Long-term outcomes from sepsis.

Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA (2010) 10.82

Epidemiology of severe sepsis. Virulence (2013) 2.26

Increased 1-year healthcare use in survivors of severe sepsis. Am J Respir Crit Care Med (2014) 1.95

The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*. Crit Care Med (2014) 1.55

Hospital-based acute care use in survivors of septic shock. Crit Care Med (2015) 1.34

An artificial intelligence tool to predict fluid requirement in the intensive care unit: a proof-of-concept study. Crit Care (2008) 1.05

Long-term survival and healthcare utilization outcomes attributable to sepsis and pneumonia. BMC Health Serv Res (2012) 1.03

Hypothermia predicts mortality in critically ill elderly patients with sepsis. BMC Geriatr (2010) 0.98

Post-Acute Care Use and Hospital Readmission after Sepsis. Ann Am Thorac Soc (2015) 0.97

Quantification of regulatory T cells in septic patients by real-time PCR-based methylation assay and flow cytometry. PLoS One (2012) 0.96

Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection. J Immunol (2013) 0.95

Model for predicting short-term mortality of severe sepsis. Crit Care (2009) 0.95

Surgical site infections following transcatheter apical aortic valve implantation: incidence and management. J Cardiothorac Surg (2012) 0.94

The effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumonia. PLoS One (2010) 0.90

Anesthesia, surgery, illness and Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry (2012) 0.90

Relevance of Foxp3⁺ regulatory T cells for early and late phases of murine sepsis. Immunology (2015) 0.90

Aggregate evaluable organ dysfunction predicts in-hospital mortality from sepsis in Uganda. Am J Trop Med Hyg (2011) 0.89

Effects of Aging on Inflammation and Hemostasis through the Continuum of Critical Illness. Aging Dis (2011) 0.86

Trends in hospitalizations of patients with sepsis and factors associated with inpatient mortality in the Region of Madrid, 2003–2011. Eur J Clin Microbiol Infect Dis (2014) 0.84

Functional outcomes of general medical patients with severe sepsis. BMC Infect Dis (2013) 0.83

Sepsis-induced long-term immune paralysis - results of a descriptive, explorative study. Crit Care (2016) 0.82

Recognizing and managing sepsis: what needs to be done? BMC Med (2015) 0.79

Cost of surviving sepsis: a novel model of recovery from sepsis in Drosophila melanogaster. Intensive Care Med Exp (2016) 0.76

Isotopic study of L-Arginine kinetics in the lung during pseudomonas sepsis in an ovine model. Int J Burns Trauma (2013) 0.75

The impact of post-operative sepsis on mortality after hospital discharge among elective surgical patients: a population-based cohort study. Crit Care (2017) 0.75

TAT-HSP70 Attenuates Experimental Lung Injury. Shock (2015) 0.75

The clinical and immunological performance of 28 days survival model of cecal ligation and puncture in humanized mice. PLoS One (2017) 0.75

Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56

Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57

Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med (2013) 17.37

A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05

Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. JAMA (2002) 9.89

RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care (2006) 9.29

Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33

The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69

National estimates of severe sepsis in United States emergency departments. Crit Care Med (2007) 5.99

Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65

Nighttime intensivist staffing and mortality among critically ill patients. N Engl J Med (2012) 5.22

Variation in critical care services across North America and Western Europe. Crit Care Med (2008) 5.00

The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med (2002) 4.72

The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64

The effect of multidisciplinary care teams on intensive care unit mortality. Arch Intern Med (2010) 4.41

Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78

Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia. Ann Emerg Med (2008) 3.44

Severe sepsis in pre-hospital emergency care: analysis of incidence, care, and outcome. Am J Respir Crit Care Med (2012) 3.36

The epidemiology of mechanical ventilation use in the United States. Crit Care Med (2010) 3.28

Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18

Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristics. Am J Respir Crit Care Med (2007) 3.17

The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17

Intensive care unit quality improvement: a "how-to" guide for the interdisciplinary team. Crit Care Med (2006) 3.15

Pneumonia: still the old man's friend? Arch Intern Med (2003) 3.12

Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes. Kidney Int (2002) 3.07

Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States. Am J Respir Crit Care Med (2002) 3.02

Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int (2009) 2.97

Prospective meta-analysis using individual patient data in intensive care medicine. Intensive Care Med (2009) 2.93

Organizational characteristics, outcomes, and resource use in 78 Brazilian intensive care units: the ORCHESTRA study. Intensive Care Med (2015) 2.92

Three-year outcomes for Medicare beneficiaries who survive intensive care. JAMA (2010) 2.87

The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med (2006) 2.84

The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. Am J Respir Crit Care Med (2012) 2.72

Trends in the epidemiology of pediatric severe sepsis*. Pediatr Crit Care Med (2013) 2.67

Critical care medicine training and certification for emergency physicians. Ann Emerg Med (2005) 2.67

End-of-life care for the critically ill: A national intensive care unit survey. Crit Care Med (2006) 2.61

Disability among elderly survivors of mechanical ventilation. Am J Respir Crit Care Med (2010) 2.50

Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med (2003) 2.44

Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. Intensive Care Med (2013) 2.44

Prioritizing the organization and management of intensive care services in the United States: the PrOMIS Conference. Crit Care Med (2007) 2.42

Relationship between staff perceptions of hospital norms and hospital-level end-of-life treatment intensity. J Palliat Med (2007) 2.39

Long-term mortality and medical care charges in patients with severe sepsis. Crit Care Med (2003) 2.39

Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. Am J Respir Crit Care Med (2008) 2.37

Is survival better at hospitals with higher "end-of-life" treatment intensity? Med Care (2010) 2.35

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med (2010) 2.31

Survival after liver transplantation in the United States: a disease-specific analysis of the UNOS database. Liver Transpl (2004) 2.31

Growth of intensive care unit resource use and its estimated cost in Medicare. Crit Care Med (2008) 2.31

Severe sepsis epidemiology: sampling, selection, and society. Crit Care (2004) 2.28

Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis. JAMA (2010) 2.27

Perceptions of safety culture vary across the intensive care units of a single institution. Crit Care Med (2007) 2.24

Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA (2014) 2.23

Plasma neutrophil gelatinase-associated lipocalin predicts recovery from acute kidney injury following community-acquired pneumonia. Kidney Int (2011) 2.22

Posttraumatic stress and complicated grief in family members of patients in the intensive care unit. J Gen Intern Med (2008) 2.12

Critical care medicine training and certification for emergency physicians. Crit Care Med (2005) 2.12

Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Crit Care Med (2005) 2.11

Severe sepsis and septic shock. N Engl J Med (2013) 2.10

A comparison of critical care research funding and the financial burden of critical illness in the United States. Crit Care Med (2012) 2.07

Do hospitals provide lower quality of care to black patients for pneumonia? Crit Care Med (2010) 2.07

Forging a critical alliance: Addressing the research needs of the United States critical illness and injury community. Crit Care Med (2009) 2.03

Use of intensive care services during terminal hospitalizations in England and the United States. Am J Respir Crit Care Med (2009) 2.00

Assessing the feasibility of the American College of Surgeons' benchmarks for the triage of trauma patients. Arch Surg (2011) 1.95

Critical care bed growth in the United States. A comparison of regional and national trends. Am J Respir Crit Care Med (2015) 1.93

How does lack of insurance affect use of intensive care? A population-based study. Crit Care Med (2006) 1.92

Temporal changes in management and outcome of septic shock in patients with malignancies in the intensive care unit. Crit Care Med (2008) 1.89

The first international consensus conference on continuous renal replacement therapy. Kidney Int (2002) 1.89

The effects of trauma center care, admission volume, and surgical volume on paralysis after traumatic spinal cord injury. Ann Surg (2009) 1.86

Using simulation to isolate physician variation in intensive care unit admission decision making for critically ill elders with end-stage cancer: a pilot feasibility study. Crit Care Med (2008) 1.81

Influence of comorbid conditions on long-term mortality after pneumonia in older people. J Am Geriatr Soc (2007) 1.79

Physician attitudes toward regionalization of adult critical care: a national survey. Crit Care Med (2009) 1.79

Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum. Crit Care Med (2005) 1.77

Understanding the potential role of statins in pneumonia and sepsis. Crit Care Med (2011) 1.77

Variability in management of early severe sepsis. Emerg Med J (2010) 1.76

Racial variation in end-of-life intensive care use: a race or hospital effect? Health Serv Res (2006) 1.76

Quality of death: assessing the importance placed on end-of-life treatment in the intensive-care unit. Med Care (2004) 1.76

A randomized trial of the effect of patient race on physicians' intensive care unit and life-sustaining treatment decisions for an acutely unstable elder with end-stage cancer. Crit Care Med (2011) 1.75

Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial. Crit Care Med (2004) 1.73

Comparison of Cox and Gray's survival models in severe sepsis. Crit Care Med (2004) 1.72

Differences in immune response may explain lower survival among older men with pneumonia. Crit Care Med (2009) 1.71

Comparison of medical admissions to intensive care units in the United States and United Kingdom. Am J Respir Crit Care Med (2011) 1.69

The lingering consequences of sepsis: a hidden public health disaster? JAMA (2010) 1.67

Informal caregiver burden among survivors of prolonged mechanical ventilation. Am J Respir Crit Care Med (2006) 1.64

Access to urban acute care services in high- vs. middle-income countries: an analysis of seven cities. Intensive Care Med (2013) 1.64

Development and validation of hospital "end-of-life" treatment intensity measures. Med Care (2009) 1.58

Reassessing the value of short-term mortality in sepsis: comparing conventional approaches to modeling. Crit Care Med (2003) 1.57

Accuracy of prehospital transport time estimation. Acad Emerg Med (2014) 1.56

No child left behind: Enrolling children and adults simultaneously in critical care randomized trials. Crit Care Med (2009) 1.56

Drotrecogin alfa (activated) treatment of older patients with severe sepsis. Clin Infect Dis (2003) 1.54

Mortality among patients admitted to strained intensive care units. Am J Respir Crit Care Med (2013) 1.53

Serum biomarkers of brain injury to classify outcome after pediatric cardiac arrest*. Crit Care Med (2014) 1.52

Testing protocols in the intensive care unit: complex trials of complex interventions for complex patients. JAMA (2008) 1.51

Trial of shift scheduling with standardized sign-out to improve continuity of care in intensive care units. Crit Care Med (2012) 1.51

Intensive care unit safety culture and outcomes: a US multicenter study. Int J Qual Health Care (2010) 1.50

Potential value of regionalized intensive care for mechanically ventilated medical patients. Am J Respir Crit Care Med (2007) 1.47

Use of Intensive Care Services for Medicare Beneficiaries Undergoing Major Surgical Procedures. Anesthesiology (2016) 1.47

A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsis. Shock (2008) 1.47

Open source clinical science for emerging infections. Lancet Infect Dis (2014) 1.47

Reorganizing adult critical care delivery: the role of regionalization, telemedicine, and community outreach. Am J Respir Crit Care Med (2010) 1.46

A clinically based discrete-event simulation of end-stage liver disease and the organ allocation process. Med Decis Making (2005) 1.45

Organizational determinants of hospital end-of-life treatment intensity. Med Care (2009) 1.45

Protocolized Care for Early Septic Shock (ProCESS) statistical analysis plan. Crit Care Resusc (2013) 1.45

Infection hospitalization increases risk of dementia in the elderly. Crit Care Med (2014) 1.43