Published in Biochem Biophys Res Commun on January 31, 2003
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Sirtuins in mammals: insights into their biological function. Biochem J (2007) 7.60
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell (2005) 6.79
Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev (2004) 4.51
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol (2006) 3.37
SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34
Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol (2004) 3.00
Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res (2008) 2.97
Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res (2007) 2.51
SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol (2005) 2.24
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
Hairy transcriptional repression targets and cofactor recruitment in Drosophila. PLoS Biol (2004) 1.63
Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol Cell Biol (2005) 1.46
Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor. Mol Endocrinol (2007) 1.43
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions. Biochim Biophys Acta (2009) 1.41
SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J Biol Chem (2009) 1.39
Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: epigenetics in pathogenesis of COPD. Antioxid Redox Signal (2008) 1.26
XB130, a novel adaptor protein, promotes thyroid tumor growth. Am J Pathol (2010) 1.21
Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. Biochem J (2007) 1.19
Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells. Br J Cancer (2005) 1.19
Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin. Cell Res (2011) 1.15
Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. Trends Mol Med (2009) 1.07
Transcriptional regulation of neuronal differentiation: the epigenetic layer of complexity. Biochim Biophys Acta (2008) 0.98
Sculpting chromatin beyond the double helix: epigenetic control of skeletal myogenesis. Curr Top Dev Biol (2011) 0.95
Transcription Regulation by Class III Histone Deacetylases (HDACs)-Sirtuins. Transl Oncogenomics (2008) 0.93
SIRT1 regulates endothelial Notch signaling in lung cancer. PLoS One (2012) 0.91
Role of Pax3 acetylation in the regulation of Hes1 and Neurog2. Mol Biol Cell (2010) 0.90
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress. Genes Cancer (2013) 0.89
Hes1: a key role in stemness, metastasis and multidrug resistance. Cancer Biol Ther (2015) 0.88
Notch- and transducin-like enhancer of split (TLE)-dependent histone deacetylation explain interleukin 12 (IL-12) p70 inhibition by zymosan. J Biol Chem (2011) 0.85
Emerging role of the MORF/MRG gene family in various biological processes, including aging. Ann N Y Acad Sci (2010) 0.85
Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development. Breast Cancer Res (2010) 0.84
Transcriptional impact of dietary methionine restriction on systemic inflammation: relevance to biomarkers of metabolic disease during aging. Biofactors (2013) 0.84
Glutamine depletion and glucose depletion trigger growth inhibition via distinctive gene expression reprogramming. Cell Cycle (2012) 0.83
Novel cis-regulatory modules control expression of the Hairy and Enhancer of Split-1 (HES1) transcription factor in myoblasts. J Biol Chem (2011) 0.82
SIRT1 Inhibits p53 but not NF-κB Transcriptional Activity during Differentiation of Mouse Embryonic Stem Cells into Embryoid Bodies. Int J Stem Cells (2012) 0.82
The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin. PLoS One (2014) 0.77
Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells. Cell Mol Neurobiol (2014) 0.77
Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. Development (2016) 0.77
Divergent modulation of neuronal differentiation by caspase-2 and -9. PLoS One (2012) 0.77
A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neurons. Sci Rep (2016) 0.77
Notch signaling represses GATA4-induced expression of genes involved in steroid biosynthesis. Reproduction (2015) 0.77
HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis. Cell Stress Chaperones (2015) 0.76
Autoregulatory Control of Smooth Muscle Myosin Light Chain Kinase Promoter by Notch Signaling. J Biol Chem (2015) 0.75
Resveratrol: A Potential Hippocampal Plasticity Enhancer. Oxid Med Cell Longev (2016) 0.75
Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway. PLoS Pathog (2016) 0.75
Embedding the Future of Regenerative Medicine into the Open Epigenomic Landscape of Pluripotent Human Embryonic Stem Cells. Annu Res Rev Biol (2013) 0.75
Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells (2006) 5.68
Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells. J Biol Chem (2004) 3.73
Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length. Science (2008) 2.97
RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Mol Cell (2009) 2.93
A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med (2009) 2.65
Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells (2003) 2.28
Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes. Nat Cell Biol (2008) 2.04
Telomere binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres. Curr Biol (2005) 2.02
The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. J Biol Chem (2002) 1.74
RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation. Genes Cells (2007) 1.71
Loss of linker histone H1 in cellular senescence. J Cell Biol (2006) 1.71
Telomere-nuclear envelope dissociation promoted by Rap1 phosphorylation ensures faithful chromosome segregation. Curr Biol (2012) 1.53
Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats. Nucleic Acids Res (2004) 1.53
Localization of hRad9, hHus1, hRad1, and hRad17 and caffeine-sensitive DNA replication at the alternative lengthening of telomeres-associated promyelocytic leukemia body. J Biol Chem (2004) 1.49
Structure of hnRNP D complexed with single-stranded telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D. J Biol Chem (2005) 1.38
Telomerase activity is required for bleomycin-induced pulmonary fibrosis in mice. J Clin Invest (2007) 1.36
Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication. Nature (2013) 1.35
Xenopus laevis Ctc1-Stn1-Ten1 (xCST) protein complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extract. J Biol Chem (2011) 1.29
Unusual telomeric DNAs in human telomerase-negative immortalized cells. Mol Cell Biol (2008) 1.29
Stable inheritance of telomere chromatin structure and function in the absence of telomeric repeats. Genes Dev (2003) 1.27
Cellular senescence and chromatin structure. Chromosoma (2007) 1.26
Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast. Genes Dev (2012) 1.15
Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells. Mol Cell Biol (2011) 1.14
Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. Mol Cell Biol (2009) 1.13
Tel2 is required for activation of the Mrc1-mediated replication checkpoint. J Biol Chem (2006) 1.10
MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase. J Biol Chem (2002) 1.08
Cohesin defects lead to premature sister chromatid separation, kinetochore dysfunction, and spindle-assembly checkpoint activation. J Biol Chem (2002) 1.03
Alternative lengthening of telomeres pathway: recombination-mediated telomere maintenance mechanism in human cells. J Biochem (2010) 1.02
Successful inactivation of endogenous Oct-3/4 and c-mos genes in mouse preimplantation embryos and oocytes using short interfering RNAs. Biochem Biophys Res Commun (2002) 1.00
The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway. J Mol Biol (2003) 0.98
Telomeric DNA ends are essential for the localization of Ku at telomeres in fission yeast. J Biol Chem (2002) 0.97
Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha. Mol Cell Biol (2005) 0.97
Transcription-induced chromatin association of RNA surveillance factors mediates facultative heterochromatin formation in fission yeast. Genes Cells (2013) 0.96
Molecular mechanisms of DNA end-loop formation by TRF2. Genes Cells (2004) 0.95
Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice. Mol Cell Biol (2002) 0.91
Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research. PLoS One (2012) 0.90
Variant forms of upstream stimulatory factors (USFs) control the promoter activity of hTERT, the human gene encoding the catalytic subunit of telomerase. FEBS Lett (2002) 0.88
Cell-cycle-dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo-like kinase. EMBO J (2006) 0.87
Stemness-related factor Sall4 interacts with transcription factors Oct-3/4 and Sox2 and occupies Oct-Sox elements in mouse embryonic stem cells. J Biol Chem (2012) 0.86
ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence. Cancer Sci (2007) 0.85
Telomerase rescues the expression levels of keratinocyte growth factor and insulin-like growth factor-II in senescent human fibroblasts. Exp Cell Res (2002) 0.85
HIRA, a conserved histone chaperone, plays an essential role in low-dose stress response via transcriptional stimulation in fission yeast. J Biol Chem (2012) 0.83
Essential roles of Xenopus TRF2 in telomere end protection and replication. Genes Cells (2011) 0.82
Large defects of type I allergic response in telomerase reverse transcriptase knockout mice. J Leukoc Biol (2007) 0.81
Interaction between DNMT1 and DNA replication reactions in the SV40 in vitro replication system. Cancer Sci (2008) 0.80
Fission yeast Ku protein is required for recovery from DNA replication stress. Genes Cells (2009) 0.79
Fission yeast Vps1 and Atg8 contribute to oxidative stress resistance. Genes Cells (2010) 0.79
Kinetics of DNA replication and telomerase reaction at a single-seeded telomere in human cells. Genes Cells (2012) 0.79
Timeless tunes: replicating happy endings. Cell Cycle (2012) 0.77
Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast. J Biol Chem (2013) 0.75
[Conserved telomeric-end structures among fission yeast and humans]. Tanpakushitsu Kakusan Koso (2008) 0.75
[Tumor-suppressing role of cellular senescence and chromatin structure]. Nihon Ronen Igakkai Zasshi (2007) 0.75
Tenth Japanese-German Workshop on Molecular and Cellular Aspects of Carcinogenesis, Essen, Germany, 29 September-1 October 2005. Cancer Sci (2006) 0.75
Stretch PCR assay. Methods Mol Biol (2002) 0.75
[Molecular biology of aging]. Nihon Ronen Igakkai Zasshi (2004) 0.75
[Replicative stress in telomeres]. Tanpakushitsu Kakusan Koso (2006) 0.75
Cell-cycle-dependent regulation of telomere binding proteins: roles of Polo-like kinase. Cell Cycle (2006) 0.75
Ninth Japanese-German Workshop on Molecular and Cellular Aspects of Carcinogenesis, Essen, Germany, 18-20 September, 2003. Cancer Sci (2004) 0.75
[Function of telomerase and heritable disease]. Tanpakushitsu Kakusan Koso (2003) 0.75
[Telomere maintenance by DNA damage sensor kinases, ATM and ATR]. Seikagaku (2014) 0.75
[Telomere dysfunction in cancer progression]. Rinsho Ketsueki (2012) 0.75