Published in Circ Res on January 17, 2008
Origin and function of myofibroblasts in kidney fibrosis. Nat Med (2013) 4.55
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med (2013) 3.35
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J (2009) 2.10
The vascular basement membrane as "soil" in brain metastasis. PLoS One (2009) 1.95
Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J Clin Invest (2009) 1.56
Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction. FEBS J (2010) 1.53
Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development (2010) 1.42
Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice. Development (2008) 1.41
Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation. Mol Cell (2013) 1.17
Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling. EMBO J (2009) 1.15
The role of stromal myofibroblast and extracellular matrix in tumor angiogenesis. Genes Cancer (2011) 1.14
Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis. Development (2011) 1.13
Characterization of Pdgfrb-Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries. Genesis (2011) 1.12
Integrins as "functional hubs" in the regulation of pathological angiogenesis. Semin Cancer Biol (2009) 1.05
CCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling. J Cell Biol (2013) 1.03
Dynamical systems approach to endothelial heterogeneity. Circ Res (2012) 1.03
Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction. Genes Dev (2009) 1.01
Targeting pericyte differentiation as a strategy to modulate kidney fibrosis in diabetic nephropathy. Semin Nephrol (2012) 1.00
Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation. Dev Biol (2014) 0.94
Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke. J Cell Biol (2013) 0.93
Regulation of vascular integrity. J Mol Med (Berl) (2009) 0.92
Brain pericytes: emerging concepts and functional roles in brain homeostasis. Cell Mol Neurobiol (2011) 0.91
When Cre-mediated recombination in mice does not result in protein loss. Genetics (2010) 0.90
An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall. Dev Biol (2012) 0.87
Decellularized matrix from tumorigenic human mesenchymal stem cells promotes neovascularization with galectin-1 dependent endothelial interaction. PLoS One (2011) 0.85
Dysfunction of brain pericytes in chronic neuroinflammation. J Cereb Blood Flow Metab (2015) 0.83
Integrin β1 is required for maintenance of vascular tone in postnatal mice. J Cell Commun Signal (2012) 0.81
Endoglin regulates mural cell adhesion in the circulatory system. Cell Mol Life Sci (2015) 0.79
β1-integrin is essential for vasoregulation and smooth muscle survival in vivo. Arterioscler Thromb Vasc Biol (2013) 0.79
In vitro proliferation and osteogenic differentiation of mesenchymal stem cells on nanoporous alumina. Int J Nanomedicine (2013) 0.79
Cyclic guanosine monophosphate-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells. Mol Biol Cell (2008) 0.78
The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes. Elife (2017) 0.76
Toward an integrative analysis of the tumor microenvironment in ovarian epithelial carcinoma. Cancer Microenviron (2011) 0.75
Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin). Hypertension (2017) 0.75
Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins. Genesis (2016) 0.75
Epithelial cell integrin β1 is required for developmental angiogenesis in the pituitary gland. Proc Natl Acad Sci U S A (2016) 0.75
Mural-Endothelial cell-cell interactions stabilize the developing zebrafish dorsal aorta. Development (2016) 0.75
The cell-matrix interface: a possible target for treating retinal vascular related pathologies. J Ophthalmic Vis Res (2012) 0.75
Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability. Nat Mater (2017) 0.75
Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2008) 7.28
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell (2009) 5.33
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell (2008) 5.02
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature (2010) 4.85
ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol (2006) 4.64
Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med (2008) 4.55
The tail of integrins, talin, and kindlins. Science (2009) 4.51
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell (2006) 4.43
Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev (2009) 3.57
Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell (2006) 3.51
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med (2013) 3.35
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev (2005) 3.29
Kindlin-2 controls bidirectional signaling of integrins. Genes Dev (2008) 3.15
Regulation of vascular morphogenesis by Notch signaling. Genes Dev (2007) 3.10
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell (2006) 3.10
Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med (2009) 2.85
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest (2008) 2.77
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev (2003) 2.68
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med (2006) 2.59
EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting. Cell (2010) 2.54
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments. Nat Cell Biol (2013) 2.52
Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat Cell Biol (2008) 2.46
Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation. Dev Cell (2012) 2.45
Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities. Development (2004) 2.44
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med (2007) 2.43
Hippocampal plasticity requires postsynaptic ephrinBs. Nat Neurosci (2003) 2.37
The Kindlins: subcellular localization and expression during murine development. Exp Cell Res (2006) 2.36
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. Neuron (2003) 2.31
Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails. J Cell Sci (2009) 2.29
The integrin-actin connection, an eternal love affair. EMBO J (2003) 2.26
Dynamics of endothelial cell behavior in sprouting angiogenesis. Curr Opin Cell Biol (2010) 2.22
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev (2003) 2.21
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell (2010) 2.17
Regulation of angiogenesis by Eph-ephrin interactions. Trends Cardiovasc Med (2007) 2.15
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature (2012) 2.13
Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice. Nat Protoc (2010) 2.12
Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell (2003) 2.11
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J (2009) 2.10
Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Mol Cell Biol (2005) 2.10
DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood (2009) 2.07
The role of laminin in embryonic cell polarization and tissue organization. Dev Cell (2003) 2.05
Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood (2010) 2.04
Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance. Development (2004) 2.04
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron (2007) 2.01
The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell (2010) 2.01
Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell (2007) 2.00
Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin. Cell Stem Cell (2008) 1.98
Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice. Circ Res (2002) 1.96
Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO Rep (2011) 1.96
Integrins in invasive growth. J Clin Invest (2002) 1.96
The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr Opin Cell Biol (2008) 1.89
Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89
Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C. Nature (2004) 1.88
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol (2007) 1.81
Mutations of the ephrin-B1 gene cause craniofrontonasal syndrome. Am J Hum Genet (2004) 1.78
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. PLoS Genet (2008) 1.78
ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med (2006) 1.75
Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proc Natl Acad Sci U S A (2003) 1.74
Genetic analysis of beta1 integrin "activation motifs" in mice. J Cell Biol (2006) 1.73
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol (2010) 1.72
Pathogenesis of arteriovenous malformations in the absence of endoglin. Circ Res (2010) 1.70
Integrin trafficking regulated by Rab21 is necessary for cytokinesis. Dev Cell (2008) 1.70
Laminin: the crux of basement membrane assembly. J Cell Biol (2004) 1.69
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res (2008) 1.68
A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy. J Clin Invest (2008) 1.67
Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev (2010) 1.64
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood (2012) 1.64
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol (2007) 1.63
Integrin-linked kinase regulates chondrocyte shape and proliferation. EMBO Rep (2003) 1.63
Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB J (2005) 1.61
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest (2014) 1.59
Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. J Exp Med (2009) 1.59
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J (2013) 1.58
The Kindlin protein family: new members to the club of focal adhesion proteins. Trends Cell Biol (2009) 1.57
Cylindroma as tumor of hair follicle origin. J Invest Dermatol (2006) 1.56
Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature (2009) 1.55
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest (2010) 1.54
Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis. Mol Cell Biol (2003) 1.54
Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol (2007) 1.53
Targeted disruption of the murine zyxin gene. Mol Cell Biol (2003) 1.51
Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail. Nat Cell Biol (2012) 1.48
Cartilage oligomeric matrix protein-deficient mice have normal skeletal development. Mol Cell Biol (2002) 1.48
Genetic analyses of integrin signaling. Cold Spring Harb Perspect Biol (2011) 1.46
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. Nature (2009) 1.45
A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1. Nat Genet (2004) 1.39
Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity (2002) 1.38
Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape. J Cell Sci (2008) 1.38
Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts. Dev Biol (2006) 1.37
Regulation of neural progenitor proliferation and survival by beta1 integrins. J Cell Sci (2005) 1.34
PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage. J Cell Sci (2005) 1.34
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. J Cell Biol (2009) 1.33
Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function. EMBO J (2007) 1.32
Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest (2013) 1.32
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption. J Cell Biol (2011) 1.32
Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Mol Cell Biol (2002) 1.31
Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. FASEB J (2003) 1.28
Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci U S A (2009) 1.27
beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development (2009) 1.27