Published in J Cell Sci on July 15, 2007
From cells to organs: building polarized tissue. Nat Rev Mol Cell Biol (2008) 5.06
Glycogen synthase kinase 3 beta: can it be a target for oral cancer. Mol Cancer (2010) 1.59
The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. Cancer Res (2008) 1.59
GSK-3 as potential target for therapeutic intervention in cancer. Oncotarget (2014) 1.56
Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators. Curr Opin Genet Dev (2010) 1.40
Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6. Hum Mol Genet (2009) 1.37
Organization of multiprotein complexes at cell-cell junctions. Histochem Cell Biol (2008) 1.33
Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis. J Biol Chem (2011) 1.30
Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr Opin Cell Biol (2009) 1.28
Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene (2008) 1.27
Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo. Biol Reprod (2010) 1.06
Tight junctions: a barrier to the initiation and progression of breast cancer? J Biomed Biotechnol (2009) 1.01
Culturing MDCK cells in three dimensions for analyzing intracellular dynamics. Curr Protoc Cell Biol (2009) 0.98
The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis. Mol Cell Biol (2008) 0.98
Regulation of primary cilia formation by ceramide. J Lipid Res (2009) 0.96
MDCK cystogenesis driven by cell stabilization within computational analogues. PLoS Comput Biol (2011) 0.96
Oncogenic suppression of apoptosis uncovers a Rac1/JNK proliferation pathway activated by loss of Par3. Oncogene (2014) 0.94
The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro. Small GTPases (2011) 0.88
Ceramide in stem cell differentiation and embryo development: novel functions of a topological cell-signaling lipid and the concept of ceramide compartments. J Lipids (2010) 0.86
PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling. Br J Cancer (2011) 0.86
Insights from studies with oral cleft genes suggest associations between WNT-pathway genes and risk of oral cancer. J Dent Res (2011) 0.85
Epithelial polarity: interactions between junctions and apical-basal machinery. Genetics (2009) 0.84
LPS receptor subunits have antagonistic roles in epithelial apoptosis and colonic carcinogenesis. Cell Death Differ (2015) 0.84
STAT1 is required for redifferentiation during Madin-Darby canine kidney tubulogenesis. Mol Biol Cell (2010) 0.83
Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3. Mol Biol Cell (2015) 0.81
Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis (2013) 0.80
Inactivation of GSK3β and activation of NF-κB pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma. Mol Biol Cell (2015) 0.80
An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2. Hum Mol Genet (2014) 0.79
Inhibition of GSK3α/β promotes increased pulmonary endothelial permeability to albumin by reactive oxygen/nitrogen species. Pulm Pharmacol Ther (2013) 0.79
Axon growth-stimulus package includes local translation. Nat Cell Biol (2009) 0.79
AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking. J Biol Chem (2014) 0.79
Apical deficiency triggers JNK-dependent apoptosis in the embryonic epidermis of Drosophila. Development (2011) 0.79
PTEN phosphatase-independent maintenance of glandular morphology in a predictive colorectal cancer model system. Neoplasia (2013) 0.78
Mechanisms of cell polarity and aquaporin sorting in the nephron. Pflugers Arch (2011) 0.78
Scribble at the crossroads. J Biol (2009) 0.77
Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development. J Cell Sci (2015) 0.76
Overexpression of interleukin-18 protein reduces viability and induces apoptosis of tongue squamous cell carcinoma cells by activation of glycogen synthase kinase-3β signaling. Oncol Rep (2015) 0.75
JAM-A and aPKC: A close pair during cell-cell contact maturation and tight junction formation in epithelial cells. Tissue Barriers (2013) 0.75
A pilot study: Screening target miRNAs in tissue of nonsyndromic cleft lip with or without cleft palate. Exp Ther Med (2017) 0.75
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science (2009) 10.78
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell (2006) 6.15
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell (2007) 5.84
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell (2010) 5.73
Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer. J Clin Oncol (2013) 5.21
A navigator for human genome epidemiology. Nat Genet (2008) 5.07
From cells to organs: building polarized tissue. Nat Rev Mol Cell Biol (2008) 5.06
Opinion: Building epithelial architecture: insights from three-dimensional culture models. Nat Rev Mol Cell Biol (2002) 4.76
A molecular network for de novo generation of the apical surface and lumen. Nat Cell Biol (2010) 3.70
Development and validation of a CGH microarray for clinical cytogenetic diagnosis. Genet Med (2005) 3.39
Genetic control of single lumen formation in the zebrafish gut. Nat Cell Biol (2007) 3.07
Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer. J Clin Oncol (2010) 3.06
Beta1-integrin orients epithelial polarity via Rac1 and laminin. Mol Biol Cell (2004) 2.95
ERK and MMPs sequentially regulate distinct stages of epithelial tubule development. Dev Cell (2004) 2.73
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A (2004) 2.66
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol Cell (2012) 2.54
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (2013) 2.49
Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells. Nat Cell Biol (2006) 2.39
Tracking the epidemiology of human genes in the literature: the HuGE Published Literature database. Am J Epidemiol (2006) 2.34
Epithelial polarity and tubulogenesis in vitro. Trends Cell Biol (2003) 2.31
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol Cell (2011) 2.29
Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases. Am J Epidemiol (2009) 2.15
Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis. Curr Biol (2008) 2.13
Molecular regulation of lumen morphogenesis. Curr Biol (2011) 1.96
The associations between race and geographic area and quality-of-care indicators in patients approaching ESRD. Clin J Am Soc Nephrol (2013) 1.87
Exocytosis: the many masters of the exocyst. Curr Biol (2002) 1.85
Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures. Mol Biol Cell (2003) 1.82
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol (2004) 1.80
The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis. BMC Genomics (2011) 1.79
The exocyst affects protein synthesis by acting on the translocation machinery of the endoplasmic reticulum. J Biol Chem (2003) 1.73
The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. J Cell Biol (2010) 1.70
Cancer GAMAdb: database of cancer genetic associations from meta-analyses and genome-wide association studies. Eur J Hum Genet (2011) 1.69
Managed care, hospice use, site of death, and medical expenditures in the last year of life. Arch Intern Med (2002) 1.65
EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. J Cell Sci (2007) 1.64
Tumor-induced osteomalacia: an important cause of adult-onset hypophosphatemic osteomalacia in China: Report of 39 cases and review of the literature. J Bone Miner Res (2012) 1.63
Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis. Mol Biol Cell (2007) 1.61
Morphological and biochemical analysis of Rac1 in three-dimensional epithelial cell cultures. Methods Enzymol (2006) 1.59
Age structure changes and extraordinary lifespan in wild medfly populations. Aging Cell (2008) 1.57
Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem (2005) 1.56
Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein. J Cell Biol (2004) 1.47
Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res (2013) 1.46
Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proc Natl Acad Sci U S A (2011) 1.45
Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture. Mol Biol Cell (2007) 1.44
Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nat Cell Biol (2012) 1.42
Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Rep (2008) 1.40
Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation. J Biol Chem (2005) 1.38
Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach. PLoS Genet (2012) 1.38
Horizon scanning for new genomic tests. Genet Med (2011) 1.36
Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis study. Arthritis Rheum (2002) 1.36
Interrelationship between non-invasive measurements of atherosclerosis: flow-mediated dilation of brachial artery, carotid intima-media thickness and pulse wave velocity. Atherosclerosis (2004) 1.35
Genetic epidemiology with a capital E, ten years after. Genet Epidemiol (2011) 1.34
The relationship of age, race, and ethnicity with survival in dialysis patients. Clin J Am Soc Nephrol (2013) 1.32
Quadriceps weakness and its relationship to tibiofemoral and patellofemoral knee osteoarthritis in Chinese: the Beijing osteoarthritis study. Arthritis Rheum (2004) 1.32
Gender and use of care: planning for tomorrow's Veterans Health Administration. J Womens Health (Larchmt) (2007) 1.30
Nudel modulates kinetochore association and function of cytoplasmic dynein in M phase. Mol Biol Cell (2007) 1.30
Monosomy 1p36 breakpoint junctions suggest pre-meiotic breakage-fusion-bridge cycles are involved in generating terminal deletions. Hum Mol Genet (2003) 1.30
Survival and aging in the wild via residual demography. Theor Popul Biol (2007) 1.27
High prevalence of lateral knee osteoarthritis in Beijing Chinese compared with Framingham Caucasian subjects. Arthritis Rheum (2002) 1.27
Tumor-targeting nanoimmunoliposome complex for short interfering RNA delivery. Hum Gene Ther (2006) 1.26
Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound. AJR Am J Roentgenol (2008) 1.26
A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol (2010) 1.25
Carotid plaque morphology and composition: initial comparison between 1.5- and 3.0-T magnetic field strengths. Radiology (2008) 1.25
Simulating properties of in vitro epithelial cell morphogenesis. PLoS Comput Biol (2006) 1.24
Changes in 18F-fluorodeoxyglucose and 18F-fluorodeoxythymidine positron emission tomography imaging in patients with non-small cell lung cancer treated with erlotinib. Clin Cancer Res (2011) 1.22
Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. Dev Cell (2002) 1.22
Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: the Beijing Osteoarthritis Study. Arthritis Rheum (2003) 1.21
Miniscalpel-needle versus triggerpoint injection for cervical myofascial pain syndrome: a randomized comparative trial. J Altern Complement Med (2007) 1.18
RNA-Seq analyses generate comprehensive transcriptomic landscape and reveal complex transcript patterns in hepatocellular carcinoma. PLoS One (2011) 1.18
ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS (2010) 1.17
Reporting of human genome epidemiology (HuGE) association studies: an empirical assessment. BMC Med Res Methodol (2008) 1.17
Image quality and radiation dose of low dose coronary CT angiography in obese patients: sinogram affirmed iterative reconstruction versus filtered back projection. Eur J Radiol (2012) 1.16
MICoA, a novel metastasis-associated protein 1 (MTA1) interacting protein coactivator, regulates estrogen receptor-alpha transactivation functions. J Biol Chem (2003) 1.15
Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25. Mol Biol Cell (2012) 1.15
Hydrogen sulfide promotes root organogenesis in Ipomoea batatas, Salix matsudana and Glycine max. J Integr Plant Biol (2009) 1.13
Estimating the costs of VA ambulatory care. Med Care Res Rev (2003) 1.13
Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides. Nat Protoc (2010) 1.13
Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway. Biochem Biophys Res Commun (2008) 1.13
Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J (2003) 1.12
The role of syntaxins in the specificity of vesicle targeting in polarized epithelial cells. Mol Biol Cell (2005) 1.09
Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation. J Biol Chem (2011) 1.09
Association of squatting with increased prevalence of radiographic tibiofemoral knee osteoarthritis: the Beijing Osteoarthritis Study. Arthritis Rheum (2004) 1.08
Intraoperative blood salvage during liver transplantation in patients with hepatocellular carcinoma: efficiency of leukocyte depletion filters in the removal of tumor cells. Transplantation (2008) 1.05
Delineation of mechanisms and regions of dosage imbalance in complex rearrangements of 1p36 leads to a putative gene for regulation of cranial suture closure. Eur J Hum Genet (2005) 1.04
ASCI 2010 appropriateness criteria for cardiac computed tomography: a report of the Asian Society of Cardiovascular Imaging Cardiac Computed Tomography and Cardiac Magnetic Resonance Imaging Guideline Working Group. Int J Cardiovasc Imaging (2010) 1.04
Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics (2008) 1.04
Profiles of oxidative stress-related microRNA and mRNA expression in auditory cells. Brain Res (2010) 1.03