Roles of cadherins and catenins in cell-cell adhesion and epithelial cell polarity.

Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication. Proc Natl Acad Sci U S A (2015) 1.26

Desmosome assembly and dynamics. Trends Cell Biol (2013) 0.96

RhoGTPases, actomyosin signaling and regulation of the epithelial Apical Junctional Complex. Semin Cell Dev Biol (2014) 0.95

An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity. Nat Cell Biol (2015) 0.93

Getting to know your neighbor: cell polarization in early embryos. J Cell Biol (2014) 0.93

Mechanotransduction: use the force(s). BMC Biol (2015) 0.90

Dynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions. Cell Adh Migr (2014) 0.86

Changes in cell and tissue organization in cancer of the breast and colon. Curr Opin Cell Biol (2013) 0.86

Cell division orientation is coupled to cell-cell adhesion by the E-cadherin/LGN complex. Nat Commun (2017) 0.84

The evolutionary origin of epithelial cell-cell adhesion mechanisms. Curr Top Membr (2013) 0.84

Plakoglobin represses SATB1 expression and decreases in vitro proliferation, migration and invasion. PLoS One (2013) 0.80

Rhinoviruses and Their Receptors: Implications for Allergic Disease. Curr Allergy Asthma Rep (2016) 0.79

PAR-6, but not E-cadherin and β-integrin, is necessary for epithelial polarization in C. elegans. Dev Biol (2015) 0.79

Levels of soluble E-cadherin in breast, gastric, and colorectal cancers. Biomed Res Int (2014) 0.78

CSPP-L Associates with the Desmosome of Polarized Epithelial Cells and Is Required for Normal Spheroid Formation. PLoS One (2015) 0.76

Interplay between cadherins and α2β1 integrin differentially regulates melanoma cell invasion. Br J Cancer (2015) 0.76

Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing. Int J Mol Sci (2015) 0.75

At the double for tumor suppressor. Elife (2016) 0.75

Changes in organelle position and epithelial architecture associated with loss of CrebA. Biol Open (2015) 0.75

Cadherin-11 endocytosis through binding to clathrin promotes cadherin-11-mediated migration in prostate cancer cells. J Cell Sci (2015) 0.75

Chibby1 knockdown promotes mesenchymal-to-epithelial transition-like changes. Cell Cycle (2017) 0.75

Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation. J Cell Biol (2016) 0.75

Temporal regulation of epithelium formation mediated by FoxA, MKLP1, MgcRacGAP and PAR-6. Mol Biol Cell (2017) 0.75

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (2007) 20.32

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature (2007) 14.06

Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (2007) 11.74

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature (2011) 9.61

Deconstructing the cadherin-catenin-actin complex. Cell (2005) 8.39

Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell (2005) 7.62

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature (2012) 6.18

Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35

Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature (2012) 3.83

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature (2012) 3.83

Structure of the δ-opioid receptor bound to naltrindole. Nature (2012) 3.69

Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol (2005) 3.41

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature (2010) 3.19

Structure and mechanism of cadherins and catenins in cell-cell contacts. Annu Rev Cell Dev Biol (2007) 2.86

Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR. Nat Struct Mol Biol (2004) 2.83

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. Proc Natl Acad Sci U S A (2012) 2.82

An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity. Bioessays (2012) 2.81

Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure (2005) 2.53

Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature (2013) 2.49

High-resolution crystal structure of human protease-activated receptor 1. Nature (2012) 2.44

Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nat Struct Biol (2002) 2.38

Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol (2009) 2.37

Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure (2008) 2.36

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO J (2008) 2.33

Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J Biol Chem (2002) 2.31

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell (2006) 2.28

The β-catenin destruction complex. Cold Spring Harb Perspect Biol (2013) 2.22

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature (2013) 2.14

Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell (2004) 2.13

Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem (2005) 2.04

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure. Nat Struct Biol (2002) 1.97

ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol Cell (2002) 1.88

Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS One (2008) 1.86

AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion. J Cell Biol (2010) 1.81

X-ray structure determination at low resolution. Acta Crystallogr D Biol Crystallogr (2009) 1.60

A monoclonal antibody for G protein-coupled receptor crystallography. Nat Methods (2007) 1.60

Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Dev Cell (2011) 1.57

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature (2016) 1.55

Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR. J Biol Chem (2004) 1.53

In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans. Proc Natl Acad Sci U S A (2010) 1.37

Crystal structure of the S.cerevisiae exocyst component Exo70p. J Mol Biol (2005) 1.37

Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism. Nature (2007) 1.36

A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins. Science (2011) 1.32

Biochemical and structural analysis of alpha-catenin in cell-cell contacts. Biochem Soc Trans (2008) 1.32

αE-catenin is an autoinhibited molecule that coactivates vinculin. Proc Natl Acad Sci U S A (2012) 1.25

Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1. J Biol Chem (2010) 1.18

N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled receptor. PLoS One (2012) 1.17

Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins. J Biol Chem (2006) 1.17

Mechanism for recognition of an unusual mycobacterial glycolipid by the macrophage receptor mincle. J Biol Chem (2013) 1.15

The cytoplasmic face of cell contact sites. Curr Opin Struct Biol (2002) 1.14

Structure of the armadillo repeat domain of plakophilin 1. J Mol Biol (2004) 1.10

Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog. Proc Natl Acad Sci U S A (2002) 1.10

Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism. J Biol Chem (2007) 1.08

Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes. J Biol Chem (2009) 1.03

αE-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factors. Mol Biol Cell (2013) 1.03

Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2. EMBO J (2003) 1.02

Trimeric structure of langerin. J Biol Chem (2010) 1.02

Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J (2014) 1.02

Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition. J Biol Chem (2002) 1.02

structural Studies of Wnts and identification of an LRP6 binding site. Structure (2013) 0.99

Danio rerio αE-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αE-catenin. J Biol Chem (2013) 0.96

Structural basis for langerin recognition of diverse pathogen and mammalian glycans through a single binding site. J Mol Biol (2010) 0.95

Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain. J Mol Biol (2011) 0.94

Catenins: playing both sides of the synapse. Curr Opin Cell Biol (2007) 0.94

Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease. J Biol Chem (2009) 0.94

In vitro methods for investigating desmoplakin-intermediate filament interactions and their role in adhesive strength. Methods Cell Biol (2004) 0.92

The first propeller domain of LRP6 regulates sensitivity to DKK1. Mol Biol Cell (2009) 0.90

α-catenin and IQGAP regulate myosin localization to control epithelial tube morphogenesis in Dictyostelium. Dev Cell (2012) 0.90

Segmented helical structure of the neck region of the glycan-binding receptor DC-SIGNR. J Mol Biol (2009) 0.90

Structural and thermodynamic characterization of cadherin·β-catenin·α-catenin complex formation. J Biol Chem (2014) 0.89

Biochemical and structural characterization of β-catenin interactions with nonphosphorylated and CK2-phosphorylated Lef-1. J Mol Biol (2010) 0.88

Cell biology: how to build a cell junction. Nature (2004) 0.87

Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. Elife (2014) 0.85

Current concepts for the combined treatment modality of ionizing radiation with anticancer agents. Curr Pharm Des (2007) 0.84

The evolutionary origin of epithelial cell-cell adhesion mechanisms. Curr Top Membr (2013) 0.84

Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation. Proc Natl Acad Sci U S A (2013) 0.84

Common polymorphisms in human langerin change specificity for glycan ligands. J Biol Chem (2013) 0.83

The beta-catenin binding protein ICAT modulates androgen receptor activity. Mol Endocrinol (2011) 0.81

Protein evolution in cell and tissue development: going beyond sequence and transcriptional analysis. Dev Cell (2011) 0.81

Applications of molecular replacement to G protein-coupled receptors. Acta Crystallogr D Biol Crystallogr (2013) 0.77

Evolution and cell physiology. 3. Using Dictyostelium discoideum to investigate mechanisms of epithelial polarity. Am J Physiol Cell Physiol (2013) 0.75

Studying epithelial morphogenesis in Dictyostelium. Methods Mol Biol (2015) 0.75