Published in J Biol Chem on May 10, 2006
CpG methylation controls reactivation of HIV from latency. PLoS Pathog (2009) 2.51
Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. PLoS Biol (2011) 2.49
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CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency. EMBO J (2007) 2.20
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The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe (2010) 1.76
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Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). PLoS Pathog (2011) 1.31
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The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription. Retrovirology (2006) 1.09
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Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein. J Biol Chem (2010) 0.94
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Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication. J Mol Biol (2011) 0.83
Structural and functional role of INI1 and LEDGF in the HIV-1 preintegration complex. PLoS One (2013) 0.82
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Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function. Retrovirology (2012) 0.82
The BAF complex and HIV latency. Transcription (2012) 0.81
Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. PLoS One (2012) 0.81
An upstream YY1 binding site on the HIV-1 LTR contributes to latent infection. PLoS One (2013) 0.79
Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1. Retrovirology (2015) 0.79
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Mutual information analysis reveals coevolving residues in Tat that compensate for two distinct functions in HIV-1 gene expression. J Biol Chem (2012) 0.78
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The effects of cocaine on HIV transcription. J Neurovirol (2015) 0.78
Didehydro-Cortistatin A: a new player in HIV-therapy? Expert Rev Anti Infect Ther (2015) 0.77
Manipulation of the host protein acetylation network by human immunodeficiency virus type 1. Crit Rev Biochem Mol Biol (2015) 0.76
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Human immunodeficiency virus Tat associates with a specific set of cellular RNAs. Retrovirology (2014) 0.76
Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein. MBio (2016) 0.76
An Essential Role of INI1/hSNF5 Chromatin Remodeling Protein in HIV-1 Posttranscriptional Events and Gag/Gag-Pol Stability. J Virol (2016) 0.75
Tat is a multifunctional viral protein that modulates cellular gene expression and functions. Oncotarget (2017) 0.75
Promising Role of Toll-Like Receptor 8 Agonist in Concert with Prostratin for Activation of Silent HIV. J Virol (2016) 0.75
Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay. Sci Rep (2016) 0.75
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HIV‑1 downregulates the expression and phosphorylation of receptor tyrosine kinase by targeting the NF‑κB pathway. Mol Med Rep (2016) 0.75
The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes. Mol Cell (2017) 0.75
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology (2011) 6.36
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J (2003) 6.11
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A (2006) 5.96
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The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol (2002) 5.37
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell (2002) 5.19
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab (2010) 4.97
NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J (2005) 4.35
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Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science (2010) 3.29
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med (2010) 3.27
Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron (2010) 3.15
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Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proc Natl Acad Sci U S A (2007) 2.97
Composition and functional specificity of SWI2/SNF2 class chromatin remodeling complexes. Biochim Biophys Acta (2004) 2.90
The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics (2011) 2.83
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77
Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Mol Cell Proteomics (2012) 2.66
CpG methylation controls reactivation of HIV from latency. PLoS Pathog (2009) 2.51
Epigenetic regulation of HIV-1 latency by cytosine methylation. PLoS Pathog (2009) 2.50
Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. PLoS Biol (2011) 2.49
Prostratin antagonizes HIV latency by activating NF-kappaB. J Biol Chem (2004) 2.47
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem (2007) 2.37
Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics. Nat Biotechnol (2003) 2.37
dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Genes Dev (2008) 2.29
SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol (2005) 2.24
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J (2013) 2.24
GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7. Mol Cell (2005) 2.21
Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell (2002) 2.20
Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes. Mol Cell Biol (2004) 2.18
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. Mol Cell Biol (2008) 2.14
HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity (2003) 2.10
A robust and highly efficient immune cell reprogramming system. Cell Stem Cell (2009) 2.06
Control of cytomegalovirus lytic gene expression by histone acetylation. EMBO J (2002) 2.06
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Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A (2013) 2.01
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BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle (2012) 1.88
The nexus of chromatin regulation and intermediary metabolism. Nature (2013) 1.87
Hepatitis C and risk of lymphoma: results of the European multicenter case-control study EPILYMPH. Gastroenterology (2006) 1.81
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. PLoS Biol (2010) 1.81
Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7. Proc Natl Acad Sci U S A (2008) 1.80
Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation. J Biol Chem (2004) 1.79
Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors. Eur J Biochem (2002) 1.78
The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe (2010) 1.76
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) (2010) 1.76
Pleiohomeotic can link polycomb to DNA and mediate transcriptional repression. Mol Cell Biol (2002) 1.74
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab (2013) 1.70
Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing. Mol Cell (2009) 1.70
Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility. FASEB J (2005) 1.70
The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons. J Neurosci (2009) 1.69
Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol (2004) 1.67
Mitochondrial sirtuins. Biochim Biophys Acta (2010) 1.67
Histone deacetylases and cancer. Mol Oncol (2012) 1.67
P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells. J Biol Chem (2003) 1.67
Functional differentiation of SWI/SNF remodelers in transcription and cell cycle control. Mol Cell Biol (2006) 1.65
Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases. J Biol Chem (2002) 1.62
Cancer-associated mutations in chromatin remodeler hSNF5 promote chromosomal instability by compromising the mitotic checkpoint. Genes Dev (2005) 1.61
Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem (2012) 1.58
Architecture of a polycomb nucleoprotein complex. Mol Cell (2006) 1.55
Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J Biol Chem (2007) 1.55
Mitochondrial sirtuins: regulators of protein acylation and metabolism. Trends Endocrinol Metab (2012) 1.52
Synergistic recognition of an epigenetic DNA element by Pleiohomeotic and a Polycomb core complex. Genes Dev (2005) 1.52
Immunosenescence and HIV. Curr Opin Immunol (2012) 1.51
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS One (2007) 1.50
Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J (2002) 1.49
MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation. Nat Immunol (2013) 1.48
Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem (2011) 1.43
Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell (2003) 1.42
Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res (2012) 1.41
GAGA can mediate enhancer function in trans by linking two separate DNA molecules. EMBO J (2002) 1.40
Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell (2013) 1.40
Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol (2012) 1.39
Snapshots: chromatin control of viral infection. Virology (2013) 1.39
The PHD type zinc finger is an integral part of the CBP acetyltransferase domain. Mol Cell Biol (2002) 1.36
Reactivation of latent HIV by histone deacetylase inhibitors. Trends Microbiol (2013) 1.35
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe (2008) 1.35
Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett (2007) 1.34
Regulatory signal transduction pathways for class IIa histone deacetylases. Curr Opin Pharmacol (2010) 1.34
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer (2010) 1.32
DNA looping induced by a transcriptional enhancer in vivo. Nucleic Acids Res (2005) 1.32
Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). PLoS Pathog (2011) 1.31