Published in Trends Cell Biol on September 18, 2009
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat Cell Biol (2011) 4.59
Recreation of the terminal events in physiological integrin activation. J Cell Biol (2010) 2.48
The FERM domain: organizing the structure and function of FAK. Nat Rev Mol Cell Biol (2010) 2.23
The tail of integrin activation. Trends Biochem Sci (2011) 1.62
Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail. Nat Cell Biol (2012) 1.48
Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation. Nat Med (2014) 1.22
Central region of talin has a unique fold that binds vinculin and actin. J Biol Chem (2010) 1.21
The integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafish. Blood (2011) 1.14
Prostaglandins in cancer cell adhesion, migration, and invasion. Int J Cell Biol (2012) 1.09
Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition. J Cell Biol (2011) 1.09
Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-C kinase 1 (RACK1). J Biol Chem (2012) 1.09
Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network. J Cell Biol (2015) 1.07
Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem (2012) 1.07
Kindlin-2 regulates hemostasis by controlling endothelial cell-surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism. Blood (2013) 1.06
Kindlin-2 mediates activation of TGF-β/Smad signaling and renal fibrosis. J Am Soc Nephrol (2013) 1.05
Cell-matrix adhesion of podocytes in physiology and disease. Nat Rev Nephrol (2013) 1.02
Integrins and integrin-associated proteins in the cardiac myocyte. Circ Res (2014) 1.00
A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation. J Biol Chem (2012) 0.97
A molecular mechanism for the requirement of PAT-4 (integrin-linked kinase (ILK)) for the localization of UNC-112 (Kindlin) to integrin adhesion sites. J Biol Chem (2012) 0.93
Kindlin-1 and -2 have overlapping functions in epithelial cells implications for phenotype modification. Am J Pathol (2011) 0.92
Mechanotransduction at focal adhesions: integrating cytoskeletal mechanics in migrating cells. J Cell Mol Med (2013) 0.92
Epithelial integrins with special reference to oral epithelia. J Dent Res (2011) 0.90
Biophysical analysis of Kindlin-3 reveals an elongated conformation and maps integrin binding to the membrane-distal β-subunit NPXY motif. J Biol Chem (2012) 0.90
Functional differences between kindlin-1 and kindlin-2 in keratinocytes. J Cell Sci (2012) 0.90
IL-1β enhances cell adhesion to degraded fibronectin. FASEB J (2012) 0.89
Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis. Nat Commun (2015) 0.87
The integrin β1 subunit regulates paracellular permeability of kidney proximal tubule cells. J Biol Chem (2014) 0.86
Stromal regulation of embryonic and postnatal mammary epithelial development and differentiation. Semin Cell Dev Biol (2014) 0.86
Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice. Arterioscler Thromb Vasc Biol (2014) 0.86
The kindlin 3 pleckstrin homology domain has an essential role in lymphocyte function-associated antigen 1 (LFA-1) integrin-mediated B cell adhesion and migration. J Biol Chem (2013) 0.85
A kinetic model for RNA-interference of focal adhesions. BMC Syst Biol (2013) 0.85
A role of kindlin-3 in integrin αMβ2 outside-in signaling and the Syk-Vav1-Rac1/Cdc42 signaling axis. PLoS One (2013) 0.85
Podocyte-actin dynamics in health and disease. Nat Rev Nephrol (2016) 0.85
Focal Contact and Hemidesmosomal Proteins in Keratinocyte Migration and Wound Repair. Adv Wound Care (New Rochelle) (2014) 0.83
Kindlin-1 regulates integrin dynamics and adhesion turnover. PLoS One (2013) 0.82
Kindlin-2 directly binds actin and regulates integrin outside-in signaling. J Cell Biol (2016) 0.81
A novel tumor suppressor function of Kindlin-3 in solid cancer. Oncotarget (2014) 0.81
Intercellular adhesion molecule 1: recent findings and new concepts involved in mammalian spermatogenesis. Semin Cell Dev Biol (2013) 0.81
β1 integrins with individually disrupted cytoplasmic NPxY motifs are embryonic lethal but partially active in the epidermis. J Invest Dermatol (2013) 0.81
Zasp regulates integrin activation. J Cell Sci (2012) 0.80
Biophysical description of multiple events contributing blood leukocyte arrest on endothelium. Front Immunol (2013) 0.80
Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit. J Biol Chem (2014) 0.80
Crystallization and preliminary X-ray crystallographic analysis of the human kindlin-2 PH domain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.80
Kindlin-3 interacts with the ribosome and regulates c-Myc expression required for proliferation of chronic myeloid leukemia cells. Sci Rep (2015) 0.78
In PC3 prostate cancer cells ephrin receptors crosstalk to β1-integrins to strengthen adhesion to collagen type I. Sci Rep (2015) 0.77
Suppressor mutations suggest a surface on PAT-4 (Integrin-linked Kinase) that interacts with UNC-112 (Kindlin). J Biol Chem (2014) 0.76
Comparative studies of vertebrate Beta integrin genes and proteins: ancient genes in vertebrate evolution. Biomolecules (2011) 0.76
Efficient production and purification of recombinant murine kindlin-3 from insect cells for biophysical studies. J Vis Exp (2014) 0.75
Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation. J Cell Biol (2017) 0.75
Of Kindlins and Cancer. Discoveries (Craiova) (2016) 0.75
PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1. Immunol Cell Biol (2016) 0.75
KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage. J Invest Dermatol (2016) 0.75
Prognostic implications of Kindlin proteins in human osteosarcoma. Onco Targets Ther (2017) 0.75
An approach for exploring interaction between two proteins in vivo. Front Physiol (2014) 0.75
Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing. Int J Mol Med (2017) 0.75
The Extreme C-terminal Region of Kindlin-2 Is Critical to its Regulation of Integrin Activation. J Biol Chem (2017) 0.75
Leukocyte adhesion deficiency III - when integrins activation fails. J Clin Immunol (2014) 0.75
Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2008) 7.28
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell (2008) 5.02
ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol (2006) 4.64
Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med (2008) 4.55
The tail of integrins, talin, and kindlins. Science (2009) 4.51
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell (2006) 4.43
Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev (2009) 3.57
Kindlin-2 controls bidirectional signaling of integrins. Genes Dev (2008) 3.15
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell (2006) 3.10
Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med (2009) 2.85
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest (2008) 2.77
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev (2003) 2.68
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med (2006) 2.59
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments. Nat Cell Biol (2013) 2.52
Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat Cell Biol (2008) 2.46
Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities. Development (2004) 2.44
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med (2007) 2.43
The Kindlins: subcellular localization and expression during murine development. Exp Cell Res (2006) 2.36
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. Neuron (2003) 2.31
Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails. J Cell Sci (2009) 2.29
The integrin-actin connection, an eternal love affair. EMBO J (2003) 2.26
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev (2003) 2.21
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell (2010) 2.17
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J (2009) 2.10
Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Mol Cell Biol (2005) 2.10
The role of laminin in embryonic cell polarization and tissue organization. Dev Cell (2003) 2.05
Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood (2010) 2.04
Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance. Development (2004) 2.04
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron (2007) 2.01
Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell (2007) 2.00
Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin. Cell Stem Cell (2008) 1.98
Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice. Circ Res (2002) 1.96
Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO Rep (2011) 1.96
Integrins in invasive growth. J Clin Invest (2002) 1.96
The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr Opin Cell Biol (2008) 1.89
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol (2007) 1.81
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. PLoS Genet (2008) 1.78
ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med (2006) 1.75
Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proc Natl Acad Sci U S A (2003) 1.74
Genetic analysis of beta1 integrin "activation motifs" in mice. J Cell Biol (2006) 1.73
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol (2010) 1.72
Integrin trafficking regulated by Rab21 is necessary for cytokinesis. Dev Cell (2008) 1.70
Laminin: the crux of basement membrane assembly. J Cell Biol (2004) 1.69
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res (2008) 1.68
A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy. J Clin Invest (2008) 1.67
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood (2012) 1.64
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol (2007) 1.63
Integrin-linked kinase regulates chondrocyte shape and proliferation. EMBO Rep (2003) 1.63
Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB J (2005) 1.61
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest (2014) 1.59
Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. J Exp Med (2009) 1.59
Cylindroma as tumor of hair follicle origin. J Invest Dermatol (2006) 1.56
Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature (2009) 1.55
Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol (2007) 1.53
Targeted disruption of the murine zyxin gene. Mol Cell Biol (2003) 1.51
Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail. Nat Cell Biol (2012) 1.48
Cartilage oligomeric matrix protein-deficient mice have normal skeletal development. Mol Cell Biol (2002) 1.48
Genetic analyses of integrin signaling. Cold Spring Harb Perspect Biol (2011) 1.46
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. Nature (2009) 1.45
Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability. Circ Res (2008) 1.43
Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity (2002) 1.38
Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape. J Cell Sci (2008) 1.38
Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts. Dev Biol (2006) 1.37
Regulation of neural progenitor proliferation and survival by beta1 integrins. J Cell Sci (2005) 1.34
PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage. J Cell Sci (2005) 1.34
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. J Cell Biol (2009) 1.33
Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function. EMBO J (2007) 1.32
Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest (2013) 1.32
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption. J Cell Biol (2011) 1.32
Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Mol Cell Biol (2002) 1.31
Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. FASEB J (2003) 1.28
Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci U S A (2009) 1.27
beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development (2009) 1.27
Integrin-linked kinase: integrin's mysterious partner. Curr Opin Cell Biol (2004) 1.27
Integrins are required for the differentiation of visceral endoderm. J Cell Sci (2009) 1.26
Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes. J Cell Sci (2006) 1.24
Protein kinase G controls brown fat cell differentiation and mitochondrial biogenesis. Sci Signal (2009) 1.24
Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage. J Cell Biol (2008) 1.24
The mechanism of kindlin-mediated activation of integrin αIIbβ3. Curr Biol (2013) 1.22
Mechanosensitivity and compositional dynamics of cell-matrix adhesions. EMBO Rep (2013) 1.22
Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. J Cell Sci (2005) 1.22
CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J (2009) 1.21
Analysis of integrin functions in peri-implantation embryos, hematopoietic system, and skin. Methods Enzymol (2007) 1.21
Kindlin-1 enhances axon growth on inhibitory chondroitin sulfate proteoglycans and promotes sensory axon regeneration. J Neurosci (2012) 1.21
The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain. Gene Expr Patterns (2003) 1.21
Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision. PLoS Biol (2007) 1.20
Mechanoinduction of lymph vessel expansion. EMBO J (2011) 1.19
Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation. J Cell Sci (2009) 1.19
Profilin 1 is required for abscission during late cytokinesis of chondrocytes. EMBO J (2009) 1.19
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. J Exp Med (2012) 1.18
Adult murine hematopoiesis can proceed without beta1 and beta7 integrins. Blood (2006) 1.16
PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions. Exp Cell Res (2003) 1.16
Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Dev Biol (2007) 1.16
Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation. EMBO Mol Med (2012) 1.16
Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling. EMBO J (2009) 1.15
Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration. Oncogene (2003) 1.14
Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis. Development (2011) 1.13
None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion. Dev Biol (2003) 1.13