Mitochondrial sirtuins.

Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol (2012) 4.86

Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci (2010) 2.36

Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol Cell (2011) 2.29

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY) (2010) 2.27

A genome-scale resource for in vivo tag-based protein function exploration in C. elegans. Cell (2012) 2.07

DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells. PLoS One (2015) 2.02

Lipid-induced mitochondrial stress and insulin action in muscle. Cell Metab (2012) 1.71

Mechanistic insights into the regulation of metabolic enzymes by acetylation. J Cell Biol (2012) 1.71

Sorting out functions of sirtuins in cancer. Oncogene (2013) 1.47

Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis. J Biol Chem (2011) 1.46

The role of mitochondrial DNA mutations and free radicals in disease and ageing. J Intern Med (2013) 1.42

Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res (2012) 1.41

4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification. Chem Res Toxicol (2011) 1.35

Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem (2011) 1.35

KAT(ching) metabolism by the tail: insight into the links between lysine acetyltransferases and metabolism. Chembiochem (2010) 1.32

Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype. J Biol Chem (2011) 1.30

SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta (2011) 1.28

SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Res (2012) 1.22

Structure-based development of novel sirtuin inhibitors. Aging (Albany NY) (2011) 1.19

Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3. PLoS One (2012) 1.13

Mitochondrial SIRT3 and heart disease. Cardiovasc Res (2010) 1.09

Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substrates. J Biomed Biotechnol (2010) 1.08

A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. J Biol Chem (2011) 1.07

Circadian clocks and metabolism. Handb Exp Pharmacol (2013) 1.07

Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol (2011) 1.03

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation. Mol Cell Proteomics (2015) 1.02

Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation. Handb Exp Pharmacol (2011) 1.02

SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis. Cancer Metab (2014) 1.00

Nutrient sensing and the circadian clock. Trends Endocrinol Metab (2012) 0.98

Mitochondrial dysregulation in the pathogenesis of diabetes: potential for mitochondrial biogenesis-mediated interventions. Exp Diabetes Res (2011) 0.98

Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma. PLoS One (2012) 0.96

Distinct effects of calorie restriction and resveratrol on diet-induced obesity and Fatty liver formation. J Nutr Metab (2011) 0.95

SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY) (2013) 0.94

Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer. BMB Rep (2013) 0.93

Role of mitochondria in alcoholic liver disease. World J Gastroenterol (2014) 0.93

Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity. Free Radic Biol Med (2012) 0.90

VDAC proteomics: post-translation modifications. Biochim Biophys Acta (2011) 0.90

Epigenomic programing: a future way to health? Microb Ecol Health Dis (2014) 0.88

Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Mitochondrion (2013) 0.87

Sirtuins, bioageing, and cancer. J Aging Res (2011) 0.86

Glucose modulates respiratory complex I activity in response to acute mitochondrial dysfunction. J Biol Chem (2012) 0.86

Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis. Cancer (2012) 0.86

The role of dietary histone deacetylases (HDACs) inhibitors in health and disease. Nutrients (2014) 0.85

Cellular Links between Neuronal Activity and Energy Homeostasis. Front Pharmacol (2012) 0.85

Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart. J Bioenerg Biomembr (2011) 0.84

Myoglobin and mitochondria: a relationship bound by oxygen and nitric oxide. Nitric Oxide (2012) 0.83

A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3. PLoS One (2015) 0.83

Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with Temozolomide. Metabolites (2014) 0.81

Role of Mitochondria in Alcoholic Liver Disease. Curr Pathobiol Rep (2013) 0.81

Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc. Endocrinology (2012) 0.80

CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. Mol Cancer Ther (2015) 0.79

Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition. Oxid Med Cell Longev (2016) 0.79

Upstream molecular signaling pathways of p27(Kip1) expression in human breast cancer cells in vitro: differential effects of 4-hydroxytamoxifen and deficiency of either D-(+)-glucose or L-leucine. Cancer Cell Int (2011) 0.79

In silico analysis of protein Lys-N(𝜀)-acetylation in plants. Front Plant Sci (2014) 0.79

A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells. Anticancer Res (2016) 0.79

Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro. J Bioenerg Biomembr (2011) 0.78

Histone lysine crotonylation during acute kidney injury in mice. Dis Model Mech (2016) 0.78

SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells. PLoS One (2015) 0.78

Roles of NAD (+) , PARP-1, and Sirtuins in Cell Death, Ischemic Brain Injury, and Synchrotron Radiation X-Ray-Induced Tissue Injury. Scientifica (Cairo) (2013) 0.77

Mechanism-based affinity capture of sirtuins. Org Biomol Chem (2010) 0.77

Mitochondria-localized NAD biosynthesis by nicotinamide mononucleotide adenylyltransferase in Jerusalem artichoke (Helianthus tuberosus L.) heterotrophic tissues. Planta (2011) 0.77

Proteome analysis of subsarcolemmal cardiomyocyte mitochondria: a comparison of different analytical platforms. Int J Mol Sci (2014) 0.76

Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders. Neurochem Res (2016) 0.75

Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis. Eur J Rheumatol (2017) 0.75

SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. J Biol Chem (2015) 0.75

Chemical and structural biology of protein lysine deacetylases. Proc Jpn Acad Ser B Phys Biol Sci (2017) 0.75

SIRT3: Oncogene and Tumor Suppressor in Cancer. Cancers (Basel) (2017) 0.75

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48

HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J (2003) 6.11

Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A (2006) 5.96

Towards an HIV cure: a global scientific strategy. Nat Rev Immunol (2012) 5.52

The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol (2002) 5.37

Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell (2002) 5.19

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab (2010) 4.97

NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J (2005) 4.35

In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J (2002) 4.28

Conserved metabolic regulatory functions of sirtuins. Cell Metab (2008) 3.86

Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33

HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science (2010) 3.29

Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol (2004) 3.00

Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proc Natl Acad Sci U S A (2007) 2.97

The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics (2011) 2.83

SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77

Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Mol Cell Proteomics (2012) 2.66

CpG methylation controls reactivation of HIV from latency. PLoS Pathog (2009) 2.51

Epigenetic regulation of HIV-1 latency by cytosine methylation. PLoS Pathog (2009) 2.50

Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. PLoS Biol (2011) 2.49

Prostratin antagonizes HIV latency by activating NF-kappaB. J Biol Chem (2004) 2.47

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A (2011) 2.41

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci (2010) 2.37

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem (2007) 2.37

Method for isolation of PCR-ready genomic DNA from zebrafish tissues. Biotechniques (2007) 2.34

SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol (2005) 2.24

Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell (2002) 2.20

HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity (2003) 2.10

Control of cytomegalovirus lytic gene expression by histone acetylation. EMBO J (2002) 2.06

Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene (2002) 2.02

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A (2013) 2.01

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle (2012) 1.88

The nexus of chromatin regulation and intermediary metabolism. Nature (2013) 1.87

Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7. Proc Natl Acad Sci U S A (2008) 1.80

Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation. J Biol Chem (2004) 1.79

The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. J Biol Chem (2006) 1.77

The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe (2010) 1.76

miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) (2010) 1.76

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab (2013) 1.70

Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility. FASEB J (2005) 1.70

The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons. J Neurosci (2009) 1.69

Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases. J Biol Chem (2002) 1.62

Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem (2012) 1.58

Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J Biol Chem (2007) 1.55

Mitochondrial sirtuins: regulators of protein acylation and metabolism. Trends Endocrinol Metab (2012) 1.52

Immunosenescence and HIV. Curr Opin Immunol (2012) 1.51

Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS One (2007) 1.50

Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J (2002) 1.49

MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation. Nat Immunol (2013) 1.48

Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem (2011) 1.43

Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell (2003) 1.42

Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res (2012) 1.41

Mitochondrial protein acetylation regulates metabolism. Essays Biochem (2012) 1.40

Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol (2012) 1.39

Reactivation of latent HIV by histone deacetylase inhibitors. Trends Microbiol (2013) 1.35

Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett (2007) 1.34

Regulatory signal transduction pathways for class IIa histone deacetylases. Curr Opin Pharmacol (2010) 1.34

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer (2010) 1.32

Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. J Med Chem (2008) 1.31

Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. Int J Cancer (2007) 1.30

Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes. Genes Dev (2007) 1.29

SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta (2011) 1.28

Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. Nat Commun (2012) 1.27

Subtype selective substrates for histone deacetylases. J Med Chem (2004) 1.25

Acetylation of mitochondrial proteins. Methods Enzymol (2009) 1.24

Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues. Am J Pathol (2004) 1.22

Preparation of enzymatically active recombinant class III protein deacetylases. Methods (2005) 1.21

A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein. PLoS One (2009) 1.21

HIV latency: experimental systems and molecular models. FEMS Microbiol Rev (2012) 1.19

Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol (2012) 1.18

Dietary restriction: standing up for sirtuins. Science (2010) 1.17

Molecular mechanisms of HIV-1 proviral latency. Expert Rev Anti Infect Ther (2005) 1.16

Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM. Mol Cell Biol (2009) 1.15

Transcriptional suppression of in vitro-integrated human immunodeficiency virus type 1 does not correlate with proviral DNA methylation. J Virol (2003) 1.15

The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS Genet (2005) 1.12

Partial chromosome sequence of Spiroplasma citri reveals extensive viral invasion and important gene decay. Appl Environ Microbiol (2010) 1.12

Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6. Mol Cancer Res (2008) 1.11

Epigenetic regulation of HIV latency. Curr Opin HIV AIDS (2011) 1.10

The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY) (2013) 1.08

Understanding HIV latency: the road to an HIV cure. Annu Rev Med (2015) 1.07

Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. J Biol Chem (2013) 1.07

Reactivation of latent HIV-1 in central memory CD4⁺ T cells through TLR-1/2 stimulation. Retrovirology (2013) 1.06

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. J Med Chem (2006) 1.06

A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. J Biol Chem (2007) 1.05