life cycle. Infect Immun 2007 1.03
98 Innate immune control of West Nile virus infection. Cell Microbiol 2011 1.02
99 Extrinsic incubation periods for horizontal and vertical transmission of West Nile virus by Culex pipiens pipiens (Diptera: Culicidae). J Med Entomol 2008 1.01
100 IL-22 signaling contributes to West Nile encephalitis pathogenesis. PLoS One 2012 1.01
101 Horizontal and vertical transmission of West Nile virus genotype NY99 by Culex salinarius and genotypes NY99 and WN02 by Culex tarsalis. Am J Trop Med Hyg 2012 1.01
102 Postgenomic analyses reveal development of infectious Anaplasma phagocytophilum during transmission from ticks to mice. J Bacteriol 2012 1.00
103 Immunity's fourth dimension: approaching the circadian-immune connection. Trends Immunol 2012 1.00
104 Early transcriptional response of human neutrophils to Anaplasma phagocytophilum infection. Infect Immun 2005 0.99
105 Anaplasma phagocytophilum AptA modulates Erk1/2 signalling. Cell Microbiol 2010 0.98
106 prM-antibody renders immature West Nile virus infectious in vivo. J Gen Virol 2011 0.98
107 Immune markers associated with host susceptibility to infection with West Nile virus. Viral Immunol 2014 0.98
108 Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi. BMC Microbiol 2012 0.97
109 Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity. J Immunol 2002 0.97
110 Impaired toll-like receptor 3-mediated immune responses from macrophages of patients chronically infected with hepatitis C virus. Clin Vaccine Immunol 2012 0.96
111 The tick salivary protein Salp15 inhibits the killing of serum-sensitive Borrelia burgdorferi sensu lato isolates. Infect Immun 2008 0.96
112 Superoxide anion production during Anaplasma phagocytophila infection. J Infect Dis 2002 0.96
113 Anaplasma phagocytophilum outer membrane protein A interacts with sialylated glycoproteins to promote infection of mammalian host cells. Infect Immun 2012 0.96
114 UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS. Cell Rep 2013 0.95
115 ELF4 is critical for induction of type I interferon and the host antiviral response. Nat Immunol 2013 0.95
116 Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein. Circulation 2013 0.95
117 Borrelia burgdorferi outer surface protein (osp) B expression independent of ospA. Microb Pathog 2004 0.94
118 West nile virus attenuates activation of primary human macrophages. Viral Immunol 2008 0.92
119 The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi. PLoS Pathog 2009 0.90
120 Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2. PLoS One 2012 0.90
121 Anopheles gambiae circumsporozoite protein-binding protein facilitates plasmodium infection of mosquito salivary glands. J Infect Dis 2013 0.90
122 Effects of Anaplasma phagocytophilum on host cell ferritin mRNA and protein levels. Infect Immun 2005 0.90
123 Antibodies targeting linear determinants of the envelope protein protect mice against West Nile virus. J Infect Dis 2007 0.90
124 Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells. Brain Behav Immun 2011 0.90
125 Dengue virus capsid protein binds core histones and inhibits nucleosome formation in human liver cells. PLoS One 2011 0.89
126 Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands. EMBO Rep 2011 0.89
127 Enhanced survival of Plasmodium-infected mosquitoes during starvation. PLoS One 2012 0.88
128 An in vivo transfection approach elucidates a role for Aedes aegypti thioester-containing proteins in flaviviral infection. PLoS One 2011 0.88
129 Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-β1/Smad6 signaling. J Immunol 2012 0.88
130 c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Infect Immun 2007 0.87
131 Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector. Virology 2011 0.87
132 Increased TLR4 expression and downstream cytokine production in immunosuppressed adults compared to non-immunosuppressed adults. PLoS One 2010 0.87
133 Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission. Proc Natl Acad Sci U S A 2013 0.87
134 Anaplasma phagocytophilum Asp14 is an invasin that interacts with mammalian host cells via its C terminus to facilitate infection. Infect Immun 2012 0.86
135 Interferon-gamma deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice. FEMS Immunol Med Microbiol 2004 0.85
136 Identification of genes critical for resistance to infection by West Nile virus using RNA-Seq analysis. Viruses 2013 0.85
137 IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis. FEMS Immunol Med Microbiol 2007 0.84
138 Seasonal prevalence of serum antibodies to whole cell and recombinant antigens of Borrelia burgdorferi and Anaplasma phagocytophilum in white-tailed deer in Connecticut. J Wildl Dis 2010 0.84
139 Coinfection with Borrelia burgdorferi sensu stricto and Borrelia garinii alters the course of murine Lyme borreliosis. FEMS Immunol Med Microbiol 2007 0.84
140 Characterization of Ixophilin, a thrombin inhibitor from the gut of Ixodes scapularis. PLoS One 2013 0.84
141 Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection. FEMS Immunol Med Microbiol 2012 0.83
142 Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moiety. Microbes Infect 2008 0.83
143 Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function. Infect Immun 2008 0.82
144 Use of recombinant antigens of Borrelia burgdorferi and Anaplasma phagocytophilum in enzyme-linked immunosorbent assays to detect antibodies in white-tailed deer. J Wildl Dis 2004 0.82
145 Antibodies to whole-cell or recombinant antigens of Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti in white-footed mice. J Wildl Dis 2006 0.82
146 A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells. Vaccine 2008 0.82
147 Anaplasma phagocytophilum surface protein AipA mediates invasion of mammalian host cells. Cell Microbiol 2014 0.82
148 Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis. FEMS Immunol Med Microbiol 2002 0.81
149 Disruption of the salivary protein 14 in Ixodes scapularis nymphs and impact on pathogen acquisition. Am J Trop Med Hyg 2006 0.81
150 Expression of Ixodes scapularis antifreeze glycoprotein enhances cold tolerance in Drosophila melanogaster. PLoS One 2012 0.81
151 Seroprevalence of antibodies against Borrelia burgdorferi and Anaplasma phagocytophilum in cats. Am J Vet Res 2005 0.80
152 The lipoprotein La7 contributes to Borrelia burgdorferi persistence in ticks and their transmission to naïve hosts. Microbes Infect 2013 0.80
153 An open-label, nonrandomized, single-center, prospective extension, clinical trial of booster dose schedules to assess the safety profile and immunogenicity of recombinant outer-surface protein A (OspA) Lyme disease vaccine. Clin Ther 2003 0.80
154 Serum antibodies to Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti in recaptured white-footed mice. J Wildl Dis 2013 0.80
155 Effective siRNA targeting of the 3' untranslated region of the West Nile virus genome. Antiviral Res 2009 0.79
156 A recombinant envelope protein-based enzyme-linked immunosorbent assay for West Nile virus serodiagnosis. Vector Borne Zoonotic Dis 2002 0.78
157 Passage through Ixodes scapularis ticks enhances the virulence of a weakly pathogenic isolate of Borrelia burgdorferi. Infect Immun 2009 0.77
158 Vaccine development: how scientific collaboration and communication help prevent the spread of disease: an interview with Erol Fikrig, MD. Yale J Biol Med 2014 0.77
159 A comparison of serologic tests for the detection of serum antibodies to whole-cell and recombinant Borrelia burgdorferi antigens in cattle. Can Vet J 2004 0.77
160 Antibodies to granulocytic ehrlichiae in cattle from Connecticut. J Med Microbiol 2002 0.77
161 Serum antibodies to whole-cell and recombinant antigens of Borrelia burgdorferi in cottontail rabbits. J Wildl Dis 2012 0.76
162 MyD88 deficiency markedly worsens tissue inflammation and bacterial clearance in mice infected with Treponema pallidum, the agent of syphilis. PLoS One 2013 0.75
163 The Lyme disease vaccine takes its toll. Vector Borne Zoonotic Dis 2002 0.75
164 Correction: The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector. Elife 2022 0.75