Published in Hum Mol Genet on July 04, 2014
An atlas of genetic correlations across human diseases and traits. Nat Genet (2015) 3.90
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol (2015) 2.78
Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study. PLoS Med (2015) 2.40
Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). Hum Mol Genet (2014) 1.58
G = E: What GWAS Can Tell Us about the Environment. PLoS Genet (2016) 1.57
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet (2016) 1.52
Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change. PLoS Med (2014) 1.42
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. Genet Epidemiol (2016) 1.35
Detection and interpretation of shared genetic influences on 42 human traits. Nat Genet (2016) 1.32
Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: application to alcohol and cardiovascular traits. Int J Epidemiol (2014) 1.09
Epigenome-wide Association Studies and the Interpretation of Disease -Omics. PLoS Genet (2016) 1.05
Adiposity as a cause of cardiovascular disease: a Mendelian randomization study. Int J Epidemiol (2015) 1.04
Using Mendelian randomization to investigate a possible causal relationship between adiposity and increased bone mineral density at different skeletal sites in children. Int J Epidemiol (2016) 1.00
Genetic Obesity and the Risk of Atrial Fibrillation- Causal Estimates from Mendelian Randomization. Circulation (2016) 1.00
Systematic identification of genetic influences on methylation across the human life course. Genome Biol (2016) 1.00
Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic. Int J Epidemiol (2016) 0.98
Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies. Am J Clin Nutr (2016) 0.98
The many weak instruments problem and Mendelian randomization. Stat Med (2014) 0.97
Approaches for drawing causal inferences from epidemiological birth cohorts: a review. Early Hum Dev (2014) 0.95
Assessing the Causal Relationship of Maternal Height on Birth Size and Gestational Age at Birth: A Mendelian Randomization Analysis. PLoS Med (2015) 0.95
DNA Methylation Variants at HIF3A Locus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts. Diabetes (2015) 0.93
Blood lipids influence DNA methylation in circulating cells. Genome Biol (2016) 0.91
An Expanded View of Complex Traits: From Polygenic to Omnigenic. Cell (2017) 0.91
DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework. Diabetes (2016) 0.90
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality. Nat Rev Cardiol (2017) 0.90
Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environ Health Perspect (2017) 0.90
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun (2016) 0.88
The role of common genetic variation in educational attainment and income: evidence from the National Child Development Study. Sci Rep (2015) 0.87
MR-PheWAS: hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization. Sci Rep (2015) 0.86
Association of IL-6 and a functional polymorphism in the IL-6 gene with cardiovascular events in patients with CKD. Clin J Am Soc Nephrol (2014) 0.86
Selecting instruments for Mendelian randomization in the wake of genome-wide association studies. Int J Epidemiol (2016) 0.85
BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization. Diabetes (2016) 0.84
The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium. Cancer Causes Control (2015) 0.84
Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses. Alzheimers Dement (2015) 0.83
Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study. EBioMedicine (2016) 0.83
Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology. J Lipid Res (2016) 0.83
Challenges and novel approaches for investigating molecular mediation. Hum Mol Genet (2016) 0.82
The Human Blood Metabolome-Transcriptome Interface. PLoS Genet (2015) 0.82
Exploring causal associations of alcohol with cardiovascular and metabolic risk factors in a Chinese population using Mendelian randomization analysis. Sci Rep (2015) 0.81
Assessing causality in associations between cannabis use and schizophrenia risk: a two-sample Mendelian randomization study. Psychol Med (2016) 0.81
Assessing the Genetic Predisposition of Education on Myopia: A Mendelian Randomization Study. Genet Epidemiol (2015) 0.81
Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci. PLoS Genet (2016) 0.80
Genetic Relationship between Schizophrenia and Nicotine Dependence. Sci Rep (2016) 0.80
Mendelian Randomization and Type 2 Diabetes. Cardiovasc Drugs Ther (2016) 0.79
Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study. Sci Rep (2015) 0.79
From stem cells to the law courts: DNA methylation, the forensic epigenome and the possibility of a biosocial archive. Int J Epidemiol (2015) 0.79
Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits. Am J Hum Genet (2017) 0.79
Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort. BMC Med (2016) 0.79
Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort, with a systematic review and meta-analysis. Int J Epidemiol (2016) 0.78
Genomics of Cancer and a New Era for Cancer Prevention. PLoS Genet (2015) 0.78
Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization. Sci Rep (2016) 0.78
The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study. Sci Rep (2016) 0.77
Assessing the genetic overlap between BMI and cognitive function. Mol Psychiatry (2016) 0.77
Mendelian Randomization as an Approach to Assess Causality Using Observational Data. J Am Soc Nephrol (2016) 0.77
Time to target uric acid to retard CKD progression. Clin Exp Nephrol (2016) 0.77
Dietary fat intake and reproductive hormone concentrations and ovulation in regularly menstruating women. Am J Clin Nutr (2016) 0.77
Using human genetics to make new medicines. Nat Rev Genet (2015) 0.77
Mendelian randomization: applications and limitations in epigenetic studies. Epigenomics (2015) 0.77
Commentary: Two-sample Mendelian randomization: opportunities and challenges. Int J Epidemiol (2016) 0.77
Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors. Am J Hum Genet (2016) 0.77
Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis. BMC Med Genet (2015) 0.76
Metabolomics in epidemiology: from metabolite concentrations to integrative reaction networks. Int J Epidemiol (2016) 0.76
Genetic determinants of serum vitamin B12 and their relation to body mass index. Eur J Epidemiol (2016) 0.76
Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study. PLoS Med (2017) 0.76
Osteoarthritis and bone mineral density: are strong bones bad for joints? Bonekey Rep (2015) 0.76
How to make DNA methylome wide association studies more powerful. Epigenomics (2016) 0.76
A Genetic Biomarker of Oxidative Stress, the Paraoxonase-1 Q192R Gene Variant, Associates with Cardiomyopathy in CKD: A Longitudinal Study. Oxid Med Cell Longev (2016) 0.75
Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study. PLoS One (2017) 0.75
Smoking and diabetes: strengthening causal inference. Lancet Diabetes Endocrinol (2015) 0.75
Associations between smoking and caffeine consumption in two European cohorts. Addiction (2016) 0.75
Is there a causal role for homocysteine concentration in blood pressure? A Mendelian randomization study. Am J Clin Nutr (2015) 0.75
A significant causal association between C-reactive protein levels and schizophrenia. Sci Rep (2016) 0.75
Contrasting the effects of intra-uterine smoking and one-carbon micronutrient exposures on offspring DNA methylation. Epigenomics (2017) 0.75
Association between cognition and gene polymorphisms involved in thrombosis and haemostasis. Age (Dordr) (2015) 0.75
Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study. Int J Cancer (2016) 0.75
Exploration of a Polygenic Risk Score for Alcohol Consumption: A Longitudinal Analysis from the ALSPAC Cohort. PLoS One (2016) 0.75
International cancer seminars: a focus on kidney cancer. Ann Oncol (2016) 0.75
Schizophrenia and neighbourhood deprivation. Transl Psychiatry (2016) 0.75
Mixing omics: combining genetics and metabolomics to study rheumatic diseases. Nat Rev Rheumatol (2017) 0.75
Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels. Int J Cancer (2016) 0.75
Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. Am J Clin Nutr (2014) 0.75
Tobacco smoking and smoking-related DNA methylation are associated with the development of frailty among older adults. Epigenetics (2016) 0.75
Estimating Marginal Healthcare Costs Using Genetic Variants as Instrumental Variables: Mendelian Randomization in Economic Evaluation. Pharmacoeconomics (2016) 0.75
Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them. Wellcome Open Res (2017) 0.75
Smoking and caffeine consumption: a genetic analysis of their association. Addict Biol (2016) 0.75
Attention Deficit Hyperactivity Disorder Symptoms and Low Educational Achievement: Evidence Supporting A Causal Hypothesis. Behav Genet (2017) 0.75
The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases. J Lipid Res (2017) 0.75
Metabolic profiling-multitude of technologies with great research potential, but (when) will translation emerge? Int J Epidemiol (2016) 0.75
Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis. J Thromb Haemost (2017) 0.75
Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nat Commun (2017) 0.75
Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment. Pharmacogenomics (2016) 0.75
Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies. Eur J Epidemiol (2017) 0.75
Heritability of the affective response to exercise and its correlation to exercise behavior. Psychol Sport Exerc (2016) 0.75
Meat Consumption During Pregnancy and Substance Misuse Among Adolescent Offspring: Stratification of TCN2 Genetic Variants. Alcohol Clin Exp Res (2017) 0.75
Nature as a trialist? Deconstructing the analogy between Mendelian Randomization and randomized trials. Epidemiology (2017) 0.75
Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis. Eur J Cancer (2017) 0.75
Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general population. Int J Epidemiol (2016) 0.75
Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study. Hum Genet (2017) 0.75
Body Mass Index and Risk of Alzheimer Disease: a Mendelian Randomization Study of 399,536 Individuals J Clin Endocrinol Metab (2017) 0.75
Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk. Am J Hum Genet (2017) 0.75
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med (2007) 18.78
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol (2003) 16.71
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med (2008) 9.39
Discovery and refinement of loci associated with lipid levels. Nat Genet (2013) 7.86
Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol (2004) 5.07
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis. J Am Coll Cardiol (2012) 4.56
Evolutionary developmental biology and the problem of variation. Evolution (2000) 3.99
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. PLoS Med (2007) 3.71
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Pleiotropy in complex traits: challenges and strategies. Nat Rev Genet (2013) 3.65
Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. BMJ (2011) 3.65
The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms. Nat Rev Genet (2011) 3.57
The impact of residual and unmeasured confounding in epidemiologic studies: a simulation study. Am J Epidemiol (2007) 3.40
How independent are "independent" effects? Relative risk estimation when correlated exposures are measured imprecisely. J Clin Epidemiol (1991) 3.37
The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr (2008) 3.18
Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? Hum Genet (2007) 3.13
Mendelian randomisation and causal inference in observational epidemiology. PLoS Med (2008) 3.12
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Data dredging, bias, or confounding. BMJ (2002) 2.87
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. Circ Cardiovasc Genet (2010) 2.76
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med (2013) 2.73
Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach. PLoS Med (2008) 2.61
Assessing intrauterine influences on offspring health outcomes: can epidemiological studies yield robust findings? Basic Clin Pharmacol Toxicol (2008) 2.59
Pleiotropic scaling of gene effects and the 'cost of complexity'. Nature (2008) 2.50
Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts. BMJ (2013) 2.41
Efficient design for Mendelian randomization studies: subsample and 2-sample instrumental variable estimators. Am J Epidemiol (2013) 2.38
Folate supplementation and cardiovascular disease. Lancet (2005) 2.36
A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk. Cell (2013) 2.28
Effect of body mass index and alcohol consumption on liver disease: analysis of data from two prospective cohort studies. BMJ (2010) 2.24
Genomic patterns of pleiotropy and the evolution of complexity. Proc Natl Acad Sci U S A (2010) 2.19
Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable. PLoS Med (2008) 2.16
Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease. Int J Epidemiol (2012) 2.12
Epidemiology--is it time to call it a day? Int J Epidemiol (2001) 2.12
Design, analysis and presentation of factorial randomised controlled trials. BMC Med Res Methodol (2003) 2.10
The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach. PLoS Med (2012) 2.09
Use of allele scores as instrumental variables for Mendelian randomization. Int J Epidemiol (2013) 2.06
Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype. Hypertension (2009) 2.01
How does body fat influence bone mass in childhood? A Mendelian randomization approach. J Bone Miner Res (2009) 2.01
One hundred years of pleiotropy: a retrospective. Genetics (2010) 1.91
Commentary: The seven plagues of epigenetic epidemiology. Int J Epidemiol (2012) 1.88
Toward a molecular understanding of pleiotropy. Genetics (2006) 1.88
From promises to practical strategies in epigenetic epidemiology. Nat Rev Genet (2013) 1.82
Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health. Genes Nutr (2010) 1.65
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Methodological challenges in mendelian randomization. Epidemiology (2014) 1.61
C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. Int J Obes (Lond) (2010) 1.53
Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study. Circulation (2003) 1.52
Mendelian randomization of blood lipids for coronary heart disease. Eur Heart J (2014) 1.51
Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002. Diabetologia (2007) 1.45
Calculating statistical power in Mendelian randomization studies. Int J Epidemiol (2013) 1.41
Random allocation in observational data: how small but robust effects could facilitate hypothesis-free causal inference. Epidemiology (2011) 1.38
Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach. J Clin Endocrinol Metab (2009) 1.27
Mendelian randomization analysis of case-control data using structural mean models. Stat Med (2010) 1.20
Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis. PLoS Med (2014) 1.19
Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study. PLoS Med (2013) 1.18
Negative control exposures in epidemiologic studies. Epidemiology (2012) 1.16
Quantification of bias in direct effects estimates due to different types of measurement error in the mediator. Epidemiology (2012) 1.11
The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study. Psychol Med (2012) 1.08
The role of measurement error and misclassification in mediation analysis: mediation and measurement error. Epidemiology (2012) 1.07
Prenatal alcohol exposure and offspring cognition and school performance. A 'Mendelian randomization' natural experiment. Int J Epidemiol (2013) 1.04
Elevated body mass index as a causal risk factor for symptomatic gallstone disease: a Mendelian randomization study. Hepatology (2013) 1.04
Misclassification of the mediator matters when estimating indirect effects. J Epidemiol Community Health (2013) 1.02
What are the key arguments against uric acid as a true risk factor for hypertension? Hypertension (2013) 1.00
Smoking is associated with, but does not cause, depressed mood in pregnancy--a mendelian randomization study. PLoS One (2011) 0.98
Usefulness of Mendelian randomization in observational epidemiology. Int J Environ Res Public Health (2010) 0.97
Mining the human phenome using allelic scores that index biological intermediates. PLoS Genet (2013) 0.94
Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach. PLoS One (2012) 0.94
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The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population. Nephrol Dial Transplant (2011) 0.89
Mendelian randomization: application to cardiovascular disease. Curr Hypertens Rep (2012) 0.88
Causal inference of gene regulation with subnetwork assembly from genetical genomics data. Nucleic Acids Res (2013) 0.81
Causal relationship between body mass index and fetuin-A level in the asian population: a bidirectional Mendelian randomization study. Clin Endocrinol (Oxf) (2013) 0.81