PubRank

Barry P Sleckman

Author PubWeight™ 97.48‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008 10.84
2 Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 2002 8.34
3 53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature 2008 3.47
4 ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature 2006 3.35
5 ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell 2007 2.78
6 Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol Cell 2009 2.08
7 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell 2013 2.05
8 RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol 2009 1.98
9 DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature 2008 1.88
10 Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J 2009 1.83
11 The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Nat Immunol 2012 1.82
12 H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature 2010 1.78
13 Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG. Cell Cycle 2009 1.75
14 Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe 2007 1.71
15 The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol 2012 1.64
16 T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat Med 2003 1.55
17 Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc. Proc Natl Acad Sci U S A 2009 1.50
18 MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med 2009 1.50
19 Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse. Eur J Immunol 2008 1.48
20 Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J Immunol 2002 1.39
21 Proteasome activator PA200 is required for normal spermatogenesis. Mol Cell Biol 2006 1.38
22 Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol 2011 1.36
23 Allelic exclusion at the TCRbeta locus. Curr Opin Immunol 2002 1.30
24 Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes. J Exp Med 2007 1.29
25 Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nat Immunol 2010 1.28
26 Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis. Proc Natl Acad Sci U S A 2009 1.25
27 Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med 2009 1.24
28 Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol 2012 1.23
29 Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help. J Exp Med 2006 1.17
30 Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses. J Immunol 2006 1.16
31 Intra- and inter-allelic ordering of T cell receptor beta chain gene assembly. Eur J Immunol 2005 1.11
32 Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility. Nat Immunol 2005 1.06
33 Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A 2011 1.05
34 Revision of T cell receptor {alpha} chain genes is required for normal T lymphocyte development. Proc Natl Acad Sci U S A 2005 1.04
35 MAPK p38 alpha is dispensable for lymphocyte development and proliferation. J Immunol 2005 1.03
36 Collateral damage from antigen receptor gene diversification. Cell 2008 1.03
37 β-Catenin induces T-cell transformation by promoting genomic instability. Proc Natl Acad Sci U S A 2013 1.03
38 T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. Proc Natl Acad Sci U S A 2003 0.99
39 Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination. Cell Cycle 2011 0.95
40 Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining. J Immunol 2008 0.94
41 The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements. J Exp Med 2013 0.93
42 Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites. J Immunol 2011 0.92
43 RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation. J Exp Med 2011 0.91
44 T cell receptor CDR3 loop length repertoire is determined primarily by features of the V(D)J recombination reaction. Eur J Immunol 2003 0.89
45 Regulation of T-cell receptor beta-chain gene assembly by recombination signals: the beyond 12/23 restriction. Immunol Rev 2004 0.89
46 Cutting edge: targeting of V beta to D beta rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors. J Immunol 2003 0.88
47 Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Mol Cell Biol 2013 0.88
48 T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med 2002 0.88
49 Developmental stage-specific regulation of TCR-alpha-chain gene assembly by intrinsic features of the TEA promoter. J Immunol 2007 0.87
50 Green fluorescent protein-glucocorticoid receptor knockin mice reveal dynamic receptor modulation during thymocyte development. J Immunol 2002 0.87
51 Lymphocyte development: integration of DNA damage response signaling. Adv Immunol 2012 0.87
52 The B12/23 restriction is critically dependent on recombination signal nonamer and spacer sequences. J Immunol 2003 0.83
53 Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility. J Immunol 2011 0.82
54 Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation. Mol Immunol 2002 0.81
55 Functional overlap in the cis-acting regulation of the V(D)J recombination at the TCRbeta locus. Mol Immunol 2008 0.81
56 Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination. Proc Natl Acad Sci U S A 2013 0.81
57 Restrictions limiting the generation of DNA double strand breaks during chromosomal V(D)J recombination. J Exp Med 2002 0.81
58 Cutting edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells. J Immunol 2013 0.80
59 Chromosomal excision of TCRdelta chain genes is dispensable for alphabeta T cell lineage commitment. Int Immunol 2005 0.80
60 Redundant and nonredundant functions of ATM and H2AX in αβ T-lineage lymphocytes. J Immunol 2012 0.80
61 The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination. Mol Cell Biol 2013 0.78
62 DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs. BMC Genomics 2013 0.77
63 Out-of-frame T cell receptor beta transcripts are eliminated by multiple pathways in vivo. PLoS One 2011 0.77
64 Integrated signaling in developing lymphocytes: the role of DNA damage responses. Cell Cycle 2012 0.77
65 SWI-SNF: promoter of accessibility. Nat Immunol 2007 0.75
66 ATM deficiency: revealing the pathways to cancer. Cell Cycle 2014 0.75