Published in J Am Coll Cardiol on March 15, 2016
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality. Nat Rev Cardiol (2017) 0.90
Commentary: Two-sample Mendelian randomization: opportunities and challenges. Int J Epidemiol (2016) 0.77
Pharmacometabolomics Meets Genetics: A "Natural" Clinical Trial of Statin Effects. J Am Coll Cardiol (2016) 0.76
Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids. Cardiovasc Diabetol (2016) 0.75
Metabolic profiling-multitude of technologies with great research potential, but (when) will translation emerge? Int J Epidemiol (2016) 0.75
Applying metabolomics to cardiometabolic intervention studies and trials: past experiences and a roadmap for the future. Int J Epidemiol (2016) 0.75
The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study. Diabetologia (2017) 0.75
The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet (2012) 17.29
2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2013) 17.18
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol (2003) 16.71
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07
Cohort Profile: the 'children of the 90s'--the index offspring of the Avon Longitudinal Study of Parents and Children. Int J Epidemiol (2012) 11.79
Application of new cholesterol guidelines to a population-based sample. N Engl J Med (2014) 8.22
Cohort Profile: the Whitehall II study. Int J Epidemiol (2004) 7.63
Cohort Profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort. Int J Epidemiol (2012) 6.91
Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation (2011) 6.36
Remnant cholesterol as a causal risk factor for ischemic heart disease. J Am Coll Cardiol (2012) 5.12
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet (2012) 4.08
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet (2014) 3.94
Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. PLoS Med (2007) 3.71
Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: a 2 × 2 factorial Mendelian randomization study. J Am Coll Cardiol (2015) 3.27
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. Trends Mol Med (2008) 2.68
Pleiotropic effects of statins: benefit beyond cholesterol reduction? A meta-regression analysis. J Am Coll Cardiol (2005) 2.67
Circulating omega-6 polyunsaturated fatty acids and total and cause-specific mortality: the Cardiovascular Health Study. Circulation (2014) 2.63
Cohort profile: the cardiovascular risk in Young Finns Study. Int J Epidemiol (2008) 2.51
High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst (2009) 2.49
Triglycerides and cardiovascular disease. Lancet (2014) 2.04
GlycA: A Composite Nuclear Magnetic Resonance Biomarker of Systemic Inflammation. Clin Chem (2015) 1.95
Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons. PLoS Med (2014) 1.60
Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change. PLoS Med (2014) 1.42
Lipoprotein subclass profiling reveals pleiotropy in the genetic variants of lipid risk factors for coronary heart disease: a note on Mendelian randomization studies. J Am Coll Cardiol (2013) 1.35
Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics. Circ Cardiovasc Genet (2015) 1.32
Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts. Circulation (2015) 1.25
Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. Circulation (2009) 1.20
Fatty acid composition of plasma, blood cells and whole blood: relevance for the assessment of the fatty acid status in humans. Prostaglandins Leukot Essent Fatty Acids (2007) 1.09
Effects of pravastatin treatment on lipoprotein subclass profiles and particle size in the PLAC-I trial. Atherosclerosis (2002) 1.08
Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study. Diabetologia (2015) 1.07
LDL cholesterol: controversies and future therapeutic directions. Lancet (2014) 1.06
Physical activity and obesity mediate the association between childhood motor function and adolescents' academic achievement. Proc Natl Acad Sci U S A (2012) 1.05
Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men: a randomized controlled trial. Arterioscler Thromb Vasc Biol (2005) 1.01
Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients. Prostaglandins Leukot Essent Fatty Acids (2004) 1.00
Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men. Diabetes (2013) 0.92
Serum Nuclear Magnetic Resonance Spectroscopy: One More Step toward Clinical Utility. Clin Chem (2015) 0.89
Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet (2014) 5.78
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol (2014) 2.10
Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet (2014) 1.71
Pre-angioplasty instantaneous wave-free ratio pullback provides virtual intervention and predicts hemodynamic outcome for serial lesions and diffuse coronary artery disease. JACC Cardiovasc Interv (2014) 1.64
The genetic architecture of type 2 diabetes. Nature (2016) 1.43
Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change. PLoS Med (2014) 1.42
Molecular mechanisms underlying variations in lung function: a systems genetics analysis. Lancet Respir Med (2015) 1.40
Sleep Duration and Risk of Type 2 Diabetes. Pediatrics (2017) 1.39
Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease. PLoS Genet (2016) 1.39
Association of Cardiometabolic Multimorbidity With Mortality. JAMA (2015) 1.32
The impact of low-frequency and rare variants on lipid levels. Nat Genet (2015) 1.20
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet (2016) 1.08
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus. PLoS Genet (2015) 1.08
Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nat Genet (2014) 1.07
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nat Genet (2016) 1.02
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry (2014) 1.01
Vigorous physical activity and carotid distensibility in young and mid-aged adults. Hypertens Res (2015) 0.90
Troponin I and cardiovascular risk prediction in the general population: the BiomarCaRE consortium. Eur Heart J (2016) 0.87
Errors of Fact in the Recent Article by Westerhof, Segers, and Westerhof. Hypertension (2015) 0.86
Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits. Diabetes (2014) 0.86
A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism. PLoS Genet (2015) 0.86
Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet (2015) 0.84
Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat Genet (2016) 0.84
Phenotype refinement strengthens the association of AHR and CYP1A1 genotype with caffeine consumption. PLoS One (2014) 0.82
Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium. PLoS One (2016) 0.82
Comparison of PCSK9 Inhibitor Evolocumab vs Ezetimibe in Statin-Intolerant Patients: Design of the Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin-Intolerant Subjects 3 (GAUSS-3) Trial. Clin Cardiol (2016) 0.82
Customised and Noncustomised Birth Weight Centiles and Prediction of Stillbirth and Infant Mortality and Morbidity: A Cohort Study of 979,912 Term Singleton Pregnancies in Scotland. PLoS Med (2017) 0.81
Childhood predictors of adult fatty liver. The Cardiovascular Risk in Young Finns Study. J Hepatol (2016) 0.81
Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence. Int J Epidemiol (2016) 0.81
metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis. Bioinformatics (2016) 0.81
Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. Sci Rep (2016) 0.81
NT-proBNP and the risk of dementia: a prospective cohort study with 14 years of follow-up. J Alzheimers Dis (2015) 0.80
Prognosis of acute coronary events is worse in patients living alone: the FINAMI myocardial infarction register. Eur J Prev Cardiol (2013) 0.80
Lifetime measures of ideal cardiovascular health and their association with subclinical atherosclerosis: The Cardiovascular Risk in Young Finns Study. Int J Cardiol (2015) 0.79
Metabolic profiling of alcohol consumption in 9778 young adults. Int J Epidemiol (2016) 0.78
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nat Genet (2017) 0.77
Metabolic signatures of birthweight in 18 288 adolescents and adults. Int J Epidemiol (2016) 0.77
Serum tissue-degrading proteinases and incident cardiovascular disease events. Eur J Prev Cardiol (2012) 0.77
Abnormal splicing of NEDD4 in myotonic dystrophy type 2: possible link to statin adverse reactions. Am J Pathol (2014) 0.77
Novel Diabetes Drugs and the Cardiovascular Specialist. J Am Coll Cardiol (2017) 0.77
Life Course Socioeconomic Position: Associations with Cardiac Structure and Function at Age 60-64 Years in the 1946 British Birth Cohort. PLoS One (2016) 0.76
Exploring causality between TV viewing and weight change in young and middle-aged adults. The Cardiovascular Risk in Young Finns study. PLoS One (2014) 0.76
Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC Med (2016) 0.76
Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet (2015) 0.76
Lipoprotein(a) and the risk of cardiovascular disease in the European population: results from the BiomarCaRE consortium. Eur Heart J (2017) 0.76
Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure. J Am Heart Assoc (2017) 0.76
The relation of rapid changes in obesity measures to lipid profile - insights from a nationwide metabolic health survey in 444 Polish cities. PLoS One (2014) 0.75
Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: a cross-sectional analysis in population-based data. Int J Epidemiol (2016) 0.75
Hypertensive Disorders of Pregnancy and Offspring Cardiac Structure and Function in Adolescence. J Am Heart Assoc (2016) 0.75
Poor Adherence to Statin and Antihypertensive Therapies as Risk Factors for Fatal Stroke. J Am Coll Cardiol (2016) 0.75
Early Antenatal Prediction of Gestational Diabetes in Obese Women: Development of Prediction Tools for Targeted Intervention. PLoS One (2016) 0.75
The Contribution of GWAS Loci in Familial Dyslipidemias. PLoS Genet (2016) 0.75
Effects of Tumour Necrosis Factor Antagonists on Insulin Sensitivity/Resistance in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. PLoS One (2015) 0.75
Low MMP-8/TIMP-1 reflects left ventricle impairment in takotsubo cardiomyopathy and high TIMP-1 may help to differentiate it from acute coronary syndrome. PLoS One (2017) 0.75
Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts. PLoS One (2017) 0.75
Prediction of sudden cardiac death with automated high-throughput analysis of heterogeneity in standard resting 12-lead electrocardiograms. Heart Rhythm (2015) 0.75
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Med (2017) 0.75
Evidence for large-scale gene-by-smoking interaction effects on pulmonary function. Int J Epidemiol (2017) 0.75
Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer. Int J Cancer (2017) 0.75
Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance: The Young Finns Study. J Am Coll Cardiol (2017) 0.75
Role of Conventional Childhood Risk Factors Versus Genetic Risk in the Development of Type 2 Diabetes and Impaired Fasting Glucose in Adulthood: The Cardiovascular Risk in Young Finns Study. Diabetes Care (2016) 0.75
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. Nat Genet (2017) 0.75
Aortic sinus diameter in middle age is associated with body size in young adulthood. Heart (2017) 0.75
Incidence rates, correlates, and prognosis of electrocardiographic P-wave abnormalities - a nationwide population-based study. J Electrocardiol (2017) 0.75
Associations of night-time road traffic noise with carotid intima-media thickness and blood pressure: The Whitehall II and SABRE study cohorts. Environ Int (2016) 0.75
Soluble HLA-DR serum levels are associated with smoking but not with acute coronary syndrome. Atherosclerosis (2017) 0.75
Cardiovascular risk prediction in children and adolescents. Clin Biochem (2014) 0.75
High-Sensitivity Cardiac Troponin Concentration and Risk of First-Ever Cardiovascular Outcomes in 154,052 Participants. J Am Coll Cardiol (2017) 0.75
High-sensitivity cardiac troponin I and NT-proBNP as predictors of incident dementia and Alzheimer's disease: the FINRISK Study. J Neurol (2016) 0.75
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe). Circulation (2017) 0.75