Published in Nat Rev Drug Discov on March 01, 2008
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Ascertainment biases in SNP chips affect measures of population divergence. Mol Biol Evol (2010) 2.56
Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases. Am J Epidemiol (2009) 2.15
Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population. Proc Natl Acad Sci U S A (2009) 1.51
New approaches to establish genetic causality. Trends Cardiovasc Med (2015) 1.41
Analytical methods for inferring functional effects of single base pair substitutions in human cancers. Hum Genet (2009) 1.39
A novel generalized ridge regression method for quantitative genetics. Genetics (2013) 1.36
Marker selection for genetic case-control association studies. Nat Protoc (2009) 1.12
Determinants of renal disease variability in ADPKD. Adv Chronic Kidney Dis (2010) 1.11
Diabetes and its comorbidities--where East meets West. Nat Rev Endocrinol (2013) 0.99
Next-generation community genetics for low- and middle-income countries. Genome Med (2012) 0.91
Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines. BMC Med Genomics (2011) 0.90
Systems genetics for drug target discovery. Trends Pharmacol Sci (2011) 0.86
Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes? Alcohol Clin Exp Res (2009) 0.85
New tools for functional genomic analysis. Drug Discov Today (2009) 0.84
Genetic evidence supporting the association of protease and protease inhibitor genes with inflammatory bowel disease: a systematic review. PLoS One (2011) 0.82
Progress toward personalized medicine for glaucoma. Expert Rev Ophthalmol (2009) 0.80
Characterization of schizophrenia adverse drug interactions through a network approach and drug classification. Biomed Res Int (2013) 0.79
In silico genotyping of the maize nested association mapping population. Mol Breed (2010) 0.79
Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Cancer Epidemiol Biomarkers Prev (2009) 0.79
The impact of phenocopy on the genetic analysis of complex traits. PLoS One (2010) 0.76
Relevant Networks involving the p53 Signalling Pathway in Renal Cell Carcinoma. Int J Biomed Sci (2011) 0.75
Genetic polymorphisms in the androgen metabolism pathway and risk of prostate cancer in low incidence Malaysian ethnic groups. Int J Clin Exp Med (2015) 0.75
Targeting Anti-Cancer Active Compounds: Affinity-Based Chromatographic Assays. Curr Pharm Des (2016) 0.75
Early Diagnosis of Sepsis: Is an Integrated Omics Approach the Way Forward? Mol Diagn Ther (2017) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
A haplotype map of the human genome. Nature (2005) 105.70
dbSNP: the NCBI database of genetic variation. Nucleic Acids Res (2001) 76.97
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet (1995) 49.77
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature (2001) 28.24
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet (2001) 22.46
Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science (2004) 21.65
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet (2007) 19.18
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
Unravelling the pathogenesis of inflammatory bowel disease. Nature (2007) 18.52
Searching for genetic determinants in the new millennium. Nature (2000) 17.50
A comprehensive review of genetic association studies. Genet Med (2002) 16.75
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet (2003) 16.51
Replication validity of genetic association studies. Nat Genet (2001) 16.30
On the allelic spectrum of human disease. Trends Genet (2001) 16.26
Replicating genotype-phenotype associations. Nature (2007) 16.11
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet (2006) 15.14
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet (2007) 14.37
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat Genet (2003) 13.60
A common variant associated with prostate cancer in European and African populations. Nat Genet (2006) 13.47
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A (2005) 13.44
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet (2007) 11.62
Most rare missense alleles are deleterious in humans: implications for complex disease and association studies. Am J Hum Genet (2007) 10.92
Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet (2007) 10.81
Population stratification and spurious allelic association. Lancet (2003) 10.53
Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci U S A (2000) 10.27
The allelic architecture of human disease genes: common disease-common variant...or not? Hum Mol Genet (2002) 10.08
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet (2007) 9.88
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet (2006) 9.56
Association study designs for complex diseases. Nat Rev Genet (2001) 8.91
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 8.65
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet (2007) 8.63
Haplotype variation and linkage disequilibrium in 313 human genes. Science (2001) 8.52
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet (2007) 8.50
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet (2006) 8.33
Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature (2007) 8.03
Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet (2006) 7.90
Large upward bias in estimation of locus-specific effects from genomewide scans. Am J Hum Genet (2001) 7.53
A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. J Clin Psychiatry (2007) 7.23
A common genetic risk factor for colorectal and prostate cancer. Nat Genet (2007) 7.11
Schizophrenia: a common disease caused by multiple rare alleles. Br J Psychiatry (2007) 7.00
A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry (2007) 6.72
Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med (2007) 6.47
Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet (2002) 6.46
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet (2006) 6.39
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
A genetic risk factor for periodic limb movements in sleep. N Engl J Med (2007) 5.77
Medical sequencing at the extremes of human body mass. Am J Hum Genet (2007) 5.61
Population genetics--making sense out of sequence. Nat Genet (1999) 5.28
On the advantage of haplotype analysis in the presence of multiple disease susceptibility alleles. Genet Epidemiol (2002) 5.17
Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Am J Hum Genet (2005) 5.00
Guilt beyond a reasonable doubt. Nat Genet (2007) 4.56
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet (2007) 4.54
Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med (2006) 3.75
Common Kibra alleles are associated with human memory performance. Science (2006) 3.30
Regulatory polymorphisms underlying complex disease traits. J Mol Med (Berl) (2004) 3.22
Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. Am J Hum Genet (2005) 3.19
Coding single-nucleotide polymorphisms associated with complex vs. Mendelian disease: evolutionary evidence for differences in molecular effects. Proc Natl Acad Sci U S A (2004) 3.03
Haplotype block structure and its applications to association studies: power and study designs. Am J Hum Genet (2002) 2.88
TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. J Biol Chem (2004) 2.84
Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study. Circulation (2007) 2.82
Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element. Hum Mol Genet (2003) 2.81
Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Hum Mol Genet (2007) 2.73
Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region. Diabetes (2004) 2.52
Drinking from the fire hose--statistical issues in genomewide association studies. N Engl J Med (2007) 2.49
A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease. Arterioscler Thromb Vasc Biol (2007) 2.47
The Type 1 Diabetes Genetics Consortium. Ann N Y Acad Sci (2006) 2.22
The use of pedigree, sib-pair and association studies of common diseases for genetic mapping and epidemiology. Nat Genet (2004) 2.16
Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study. Diabetes (2007) 2.03
CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med (2005) 2.01
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. Proc Natl Acad Sci U S A (2007) 1.95
Identification of four gene variants associated with myocardial infarction. Am J Hum Genet (2005) 1.89
Diabetes and risk of prostate cancer in a prospective cohort of US men. Am J Epidemiol (2005) 1.69
Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population. Mol Vis (2005) 1.62
Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework. Mol Psychiatry (2005) 1.58
Conjuring SNPs to detect associations. Nat Genet (2007) 1.57
Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. J Hum Genet (2007) 1.55
KIBRA gene variants are associated with episodic memory in healthy elderly. Neurobiol Aging (2007) 1.46
Nonreplication in genetic association studies of obesity and diabetes research. J Nutr (2003) 1.41
Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C. Gastroenterology (2006) 1.38
Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk. Neurobiol Aging (2007) 1.23
Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study. PLoS Genet (2006) 1.16
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Carrier testing for severe childhood recessive diseases by next-generation sequencing. Sci Transl Med (2011) 8.20
A highly annotated whole-genome sequence of a Korean individual. Nature (2009) 6.91
The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature (2011) 4.94
Expanding the genetic map of maize with the intermated B73 x Mo17 (IBM) population. Plant Mol Biol (2002) 4.28
Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature (2010) 3.90
Rate and pattern of mutation at microsatellite loci in maize. Mol Biol Evol (2002) 3.03
Legume genome evolution viewed through the Medicago truncatula and Lotus japonicus genomes. Proc Natl Acad Sci U S A (2006) 2.61
C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response. PLoS Negl Trop Dis (2010) 2.29
Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum. PLoS One (2008) 2.22
Genome-wide association genetics of an adaptive trait in lodgepole pine. Mol Ecol (2012) 2.12
Management of High-Throughput DNA Sequencing Projects: Alpheus. J Comput Sci Syst Biol (2008) 1.85
Genome sequencing and mapping reveal loss of heterozygosity as a mechanism for rapid adaptation in the vegetable pathogen Phytophthora capsici. Mol Plant Microbe Interact (2012) 1.59
Legume genomes: more than peas in a pod. Curr Opin Plant Biol (2003) 1.56
Legumes as a model plant family. Genomics for food and feed report of the Cross-Legume Advances Through Genomics Conference. Plant Physiol (2005) 1.52
Whole-genome nucleotide diversity, recombination, and linkage disequilibrium in the model legume Medicago truncatula. Proc Natl Acad Sci U S A (2011) 1.46
The Legume Information System (LIS): an integrated information resource for comparative legume biology. Nucleic Acids Res (2005) 1.43
Chromosome-level homeology in paleopolyploid soybean (Glycine max) revealed through integration of genetic and chromosome maps. Genetics (2005) 1.33
Meiosis-specific gene discovery in plants: RNA-Seq applied to isolated Arabidopsis male meiocytes. BMC Plant Biol (2010) 1.25
Databases and information integration for the Medicago truncatula genome and transcriptome. Plant Physiol (2005) 1.23
Comparative genomics of the core and accessory genomes of 48 Sinorhizobium strains comprising five genospecies. Genome Biol (2013) 1.18
Identification of diagnostic biomarkers for infection in premature neonates. Mol Cell Proteomics (2008) 1.18
Candidate genes and genetic architecture of symbiotic and agronomic traits revealed by whole-genome, sequence-based association genetics in Medicago truncatula. PLoS One (2013) 1.08
Comparative genomic analysis of sequences sampled from a small region on soybean (Glycine max) molecular linkage group G. Genome (2002) 0.99
Population genomics of the facultatively mutualistic bacteria Sinorhizobium meliloti and S. medicae. PLoS Genet (2012) 0.97
Phylogenetic signal variation in the genomes of Medicago (Fabaceae). Syst Biol (2013) 0.93
Nested association mapping for identification of functional markers. Genetics (2010) 0.88
Genome-wide association studies: progress in identifying genetic biomarkers in common, complex diseases. Biomark Insights (2007) 0.88
Transcriptome profiling of cytokinin and auxin regulation in tomato root. J Exp Bot (2013) 0.87
Population-based study of genetic variation in individuals with autism spectrum disorders from Croatia. BMC Med Genet (2010) 0.86
Genome-wide association study for oat (Avena sativa L.) beta-glucan concentration using germplasm of worldwide origin. Theor Appl Genet (2012) 0.86
Genome Sequence of Non-O1 Vibrio cholerae PS15. Genome Announc (2013) 0.86
The transcriptome landscape of early maize meiosis. BMC Plant Biol (2014) 0.84
Transcriptome analysis of cytokinin response in tomato leaves. PLoS One (2013) 0.83
High-density genome-wide association mapping implicates an F-box encoding gene in Medicago truncatula resistance to Aphanomyces euteiches. New Phytol (2013) 0.83
Next-generation transcriptome sequencing, SNP discovery and validation in four market classes of peanut, Arachis hypogaea L. Mol Genet Genomics (2015) 0.82
Characterization of a set of novel meiotically-active promoters in Arabidopsis. BMC Plant Biol (2012) 0.81
Family-based association mapping in crop species. Theor Appl Genet (2013) 0.80
Analysis of the transcriptomes downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch signaling pathways in Drosophila melanogaster. PLoS One (2012) 0.80
In silico genotyping of the maize nested association mapping population. Mol Breed (2010) 0.79
Improved Hybrid Genome Assemblies of Two Strains of Bacteroides xylanisolvens, SD_CC_1b and SD_CC_2a, Obtained Using Illumina and 454 Sequencing Technologies. Genome Announc (2014) 0.75
A transcriptomic approach to elucidate the physiological significance of human cytochrome P450 2S1 in bronchial epithelial cells. BMC Genomics (2013) 0.75
Leveraging model legume information to find candidate genes for soybean sudden death syndrome using the legume information system. Methods Mol Biol (2007) 0.75
Genetic Characterization of the Soybean Nested Association Mapping Population. Plant Genome (2017) 0.75